Engineered bacteriophages for the control of E. coli O157
Auf einen Blick
- Projektleiter/in : Prof. Dr. Lars Fieseler
- Co-Projektleiter/in : Dr. Lukas Neutsch
- Projektteam : Alexander Hämmerli, Dr. Leandra Knecht, Prof. Dr. Martin Loessner, Prof. Dr. Roger Stephan
- Projektstatus : abgeschlossen
- Drittmittelgeber : Interne Förderung
- Kontaktperson : Lars Fieseler
Beschreibung
Bacteriophages (phages) represent a very promising alternative to antibiotics to combat infections caused by Shiga Toxin producing E. coli O157. In this research project, two different O157-specific bacteriophages will be genetically engineered to effectively control E. coli O157. In addition, a scalable setup for phage propagation in bioreactors under strictly defined conditions will be established, aligned to current QbD and GMP principles. Novel real-time monitoring and control concepts will be implemented to optimize production yields and pave the way for broader use in medical applications.