Dr. Evelyn Wolfram

Dr. Evelyn Wolfram

Dr. Evelyn Wolfram
ZHAW Life Sciences und Facility Management
Einsiedlerstrasse 29
8820 Wädenswil

+41 (0) 58 934 55 42
evelyn.wolfram@zhaw.ch

Persönliches Profil

Leitungsfunktion

  • Abteilungsleitung Fachgruppe Phytopharmazie und Naturstoffe

Tätigkeit an der ZHAW als

Dozentin und Fachgruppenleitung Phytopharmazie und Naturstoffe

https://www.zhaw.ch/icbt/phytopharmazie

Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse

Phytochemische Analytik; Qualitätskontrolle und Arzneibuchmethoden in der Phytopharmazie, Kosmetik und Health Food, Extraktionsentwicklung und -Optimierung, In-Prozess Kontrolle, In vitro Vermehrung von Medizinalpflanzen, Bioautographie, Effect-Directed Analysis, UHPLC, HPLC, HPTLC, Methodenentwicklung bei Quality by Design Ansatz, Qualitätssicherung und Standardisierung in der Phytotherapie, Biotechnologie in der Medizinalpflanzenforschung, Qualitätsmanagement

Aus- und Fortbildung

Dr.-Ing. Biotechnologie, Forschungszentrum Jülich und TU München
Diplom-Ingenieur Technischer Umweltschutz - Vertiefung Wasserreinhaltung, TU BerlinMaster of Science, Civil and Environmental Engineering, University of Massachusetts


Beruflicher Werdegang

Cytos Biotechnology AG, Schlieren Schweiz
Emil Flachsmann AG/Frutarom Inc., Wädenswil Schweiz
Cosmetochem AG, Steinhausen Schweiz
Associate Professor an der Alexandru Ioan Cuza Universität, Iasi Rumänien
Associate Professor and der Ovidius Universität, Constanta Rumänien

Mitglied in Netzwerken

Projekte

Mitarbeit an folgenden Projekten

Publikationen

Monographien und Herausgeberschaften

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Parallele Substratkontrolle in Bioreaktoren mit geringem Volumen

: Dissertation an der TU München.

Jülich: Berichte des Forschungszentrums Jülich.

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Determination of the Decay Rate for Indicator Bacteria Introduced by Sea Gulls to an Oligotrophic Drinking Water Reservoir

: Master Thesis.

Amherst: University of Massachusetts.

Beiträge, peer-reviewed

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Bioassay-coupled Chromatography: Challenges and Applications in Natural Product Research

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Phytochemical Analysis, 28 73. Peer reviewed.

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High-Performance Thin-Layer Chromatographic Fingerprint Method for the Detection of Sennosides in Cassia senna L. and Cassia angustifolia Vahl

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Journal of Planar Chromatography , 30, 4. 238-244. Peer reviewed.

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Recent advances in effect-directed enzyme assays based on thin-layer chromatography

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Phytochemical Analysis, 28 74–86. Peer reviewed.

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Biotechnological yield of phytopharmaceuticals of valuable Balkan medicinal plants

.

Planta Medica , 81(S 01), S1-S381 . Peer reviewed.

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Direct coupling of HPTLC with MALDI-TOF MS for qualitative detection of flavonoids on phytochemical fingerprints

.

Phytochemical Analysis, 27, 3-4. 222–228. Peer reviewed.

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HPTLC and HPTLC-coupled Bioassays for Bioprocess Control of Medicinal Plant In Vitro Cultures from the Balkan region

.

Planta Medica , 81 (S 01), S1-S381 . Peer reviewed.

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Modernisierung der Monografien für Thymianfluidextrakt und Thymiansirup der Schweizer Pharmakopöe

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Zeitschrift für Phytotherapie, 37, S01. P24. Peer reviewed.

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Optimization of LC separation of anthraquinones in Sennae fructus and Sennae folium supported by an in-silico tool

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Planta Medica , 81/S01, S1-S381. Peer reviewed.

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Untersuchungen zum Extraktionsverhalten der Anthranoide in Sennae folium/fructus unter Berücksichtigung der Aglyka

.

Zeitschrift für Phytotherapie, 37, S01. V30. Peer reviewed.

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Der Medizinnobelpreis 2015 – Auswirkungen auf die Phytopharmazie?

.

Schweizerische Zeitschrift für Ganzheitsmedizin, 27, 6. 320-321. Peer reviewed.

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Highly oxygenated sesquiterpenes in Artemisia alba Turra

.

Phytochemistry, 110, 140–149. Peer reviewed.

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In vitro culture development and polyphenolics production of Artemisia alba Turra

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Journal of BioSciences and Biotechnology, Special Issue Second National Youth Conference "Biological sciences for a better future" Plovdiv, October 30-31, 2015 , Online. 131-136. Peer reviewed.

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Optimization of an UHPLC method for flavonoids from Hypericum species

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Planta Medica, 81, 16. PW-194. Peer reviewed.

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Polyphenol, anthocyanin and antioxidant content in different parts of maqui fruits (Aristotelia chilensis) during ripening and conservation treatments after harvest

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Industrial Crops and Products, 76 158–165. Peer reviewed.

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Relations between polyphenolics production and enzymatic antioxidant defense in Pulsatilla montana ssp. balcana in vitro

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Planta Medica, 81, 16. PW_04. Peer reviewed.

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A validated method for the analysis of frangulin A/B and glucofrangulin A/B using HPLC and UHPLC

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Journal of Natural Products, 77 489-496. Peer reviewed.

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An HPLC method to determine sennoside A and sennoside B in Sennae fructus and Sennae folium

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Pharmeuropa Bio and Scientific Notes, October 92-102. Peer reviewed.

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Bioautographic screening of Xanthine Oxidase inhibition and antioxidant activities for bioprocess control of in vitro cultivated medicinal and aromatic plants of the Balkan region

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Planta medica, 80, 16. P2B62. Peer reviewed.

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In situ and in vitro comparative study on the bioproductivity of Arnicae folium et caulis from the northern area of the Romanian Eastern Carpathians

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Journal of Plant Development, 21 P3. Peer reviewed.

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Arnica montana L. cell suspension culture as a biotechnological approach for the production of bioactive secondary metabolites

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Planta medica, 79, 13. PN105. Peer reviewed.

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Enzymatic activity and physiological status affect essential oils and polyphenolics production in Artemisia alba tissue cultures

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Planta Med, 79, 13. Peer reviewed.

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Highly oxygnated sesquiterpenes from the aerial parts of Artemisia alba Turra

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Planta Med, 79, 13. Peer reviewed.

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HPTLC method for phytochemical and radical scavenging profiles of Chilean "Maqui" berries (Aristotelia chilensis) at different ripening stages from cultivated accessions

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Planta Med, 79, 13. Peer reviewed.

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New HPLC - method to determine Frangulin A and B as well as Glucofrangulin A and B in Frangulae cortex

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Planta Med, 79, 13. Peer reviewed.

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New UHPLC - method to determine Aloin A and B in Aloe capensis

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Planta Med, 79, 13. Peer reviewed.

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Optimization of in vitro culture system for biomass and polyphenolics production in Inula britannica and Sideritis scardica Sofia 2 cultivar

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Planta Med, 79, 13. Peer reviewed.

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Phytochemical assessment of the effect of stimulated in vitro multiplication on the metabolic profile of in vitro cultured Hypericum richeri and Artemisia alba

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Planta Med, 79, 13. Peer reviewed.

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The Mangosteen Fruit and their active xanthones - an actual literature survey and an outlook for application in cosmetics

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In: Kosmetik Jahrbuch. Augsburg: Verlag Robert Fischer (in press). Peer reviewed.

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Extract and extract might not be the same! Evaluation of the quality of plant extracts

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In: Kosmetik Jahrbuch. Augsburg: Verlag Robert Fischer. Peer reviewed.

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HPTLC methods for identification of green tea and green tea extract

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Journal of liquid chromatography, 29, 13-16. 2141-2151. Peer reviewed.

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Diastereoselective synthesis of optically active (2R,5R)-hexandiol

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Appl. Microbiol. Biotechnol., 58, 5. 595-599. Peer reviewed.

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Coliform Transport in a Pristine Reservoir: Modeling and Field Studies

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Wat. Sci. Tech., 37, 2. 137-144. Peer reviewed.

Beiträge, nicht peer-reviewed

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Polysaccharide and essential oils coatings for active food packaging materials

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In: Baltic polymer symposium 2016. ISBN 9786090212356. (88). Klaipeda: Klaipeda.

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Phytochemical Composition of Arnicae flos from Wild Populations in the Northern Area of the Romanian Eastern Carpathians

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REVISTA DE CHIMIE (Bucharest), 66, 5. 784-787.

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Effect of plant growth regulators on growth patterns and enzymatic antioxidant activities in Hypericum calycinum shoot cultures

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Bulgarian Journal of Agricultural Science, 20 , Supplement 1. 46-50.

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Phytochemical analysis using HPTLC and modern LC for application in quality control and medicinal plants research - trends and tools

: Plenary Lecture PL3.

In: Phytochemical Society of Europe (Hg.). Phytochemistry in Medicine and Pharmacognosy. 2014 Phytochemical Society of Europe Conference. Piatra Neamt, RO: PSE, Leicester.

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Effect of plant growth regulators on growth patterns and physiological status of Hypericum calycinum shoot cultures

: Poster.

In: Kliment days, International Conference, Bioscience,. 20.11.2013 Sofia . Sofia: Book of Abstracts Vol IV.

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The Bulgarian Swiss Joint Research Project PhytoBalk - an example of application of biotechnological methods for the conservation of valuable medicinal plants germplasm and region independent biotechnological production of plant derived pharmaceuticals

: Poster.

In: 2nd GRF One Health Summit. International Symposium. (17.-20. November 2013). Davos: Global Risk Forum Davos.

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Method for the determination of product and substrate concentrations in a medium

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PCT Patent application, WO/2001/090720.

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Verfahren und Vorrichtung für die Bestimmung von Substrat- und Produktkonzentrationen in einem Medium

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Deutsche Patente, 100.24.992, 100.24.9998.1, 100.24.969.8.

Übrige Publikationen

Meier N, Meier B, Peter S, Wolfram E. In-Silico UHPLC Method Optimization for Aglycones in the Herbal Laxatives Aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots. Molecules. 2017; 22 (11), 1838.

Meier N, Peter S, Meier B, Wolfram E. High-performance thin layer chromatographic fingerprint method for the detection of sennosides in Cassia senna L. and Cassia angustifolia Vahl. Journal of Planar Chromatography - Modern TLC 2017; 30 (4), 238–244.