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Section for Organic and Medicinal Chemistry

«With our medicinal chemistry expertise, structure-based design and organic synthesis, we develop new treatment options for patients.»

Prof. Dr. Rainer Riedl, Head of Centre

Areas of expertise

Medicinal Chemistry

SNSF-Sinergia project on antiviral drug discovery at the ICBT

Disease-causing protein beaten at its own game

Our Medicinal Chemistry activities span from hit identification, through hit to lead development and lead optimization to delivering active pharmaceutical ingredients (APIs) for in vitro and in vivo studies. Our focus is on the development of clinical candidates with our industry partners and includes the structural analysis of the target proteins (and their complexes) and results in the delivery of novel and patentable small organic ligands for clinical trials by using a combination of classical SAR profiling and state of the art fragment-based approaches.

  • structural analysis of the target protein (X-ray analysis of co-crystal structures)
  • NMR binding studies (ligand/protein)
  • fragment-based design of novel ligands
  • effective application of industry standard docking software
  • multi-step organic synthesis of ligands
  • establishment of structure activity relationships (SAR)
  • development of data bank based IT solutions for the information management of chemical and biological data (SAR, inventory, etc.)

Organic Synthesis + Synthetic Methodology

Organic Analysis + Structure Elucidation

We have the expertise and equipment for Analyses and Structure Elucidation of Organic Molecules of both routine in house samples or those of our customers, as well as ongoing research activities in the isolation, identification and optimization of biogenic drug molecules.

Cheminformatics

Research and Business Services

Collaborations

We offer a multitude of possible R & D collaborations. Long term CTI funded research projects are possible as well as mid-term contract research projects. Bachelor and Master Theses complement our research collaborations. 

Medicinal Chemistry

Organic Synthesis and Organic Analytics

Cheminformatics

Technologies

Equipment

Awards

Networking

  • go to website Alexander von Humboldt Foundation
  • go to website biotechnet Switzerland
  • go to website Swiss Academy of Engineering Sciences
  • go to website German National Academic Foundation
  • go to website Swiss Chemical Society