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Excelzyme: A Swiss University−Industry Collaboration for Accelerated Biocatalyst Development. S. H. Malca, P. Stockinger, N. Duss, Daniela Milbredt, H. Iding & R. Buller. CHIMIA (2024) March 27. https://doi:10.2533/chimia.2024.108.

Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor. S. Honda Malca, N. Duss, J. Meierhofer, D. Patsch, M. Niklaus, S. Reiter, S. P. Hanlon, D. Wetzl, B. Kuhn, H. Iding & R. Buller. Communications Chemistry (2024) February 28.


From nature to industry: Harnessing enzymes for biocatalysis. R. Buller, S. Lutz, R. J. Kazlauskas, R. Snajdrova, J. C. Moore & U. T. Bornscheuer. Science (2023) November 24.

LibGENiE – A bioinformatic pipeline for the design of information-enriched enzyme libraries. D. Patsch, M. Eichenberger, M. Voss, U. T. Bornscheuer & R. M. Buller. Computational and Structural Biotechnology Journal 14 September 2023.

The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis. M. Eichenberger, T. Schwander, S. Hüppi, J. Kreuzer, P. R. E. Mittl, F. Peccati, G. Jiménez-Osés, M. Naesby & R. M. Buller. Nature Catalysis August 31, 2023.

Advances in Noncanonical Amino Acid Incorporation for Enzyme Engineering Applications. S. Giger & R. Buller. Chimia June 28th, 2023.

Improving Enzyme Fitness with Machine Learning. D. Patsch & R. Buller. Chimia March 29th, 2023.

Halogenases for the synthesis of small molecules. E. Hegarty, J. Büchler & R. Buller. Current Opinion in Green and Sustainable Chemistry, February 10, 2023.


A Collaborative Journey towards the Late‐Stage Functionalization of Added‐Value Chemicals Using Engineered Halogenases. J. Büchler, E. Hegarty, K. Schroer, R. Snajdrova, N. J. Turner, O. Loiseleur, R. Buller & C. Le Chapelain. Helvetica Chimica Acta November 2022. https://10.1002/hlca.202200128

Enzyme engineering enables inversion of substrate stereopreference of the halogenase WelO5*. M. Voss, S. Hüppi, D. Schaub, T. Hayashi, M. Ligibel, E. Sager, K. Schroer, R. Snajdrova & R. M. U. Buller. ChemCatChem October 24, 2022.

Development of an Ene Reductase-Based Biocatalytic Process for the Production of Flavor Compounds. A. Papadopoulou, C. Peters, S. Borchert, K. Steiner & R. Buller. Org. Process Res. Dev. June 14, 2022.

Engineering Fe(III)/α-Ketoglutarate-Dependent Halogenases and Desaturases. A. Papadopoulou, F. Meyer & R. Buller. Biochemistry April 21, 2022.

Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens. J. Büchler, S. Honda Malca, D. Patsch, M. Voss, N. J. Turner, U. T. Bornscheuer, O. Allemann, C. Le Chapelain, A. Lumbroso, O. Loiseleur & R. Buller. Nature Communications. January 18, 2022.


Asymmetric Cation-Olefin Monocyclization by Engineered Squalene-Hopene Cyclases. M. Eichenberger, S. Hüppi, D. Patsch, N. Aeberli, R. Berweger, S. Dossenbach, E. Eichhorn, F. Flachsmann, L. Hortencio, F. Voirol, S. Vollenweider, U. Bornscheuer, R. M. U. Buller. Angesandte Chemie. August 4, 2021.

“Re-programming and optimization of a L-proline cis-4-hydroxylase for the cis-3-halogenation of its native substrate“ A. Papadopoulou, J. Meierhofer, F. Meyer, T. Hayashi, S. Schneider, E. Sager, R. M. U. Buller. ChemCatChem. June 7, 2021.

“Modulating Chemoselectivity in a Fe(II)/α-Ketoglutarate-Dependent Dioxygenase for the Oxidative Modification of a Nonproteinogenic Amino Acid” F. Meyer, R. Frey, M.Ligibel, E. Sager, K. Schroer, R. Snajdrova, R. Buller. ACS Catalysis. May 10, 2021.


“Multi‐faceted set‐up of a diverse ketoreductase library enables the synthesis of pharmaceutically‐relevant secondary alcohols” M. Voss, R. Küng, T. Hayashi, M. Jonczyk, M. Niklaus, H. Iding, D. Wetzl, R. M. U. Buller. ChemCatChem. December 11, 2020.

Biocatalysis in the Swiss Manufacturing Environment” K. Hecht, H.-P. Meyer, R. Wohlgemuth, R. Buller. Catalysts. December 4, 2020.

“Characterization of the novel Ene Reductase Ppo-Er1 from Paenibacillus polymyxa” D. Aregger, C. Peters, R. M. Buller. Catalysts. February 19, 2020.

“Exploring the biocatalytic potential of Fe/α-ketoglutarate dependent halogenases” M. Voss, S. H. Malca, R. Buller. Chemistry - A European Journal. January 22, 2020.


“Recent Advances in Flavin-Dependent Halogenase Biocatalysis: Sourcing, Engineering, and Application” J. Büchler, A. Papadopoulou, R. Buller. Catalysts. December 5, 2019.

“Evolved Aliphatic Halogenases Enable Regiocomplementary C-H Functionalization of an Added-Value Chemical” T. Hayashi, M. Ligibel, E. Sager, M. Voss, J. Hunziker, K. Schroer, R. Snajdrova, R. Buller. Angewandte Chemie. October 7, 2019.

Enzymatic PET Degradation A. Papadopoulou, K. Hecht, R. Buller. CHIMIA. September 2019.

Industrial Application of 2-Oxoglutarate-Dependent Oxgenases C. Peters, R. M. Buller. Catalysts February 28, 2019.

Novel Old Yellow Enzyme Subclasses C. Peters, D. Frasson, M. Sievers, R. Buller. ChemBioChem. Feb. 2019. 13 February 13, 2019.

Linear enzyme cascade for the production of (-)-iso-isopulegolC. Peters, R. Buller. Zeitung für Naturforschung C. January 11, 2019.


Directed evolution of carbon-hydrogen bond activating enzymes R. Frey, T. Hayashi, R. M. Buller. Current Opinion in Biotechnology. December 21, 2018.


Ene-Reductases in Pharmaceutical ChemistryK. Hecht, R. Buller. Pharmaceutical Biocatalysis: Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients December 2019.

An Appreciation of Biocatalysis in the Swiss Manufacturing Environment” R. Buller, K. Hecht, M. A. Mirata and H-P. Meyer. Biocatalysis: An Industrial Perspective. November 9, 2017



"Biocatalysis and biosynthesis(PDF 57,6 KB)" R. Buller. Technology Outlook – SATW. April 2021.

"Biocatalytic Potential of alpha alpha-Ketoglutarate Dependent Dioxygenases(PDF 529,4 KB)" J. Taubitz ÁJour September 2021. (in German)

"Engineering of Epimerases towards Pharmaceutical Applications(PDF 472,4 KB)" R. Giger. ÁJour September 2021. (in German)

Biokatalyse und Biosynthese - Nachhaltige chemische Produktion R. Buller. Technology Outlook – SATW. April 2019.

“10th Wädenswil Day of Life Sciences Hosts 2nd CCBIO Symposium Industrial Biocatalysis”. K. Hecht. Chimia. September 2018.