Prof. Dr. Lars Fieseler

ZHAW Life Sciences und Facility Management
Zentrum für Lebensmittelsicherheit und –qualitätsmanagement
Einsiedlerstrasse 31
8820 Wädenswil

+41 (0) 58 934 54 07
lars.fieseler@zhaw.ch

Persönliches Profil

Leitungsfunktion

Zentrumsleitung Zentrum für Lebensmittelsicherheit und Qualitätsmanagement
Schwerpunktleitung Zentrum für Phagentechnologien
Leitung Forschungsgruppe Lebensmittelmikrobiologie

Tätigkeit an der ZHAW

Dozent im Studiengang Lebensmitteltechnologie mit den Schwerpunkten Mikro- und Molekularbiologie

www.zhaw.ch/ilgi

Lehrtätigkeit in der Weiterbildung

Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse

Lebensmittelmikrobiologie
Isolation und Charakterisierung von Bakteriophagen zur Kontrolle pathogener Bakterien
Biologische Verfahren zur Haltbarmachung von Lebensmitteln
Nachweis pathogener Bakterien in Lebensmitteln

Beruflicher Werdegang

2013 Professor für Lebensmittelsicherheit und -qualität
2011 Leitung der Fachstelle Mikrobiologie am Institut für Lebensmittel- und Getränkeinnovation (ILGI) der Zürcher Hochschule für angewandte Wissenschaften (ZHAW)
2006-2011 ETH Zürich, Institut für Lebensmittel, Ernährung und Gesundheit
2006-2008 Feodor Lynen-Forschungsstipendium (Alexander von Humboldt-Stiftung)
2005 Promotion an der Julius-Maximilians-Universität Würzburg (Dr. rer. nat.)
2000 Diplom (Biologie) der Julius-Maximilians-Universität Würzburg

Mitglied in Netzwerken

Projekte

Publikationen

Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed

Desroche, Nicolas; De Oliveira, Déborah; Imhaus, Anne-Flore; Hupfeld, Mario; Fieseler, Lars,

2023.

Validation of N-Light™ salmonella risk test kit for detection of Salmonella spp. on environmental surfaces : AOAC Performance Tested MethodsSM 072204.

Journal of AOAC INTERNATIONAL.

Verfügbar unter: https://doi.org/10.1093/jaoacint/qsad017
Witte, Sander; Huijboom, Linda; Klamert, Silvia; van de Straat, Leoni; Hagens, Steven; Fieseler, Lars; de Vegt, Bert T.; van Mierlo, Joël T.,

2022.

Application of bacteriophages EP75 and EP335 efficiently reduces viable cell counts of Escherichia coli O157 on beef and vegetables.

Food Microbiology.

104(103978).

Verfügbar unter: https://doi.org/10.1016/j.fm.2022.103978
Knecht, Leandra E.; Heinrich, Nadine; Born, Yannick; Felder, Katja; Pelludat, Cosima; Loessner, Martin J.; Fieseler, Lars; et al.,

2022.

Bacteriophage S6 requires bacterial cellulose for Erwinia amylovora infection.

Environmental Microbiology.

24(8), S. 3436-3450.

Verfügbar unter: https://doi.org/10.1111/1462-2920.15973
Pacher, Nicola; Burtscher, Johanna; Johler, Sophia; Etter, Danai; Bender, Denisse; Fieseler, Lars; Domig, Konrad J.,

2022.

Ropiness in bread : a re-emerging spoilage phenomenon.

Foods.

11(19), S. 3021.

Verfügbar unter: https://doi.org/10.3390/foods11193021
Knecht, Leandra E.; Born, Yannick; Pelludat, Cosima; Pothier, Joël F.; Smits, Theo H. M.; Loessner, Martin J.; Fieseler, Lars,

2022.

Spontaneous resistance of Erwinia amylovora against bacteriophage Y2 affects infectivity of multiple phages.

Frontiers in Microbiology.

13(908346).

Verfügbar unter: https://doi.org/10.3389/fmicb.2022.908346
Larose, Delphine; Desroche, Nicolas; Reinau, Lukas; Hupfeld, Mario; Fieseler, Lars,

2021.

Validation of N-Light™ L. monocytogenes for detection of Listeria monocytogenes on environmental surfaces : AOAC Performance Tested Method℠ 122002.

Journal of AOAC INTERNATIONAL.

Verfügbar unter: https://doi.org/10.1093/jaoacint/qsab165
Pertics, Botond Zsombor; Szénásy, Dalma; Dunai, Dániel; Born, Yannick; Fieseler, Lars; Kovács, Tamás; Schneider, György,

2020.

Isolation of a novel lytic bacteriophage against a nosocomial methicillin-resistant Staphylococcus aureus belonging to ST45.

BioMed Research International.

2020(5463801), S. 1-10.

Verfügbar unter: https://doi.org/10.1155/2020/5463801
Ganz, Giverny; Reinau, Lukas; Imhaus, Anne Flore; Hupfeld, Mario; Fieseler, Lars,

2020.

AquaSparkTM : rapid environmental monitoring of Listeria monocytogenes.

Chimia.

74(10), S. 791-797.

Verfügbar unter: https://doi.org/10.2533/chimia.2020.791
Knecht, Leandra E.; Veljkovic, Marjan; Fieseler, Lars,

2020.

Diversity and function of phage encoded depolymerases.

Frontiers in Microbiology.

10(2949).

Verfügbar unter: https://doi.org/10.3389/fmicb.2019.02949
van Mierlo, Joël; Hagens, Steven; Witte, Sander; Klamert, Silvia; van de Straat, Leoni; Fieseler, Lars,

2019.

Complete genome sequences of escherichia coli phages vB_EcoM-EP75 and vB_EcoP-EP335.

Microbiology Resource Announcements.

8(16).

Verfügbar unter: https://doi.org/10.1128/MRA.00078-19
Born, Yannick; Knecht, Leandra E.; Eigenmann, Mirjam; Bolliger, Michel; Klumpp, Jochen; Fieseler, Lars,

2019.

A major-capsid-protein-based multiplex PCR assay for rapid identification of selected virulent bacteriophage types.

Archives of Virology.

164(3), S. 819-830.

Verfügbar unter: https://doi.org/10.1007/s00705-019-04148-6
Roth-Konforti, Michal; Green, Ori; Hupfeld, Mario; Fieseler, Lars; Heinrich, Nadine; Ihssen, Julian; Vorberg, Raffael; Wick, Lukas; Spitz, Urs; Shabat, Doron,

2019.

Ultrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probes.

Angewandte Chemie: International Edition.

58(30), S. 10361-10367.

Verfügbar unter: https://doi.org/10.1002/anie.201904719
Knecht, Leandra E.; Born, Yannick; Pothier, Joël F.; Loessner, Martin J.; Fieseler, Lars,

2018.

Complete genome sequences of erwinia amylovora phages vB_EamP-S2 and vB_EamM-Bue1.

Microbiology Resource Announcements.

7(3).

Verfügbar unter: https://doi.org/10.1128/MRA.00891-18
Buttimer, Colin; Born, Yannick; Lucid, Alan; Loessner, Martin J.; Fieseler, Lars; Coffey, Aidan,

2018.

Erwinia amylovora phage vB_EamM_Y3 represents another lineage of hairy myoviridae.

Research in Microbiology.

169(9), S. 505-514.

Verfügbar unter: https://doi.org/10.1016/j.resmic.2018.04.006
Born, Yannick; Fieseler, Lars; Thöny, Valentin; Leimer, Nadja; Duffy, Brion; Loessner, Martin J.,

2017.

Engineering of bacteriophages Y2::dpoL1-C and Y2::luxAB for efficient control and rapid detection of the fire blight pathogen, Erwinia amylovora.

Applied and Environmental Microbiology.

83(12), S. e00341-17.

Verfügbar unter: https://doi.org/10.1128/AEM.00341-17
Shen, Yang; Boulos, Samy; Sumrall, Eric; Gerber, Benjamin; Julian-Rodero, Alicia; Eugster, Marcel R.; Fieseler, Lars; Nyström, Laura; Ebert, Marc-Olivier; Loessner, Martin J.,

2017.

Structural and functional diversity inListeriacell wall teichoic acids.

Journal of Biological Chemistry.

292(43), S. 17832-17844.

Verfügbar unter: https://doi.org/10.1074/jbc.M117.813964
Schmitter, Sibylle; Fieseler, Lars; Klumpp, Jochen; Bertram, Ralph; Loessner, Martin J.,

2017.

TetR-dependent gene regulation in intracellular Listeria monocytogenes demonstrates the spatiotemporal surface distribution of ActA.

Molecular Microbiology.

105(3), S. 413-425.

Verfügbar unter: https://doi.org/10.1111/mmi.13706
Krapf, Tamara; Kuhn, Roger; Kauf, Peter; Gantenbein-Demarchi, Corinne; Fieseler, Lars,

2016.

Quantitative real time PCR does not reliably detect single fecal indicator bacteria in drinking water.

Water Science and Technology.

16(6), S. 1674-1682.

Verfügbar unter: https://doi.org/10.2166/ws.2016.052
Schwendimann, Livia Maya; Kauf, Peter; Fieseler, Lars; Gantenbein-Demarchi, Corinne; Miescher Schwenninger, Susanne,

2015.

Development of a quantitative PCR assay for rapid detection of Lactobacillus plantarum and Lactobacillus fermentum in cocoa bean fermentation.

Journal of Microbiological Methods.

115, S. 94-99.

Verfügbar unter: https://doi.org/10.1016/j.mimet.2015.05.022
Born, Yannick; Bosshard, Lars; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

2015.

Protection of Erwinia amylovora bacteriophage Y2 from UV-induced damage by natural compounds.

Bacteriophage.

5(4), S. e1074330.

Verfügbar unter: https://doi.org/10.1080/21597081.2015.1074330
Fieseler, Lars; Doyscher, Dominik; Loessner, Martin; Schuppler, Markus,

2014.

Acanthamoeba release compounds which promote growth of Listeria monocytogenes and other bacteria.

Applied Microbiology and Biotechnology.

98(7), S. 3091-3097.

Verfügbar unter: https://doi.org/10.1007/s00253-014-5534-9
Born, Yannick; Fieseler, Lars; Klumpp, Jochen; Eugster, Marcel R.; Zurfluh, Katrin; Duffy, Brion; Loessner, Martin J.,

2014.

The tail-associated depolymerase of Erwinia amylovoraphage L1 mediates host cell adsorption and enzymatic capsule removal, which can enhance infection by other phage.

Environmental Microbiology.

16(7), S. 2168-2180.

Verfügbar unter: https://doi.org/10.1111/1462-2920.12212
Doyscher, Dominik; Fieseler, Lars; Dons, Lone; Loessner, Martin J.; Schuppler, Markus,

2013.

Acanthamoeba feature a unique backpacking strategy to trap and feed on Listeria monocytogenes and other motile bacteria.

Environmental Microbiology.

15(2), S. 433-446.

Verfügbar unter: https://doi.org/10.1111/j.1462-2920.2012.02858.x
Guenther, Susanne; Herzig, Oliver; Fieseler, Lars; Klumpp, Jochen; Loessner, Martin J.,

2012.

Biocontrol of Salmonella Typhimurium in RTE foods with the virulent bacteriophage FO1-E2.

International Journal of Food Microbiology.

154(1-2), S. 66-72.

Verfügbar unter: https://doi.org/10.1016/j.ijfoodmicro.2011.12.023
Born, Yannick; Fieseler, Lars; Marazzi, Janine; Lurz, Rudi; Duffy, Brion; Loessner, Martin J.,

2011.

Novel virulent and broad-host-range Erwinia amylovora bacteriophages reveal a high degree of mosaicism and a relationship to enterobacteriaceae phages.

Applied and Environmental Microbiology.

77(17), S. 5945-5954.

Verfügbar unter: https://doi.org/10.1128/AEM.03022-10

Buchbeiträge, peer-reviewed

Fieseler, Lars; Loessner, Martin,

2013.

Bacteriophage biocontrol

.

In:

Labbé, Ronald G.; García, Santos, Hrsg.,

Guide to foodborne pathogens.

New York:

Wiley.

S. 448-456.

Verfügbar unter: https://doi.org/10.1002/9781118684856.ch28

Konferenzbeiträge, peer-reviewed

Gayder, Steven; Fieseler, Lars; Castle, Alan; Svircev, Antonet,

2022.

A novel genome-wide, qPCR-based approach to identify genetic determinants of phage host range [Poster].

In:

Viruses of Microbes (VoM), Guimarães, Portugal, 18-22 July 2022.

ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

Verfügbar unter: https://doi.org/10.21256/zhaw-27325
Knecht, Leandra; Heinrich, Nadine; Felder, Katja; Born, Yannick; Pelludat, Cosima; Loessner, Martin; Fieseler, Lars,

2018.

Mutations in the bcs operon of Erwinia amylovora abolish infection by bacteriophages S6 and M7 [Poster].

In:

Viruses of Microbes (VoM), Wroclaw, Poland, 9-13 July 2018.
Buttimer, Collin; Born, Yannick; Hendrix, Hanne; Oliveria, Hugo; McAuliffe, Olivia; Neve, Horst; Ross, R. Paul; Hill, Colin; Noben, Jean-Paul; O'Mahony, Jim; Fieseler, Lars; Lavigne, Rob; Coffey, Aidan; et al.,

2017.

Hairy jumbo phages of Enterobacteriaceae [Poster].

In:

2017 Evergreen International Phage Meeting, Evergreen State College, USA, 6-11 August 2017.

ResearchGate.

Verfügbar unter: https://doi.org/10.13140/RG.2.2.19768.42243

Weitere Publikationen

Gerber, Nicole; Fieseler, Lars; Hirsch, Sven; Neutsch, Lukas; Papadopoulou, Athina; Smits, Theo,

2022.

Zusammenarbeit und wissenschaftlicher Austausch sind der Schlüssel zu erfolgreicher Forschung : der ZHAW Health Research Hub bringt’s unter einen Hut.

Clinicum.

2022(6), S. 80-81.

Verfügbar unter: https://doi.org/10.21256/zhaw-26376
Stöppelmann, Felix; Fieseler, Lars,

2020.

Massnahmen zur Beherrschung mikrobiologischer Risiken verursacht durch Vibrio spp..
Wetzel, Silvan; Fieseler, Lars,

2020.

Risk evaluation of E. coli ST 131 as a foodborne pathogen in Switzerland.
Wetzel, Silvan; Fieseler, Lars,

2020.

Shiga-toxin producing escherichia coli in flour, wheat grain and flour products.
Knecht, Leandra; Born, Yannick; Loessner, Martin; Fieseler, Lars,

2016.

Identification of phage receptors in Erwinia amylovora after transposon mutagenesis [Poster].

In:

Viruses of Microbes (VoM), Liverpool, United Kingdom, 18-22 July 2016.
Freimüller Leischtfeld, Susette; Weber, Stefan; Kuhn, Roger; Schmid, Jürg; Fieseler, Lars,

2015.

Molekulare Schnellmethode für den Legionellen-Test.

Alimenta.

2015(8).

Verfügbar unter: https://www.foodaktuell.ch/molekulare-schnellmethode-fuer-den-legionellen-test/
Born, Yannick; Fieseler, Lars,

2015.

A bacteriophage cocktail to control Salmonella Typhimurium [Poster].

In:

21st Biennial Evergreen International Phage Biology Meeting, Olympia, USA, 2-7 August 2015.
Born, Yannick; Knecht, Leandra; Pelludat, Cosima; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

2015.

Bakteriophagen zur Bekämpfung von Feuerbrand [Poster].

In:

1. Nationale Tagung - Gemeinsam gegen Feuerbrand, Wädenswil, 2015.
Adlhart, Christian; Born, Yannick; Fuchs, Michael; Fieseler, Lars; Pavlovic, Branislav,

2015.

Encapsulation and controlled release of bacteriophages for food protection using electrospun nanofibers [Paper].

In:

Proceedings of the NART conference 2015.

NART 2015, Nanofibers, Applications and Related Technologies, Liberec, Czech Republic, 31 August - 2 September 2015.

S. 49-56.
Gantenbein-Demarchi, Corinne; Kuhn, Roger; Kauf, Peter; Schmid, Jürg; Krapf, Tamara; Fieseler, Lars,

2015.

Fäkalindikatoren im Trinkwasser nachweisen.

Alimenta.
Born, Yannick; Klumpp, Jochen; Zurfluh, Katrin; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

2015.

Implications of the phage depolymerase DpoL1 on Erwinia amylovora [Poster].

In:

21st Biennial Evergreen International Phage Biology Meeting, Olympia, USA, 2-7 August 2015.
Leiblein, Thomas; Kroslakova, Ivana; Freimüller Leischtfeld, Susette; Fieseler, Lars; Hofer, Susanne,

2015.

Legionella in FM : Detection of Legionella pneumophila in waterlines of dental surgeries in the Canton of Zurich, Switzerland [Paper].

In:

Alexander, Keith; Price, Ilfryn, Hrsg.,

EuroFM Research Papers, Section 5, Development Papers.

EuroFM Conference 2015, Glasgow, Ireland, 1-3 June 2015.

European Facilities Management Network (EuroFM).

S. 26-33.
Fieseler, Lars,

2015.

Nachweis und Kontrolle der Keimbelastung im Lebensmittel.

Lebensmittel-Technologie.

2015(4), S. 12-13.
Fieseler, Lars; Gantenbein-Demarchi, Corinne; Miescher Schwenninger, Susanne; Kuhn, Roger; Kleinert, Michael,

2013.

Rope in bread : a critical challenge for the bakery industry [Poster].

In:

4th MoniQA International Conference, Budapest, Hungary, 26 February - 1 March 2013.
Gantenbein-Demarchi, Corinne; Kuhn, Roger; Krapf, Tamara; Fieseler, Lars,

2012.

Detection of faecal indicator organisms by RT-qPCR [Poster].

In:

SGM Annual Congress 2012 - Swiss Society for Microbiology, St. Gallen, 21-22 June 2012.
Fieseler, Lars; Loessner, Martin; Hagens, Steven,

2011.

Bacteriophages and food safety

.

In:

Lacroix, Christophe, Hrsg.,

Protective cultures, antimicrobial metabolites and bacteriophages for food and beverage biopreservation.

Oxford:

Woodhead Publishing.

S. 161-178.

Woodhead Publishing Series in Food Science, Technology and Nutrition ; 201.

Verfügbar unter: https://doi.org/10.1533/9780857090522.1.161
Heller, Knut; Loessner, Martin; Fieseler, Lars,

2011.

Bakteriophagen : Grundlagen, Rolle in Lebensmitteln und Anwendungen zum Nachweis sowie der Kontrolle von Krankheitserregern.

1. Auflage.

Hamburg:

Behr.

ISBN 978-3-89947-594-4.

Mündliche Konferenzbeiträge und Abstracts

Gayder, Steven; Kammerecker, Sandrine; Gervásio, Kellen; Henriques, André; Torres-Cortés, Gloria; Kőrösiné Papp, Szilvia; Kovács, Tamás; Raffai, Krisztina; Cabezón Largas, Sixto; de Santos Prieto, Borja; Fieseler, Lars,

2022.

A qPCR-based, population dynamics approach for the development of a bacteriophage-based biopesticide.

In:

Third International Symposium on Fire Blight of Rosaceous Plants, Dresden-Pillnitz, Germany, 6-9 September 2022.
Kammerecker, Sandrine; Gayder, Steven; Gervásio, Kellen; Henriques, André; Torres-Cortés, Gloria; Kőrösiné Papp, Szilvia; Kovács, Tamás; Raffai, Krisztina; Cabezón Largas, Sixto; de Santos Prieto, Borja; Fieseler, Lars,

2022.

PhageFire : formulation of a bacteriophage-based biopesticide against Erwinia amylovora.

In:

Third International Symposium on Fire Blight of Rosaceous Plants, Dresden-Pillnitz, Germany, 6-9 September 2022.
Fieseler, Lars,

2017.

Bacteriophages for the control of pathogenic bacteria.

In:

BioTech 2017 Conference, Prague, Czech Republic, 13-17 June 2017.
Born, Yannick; Leimer, Nadja; Thöny, Valentin; Zurfluh, Katrin; Eugster, Marcel; Klumpp, Jochen; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

2016.

Engineered phages for efficient control and rapid detection of viable Erwinia amylovora cells.

In:

Viruses of Microbes (VoM), Liverpool, United Kingdom, 18-22 July 2016.
Born, Yannick; Fieseler, Lars,

2016.

The effectiveness of T5-like phages to control Salmonella enterica.

In:

3rd International Conference «Bacteriophages», Moscow, Russia, 13-15 October 2016.
Fieseler, Lars; Klumpp, Jochen,

2014.

A cocktail of two bacteriophages is required to control Salmonella in vitro.

In:

Viruses of Microbes (VoM), Zurich, Switzerland, 14-18 July 2014.
Fieseler, Lars,

2014.

Bakteriophagen zur Kontrolle von Salmonella Typhimurium in Lebensmitteln.

In:

7. Symposium: Schnellmethoden und Automatisierung in der Lebensmittel‐Mikrobiologie, Lemgo, Germany, 1-2 July 2014.
Hinderling, Christian; Kroslakova, Ivana; Gantenbein-Demarchi, Corinne; Freimüller Leischtfeld, Susette; Delueg, Stephanie; Miescher Schwenninger, Susanne; Fieseler, Lars,

2012.

Development of an efficient strategy for the identification of the dominant microflora of cocoa fermentation.

In:

1st Swiss International Congress on Industrial Microbiology (MICROSCON), Olten, Switzerland, 16-17 October 2012.

Publikationen vor Tätigkeit an der ZHAW

www.ncbi.nlm.nih.gov/pubmed/

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