Tissue Engineering for Drug Development and Substance Testing
The competence center TEDD is led by Prof. Dr. Michael Raghunath.
Michael Raghunath MD PhD is a physician-scientist heading the Center for Cell Biology and Tissue Engineering at the Institute for Chemistry and Biotechnology at the Zürich University of Applied Sciences. Before that (2003-2016) he was a tenured Associate Professor jointly appointed between the Departments of Biomedical Engineering (Faculty of Engineering) and Biochemistry (Yong Loo Lin School of Medicine) at the National University of Singapore (NUS). He still holds a joint position with the Institute for Medical Biology (IMB), A*STAR. His basic and translational research experience spans more than 25 yrs. during which he became an internationally distinguished scientist in the field of matrix biology (pathobiochemistry of collagens and elastic microfibrils) and skin biology (wound repair, cornification disorders). Developing macromolecular crowding as the principle in cell biology, he has created a novel field in Tissue Engineering to build cell-specific and lineage-directing microenvironments. Dr Raghunath was trained in immunology (1988-1990; University of Heidelberg), matrix biology and wound healing (postdoc at University of Zurich, Switzerland, 1990-1995). His independent career started 1995 with a professorial qualification grant from the German Science Foundation at the University of Muenster. After clinical training in dermatology, in Muenster from 1997-2000, he joined Dr Suwelack Skin& HealthCare AG as R&D director to position the company in the wound care market. From 2005-2009 he was Deputy Head Research (Bioengineering) and from 2005-2008 Chair of the Graduate Programme in Bioengineering in the NUS Graduate School of Integrative Sciences & Engineering. Recent Awards and Honours include SMART Faculty Fellowship 2013, 2014, ETS Walton Visiting Fellow at National University of Ireland, Galway, 2010/11; Raine Visiting Professorship at UWA 2008/09. Michael is the member of TERMIS (Councilmember Asia-Pacific Chapter 2011-2013); Biomedical Engineering Society Singapore, Scientific Advisory Board of the German Marfan Foundation; Biophysical Society; Editorial Boards: Journal of Tissue Engineering and Regenerative Medicine, Frontiers Bioengineering and Biotechnology.
His current research interests (see previous website of the Tissue Modulation Laboratory at NUS; www.tissuemodulation.com) are (1) Tissue Modulating Materials (2) application of macromolecular crowding for tissue engineering and cell based therapies (3) white and brown adipose tissue engineering (4) platform to differentiate pericytes from peripheral blood.
Dr Katarzyna Kopanska is responsible for project management and science communication.
Katarzyna holds a position of Scientific Associate and Project Manager at the Institute of Chemistry and Biotechnology at ZHAW. She is specialized in interdisciplinary projects and has extensive expertise in 3D models generation and analysis. Katarzyna has also expertise in digital science communication, community building and professional networking. Katarzyna holds PhD from the University of Cambridge (Hughes Hall), UK in Life Sciences completed at the Medical Research Council, UK. She did her postdoctoral projects at the Scripps Institution of Oceanography in La Jolla, CA, USA and cancer research centre Institute Curie in Paris, France. She completed the Master of Science in Engineering in Biotechnology at the Warsaw University of Life Science (SGGW) in Poland. She also worked for the pharma company Bristol-Myers Squibb.
Ms Sandra Laternser is managing exhibitions during TEDD events and further supports the team in other tasks.
Sandra completed her BSc degree in microbiology in 2011 and her MSc degree in cell biology in 2013 at ZHAW in Wädenswil. During her Master thesis she worked together with InSphero and University Hospital Balgrist on bone cancer (osteosarcoma) 3D models for drug development. Currently she is working as Scientific Associate at the Institute of Chemistry and Biotechnology (ICBT) at ZHAW. She has extensive expertise in 3D models, especially in cancer microtissues and 3D bioprinting. Furthermore she is specialized in interdisciplinary projects.
TEDD is guided by the steering committee that consists of experienced academic and industrial professionals. Members of steering committee meet on the regular basis to identify milestones for TEDD.
Members of steering committee:
- Michael Raghunath, ICBT, ZHAW, Wädenswil
- Katharina Maniura, Empa, St. Gallen
- Jens Kelm, PreComb Therapeutics AG, Wädenswil
- Oliver Peter, Actelion, Allschwil
- Giuseppe Perale, IBI-S.A.,Mezzovico-Vira
Past members of the Steering Committee:
- Christoph Rindlisbacher, CELLnTEC, Bern
Steering committee is mentored by the international advisory board. The advisors are academic and industrial world recognized experts. The board is involved in defining well adapted strategies according to the international recognise needs and requirements with the final goal to implement 3D cell culture into routine application.
Members of the advisory board:
- Ursula Graf-Hausner, graf 3dcellculture
- Markus Ehrat, EK Biosciences GmbH
- Uwe Marx, TU Berlin
- Thomas Singer, F. Hoffmann-La Roche
- Marcus Textor, ETH Zürich
Past members of the advisory board:
- David W. Grainger, University of Utah