Prof. Dr. Rainer Riedl

Prof. Dr. Rainer Riedl
ZHAW
Life Sciences und Facility Management
Fachstelle Pharmazeutische Wirkstoffforschung und Arzneimittelentwicklung
Einsiedlerstrasse 31
8820 Wädenswil
Persönliches Profil
Leitungsfunktion
Leitung Competence Center for Drug Discovery<br />
Head of Center for Drug Discovery and Pharmaceutical Product Development<br />
Head of Organic and Medicinal Chemistry
Tätigkeit an der ZHAW
Professor of Organic and Medicinal Chemistry
www.zhaw.ch/icbt/organic-and-medicinal-chemistry/
Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse
Drug discovery
Rational drug design
Development of structure activity relationships
Generation of lead structures
Development of clinical candidates
Structure based drug design
Organic chemistry
Natural products
Solid phase synthesis
Microwave assisted synthesis
Microreactors
Protein-protein interactions
Cheminformatics
Computational chemistry
Combinatorial chemistry
Catalyst development
SixSigma process optimization
Aus- und Fortbildung
May 2011 - November 2012
CAS University Didactic
PH Zurich, Switzerland
March 2004 - March 2005
Hagener Management Studies, Department of Business Administration and Economics,
University of Hagen, Germany
August 1995 - December 1998
Ph.D. studies, Department of Organic Chemistry, University of
Heidelberg, Germany and Department of Organic Chemistry,
University of Cologne, Germany, under the supervision of Prof. Dr. A.
Berkessel “Combinatorial de novo synthesis of artificial
phosphodiesterases”, summa cum laude
July 1995
German Chemistry Diploma, Department of Organic Chemistry,
University of Heidelberg, Germany, under the supervision of Prof. Dr.
A. Berkessel “En route to the combinatorial syntheses of artificial
phosphodiesterases”, summa cum laude
October 1990 - October 1994
Undergraduate and graduate studies of chemistry at the
University of Heidelberg, Germany
Fellowships and awards:
September 2013 Swiss Chemical Society FH award winner project in the category "Molecules for the Life Sciences": Tackling antibiotic resistance by transcription regulator inhibitory compounds.
November 2006 Eli Lilly Protease Platform Library Design Award
February 2006 Eli Lilly Recognition Grant
November 2000 Liebig habilitation fellowship of the Fonds der Chemischen Industrie
February 1999 Feodor-Lynen postdoctoral fellowship of the Alexander von Humboldt Stiftung
May 1998 Kurt-Alder-award for Ph.D. thesis (combinatorial catalyst development), Department of Organic Chemistry, University of Cologne, Germany
February 1996 Ph.D. fellowship of the Stiftung Stipendien-Fonds des Verbands der Chemischen Industrie, Germany
December 1995 Dr. Sophie-Bernthsen-award, Department of Organic Chemistry, University of Heidelberg, Germany
August 1995 Fellowship of the Graduiertenkolleg “Selectivity in organic and organometallic synthesis and catalysis”, Departments of Organic and Inorganic Chemistry, University of Heidelberg, Germany
December 1993 Procter & Gamble award, Department of Organic Chemistry, University of Heidelberg, Germany
October 1990 Fellowship of the Studienstiftung des deutschen Volkes (German National Scholarship Foundation)
July 1990 Book award of the Fonds der Chemischen Industrie, Germany
July 1990 Bronze medal for the Federal Republic of Germany at the International Olympiad of Chemistry (IChO) 1990, Paris, France
Beruflicher Werdegang
since February 2009 Head of Organic Chemistry and Medicinal Chemistry at ZHAW
August 2007 - January 2009
Senior Research Scientist, Eli Lilly Corporate Center,
Indianapolis, USA, Discovery Chemistry Research and Technology
October 2005 - July 2007
Senior Research Scientist, Eli Lilly Research Lab Hamburg,
Discovery Chemistry Research and Technology
October 2005 - July 2007
SixSigma Green Belt at Eli Lilly Research Lab Hamburg, Discovery
Chemistry Research and Technology
April 2002 – September 2005
Research Scientist, lab leader, Eli Lilly Research Lab Hamburg,
Discovery Chemistry Research and Technology
November 2000 - December 2001
Habilitand at the Laboratory of Organic Chemistry, ETH Zurich, Switzerland
February 1999 - September 2000
Postdoctoral scientist with Prof. Dr. Peter Schultz, University of
California, Berkeley, USA and at The Scripps Research Institute,
La Jolla, USA
Mitglied in Netzwerken
- Alexander von Humboldt Foundation
- Swiss Chemical Society
- Studienstiftung des Deutschen Volkes
- Biotechnet Switzerland
- Schweizerische Akademie der Technischen Wissenschaften
Projekte
- Synthesis of peptidic active ingredients / ProjektleiterIn / Projekt laufend
- Therapie für den NRAS-Melanom-Subtyp / ProjektleiterIn / Projekt laufend
- Plattform zur Identifizierung von Wirkstofftargets / ProjektleiterIn / Projekt laufend
- Protease-Inhibitoren gegen SARS-CoV-2 / ProjektleiterIn / Projekt laufend
- Extrazelluläre Vesikel für den Transport von antimikrobiellen Proteinen zum Zielgewebe / Stellv. ProjektleiterIn / Projekt laufend
- Developing novel and effective therapies for treatment of childhood brain cancers / ProjektleiterIn / Projekt laufend
- Entwicklung einer neuartigen Behandlung gegen pathologische Haut- und Sehnenkalzifizierung auf Basis eines Gasotransmitters / ProjektleiterIn / Projekt laufend
- Morbillivirus cell entry machinery: mechanisms, structures and antiviral drug discovery / Co-ProjektleiterIn / Projekt laufend
- Entwicklung neuer Therapieansätze zur Behandlung von Krebs / ProjektleiterIn / Projekt abgeschlossen
- Plants and Minerals in Byzantine Popular Pharmacy. A New Multidisciplinary Approach / Stellv. ProjektleiterIn / Projekt abgeschlossen
- Entwicklung von niedermolekularen Verbindungen zur Blockierung des CD93 Signalwegs bei Leukämiepatienten / ProjektleiterIn / Projekt abgeschlossen
- Inflammasominhibitoren / ProjektleiterIn / Projekt abgeschlossen
- Burn Wound Treatment / ProjektleiterIn / Projekt abgeschlossen
- Modulatoren der MMP-Hemopexin-Domäne / ProjektleiterIn / Projekt abgeschlossen
- Neue Antibiotika: RNA-Polymerase-Inhibitoren / ProjektleiterIn / Projekt abgeschlossen
- Antivirale Wirkstoffe / ProjektleiterIn / Projekt abgeschlossen
- MMP-Inhibitor-Hydrogel zur Wundheilung / ProjektleiterIn / Projekt abgeschlossen
- Induktion der Wirkstoffbildung bei Actinomyceten / Stellv. ProjektleiterIn / Projekt abgeschlossen
- A topical anti-infective / ProjektleiterIn / Projekt abgeschlossen
- Identifizierung und Charakterisierung von Wirkstoffen aus Actinomyceten aus der Schweiz gegen pathogene Bakterien / ProjektleiterIn / Projekt abgeschlossen
- Novel Antimicrobials for Life-Threatening Infections / ProjektleiterIn / Projekt abgeschlossen
- Virus cell entry machinery: antiviral drug discovery / ProjektleiterIn / Projekt abgeschlossen
- Dynamic combinatorial chemistry in drug discovery / ProjektleiterIn / Projekt abgeschlossen
- New antileishmanial and antitrypanosomal drugs / ProjektleiterIn / Projekt abgeschlossen
- New drugs for the treatment of protozoal infections derived from natural products / ProjektleiterIn / Projekt abgeschlossen
- Kinetische Struktur-Aktivitäts-Beziehungen und röntgenkristallographische Bestimmung des Bindungsmodus von niedermolekularen Wirkstoffmolekülen / ProjektleiterIn / Projekt abgeschlossen
- Development of high temperature resistant, synergistic biocidal products for protection of PVC against microbial infestation for commercial product applications / ProjektleiterIn / Projekt abgeschlossen
- HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory Compound (TRIC) that increases antibiotic susceptibility of multidrug resistant staphylococci / ProjektleiterIn / Projekt abgeschlossen
- Forschungs- und Entwicklungsarbeiten auf dem Gebiet von potentiellen Wirkstoffen gegen Diabetes / ProjektleiterIn / Projekt abgeschlossen
- Prevention of undesired interactions between biocides and additives in synthetic materials to improve efficacy and to reduce the necessary amount of biocides / ProjektleiterIn / Projekt abgeschlossen
- Development of a software to analyse chemical and biological data: CyBy2 / ProjektleiterIn / Projekt abgeschlossen
- HIT to LEAD to Candidate development of a Transcription Repressor Inhibitory Compound (TRIC), which switches off bacterial resistance to a broad band antibiotic / ProjektleiterIn / Projekt abgeschlossen
- Isolation, Identifikation und medizinalchemische Optimierung von biogenen Wirkstoffen / ProjektleiterIn / Projekt abgeschlossen
- Identification of novel targets and drug candidates against multi-drug resistant bacteria / ProjektleiterIn / Projekt abgeschlossen
Publikationen
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Kalbermatter, David; Jeckelmann, Jean-Marc; Wyss, Marianne; Shrestha, Neeta; Pliatsika, Dimanthi; Riedl, Rainer; Lemmin, Thomas; Plattet, Philippe; Fotiadis, Dimitrios,
2023.
Structure and supramolecular organization of the canine distemper virus attachment glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America.
120(6), S. e2208866120.
Verfügbar unter: https://doi.org/10.1073/pnas.2208866120
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Sabani, Besmira; Brand, Michael; Albert, Ina; Inderbitzin, Joelle; Eichenseher, Fritz; Schmelcher, Mathias; Rohrer, Jack; Riedl, Rainer; Lehmann, Steffi,
2023.
Nanomedicine: Nanotechnology, Biology and Medicine.
47(102607).
Verfügbar unter: https://doi.org/10.1016/j.nano.2022.102607
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Bagatella, Stefano; Haghayegh Jahromi, Neda; Monney, Camille; Polidori, Margherita; Gall, Flavio Max; Marchionatti, Emma; Serra, Fabienne; Riedl, Rainer; Engelhardt, Britta; Oevermann, Anna,
2022.
Journal of Neuroinflammation.
19(304).
Verfügbar unter: https://doi.org/10.1186/s12974-022-02653-1
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Kiss, Cedric; Gall, Flavio M.; Dreier, Birgit; Adams, Michael; Riedl, Rainer; Plückthun, Andreas; Mittl, Peer R. E.,
2022.
Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
Acta Crystallographica. Section D: Structural Biology.
78(12), S. 1439-1450.
Verfügbar unter: https://doi.org/10.1107/S2059798322010762
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Brand, Michael; Bommeli, Elias Benjamin; Rütimann, Marc; Lindenmann, Urs; Riedl, Rainer,
2022.
Discovery of a dual SENP1 and SENP2 inhibitor.
International Journal of Molecular Sciences.
23(20), S. 12085.
Verfügbar unter: https://doi.org/10.3390/ijms232012085
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Fischer, Thomas; Riedl, Rainer,
2022.
Paracelsus' legacy in the faunal realm : drugs deriving from animal toxins.
Drug Discovery Today.
27(2), S. 567-575.
Verfügbar unter: https://doi.org/10.1016/j.drudis.2021.10.003
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Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer,
2021.
Angewandte Chemie: International Edition.
60(28), S. 15613-15621.
Verfügbar unter: https://doi.org/10.1002/anie.202102153
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Zizzari, Alessandra Tania; Pliatsika, Dimanthi; Gall, Flavio; Fischer, Thomas; Riedl, Rainer,
2021.
New perspectives in oral peptide delivery.
Drug Discovery Today.
26(4), S. 1097-1105.
Verfügbar unter: https://doi.org/10.1016/j.drudis.2021.01.020
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Shrestha, Neeta; Gall, Flavio; Vesin, Jonathan; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe,
2021.
Antiviral screen against canine distemper virus-induced membrane fusion activity.
Viruses.
13(1), S. 128.
Verfügbar unter: https://doi.org/10.3390/v13010128
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Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer,
2021.
Angewandte Chemie.
133(28), S. 15741-15749.
Verfügbar unter: https://doi.org/10.1002/ange.202102153
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Shrestha, Neeta; Gall, Flavio Max; Mathieu, Cyrille; Hierweger, Melanie Michaela; Brügger, Melanie; Alves, Marco P.; Vesin, Jonathan; Banfi, Damiano; Kalbermatter, David; Horvat, Branka; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe,
2021.
mBio.
12(6), S. e0262121.
Verfügbar unter: https://doi.org/10.1128/mBio.02621-21
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Neidhart, Berna; Kowalska, Malwina; Valentin, Jules D. P.; Gall, Flavio; Ren, Qun; Riedl, Rainer; Pot, Simon; Rottmar, Markus,
2021.
Biomacromolecules.
22(2), S. 629-639.
Verfügbar unter: https://doi.org/10.1021/acs.biomac.0c01473
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Fischer, Thomas; Riedl, Rainer,
2020.
Challenges with matrix metalloproteinase inhibition and future drug discovery avenues.
Expert Opinion on Drug Discovery.
16(1), S. 75-88.
Verfügbar unter: https://doi.org/10.1080/17460441.2020.1819235
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Kalbermatter, David; Shrestha, Neeta; Gall, Flavio; Wyss, Marianne; Riedl, Rainer; Plattet, Philippe; Fotiadis, Dimitrios,
2020.
Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain.
Journal of Structural Biology: X.
4, S. 100021.
Verfügbar unter: https://doi.org/10.1016/j.yjsbx.2020.100021
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Lindenmann, Urs; Brand, Michael; Gall, Flavio; Frasson, David; Hunziker, Lukas; Kroslakova, Ivana; Sievers, Martin; Riedl, Rainer,
2020.
Discovery of a class of potent and selective non‐competitive sentrin‐specific protease 1 inhibitors.
ChemMedChem.
15(8), S. 675-679.
Verfügbar unter: https://doi.org/10.1002/cmdc.202000067
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Arn, Fabienne; Frasson, David; Kroslakova, Ivana; Rezzonico, Fabio; Pothier, Joël; Riedl, Rainer; Sievers, Martin,
2020.
Chimia.
74(5), S. 382-390.
Verfügbar unter: https://doi.org/10.2533/chimia.2020.382
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Höck, Stefan; Riedl, Rainer,
2019.
CyBy2 : a strongly typed, purely functional framework for chemical data management.
Journal of Cheminformatics.
11(80).
Verfügbar unter: https://doi.org/10.1186/s13321-019-0403-2
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Fischer, Thomas; Gazzola, Silvia; Riedl, Rainer,
2019.
Approaching target selectivity by de novo drug design.
Expert Opinion on Drug Discovery.
14(8), S. 791-803.
Verfügbar unter: https://doi.org/10.1080/17460441.2019.1615435
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Fischer, Thomas; Senn, Nicole; Riedl, Rainer,
2019.
Design and structural evolution of matrix metalloproteinase inhibitors.
Chemistry – A European Journal.
25(34), S. 7960-7980.
Verfügbar unter: https://doi.org/10.1002/chem.201805361
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Gall, Flavio; Hohl, Deborah; Frasson, David; Wermelinger, Tobias; Mittl, Peer R. E.; Sievers, Martin; Riedl, Rainer,
2019.
Angewandte Chemie: International Edition.
58(12), S. 4051-4055.
Verfügbar unter: https://doi.org/10.1002/anie.201812348
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Gall, Flavio; Hohl, Deborah; Frasson, David; Wermelinger, Tobias; Mittl, Peer R. E.; Sievers, Martin; Riedl, Rainer,
2019.
Angewandte Chemie.
131(12), S. 4091-4096.
Verfügbar unter: https://doi.org/10.1002/ange.201812348
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Fischer, Thomas; Koulas, Symeon M.; Tsagkarakou, Anastasia S.; Kyriakis, Efthimios; Stravodimos, George A.; Skamnaki, Vassiliki T.; Liggri, Panagiota G.V.; Zographos, Spyros E.; Riedl, Rainer; Leonidas, Demetres D.,
2019.
Molecules.
24(7), S. 1322.
Verfügbar unter: https://doi.org/10.3390/molecules24071322
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Fischer, Thomas; Riedl, Rainer,
2019.
Inhibitory antibodies designed for matrix metalloproteinase modulation.
Molecules.
24(12), S. 2265.
Verfügbar unter: https://doi.org/10.3390/molecules24122265
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Kalbermatter, David; Shrestha, Neeta; Ader-Ebert, Nadine; Herren, Michael; Moll, Pascal; Plemper, Richard K.; Altmann, Karl-Heinz; Langedijk, Johannes P.; Gall, Flavio; Lindenmann, Urs; Riedl, Rainer; Fotiadis, Dimitrios; Plattet, Philippe,
2018.
Virus Research.
259, S. 28-37.
Verfügbar unter: https://doi.org/10.1016/j.virusres.2018.10.003
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Agnello, Stefano; Brand, Michael; Chellat, Mathieu; Gazzola, Silvia; Riedl, Rainer,
2018.
A Structural view on medicinal chemistry strategies against drug resistance.
Angewandte Chemie.
58(11), S. 3300-3345.
Verfügbar unter: https://doi.org/10.1002/anie.201802416
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Agnello, Stefano; Brand, Michael; Chellat, Mathieu; Gazzola, Silvia; Riedl, Rainer,
2018.
Eine strukturelle Evaluierung medizinalchemischer Strategien gegen Wirkstoffresistenzen.
Angewandte Chemie.
131(11), S. 3336-3383.
Verfügbar unter: https://doi.org/10.1002/ange.201802416
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Fischer, Thomas; Riedl, Rainer,
2017.
ChemistryOpen.
6(2), S. 165.
Verfügbar unter: https://doi.org/10.1002/open.201700043
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Fischer, Thomas; Riedl, Rainer,
2017.
ChemistryOpen.
6(2), S. 167.
Verfügbar unter: https://doi.org/10.1002/open.201700042
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Fischer, Thomas; Riedl, Rainer,
2017.
Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor.
Molecules.
22(9).
Verfügbar unter: https://doi.org/10.3390/molecules22091548
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Abu Eid, Sameer; Adams, Michael; Scherer, Thomas; Torres-Gómez, Héctor Manuel; Hackl, Martina Theresa; Kaplanian, Mairam; Riedl, Rainer; Luger, Anton; Fürnsinn, Clemens,
2017.
Emodin : a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents.
European Journal of Pharmacology.
798, S. 77-84.
Verfügbar unter: https://doi.org/10.1016/j.ejphar.2017.01.022
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Chellat, Mathieu F.; Riedl, Rainer,
2017.
Pseudouridimycin : das erste Nukleosid-Analogon, das bakterielle RNA-Polymerase selektiv inhibiert.
Angewandte Chemie.
129(43), S. 13364-13366.
Verfügbar unter: https://doi.org/10.1002/ange.201708133
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Chellat, Mathieu F.; Riedl, Rainer,
2017.
Pseudouridimycin : the first nucleoside analogue that selectively inhibits bacterial RNA polymerase.
Angewandte Chemie: International Edition.
56(43), S. 13184-13186.
Verfügbar unter: https://doi.org/10.1002/anie.201708133
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Fischer, Thomas; Riedl, Rainer,
2017.
ChemistryOpen.
6(2), S. 192-195.
Verfügbar unter: https://doi.org/10.1002/open.201600158
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Senn, Nicole; Ott, Michael; Lanz, Jan; Riedl, Rainer,
2017.
Journal of Medicinal Chemistry.
60(23), S. 9585-9598.
Verfügbar unter: https://doi.org/10.1021/acs.jmedchem.7b01001
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Chellat, Mathieu F.; Raguž, Luka; Riedl, Rainer,
2016.
Antibiotikaresistenzen gezielt überwinden.
Angewandte Chemie.
128(23), S. 6710-6738.
Verfügbar unter: https://doi.org/10.1002/ange.201506818
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Fischer, Thomas; Riedl, Rainer,
2016.
International Journal of Molecular Sciences.
17(3/314).
Verfügbar unter: https://doi.org/10.3390/ijms17030314
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Chellat, Mathieu F.; Raguž, Luka; Riedl, Rainer,
2016.
Targeting antibiotic resistance.
Angewandte Chemie: International Edition.
55(23), S. 6600-6626.
Verfügbar unter: https://doi.org/10.1002/anie.201506818
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Todorova, Milka; Trendafilova, Antoaneta; Danova, Kalina; Simmons, Luke; Wolfram, Evelyn; Meier, Beat; Riedl, Rainer; Evstatieva, Luba,
2015.
Highly oxygenated sesquiterpenes in Artemisia alba Turra.
Phytochemistry.
110, S. 140-149.
Verfügbar unter: https://doi.org/10.1016/j.phytochem.2014.12.008
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Lanz, Jan; Riedl, Rainer,
2015.
ChemMedChem.
10(3), S. 451-454.
Verfügbar unter: https://doi.org/10.1002/cmdc.201402478
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Fischer, Thomas; Riedl, Rainer,
2013.
ChemMedChem.
8(9), S. 1457-1461.
Verfügbar unter: https://doi.org/10.1002/cmdc.201300278
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Höck, Stefan; Riedl, Rainer,
2012.
chemf : a purely functional chemistry toolkit.
Journal of Cheminformatics.
4(38).
Verfügbar unter: https://doi.org/10.1186/1758-2946-4-38
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Höck, Stefan; Riedl, Rainer,
2012.
CyBy2 : a structure-based data management tool for chemical and biological data.
Chimia.
66(3), S. 132-134.
Verfügbar unter: https://doi.org/10.2533/chimia.2012.132a
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Höck, Stefan; Marti, Roger; Riedl, Rainer; Simeunovic, Marina,
2010.
Thermal cleavage of the Fmoc protection group.
Chimia.
64(3), S. 200-202.
Verfügbar unter: https://doi.org/10.2533/chimia.2010.200
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Heuser, Stefan; Barrett, David G.; Berg, Martina; Bonnier, Benjamin; Kahl, Astrid; Luz De La Puente, Maria; Oram, Niall; Riedl, Rainer; Roettig, Ulrike; Gil, Gema Sanz; Seger, Erich; Steggles, David J.; Wanner, Jutta; Weichert, Andreas G.,
2006.
Synthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators.
Tetrahedron Letters.
47(16), S. 2675-2678.
Verfügbar unter: https://doi.org/10.1016/j.tetlet.2006.02.110
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Supekova, Lubica; Pezacki, John Paul; Su, Andrew I.; Loweth, Colin J.; Riedl, Rainer; Geierstanger, Bernhard; Schultz, Peter G.; Wemmer, David E.,
2002.
Genomic effects of polyamide/DNA interactions on mRNA expression.
Chemistry & Biology.
9(7), S. 821-827.
Verfügbar unter: https://doi.org/10.1016/S1074-5521(02)00174-6
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Berkessel, Albrecht; Riedl, Rainer,
2000.
Combinatorial de novo synthesis of catalysts : how much of a hit-structure is needed for activity?.
Journal of Combinatorial Chemistry.
2(3), S. 215-219.
Verfügbar unter: https://doi.org/10.1021/cc990073i
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Riedl, Rainer; Tappe, Robert; Berkessel, Albrecht,
1998.
Journal of the American Chemical Society.
120(35), S. 8994-9000.
Verfügbar unter: https://doi.org/10.1021/ja980183d
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Berkessel, Albrecht; Riedl, Rainer,
1997.
Fluorescence reporters for phosphodiesterase activity.
Angewandte Chemie: International Edition.
36(13-14), S. 1481-1483.
Verfügbar unter: https://doi.org/10.1002/anie.199714811
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Berkessel, Albrecht; Riedl, Rainer,
1997.
Fluoreszenz-Reporter für Phosphodiesterase-Aktivität.
Angewandte Chemie.
109(13-14), S. 1518-1520.
Verfügbar unter: https://doi.org/10.1002/ange.19971091313
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Riedl, Rainer,
1998.
Köln:
Universität zu Köln.
Verfügbar unter: http://kups.ub.uni-koeln.de/573/
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Gall, Flavio; Hohl, Deborah; Frasson, David; Wermelinger, Tobias; Mittl, Peer R. E.; Sievers, Martin; Riedl, Rainer,
2019.
Angewandte Chemie: International Edition.
58(12), S. 3653.
Verfügbar unter: https://doi.org/10.1002/anie.201901671
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Riedl, Rainer,
2014.
Horizon 2020 Projects.
2014(4), S. 130.
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Riedl, Rainer,
2014.
Nicht nur Metalloproteasen im Visier.
Chemie Plus.
2014(4), S. 30-31.
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Riedl, Rainer,
2013.
Bridging the disciplines : cancer diagnostics & treatment.
Pan European Networks: Science & Technology.
7, S. 240-241.
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Riedl, Rainer; Höck, Stefan,
2013.
CyBy² : clevere Handhabung strukturbasierter Datensätze.
Transfer.
2013(1), S. 3.
Verfügbar unter: https://doi.org/10.21256/zhaw-2864
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Riedl, Rainer,
2013.
Drug discovery through a chemist’s eyes.
International Innovation - EuroFocus.
18, S. 103.
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Riedl, Rainer,
2013.
Organic chemistry : the heart and soul of drug discovery.
International Innovation - EuroFocus.
18, S. 104-105.
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Fischer, Thomas; Riedl, Rainer,
2012.
Design, synthesis and biological testing of novel MMP-inhibitors [Poster].
In:
Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 13 September 2012.
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Riedl, Rainer; Höck, Stefan,
2012.
Enhancing CyBy2 : visualization of structure activity relationships of large datasets [Poster].
In:
Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 13 September 2012.
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Riedl, Rainer; Fischer, Thomas,
2012.
Structure based design and synthesis of novel MMP inhibitors [Poster].
In:
19th EuroQSAR: «Knowledge Enabled Ligand Design», Vienna, Austria, 26-30 August 2012.
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Riedl, Rainer; Brand, Michael,
2012.
Synthese und medizinalchemische Optimierung von Tetrazyklinanaloga.
À Jour: SVC - Chemie, Life Sciences & Biotechnologie.
2012(1), S. 10-11.
-
Riedl, Rainer; Fischer, Thomas; Züger, Patrik; Brand, Michael,
2011.
Structure based design and synthesis of novel MMP inhibitors [Poster].
In:
Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.
-
Riedl, Rainer; Brand, Michael; Sephton, Mark,
2011.
Synthesis of tetracycline analogues [Poster].
In:
Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.
-
Riedl, Rainer; Höck, Stefan,
2011.
CyBy2 : a modular rich client for the chemical and biological information management [Poster].
In:
Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.
-
Riedl, Rainer; Fischer, Thomas,
2010.
Fragment based scaffold hopping in drug discovery [Poster].
In:
Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 16 September 2010.
-
Riedl, Rainer; Höck, Stefan; Kunz, Laura,
2010.
Profiling H-bond properties of fragments [Poster].
In:
Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 16 September 2010.
-
Riedl, Rainer,
2013.
Tackling antibiotic resistance.
In:
ILMAC 2013, 19. Internationale Fachmesse für Laboratoriums- und Verfahrenstechnik, Messtechnik und Automatik in der Chemie (ILMAC), Basel, 24.-27. September 2013.
-
Riedl, Rainer,
2011.
Drug discovery in the academic setting.
In:
3. Wädenswiler Chemietag «Medizinalchemie - Fokus Wirkstoffentwicklung», Wädenswil, 16. Juni 2011.
-
Riedl, Rainer,
2010.
Structure activity relationship within a gene switching system.
In:
Symposium - Synthetic Biotechnology, Basel, 18.-19. November 2010.
-
Riedl, Rainer,
2010.
In:
Biotech in Medicine - Olten Meeting, Olten, 24. November 2010.
Patente und Patentanmeldungen
-
Knechtle, Philipp; Gombert, Frank Otto; Riedl, Rainer; Lindenmann, Urs; Krebs, Walter; Wipfli, Dennis; Albert, Ina; Wegmann, Sandro; Schmid, Andrina,
2023.
Patentnummer WO2023001905 A1
(2023-01-26)
.
Verfügbar unter: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2023001905A1
-
So, Alexander; Busso, Natalie; Nasi, Sonia; Brand, Michael; Gall, Flavio Max; Riedl, Rainer; Germann, Stefan,
2022.
Methods and compositions for treating conditions associated with hypermineralization.
Patentnummer WO2022194953 A1
(2022-09-22)
.
Verfügbar unter: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022194953A1
-
Adams, Michael; Kemmler, Michael; Riedl, Rainer; Pliatsika, Dimanthi; Imanidis, Georgios; Herzig, Susanne; Kaiser, Marcel; Mäser, Pascal,
2022.
Patentnummer WO2022167656 A1
(2022-08-11)
.
Verfügbar unter: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1
-
Agnello, Stefano; Adams, Michael; Kaiser, Marcel; Mäser, Pascal; Urban, Alexander; Raguz, Luka; Riedl, Rainer,
2018.
Patentnummer EP3345917 A1
(2018-07-11)
.
Verfügbar unter: https://worldwide.espacenet.com/patent/search?q=pn%3DEP3345917A1
-
Schneider, Peter; Riedl, Rainer; Tigges, Marcel; Gitzinger, Marc; Pieren, Michel; Levi, Assaf; Sephton, Mark; Schellhorn, Birgit; Züger, Patrik; Brand, Michael; Gygax, Daniel; Spies, Peter,
2015.
Composition for treatment of pathogens that are resistant to tetracyclines.
Patentnummer EP2950793 A1
(2015-12-09)
.
Verfügbar unter: https://worldwide.espacenet.com/patent/search?q=pn%3DEP2950793A1
-
Weichert, Andreas Gerhard; Barrett, David Gene; Heuser, Stefan; Riedl, Rainer; Tebbe, Mark Joseph; Zaliani, Andrea,
2011.
Substituted arylcyclopropylacetamides as glucokinase activators.
Patentnummer EP1585739 B1
(2011-04-20)
.
Verfügbar unter: https://worldwide.espacenet.com/patent/search?q=pn%3DEP1585739B1
-
Weichert, Andreas; Barrett, David; Heuser, Stefan; Riedl, Rainer; Tebbe, Mark; Zaliani, Andrea,
2004.
Patentnummer WO2004063194 A1
(2004-07-29)
.
Verfügbar unter: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2004063194A1