Dr. Kerstin Gari
Dr. Kerstin Gari
ZHAW
Life Sciences und Facility Management
Fachgruppe Biochemie
Einsiedlerstrasse 31
8820 Wädenswil
Persönliches Profil
Leitungsfunktion
Leitung Fachgruppe Biochemie
Tätigkeit an der ZHAW
Dozentin für Biochemie
www.zhaw.ch/de/lsfm/institute-zentren/icbt/biochemie-und-bioanalytik/biochemie/
Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse
Krebsforschung, Genomstabilität, DNA-Replikation und DNA-Reparatur, Eisen-Schwefel-Cluster
Aus- und Fortbildung
2003-2007: PhD in Life Sciences, Universität Lausanne
1997-2002: Diplom in Biologie, Universität Heidelberg, Deutschland
2000–2001: Maîtrise in Zellbiologie und Physiologie, Universität Montpellier, Frankreich
Beruflicher Werdegang
2013-2020: SNF-Assistenzprofessorin, Universität Zürich
2009-2013: Postdoktorandin, London Research Institute, England
2008: Postdoktorandin, Universität Lausanne
Projekte
Publikationen
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Lee, Wei Ting C.; Yin, Yandong; Morten, Michael J.; Tonzi, Peter; Gwo, Pam Pam; Odermatt, Diana C.; Modesti, Mauro; Cantor, Sharon B.; Gari, Kerstin; Huang, Tony T.; Rothenberg, Eli,
2021.
Nature Communications.
12(1), S. 2525.
Verfügbar unter: https://doi.org/10.1038/s41467-021-22830-9
Publikationen vor Tätigkeit an der ZHAW
Peer-reviewed articles:
Lee, W.T.C., Yin, Y., Morten, M.J., Tonzi, P., Odermatt, D.C., Modesti, M., Cantor, S.B., Gari, K., Huang, T.T. & Rothenberg, E. (2021) Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling. Nat Commun 12, 2525 (2021).
Mariotti, L., Wild, S., Brunoldi, G., Piceni, A., Ceppi, I., Kummer, S., Lutz, R.E., Cejka, P. & Gari, K. (2020) The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2. Commun Biol, 3, 322.
Odermatt, D.C., Lee, W.T.C, Wild, S., Jozwiakowski S.K., Rothenberg, E. & Gari, K. (2020) Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism. PLOS Genetics, 16(6): e1008740.
Simon, A.K., Kummer, S., Wild, S., Lezaja, A., Teloni, F., Jozwiakowski S.K., Altmeyer, M. & Gari, K. (2020) The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation. Life Sci Alliance, 3(3): e201900547.
Porebski, B., Wild, S., Kummer, S., Scaglione, S., Gaillard, P.H.L. & Gari, K. (2019) WRNIP1 protects reversed DNA replication forks from SLX4-dependent nucleolytic cleavage. iScience 21, 31-41.
Jozwiakowski, S.K., Kummer, S. & Gari, K. (2019) Human DNA polymerase delta requires an iron–sulfur cluster for high-fidelity DNA synthesis. Life Sci Alliance, 2: e201900321.
Odermatt, D.C. & Gari, K. (2017) The CIA targeting complex is highly regulated and provides two distinct binding sites for client iron-sulfur proteins. Cell Reports, 18, 1434-1443.
Lossaint, G., Larroque, M., Ribeyre, C., Bec, N., Larroque, C., Décaillet, C., Gari, K. & Constantinou, A. (2013) FANCD2 binds MCM proteins and controls replisome function upon activation of S phase checkpoint signaling. Mol Cell, 51, 678-90.
Gari, K., León Ortiz, A.M., Borel, V., Flynn, H., Skehel, J.M. & Boulton, S.J. (2012) MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science 337, 243-5.
Gari, K. & Constantinou, A. (2009) The role of the Fanconi anemia network in the response to DNA replication stress. Crit Rev Biochem Mol Biol, 44(5), 292-325.
Gari, K., Décaillet, C., Delannoy, M., Wu, L. & Constantinou, A. (2008) Remodeling of DNA replication structures by the branchpoint translocase FANCM. PNAS, 105, 16107-12.
Gari, K., Décaillet, C., Stasiak, A.Z., Stasiak, A. & Constantinou, A. (2008) The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell, 29, 141-8.
Rehwinkel, J., Herold, A., Gari, K., Kocher, T., Rode, M., Ciccarelli, F.L., Wilm, M. & Izaurralde, E. (2004) Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol, 11, 558-66.
Book chapter:
Gari, K. (2014) Iron-sulfur proteins and genome stability. De Gruyter: Iron-Sulfur Clusters in Chemistry and Biology (1st edition 2014: Chapter 20; 2nd edition 2017: Volume II, Chapter 13).