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Dr. Kerstin Gari

Dr. Kerstin Gari

Dr. Kerstin Gari

ZHAW School of Life Sciences and Facility Management
Fachgruppe Biochemie
Einsiedlerstrasse 31
8820 Wädenswil

+41 (0) 58 934 50 49
kerstin.gari@zhaw.ch

Personal profile

Management role

Head, Biochemistry Group

Position at the ZHAW

Lecturer in Biochemistry

https://www.zhaw.ch/de/lsfm/institute-zentren/icbt/

Expertise and research interests

Cancer biology, Genome stability, DNA replication and repair, Iron-sulphur clusters

Educational background

2003-2007: PhD in Life Sciences, University of Lausanne

1997-2002: Diploma in Biology, University of Heidelberg, Germany

2000–2001: Maîtrise in Cell Biology and Physiology, University of Montpellier, France

Professional milestones

2013–2020: SNSF Assistant Professor, University of Zurich

2009–2013: Post-doctoral Fellow, London Research Institute, UK

2008: Post-doctoral Fellow, University of Lausanne

Publications

Publications before appointment at the ZHAW

Peer-reviewed articles:

Lee, W.T.C., Yin, Y., Morten, M.J., Tonzi, P., Odermatt, D.C., Modesti, M., Cantor, S.B., Gari, K., Huang, T.T. & Rothenberg, E. (2021) Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling. Nat Commun 12, 2525 (2021).

Mariotti, L., Wild, S., Brunoldi, G., Piceni, A., Ceppi, I., Kummer, S., Lutz, R.E., Cejka, P. & Gari, K. (2020) The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2. Commun Biol, 3, 322.

Odermatt, D.C., Lee, W.T.C, Wild, S., Jozwiakowski S.K., Rothenberg, E. & Gari, K. (2020) Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism. PLOS Genetics, 16(6): e1008740.

Simon, A.K., Kummer, S., Wild, S., Lezaja, A., Teloni, F., Jozwiakowski S.K., Altmeyer, M. & Gari, K. (2020) The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation. Life Sci Alliance, 3(3): e201900547.

Porebski, B., Wild, S., Kummer, S., Scaglione, S., Gaillard, P.H.L. & Gari, K. (2019) WRNIP1 protects reversed DNA replication forks from SLX4-dependent nucleolytic cleavage. iScience 21, 31-41.

Jozwiakowski, S.K., Kummer, S. & Gari, K. (2019) Human DNA polymerase delta requires an iron–sulfur cluster for high-fidelity DNA synthesis. Life Sci Alliance, 2: e201900321.

Odermatt, D.C. & Gari, K. (2017) The CIA targeting complex is highly regulated and provides two distinct binding sites for client iron-sulfur proteins. Cell Reports, 18, 1434-1443.

Lossaint, G., Larroque, M., Ribeyre, C., Bec, N., Larroque, C., Décaillet, C., Gari, K. & Constantinou, A. (2013) FANCD2 binds MCM proteins and controls replisome function upon activation of S phase checkpoint signaling. Mol Cell, 51, 678-90.

Gari, K., León Ortiz, A.M., Borel, V., Flynn, H., Skehel, J.M. & Boulton, S.J. (2012) MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science 337, 243-5.

Gari, K. & Constantinou, A. (2009) The role of the Fanconi anemia network in the response to DNA replication stress. Crit Rev Biochem Mol Biol, 44(5), 292-325.

Gari, K., Décaillet, C., Delannoy, M., Wu, L. & Constantinou, A. (2008) Remodeling of DNA replication structures by the branchpoint translocase FANCM. PNAS, 105, 16107-12.

Gari, K., Décaillet, C., Stasiak, A.Z., Stasiak, A. & Constantinou, A. (2008) The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell, 29, 141-8.

Rehwinkel, J., Herold, A., Gari, K., Kocher, T., Rode, M., Ciccarelli, F.L., Wilm, M. & Izaurralde, E. (2004) Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol, 11, 558-66.


Book chapter:

Gari, K. (2014) Iron-sulfur proteins and genome stability. De Gruyter: Iron-Sulfur Clusters in Chemistry and Biology (1st edition 2014: Chapter 20; 2nd edition 2017: Volume II, Chapter 13).