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Dr. Victor Garcia

Dr. Victor Garcia

Dr. Victor Garcia
ZHAW Life Sciences und Facility Management
Fachstelle Computational Genomics


Persönliches Profil

Tätigkeit an der ZHAW als



Lehrtätigkeit in der Weiterbildung

Mein neuer Begleiter: der Algorithmus. Ein Einstieg in technische und ethische Aspekte

Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse

bioinformatics, human immunodeficiency virus (HIV), sexually transmitted diseases, population genetics, theoretical biology

Aus- und Fortbildung

02.2011 – 01.2015 Swiss Federal Institute of Technology Zurich, ETH
PhD in Theoretical Biology (Bonhoeffer group)
- Simulated within-host evolutionary dynamics of HIV (stochastic ODE)
- Collaborated on interdisciplinary project on stabilization of cooperative virulence (second-author, published in Nature)
- Estimated killing efficacies of killer T cells with statistical methods

09.2013 – 06.2014 Stanford University
Visiting Research Scholar (Lab of M.W. Feldman)
- Awarded Doc.Mobility fellowship of SNF
- Identified multidimensional association patterns in genetic data of HIV during early infection phase
- Collaborated on two projects on stochastic gene regulatory networks dynamics

10.2003 – 08.2008 Swiss Federal Institute of Technology Zurich, ETH
Diploma in Theoretical Physics
- Diploma thesis title “Brownian Agents and Bacterial Motility”: top mark
- Semester work “Simulation of a Khepera robot” at INI: top mark

10.2005 – 03.2006 Exchange Semester at Universidad Complutense de Madrid, Spain

Beruflicher Werdegang

07.2016 – 12.2016 University of Bern
Postdoc in Immuno-Epidemiology (Low and Althaus groups)
- Development of a model for Mycoplasma genitalium transmission, accounting for resistance emergence as well as symptomatic and asymptomatic infection phenotypes
- Quantification of the impact of sexual age mixing patterns on Chlamydia trachomatis prevalence
- Collaboration on project on the impact of regionally heterogeneous vaccination on human papillomavirus (HPV) transmission in Switzerland

11.2015 – 06.2016 Stanford University
Postdoc (Lab of M.W. Feldman)
- Awarded SNF Early.Postdoc Fellowship
- Quantified estimation biases stemming from a standard aggregation procedure performed on escape rates of human immunodeficiency virus (HIV) with stochastic population genetics models (C#)
- Described oscillatory multilocus linkage disequilibrium in systems with tight linkage evolving under strong selection

08.2015 – 10.2015 University of Bern
Postdoc in Immuno-Epidemiology (Low and Althaus groups)
- Development of a generic model for sexually transmitted diseases for Bayesian inference

03.2015 – 07.2015 Zurich University of Applied Sciences, ZHAW
Internship in Bioinformatics (Anisimova group), (50%)
- Initiated project to recalculate codon bias indices while accounting for programmed ribosomal frameshifting (slippery sites) in yeast

02.2015 – 07.2015 Swiss Federal Institute of Technology Zurich, ETH PostDoc in Theoretical Biology (Bonhoeffer group), (50%)
- Investigated efficacy of cancer immunotherapy (stochastic ODE, mathematical analysis)

11.2010 – 12.2010 AXA Leben AG, Winterthur, Switzerland
- Projects in product-management and pricing

06.2010 – 11.2010 Quant-Team AXA Investment Managers, London and Zurich
- Generated of key risk indicator reports, programming in VBA

06.2009 – 06.2010 Product-Management and Pricing at AXA Leben AG, Winterthur
- Designed and programmed insurance products in C#

Mitglied in Netzwerken



Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed Weitere Publikationen Publikationen vor Tätigkeit an der ZHAW

- Victor Garcia, Marcus W. Feldman, Roland Regoes, Interference between multiple CD8+ T cell escape mutation in early HIV infection, PLoS Computational Biology, 12(2): e1004721, doi: 10.1371/journal.pcbi.1004721, 2016

- Victor Garcia, Kirsten Richter, Frederik Graw, Annette Oxenius, Roland Regoes, Estimating the in vivo killing efficacy of cytotoxic T lymphocytes across different MHC-peptide complex densities, PLoS Computational Biology, 11(5): e1004178, doi: 10.1371/journal.pcbi.1004178, 2015

- Ricardo Pinho*, Victor Garcia*, Marcus W. Feldman (* = equal contribution),
Phenotype accessibility and noise in gene regulatory networks, PLoS One, 10(4): e0119972, doi:10.1371/journal.pone.0119972, 2015

- Victor Garcia, Roland Regoes, The effect of clonal interference on the CD8+ T cell escape rates in HIV, Frontiers in Immunology, doi: 10.3389/fimmu.2014.00661, 2015

- Mederic Diard, Victor Garcia, Lisa Maier, Mitja N. P. Remus-Emsermann, Roland R. Regoes, Martin Ackermann, and Wolf-Dietrich Hardt. Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature, 494(7437):353–356, 02 21, 2013.

- Ricardo Pinho, Victor Garcia, Manuel Irimia, Marcus W. Feldman, Stability depends on autoregulation in Boolean gene regulatory networks, PLoS Computational Biology, 10(11): e1003916. doi: 10.1371/journal.pcbi.1003916, 2014

- Victor Garcia, Mirko Birbaumer, and Frank Schweitzer. Testing an agent-based model of bacterial cell motility: How nutrient concentration affects speed distribution. The European Physical Journal B-Condensed Matter and Complex Systems, 82(3):235– 244, 2011.