Dr. Markus Rimann

Persönliches Profil

Tätigkeit an der ZHAW

Head of TEDD Competence Centre
Group Leader 3D Tissues and Biofabrication
3D Bioprinting
Development and application of novel biomaterials in Tissue Engineering
Tissue Engineering
Automated Systems


www.zhaw.ch/icbt/3d-tissues-and-biofabrication/

Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse

Bioprinting
Biofabrication
Scaffold-based and scaffold-free 3D cell culture models
Drug development
Automation of advanced cell culture systems

Aus- und Fortbildung

Markus Rimann completed his degree in Biology, specialty in Biotechnology, at the ETH Zurich in 2005. As a PhD student, he was developing a somatic gene therapy approach to improve cutaneous wound healing. He received his Dr. sc. nat. from the ETH Zurich in 2009. As postdoc at the Center for Applied Biotechnology and Molecular Medicine (CABMM) at the University of Zurich, he was focusing on the usage and tracking of mesenchymal stem cells (MSCs) for the treatment of osteoporosis. Since 2011, he works at the Zurich University of Applied Sciences (ZHAW) in the Tissue Engineering team of Prof. Dr. Graf-Hausner. On one hand, he was responsible for the successful implementation of the promising bioprinting technology at the ZHAW and on the other hand, he was involved in initiating the TEDD (Tissue Engineering for Drug Development and Substance Testing) Competence Centre. The TEDD network is a collaborative innovation platform, dedicated to 3D cell culture technology and organ-like tissue models for drug development, substance testing, personalized and regenerative medicine. The network pools and transfers knowledge and technologies by combining diverse skills through integrative cooperation among academic, clinical and industrial partners. He works with different 3D cell culture systems with or without scaffolds. His research is mainly application-driven to make organotypic model systems available for industry as well as for the clinics. The focus is on developing 3D cell models for substance testing including automated production, maintenance and analysis. From 2016, he became a group leader in the team of Prof. Dr. Raghunath, the successor of Prof. Dr. Graf-Hausner. Since August 2019, he is leading the TEDD Competence Centre.

Mitglied in Netzwerken

• Dechema, member of the scientific committee of the 3D cell culture symposium
• Animalfree Research, Foundation Board Member
• EUROoCS, member of the European Organ-on-Chip Society
• biotechnet, Board Member
• TERMIS, member of the Tissue Engineering and Regenerative Medicine International Society

Projekte

• Herstellung von Clean Meat mittels essbaren Scaffolds / ProjektleiterIn / Projekt laufend
• Hin zu mechanisch biokompatiblen Implantatmaterialien zur Behandlung von Beckenbodensenkungen / Teammitglied / Projekt laufend
• 3D Gewebe TEDD / ProjektleiterIn / Projekt laufend
• Tumormikroumgebung 3D / Stellv. ProjektleiterIn / Projekt abgeschlossen
• Bioprinting von Biofilmen / Stellv. ProjektleiterIn / Projekt abgeschlossen
• Transglutaminase crosslinking potential / Stellv. ProjektleiterIn / Projekt abgeschlossen
• Bioprinting of vascular structures / Stellv. ProjektleiterIn / Projekt abgeschlossen

Publikationen

• D'Agostino, Stefania; Rimann, Markus; Gamba, Piergiorgio; Perilongo, Giorgio; Pozzobon, Michela; Raghunath, Michael,

  2022.

  Macromolecular crowding tuned extracellular matrix deposition in a bioprinted human rhabdomyosarcoma model.

  Bioprinting.

  27(e00213).

  Verfügbar unter: https://doi.org/10.1016/j.bprint.2022.e00213

• Rimann, Markus; Jüngel, Astrid; Mousavi, Sara; Moeschlin, Nicole; Calcagni, Maurizio; Wuertz-Kozak, Karin; Brunner, Florian; Dudli, Stefan; Distler, Oliver; Adlhart, Christian,

  2022.

  Acrylonitrile and pullulan based nanofiber mats as easily accessible scaffolds for 3D skin cell models containing primary cells.

  Cells.

  11(3), S. 445.

  Verfügbar unter: https://doi.org/10.3390/cells11030445

• Alave Reyes-Furrer, Angela; De Andrade, Sonia; Bachmann, Dominic; Jeker, Heidi; Steinmann, Martin; Accart, Nathalie; Dunbar, Andrew; Rausch, Martin; Bono, Epifania; Rimann, Markus; Keller, Hansjörg,

  2021.

  Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses.

  Communications Biology.

  4(1), S. 1183.

  Verfügbar unter: https://doi.org/10.1038/s42003-021-02691-0

• Kopanska, Katarzyna; Rimann, Markus,

  2020.

  Swiss-Chinese cooperation for organs-on-a-chip and stem cell research.

  ALTEX - Alternatives to Animal Experimentation.

  37(3).

  Verfügbar unter: https://doi.org/10.14573/altex.2006161

• Kopanska, Katarzyna; Rimann, Markus,

  2020.

  TEDD Competence Centre Report 2019.

  Chimia.

  74(5), S. 426-428.

  Verfügbar unter: https://doi.org/10.2533/chimia.2020.426

• Kopanska, Katarzyna S.; Rimann, Markus; Laternser, Sandra; Raghunath, Michael,

  2019.

  Advanced in vitro models analysis.

  ALTEX - Alternatives to Animal Experimentation.

  36(1), S. 144-147.

  Verfügbar unter: https://doi.org/10.14573/altex.1812131

• Randall, Matthew J.; Jüngel, Astrid; Rimann, Markus; Wuertz-Kozak, Karin,

  2018.

  Advances in the biofabrication of 3D skin in vitro : healthy and pathological models.

  Frontiers in Bioengineering and Biotechnology.

  6(154), S. 154.

  Verfügbar unter: https://doi.org/10.3389/fbioe.2018.00154

• Laternser, Sandra; Keller, Hansjoerg; Leupin, Olivier; Rausch, Martin; Graf-Hausner, Ursula; Rimann, Markus,

  2018.

  A novel microplate 3D bioprinting platform for the engineering of muscle and tendon tissues.

  SLAS Technology: Translating Life Sciences Innovation.

  23(6), S. 599-613.

  Verfügbar unter: https://doi.org/10.1177/2472630318776594

• Raghunath, Michael; Rimann, Markus; Kopanska, Katarzyna S.; Laternser, Sandra,

  2018.

  TEDD annual meeting with 3D bioprinting workshop.

  Chimia.

  72(1/2), S. 76-79.

  Verfügbar unter: https://doi.org/10.2533/chimia.2018.76

• Rimann, Markus,

  2018.

  ZHAW Waedenswil : a new approach in the fight against cancer.

  Chimia.

  72(3), S. 166-168.

  Verfügbar unter: https://doi.org/10.2533/chimia.2018.166

• Rimann, Markus; Bono, Epifania; Annaheim, Helene; Bleisch, Matthias; Graf-Hausner, Ursula,

  2015.

  Standardized 3D bioprinting of soft tissue models with human primary cells.

  SLAS Technology: Translating Life Sciences Innovation.

  21(4), S. 496-509.

  Verfügbar unter: https://doi.org/10.1177/2211068214567146

• Fuchs, Bruno; Rimann, Markus; Graf-Hausner, Ursula; Laternser, Sandra; Kelm, Jens; Gvozdenovic, Ana; Muff, Roman,

  2014.

  An in vitro osteosarcoma 3D microtissue model for drug development.

  Journal of Biotechnology.

  189, S. 129-135.

  Verfügbar unter: https://doi.org/10.1016/j.jbiotec.2014.09.005

• Rimann, Markus; Graf-Hausner, Ursula; Patocchi-Tenzer, Isabel; Angres, Brigitte; Braum, Susanne,

  2014.

  Automation of 3D cell culture using chemically defined hydrogels.

  SLAS Technology: Translating Life Sciences Innovation.

  19(2), S. 191-197.

  Verfügbar unter: https://doi.org/10.1177/2211068213508651

• Rimann, Markus; Angres, Brigitte; Patocchi-Tenzer, Isabel; Braum, Susanne; Graf-Hausner, Ursula,

  2013.

  TEDD - innovation network for 3D cell cultivation : 3D cell culture for drug development.

  Chimia.

  67(11), S. 822-824.

  Verfügbar unter: https://doi.org/10.2533/chimia.2013.822

• Rimann, Markus; Graf-Hausner, Ursula,

  2012.

  Synthetic 3D multicellular systems for drug development.

  Current Opinion in Biotechnology.

  23(5), S. 803-809.

  Verfügbar unter: https://doi.org/10.1016/j.copbio.2012.01.011

• Rimann, Markus; Graf-Hausner, Ursula; Müller, Michael,

  2017.

  Bioresorbable polymers for bioprinting applications

  .

  In:

  Perale, Giuseppe; Hilborn, Jöns, Hrsg.,

  Bioresorbable polymers for biomedical applications : from fundamentals to translational medicine.

  Amsterdam:

  Elsevier.

  S. 331-362.

  Woodhead Publishing series in biomaterials ; 120.

  Verfügbar unter: https://doi.org/10.1016/B978-0-08-100262-9.00015-X

• Bono, Epifania; Sheard, Jonathan; Mikkonen, Piia; Rimann, Markus,

  2022.

  Automation of 3D cell culture using cellulose-based scaffolds [Poster].

  In:

  Biointerfaces International Conference (BIC), Zurich, Switzerland, 12-15 September 2022.

  Winterthur:

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-25998

• Kopanska, Katarzyna S; Rimann, Markus,

  2022.

  Cross-industrial applications of organotypic models.

  ALTEX - Alternatives to Animal Experimentation.

  39(1), S. 155-158.

  Verfügbar unter: https://doi.org/10.14573/altex.2112202

• Kopanska, Katarzyna S.; Rimann, Markus,

  2021.

  TEDD annual meeting 2020 : 10th anniversary, 10 years of innovation in tissue engineering.

  ALTEX - Alternatives to Animal Experimentation.

  38(1), S. 166-167.

  Verfügbar unter: https://doi.org/10.14573/altex.2012151

• Bono, Epifania; Evers, Christoph; Schmid, Franca; Graf-Hausner, Ursula; Rimann, Markus,

  2017.

  In vitro characterization of a new composite material for biomedical applications and 3D (bio)printing [Poster].

  In:

  TEDD Annual Meeting, Wädenswil, 8-9 November 2017.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-3587

• Rimann, Markus; Bono, Epifania; Picenoni, Armin; Felley-Bosco, Emanuela; Meyer, Andreas; Pelleaux, René; Hund, Corinna,

  2017.

  Development of a matrix-based technology platform for the high throughput analysis of 3D cell cultures [Poster].

  In:

  Swiss Medtech Day, Bern, 13 June 2017.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-3588

• Bono, Epifania; Mathes, Stephanie; Rimann, Markus,

  2017.

  Evaluation of 3D hepatic tissue models for bioprinting [Poster].

  In:

  TERMIS-EU 2017 Conference, Davos, 26-30 June 2017.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-3590

• Rimann, Markus; Laternser, Sandra; Bono, Epifania; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Hartmann, Lilian; Alave-Reyes, Angela; Thurner, Marc; Scheidegger, Andreas; Graf-Hausner, Ursula,

  2016.

  A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues [Poster].

  In:

  Swiss Medtech Day, Bern, 7 June 2016.

• Rimann, Markus; Graf-Hausner, Ursula; Nosswitz, Michael; Wagner, Carsten; Morel, Alexandre,

  2016.

  Bioprinted kidney model for nephrotoxicity assessment [Poster].

  In:

  Swiss Medtech Day, Bern, 7 June 2016.

• Rimann, Markus; Mathes, Stephanie; Raghunath, Michael; Rohrer, Jack,

  2016.

  Zurich university of applied sciences : center for cell biology and tissue engineering [Poster].

  In:

  Roche Symposium, Basel, 2016.

• Raghunath, Michael; Rimann, Markus; Mathes, Stephanie; Rohrer, Jack,

  2016.

  Zurich University of Applied Sciences : center for cell biology and tissue engineering [Poster].

  In:

  Roche Symposium, Basel, 2016.

• Graf-Hausner, Ursula; Rimann, Markus; Bono, Epifania; Laternser, Sandra; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Richter, Jens; Alave, Angela; Thurner, Marc; Scheidegger, Andreas,

  2015.

  A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues [Poster].

  In:

  CTI Medtech Event, Bern, 8. September 2015.

• Rimann, Markus; Laternser, Sandra; Bono, Epifania; Keller, Hansjörg; Leupin, Olivier; Fässler, Thomas; Eggmann, Kurt; Thurner, Marc; Graf-Hausner, Ursula,

  2015.

  Bioprinted muscle/tendon for drug assessment [Poster].

  In:

  NTN Swiss Biotech Innovation Day: The potential of industry-academia collaborations, Zug, 19 August 2015.

• Graf-Hausner, Ursula; Rimann, Markus; Bono, Epifania; Laternser, Sandra; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Munz, Peter; Hauer, Matthias; Keller, Hansjörg; Richter, Jens; Alave, Angela; Leupin, Olivier; Thurner, Marc; Scheidegger, Andreas,

  2014.

  A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues [Poster].

  In:

  CTI Medtech Event, Bern, 2. September 2014.

• Pörtner, Ralf; Wagner, Ilka; Atanasova, Tamara; Gautam, Richa; Gattlen, Jasmin; Rimann, Markus; Bono, Epifania; Graf-Hausner, Ursula; Marx, Uwe,

  2014.

  Aktuelle Trends bei der in vitro-Substanztestung in Deutschland und in der Schweiz.

  BIOspektrum.

  20(4), S. 470-472.

  Verfügbar unter: https://doi.org/10.1007/s12268-014-0466-6

• Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Meier, Christoph; Bossen, Anke; Graf-Hausner, Ursula,

  2014.

  Skin bioprinting : an innovative approach to produce standardized skin models on demand [Poster].

  In:

  Swiss Biotech Innovation Day 2014 «the Potential of Industry-Academia Collaborations», Basel, 28 August 2014.

• Rimann, Markus; Annaheim, Helene; Meier, Christoph; Bossen, Anke; Kuster, Michael; Scheidegger, Andreas; Thurner, Marc; Graf-Hausner, Ursula,

  2013.

  Skin bioprinting : an innovative approach to produce standardized skin models on demand [Poster].

  In:

  CTI Medtech Event 2013, Bern, 27. August 2013.

• Rimann, Markus; Novak, Franziska; Fried, Nicole; Kelm, Jens M.; Graf-Hausner, Ursula,

  2012.

  Cryopreservation of spherical tumor microtissues [Poster].

  In:

  3D Cell Culture 2012: Zurich, 14-16 March 2012.

• Rimann, Markus; Annaheim, Helene; Meier, Christoph; Bossen, Anke; Scheidegger, Andreas; Kuster, Michael; Thurner, Marc; Graf-Hausner, Ursula,

  2012.

  Skin bioprinting : an innovative approach to produce standardized skin models on demand [Poster].

  In:

  CTI Medtech Event 2012, Luzern, 24. September 2012.

• Rimann, Markus; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Meier, Christoph; Bossen, Anke; Graf-Hausner, Ursula,

  2011.

  Organomimetic skin model production based on a novel bioprinting technology [Poster].

  In:

  CTI Medtech Event 2011, Bern, 23. August 2011.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula; Raghunath, Michael,

  2017.

  3D bioprinted tissue models for substance testing.

  In:

  International Conference and Exhibition - Society for Laboratory Automation and Screening (SLAS 2017), Washington, USA, 4–8 February 2017.

• Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Graf-Hausner, Ursula,

  2016.

  Standardized 3D bioprinting of skin models for drug development.

  In:

  4th International Cosmetic Innovation Days «Cosminnov», Orléans, France, 24-25 May 2016.

• Rimann, Markus; Laternser, Sandra; Bono, Epifania; Nosswitz, Michael; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

  2016.

  Bioprinted tissues for substance testing.

  In:

  3D Cell Culture 2016, Freiburg, Germany, 19-21 April 2016.

• Rimann, Markus; Mathes, Stephanie; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Graf-Hausner, Ursula,

  2016.

  3D models for compound testing.

  In:

  3rd 3D Models & Drug Screening Conference, Berlin, Germany, 11-12 May 2016.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

  2016.

  3D tissue models : new perspectives in medicine.

  In:

  2016 Conference and Exhibition for Cutting-Edge Medicine (CLINAM 9), Basel, 26-29 June 2016.

• Rimann, Markus,

  2016.

  3D tissues and biofabrication for therapy and industrial applications.

  In:

  Spiez Convergence, Spiez, 5-8 September 2016.

• Graf-Hausner, Ursula; Rimann, Markus; Laternser, Sandra; Bono, Epifania; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Hartmann, Lilian; Alave-Reyes, Angela; Thurner, Marc; Scheidegger, Andreas,

  2016.

  A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues.

  In:

  Swiss Medtech Day, Bern, 7 June 2016.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

  2016.

  Bioprinted tissue models for substance evalution.

  In:

  Basel Life Science Week 2016, Basel, 19-23 September 2016.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula; Raghunath, Michael,

  2016.

  Bioprinted tissues for substance evaluation.

  In:

  Biointerfaces International 2016 Conference, Zurich, 23-25 August 2016.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Keller, Hansjörg; Leupin, Olivier; Graf-Hausner, Ursula,

  2015.

  Bioprinted soft tissue models for compound testing.

  In:

  International Conference on Biofabrication (Biofabrication 2015), Utrecht, Netherlands, 7-9 November 2015.

• Rimann, Markus,

  2015.

  Bioprinting : break-out session.

  In:

  Expert Forum on 3D printing «Changing the World one Print at a Time» - Swiss Re, Rüschlikon, 30. September 2015.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

  2015.

  Soft tissue bioprinting in tissue engineering for drug development.

  In:

  Olten Meeting 2015: Antibiotics and Bioprinting - for a better life, Biotechnet Switzerland, Olten, 18 November 2015.

• Rimann, Markus; Galea, Laetitia,

  2015.

  Tissue bioprinting for compound evaluation.

  In:

  CTI Medtech Event, Bern, 8. September 2015.

• Rimann, Markus,

  2014.

  Competence centre TEDD tissue engineering for drug development.

  In:

  15th Edition of the Swiss Soft Days (SSD), Lausanne, 2 October 2014.

• Rimann, Markus,

  2014.

  Additive Verfahren mit biologischen Materialien.

  In:

  3D Druck und Healthtech - Healthtech Cluster Switzerland, Schwyz, 28. August 2014.

• Rimann, Markus,

  2014.

  Bioprinting : aktueller Stand in der Forschung.

  In:

  3D Druck: Revolution in Technik, Recht und Medizin?, Winterthur, 27. August 2014.

• Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Meier, Christoph; Bossen, Anke; Graf-Hausner, Ursula,

  2014.

  Skin bioprinting : an approach to produce standardized skin models on demand.

  In:

  DECHEMA - 3D Cell Culture 2014, Freiburg, Germany, 25-27 June 2014.

• Rimann, Markus,

  2014.

  3D cell-based assays for drug de-risking.

  In:

  SLAS Short course, Basel, September 2014.

• Rimann, Markus,

  2014.

  A 3D osteosarcoma model.

  In:

  Wissenschaftliches Forum über «Challenges and Opportunities in the Development of Novel Anti-Tumor Therapies», Schlieren, September 2014.

• Rimann, Markus,

  2014.

  Bioprinting von 3D Gewebemodellen.

  In:

  5. Kongress Industrielle Zelltechnik, Lübeck, Deutschland, 11.-12. September 2014.

• Fuchs, Bruno; Rimann, Markus; Graf-Hausner, Ursula; Laternser, Sandra; Gvozdenovic, Ana; Kelm, Jens M.; Muff, Roman,

  2014.

  Human 3D osteosarcoma models for drug testing.

  In:

  3D Cell Culture 2014, Freiburg, Germany, 25-27 June 2014.

• Rimann, Markus,

  2013.

  Automation of 3D cell cultures using defined biomimetic hydrogels.

  In:

  FAST Congress, Boston, USA, 17-19 October 2013.

• Rimann, Markus; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Meier, Christoph; Bossen, Anke; Graf-Hausner, Ursula,

  2012.

  Organomimetic skin model production based on a novel bioprinting technology.

  In:

  3D Cell Culture 2012: Zurich, 14-16 March 2012.

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