Prof. Dr. Rebecca Buller

Prof. Dr. Rebecca Buller

Prof. Dr. Rebecca Buller
ZHAW Life Sciences und Facility Management
Einsiedlerstrasse 31
8820 Wädenswil

+41 (0) 58 934 54 38
rebecca.buller@zhaw.ch

Persönliches Profil

Tätigkeit an der ZHAW als

Head of Competence Center for Biocatalysis
Head of Center Biocatalysis and Processtechnology
Lecturer Biochemical Engineering

Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse

Biocatalysis
Biotransformation
Process Development
Process Scale-Up
Enzyme Engineering
Directed Evolution

Aus- und Fortbildung

11/2006 – 02/2011
Ph.D. studies, Institute of Organic Chemistry
Department of Chemistry and Applied Biosciences
ETH Zurich, Switzerland
Supervisor Prof. Dr. Donald Hilvert
“Directed Evolution of Artificial Enzymes”

09/2006
Chemistry Diploma, Institute of Biochemistry
Westfälische Wilhelms Universität, Münster, Germany
Supervisor Prof. Dr. Hans-Joachim Galla
“Expression and functional characterization of an ABC- transporter in vitro"

11/2004 – 11/2005
Visiting Researcher, Department of Chemistry and Biochemistry
University of California, Santa Barbara, USA
Supervisors Prof. Dr. Peter Ford and Prof. Dr. Martin Sagermann
“S-Nitrosation of proteins: Investigation of functional and structural modifications”
“Engineering of a biological NO sensor”

10/2001 – 09/2006
Undergradutae and graduate studies of Chemistry
Westfälische Wilhelms Universität, Münster, Germany

Beruflicher Werdegang

Since 10/2015
Head of Competence Center for Biocatalysis
Lecturer for Biochemical Engineering
ZHAW - University of Applied Sciences, Wädenswil, Switzerland

10/2014 - 09/2015
Senior Scientist, Laboratory Head, Firmenich SA, Geneva, Switzerland
Development of Biocatalytic Processes

05/2011 - 09/2014
Scientist, Laboratory Head, Firmenich SA, Geneva, Switzerland
Development of Biocatalytic Processes

Publikationen vor Tätigkeit an der ZHAW

Precision is essential for efficient catalysis in an evolved Kemp eliminase
Rebecca Blomberg, Hajo Kries, Daniel Pinkas, Per Mittl, Markus Grütter, Heidi Privett, Stephen Mayo, and Donald Hilvert
Nature 503, 418-421 (2013)

De novo enzymes by computational design
Hajo Kries*, Rebecca Blomberg*, and Donald Hilvert
Curr Opin Chem Biol. 17, 221-8 (2013) (* joint first authors)

Computational design of catalytic dyads and oxyanion holes for ester hydrolysis
Florian Richter*, Rebecca Blomberg*, Sagar D. Khare, Gert Kiss, Alexandre P. Kuzin, Adam J. T. Smith, Jasmine Gallaher, Zbigniew Pianowski, Roger C. Helgeson, Alexej Grjasnow, Rong Xiao, Jayaraman Seetharaman, Min Su, Sergey Vorobiev, Scott Lew, Farhad Forouhar, Gregory J. Kornhaber, John F. Hunt, Gaetano T. Montelione, Liang Tong, K. N. Houk, Donald Hilvert, and David Baker
J Am Chem Soc. 134, 16197-206 (2012) (* joint first authors)

Iterative approach to computational enzyme design
Heidi K. Privett, Gert Kiss, Toni M. Lee, Rebecca Blomberg, Roberto A. Chica, Leonard M. Thomas, Donald Hilvert, Kendall N. Houk, and Stephen L. Mayo
Proc Natl Acad Sci USA 109, 3790-5 (2012)

Design of a Highly Specific and Noninvasive Biosensor
Suitable for Real-Time in vivo Imaging of Mercury (II) Uptake
Richard Chapleau, Rebecca Blomberg, Peter Ford, and Martin Sagermann
Protein Science 17, 614-622 (2008)