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2022

Enzyme engineering enables inversion of substrate stereopreference of the halogenase WelO5*. M. Voss, S. Hüppi, D. Schaub, T. Hayashi, M. Ligibel, E. Sager, K. Schroer, R. Snajdrova & R. M. U. Buller. ChemCatChem October 24, 2022. https://doi.org/10.1002/cctc.202201115

Development of an Ene Reductase-Based Biocatalytic Process for the Production of Flavor Compounds. A. Papadopoulou, C. Peters, S. Borchert, K. Steiner & R. Buller. Org. Process Res. Dev. June 14, 2022. https://pubs.acs.org/doi/10.1021/acs.oprd.2c00096

Engineering Fe(III)/α-Ketoglutarate-Dependent Halogenases and Desaturases. A. Papadopoulou, F. Meyer & R. Buller. Biochemistry April 21, 2022. https://doi.org/10.1021/acs.biochem.2c00115

Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens. J. Büchler, S. Honda Malca, D. Patsch, M. Voss, N. J. Turner, U. T. Bornscheuer, O. Allemann, C. Le Chapelain, A. Lumbroso, O. Loiseleur & R. Buller. Nature Communications. January 18, 2022. https://doi.org/10.1038/s41467-022-27999-1

2021

Asymmetric Cation-Olefin Monocyclization by Engineered Squalene-Hopene Cyclases. M. Eichenberger, S. Hüppi, D. Patsch, N. Aeberli, R. Berweger, S. Dossenbach, E. Eichhorn, F. Flachsmann, L. Hortencio, F. Voirol, S. Vollenweider, U. Bornscheuer, R. M. U. Buller. Angewandte Chemie. August 4, 2021. https://doi.org/10.1002/anie.202108037

“Re-programming and optimization of a L-proline cis-4-hydroxylase for the cis-3-halogenation of its native substrate“ A. Papadopoulou, J. Meierhofer, F. Meyer, T. Hayashi, S. Schneider, E. Sager, R. M. U. Buller.ChemCatChem. June 7, 2021.https://doi.org/10.1002/cctc.202100591

“Modulating Chemoselectivity in a Fe(II)/α-Ketoglutarate-Dependent Dioxygenase for the Oxidative Modification of a Nonproteinogenic Amino Acid” F. Meyer, R. Frey, M.Ligibel, E. Sager, K. Schroer, R. Snajdrova, R. Buller. ACS Catalysis. May 10, 2021. https://doi.org/10.1021/acscatal.1c00678

2020

“Multi‐faceted set‐up of a diverse ketoreductase library enables the synthesis of pharmaceutically‐relevant secondary alcohols” M. Voss, R. Küng, T. Hayashi, M. Jonczyk, M. Niklaus, H. Iding, D. Wetzl, R. M. U. Buller. ChemCatChem. December 11, 2020. https://doi.org/10.1002/cctc.202001871

Biocatalysis in the Swiss Manufacturing Environment” K. Hecht, H.-P. Meyer, R. Wohlgemuth, R. Buller. Catalysts. December 4, 2020.  https://doi.org/10.3390/catal10121420

“Characterization of the novel Ene Reductase Ppo-Er1 from Paenibacillus polymyxa” D. Aregger, C. Peters, R. M. Buller. Catalysts. February 19, 2020. doi.org/10.3390/catal10020254.

“Exploring the biocatalytic potential of Fe/α-ketoglutarate dependent halogenases” M. Voss, S. H. Malca, R. Buller. Chemistry - A European Journal. January 22, 2020. doi.org/10.1002/chem.201905752.

2019

“Recent Advances in Flavin-Dependent Halogenase Biocatalysis: Sourcing, Engineering, and Application” J. Büchler, A. Papadopoulou, R. Buller. Catalysts. December 5, 2019. https://doi.org/10.3390/catal9121030

“Evolved Aliphatic Halogenases Enable Regiocomplementary C-H Functionalization of an Added-Value Chemical” T. Hayashi, M. Ligibel, E. Sager, M. Voss, J. Hunziker, K. Schroer, R. Snajdrova, R. Buller. Angewandte Chemie. October 7, 2019. doi.org/10.1002/anie.201907245.

Enzymatic PET Degradation A. Papadopoulou, K. Hecht, R. Buller. CHIMIA. September 2019. doi.org/10.2533/chimia.2019.743.

Industrial Application of 2-Oxoglutarate-Dependent Oxgenases C. Peters, R. M. Buller. Catalysts February 28, 2019. doi.org/10.3390/catal9030221.

Novel Old Yellow Enzyme Subclasses C. Peters, D. Frasson, M. Sievers, R. Buller. ChemBioChem. Feb. 2019. 13 February 13, 2019. doi.org/10.1002/cbic.201800770

Linear enzyme cascade for the production of (-)-iso-isopulegolC. Peters, R. Buller. Zeitung für Naturforschung C. January 11, 2019.  doi.org/10.1515/znc-2018-0146

2018

Directed evolution of carbon-hydrogen bond activating enzymes R. Frey, T. Hayashi, R. M. Buller. Current Opinion in Biotechnology. December 21, 2018. doi.org/10.1016/j.copbio.2018.12.004

Buchkapitel

Ene-Reductases in Pharmaceutical ChemistryK. Hecht, R. Buller. Pharmaceutical Biocatalysis: Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients December 2019.

An Appreciation of Biocatalysis in the Swiss Manufacturing Environment” R. Buller, K. Hecht, M. A. Mirata and H-P. Meyer. Biocatalysis: An Industrial Perspective. November 9, 2017

Videos

Sonstiges

"Biocatalysis and biosynthesis(PDF 57,1 KB)" R. Buller. Technology Outlook – SATW. April 2021.

"Biocatalytic Potential of alpha alpha-Ketoglutarate Dependent Dioxygenases(PDF 529,4 KB)" J. Taubitz ÁJour September 2021.

"Engineering of Epimerases towards Pharmaceutical Applications(PDF 605,8 KB)" R. Giger ÁJour September 2021.

Biokatalyse und Biosynthese - Nachhaltige chemische Produktion R. Buller. Technology Outlook – SATW. April 2019.

“10th Wädenswil Day of Life Sciences Hosts 2nd CCBIO Symposium Industrial Biocatalysis”. K. Hecht. Chimia. September 2018. doi.org/10.2533/chimia.2018.661.