Prof. Dr. Rainer Riedl
Prof. Dr. Rainer Riedl
ZHAW
Life Sciences und Facility Management
Einsiedlerstrasse 31
8820 Wädenswil
Persönliches Profil
Leitungsfunktion
-
Leitung Drug Discovery and Pharmaceutical Product Development<br /><br /><br /><br />
Organic and Medicinal Chemistry
Tätigkeit an der ZHAW als
Professor of Organic and Medicinal Chemistry
www.zhaw.ch/icbt/organic-and-medicinal-chemistry/
Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse
Drug discovery
Rational drug design
Development of structure activity relationships
Generation of lead structures
Development of clinical candidates
Structure based drug design
Organic chemistry
Natural products
Solid phase synthesis
Microwave assisted synthesis
Microreactors
Protein-protein interactions
Cheminformatics
Computational chemistry
Combinatorial chemistry
Catalyst development
SixSigma process optimization
Aus- und Fortbildung
May 2011 - November 2012
CAS University Didactic
PH Zurich, Switzerland
March 2004 - March 2005
Hagener Management Studies, Department of Business Administration and Economics,
University of Hagen, Germany
August 1995 - December 1998
Ph.D. studies, Department of Organic Chemistry, University of
Heidelberg, Germany and Department of Organic Chemistry,
University of Cologne, Germany, under the supervision of Prof. Dr. A.
Berkessel “Combinatorial de novo synthesis of artificial
phosphodiesterases”, summa cum laude
July 1995
German Chemistry Diploma, Department of Organic Chemistry,
University of Heidelberg, Germany, under the supervision of Prof. Dr.
A. Berkessel “En route to the combinatorial syntheses of artificial
phosphodiesterases”, summa cum laude
October 1990 - October 1994
Undergraduate and graduate studies of chemistry at the
University of Heidelberg, Germany
Fellowships and awards:
September 2013 Swiss Chemical Society FH award winner project in the category "Molecules for the Life Sciences": Tackling antibiotic resistance by transcription regulator inhibitory compounds.
November 2006 Eli Lilly Protease Platform Library Design Award
February 2006 Eli Lilly Recognition Grant
November 2000 Liebig habilitation fellowship of the Fonds der Chemischen Industrie
February 1999 Feodor-Lynen postdoctoral fellowship of the Alexander von Humboldt Stiftung
May 1998 Kurt-Alder-award for Ph.D. thesis (combinatorial catalyst development), Department of Organic Chemistry, University of Cologne, Germany
February 1996 Ph.D. fellowship of the Stiftung Stipendien-Fonds des Verbands der Chemischen Industrie, Germany
December 1995 Dr. Sophie-Bernthsen-award, Department of Organic Chemistry, University of Heidelberg, Germany
August 1995 Fellowship of the Graduiertenkolleg “Selectivity in organic and organometallic synthesis and catalysis”, Departments of Organic and Inorganic Chemistry, University of Heidelberg, Germany
December 1993 Procter & Gamble award, Department of Organic Chemistry, University of Heidelberg, Germany
October 1990 Fellowship of the Studienstiftung des deutschen Volkes (German National Scholarship Foundation)
July 1990 Book award of the Fonds der Chemischen Industrie, Germany
July 1990 Bronze medal for the Federal Republic of Germany at the International Olympiad of Chemistry (IChO) 1990, Paris, France
Beruflicher Werdegang
since February 2009 Head of Organic Chemistry and Medicinal Chemistry at ZHAW
August 2007 - January 2009
Senior Research Scientist, Eli Lilly Corporate Center,
Indianapolis, USA, Discovery Chemistry Research and Technology
October 2005 - July 2007
Senior Research Scientist, Eli Lilly Research Lab Hamburg,
Discovery Chemistry Research and Technology
October 2005 - July 2007
SixSigma Green Belt at Eli Lilly Research Lab Hamburg, Discovery
Chemistry Research and Technology
April 2002 – September 2005
Research Scientist, lab leader, Eli Lilly Research Lab Hamburg,
Discovery Chemistry Research and Technology
November 2000 - December 2001
Habilitand at the Laboratory of Organic Chemistry, ETH Zurich, Switzerland
February 1999 - September 2000
Postdoctoral scientist with Prof. Dr. Peter Schultz, University of
California, Berkeley, USA and at The Scripps Research Institute,
La Jolla, USA
Mitglied in Netzwerken
- Alexander von Humboldt Foundation
- Swiss Chemical Society
- Studienstiftung des Deutschen Volkes
- Biotechnet Switzerland
- Schweizerische Akademie der Technischen Wissenschaften
Publikationen
Monographien und Herausgeberschaften
(1998).
Kombinatorische de novo Synthese von künstlichen Phosphodiesterasen
.
Cologne: University of Cologne.
Beiträge, peer-reviewed
Agnello, Stefano; ; ; ; (2017).
Antiprotozoal compounds
.
Eur. Pat. Appl. 2017, EP 17150353.5 Peer reviewed.
Fischer, Thomas; (2017).
Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor
.
Molecules, 22 1548. Peer reviewed.
; ; ; ; ; ; ; ; (2017).
Emodin, a putative antidiabetic compound, deteriorates glucose tolerance in rodents
.
Eur J Pharmacol., 798, 77-84. Peer reviewed.
Fischer, Thomas; (2017).
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
.
ChemistryOpen, 6, 2. DOI: 10.1002/open.201600158. Peer reviewed.
Fischer, Thomas; (2017).
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
: Cover Picture.
ChemistryOpen, 6, 2. DOI: 10.1002/open.201700043. Peer reviewed.
Fischer, Thomas; (2017).
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
: Cover Profile.
ChemistryOpen, 6, 2. DOI: 10.1002/open.201700042. Peer reviewed.
; ; (2016).
Antibiotikaresistenzen gezielt überwinden
.
Angew.Chem., 128, 6710–6738, DOI:10.1002/ange.201506818. Peer reviewed.
Fischer, Thomas; (2016).
Molecular Recognition of the Catalytic Zinc(II) Ion in MMP-13: Structure-Based Evolution of an Allosteric Inhibitor to Dual Binding Mode Inhibitors with Improved Lipophilic Ligand Efficiencies
.
Int. J. Mol. Sci., 17, 3. 314, doi:10.3390/ijms17030314. Cover story March 2016. Peer reviewed.
; ; (2016).
Targeting Antibiotic Resistance
.
Angew. Chem. Int. Ed., 55, 6600-6626, DOI: 10.1002/anie.201506818. Peer reviewed.
; ; ; ; Wolfram, Evelyn; ; ; (2015).
Highly oxygenated sesquiterpenes in Artemisia alba Turra
.
Phytochemistry, 110, 140–149. Peer reviewed.
; (2015).
Merging Allosteric and Active Site Binding Motifs: De novo Generation of Target Selectivity and Potency via Natural-Product-Derived Fragments
.
ChemMedChem, 10, 451-454 onlinelibrary.wiley.com/doi/10.1002/cmdc.201402478/abstract. Cover story 03/2015. Peer reviewed.
; (2014).
Composition for treatment of pathogens that are resistant to tetracyclines
.
Eur. Pat. Appl. (2014), EP 2762134 A1 20140806. Peer reviewed.
; (2014).
Composition for treatment of pathogens that are resistant to tetracyclines
.
PCT Int. Appl. (2014), WO 2014118361 A1 20140807. Peer reviewed.
Fischer, Thomas; (2013).
Strategic Targeting of Multiple Water- Mediated Interactions: A Concise and Rational Structure-Based Design Approach to Potent and Selective MMP-13 Inhibitors
.
ChemMedChem, 8 1457–1461. doi: 10.1002/cmdc.201300278. Cover story 9/2013. Peer reviewed.
; (2012).
chemf: A purely functional chemistry toolkit
: doi:10.1186/1758-2946-4-38 Highly accessed.
Journal of Cheminformatics, 4 38. Peer reviewed.
Höck, Stefan; (2012).
CyBy 2 : A structure based data management tool for chemical and biological data
.
Chimia, 66, 3. 132-134. Peer reviewed.
Höck, Stefan; ; ; (2010).
Thermal Cleavage of the Fmoc Protection Group
.
Chimia, 64, 3. 200-202. Peer reviewed.
; ; ; ; ; ; ; ; ; ; ; (2006).
Synthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators
.
Tetrahedron Letters, 47(16). 2675-2678. Peer reviewed.
; ; ; ; ; (2004).
Preparation of aryl substituted cyclopropylcarboxamides for therapeutic use as glucokinase activators
.
PCT International Patent Application, WO 2004063179 A1, 20040729. Peer reviewed.
; ; ; ; ; (2004).
Preparation of heteroaryl compounds for the treatment of type II diabetes
.
PCT International Patent Application, WO 2004063194 A1, 20040729. Peer reviewed.
; ; ; ; ; ; ; (2002).
Genomic Effects of Polyamide/DNA Interactions on mRNA Expression
.
Chemistry & Biology, 9(7). 821-827. Peer reviewed.
; (2000).
Combinatorial de novo Synthesis of Catalysts: How much of a Hit Structure is Needed for Activity
.
J. Comb. Chem., 2(3). 215-219. Peer reviewed.
; ; (1998).
Probing the scope of the asymmetric dihydroxylation of polymer-bound olefins: Monitoring by HRMAS-NMR allows for reaction control and on-bead measurement of enantiomeric excess
.
J. Am. Chem. Soc., 120(35). 8994-9000. Peer reviewed.
; (1997).
Fluorescence Reporters for Phosphodiesterase Activity
.
Angew. Chem. Int. Ed. Engl., 36(13/14). 1481-1483. Peer reviewed.
; (1997).
Fluoreszenz-Reporter für Phosphodiesterase-Aktivität
.
Angew. Chem., 109(13/14). 1518-1520. Peer reviewed.
Beiträge, nicht peer-reviewed
(2014).
Fighting the resistance
.
Horizon 2020 projects: portal, 4. 130.
(2014).
Nicht nur Metalloproteasen im Visier
.
Chemie Plus, 4. 30-31.
(2013).
BRIDGING THE DISCIPLINES
: CANCER DIAGNOSTICS & TREATMENT.
Pan European Networks, 07 240-241.
; (2013).
CyBy²: Clevere Handhabung strukturbasierter Datensätze
.
transfer, 1. 3.
(2013).
Organic chemistry: the heart and soul of drug discovery
.
International Innovation Report, 18 104-105.
(2013).
Tackling antibiotic resistance
: Invited lecture.
In: ILMAC Award 2013. Basel: 25. September.
Fischer, Thomas; (2012).
Design, synthesis and biological testing of novel MMP-Inhibitors
: Poster presentation.
In: SCS Fall meeting 2012 ETHZ. Symposium. (13.09.2012). Zurich: Swiss Chemical Society.
; (2012).
Enhancing CyBy2: Visualization of Structure Activity Relationships of large Datasets
: Poster presentation.
In: SCS Fall meeting 2012 ETHZ. Symposium. (13.09.2012). Zurich: Swiss Chemical Society.
Fischer, Thomas; (2012).
Structure based design and synthesis of novel MMP Inhibitors
: Poster presentation.
In: . Symposium. (26.08.2012). Vienna: 19th EuroQSAR.
; (2012).
Synthese und medizinalchemische Optimierung von Tetrazyklinanaloga
.
SVC A Jour, 1. 10-11.
; (2011).
CyBy2: A modular Rich Client for the chemical and biological Information Management
: Poster presentation.
In: SCS Fall meeting 2011 EPFL. Symposium. (9.9.2011). Lausanne: Swiss Chemical Society.
(2011).
Drug discovery in the academic setting
: Invited lecture.
In: ZHAW Chemietag Medizinalchemie. Symposium. (16.6.2011). Wädenswil: ZHAW.
; ; ; (2011).
Structure based design and synthesis of novel MMP inhibitors
: Poster presentation.
In: SCS Fall meeting 2011 EPFL. Symposium. (9.9.2011). Lausanne: Swiss Chemical Society.
; ; (2011).
Synthesis of tetracycline analogues
: Poster presentation.
In: SCS Fall meeting 2011 EPFL. Symposium. (9.9.2011). Lausanne: Swiss Chemical Society.
Fischer, Thomas; (2010).
Fragment based Scaffold Hopping in Drug Discovery
: Poster presentation.
In: SCS Fall meeting 2010 ETHZ. Symposium. (16.9.2010). Zurich: Swiss Chemical Society.
; ; (2010).
Profiling H-Bond Properties of Fragments
: Poster presentation.
In: SCS Fall meeting 2010 ETHZ. Symposium. (16.9.2010). Zurich: Swiss Chemical Society.
(2010).
Structure activity relationship within a gene switching system
: Invited lecture.
In: Synthetic Biotechnology. Symposium. (18./19.11.2010). Basel: SATW.
(2010).
Structure based drug design
: Invited lecture.
In: Olten Meeting 2010. Symposium. (24.11.2010). Olten: biotechnet.