Dr. Victor Garcia

Persönliches Profil

Tätigkeit an der ZHAW

PostDoc

www.zhaw.ch/de/lsfm/institute-zentren/ias/

Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse

bioinformatics, human immunodeficiency virus (HIV), sexually transmitted diseases, population genetics, theoretical biology

Aus- und Fortbildung

02.2011 – 01.2015 Swiss Federal Institute of Technology Zurich, ETH
PhD in Theoretical Biology (Bonhoeffer group)
- Simulated within-host evolutionary dynamics of HIV (stochastic ODE)
- Collaborated on interdisciplinary project on stabilization of cooperative virulence (second-author, published in Nature)
- Estimated killing efficacies of killer T cells with statistical methods

09.2013 – 06.2014 Stanford University
Visiting Research Scholar (Lab of M.W. Feldman)
- Awarded Doc.Mobility fellowship of SNF
- Identified multidimensional association patterns in genetic data of HIV during early infection phase
- Collaborated on two projects on stochastic gene regulatory networks dynamics

10.2003 – 08.2008 Swiss Federal Institute of Technology Zurich, ETH
Diploma in Theoretical Physics
- Diploma thesis title “Brownian Agents and Bacterial Motility”: top mark
- Semester work “Simulation of a Khepera robot” at INI: top mark

10.2005 – 03.2006 Exchange Semester at Universidad Complutense de Madrid, Spain

Beruflicher Werdegang

07.2016 – 12.2016 University of Bern
Postdoc in Immuno-Epidemiology (Low and Althaus groups)
- Development of a model for Mycoplasma genitalium transmission, accounting for resistance emergence as well as symptomatic and asymptomatic infection phenotypes
- Quantification of the impact of sexual age mixing patterns on Chlamydia trachomatis prevalence
- Collaboration on project on the impact of regionally heterogeneous vaccination on human papillomavirus (HPV) transmission in Switzerland

11.2015 – 06.2016 Stanford University
Postdoc (Lab of M.W. Feldman)
- Awarded SNF Early.Postdoc Fellowship
- Quantified estimation biases stemming from a standard aggregation procedure performed on escape rates of human immunodeficiency virus (HIV) with stochastic population genetics models (C#)
- Described oscillatory multilocus linkage disequilibrium in systems with tight linkage evolving under strong selection

08.2015 – 10.2015 University of Bern
Postdoc in Immuno-Epidemiology (Low and Althaus groups)
- Development of a generic model for sexually transmitted diseases for Bayesian inference

03.2015 – 07.2015 Zurich University of Applied Sciences, ZHAW
Internship in Bioinformatics (Anisimova group), (50%)
- Initiated project to recalculate codon bias indices while accounting for programmed ribosomal frameshifting (slippery sites) in yeast

02.2015 – 07.2015 Swiss Federal Institute of Technology Zurich, ETH PostDoc in Theoretical Biology (Bonhoeffer group), (50%)
- Investigated efficacy of cancer immunotherapy (stochastic ODE, mathematical analysis)


11.2010 – 12.2010 AXA Leben AG, Winterthur, Switzerland
- Projects in product-management and pricing

06.2010 – 11.2010 Quant-Team AXA Investment Managers, London and Zurich
- Generated of key risk indicator reports, programming in VBA

06.2009 – 06.2010 Product-Management and Pricing at AXA Leben AG, Winterthur
- Designed and programmed insurance products in C#

Mitglied in Netzwerken

Swiss Institute of Bioinformatics

Projekte

• A top-down indicator of lean-green alignment in small and medium-sized enterprises / Stellv. ProjektleiterIn / Projekt abgeschlossen
• Die Exploration der Gen-Harmonisierung / Stellv. ProjektleiterIn / Projekt abgeschlossen
• Digitale Werkzeuge zur Codonoptimierung / ProjektleiterIn / Projekt abgeschlossen
• Dynamik Knowledge Platform / Co-ProjektleiterIn / Projekt abgeschlossen
• The effect of programmed ribosomal frameshifting on codon usage bias / Teammitglied / Projekt abgeschlossen
• Exploring the silent fitness landscape / Teammitglied / Projekt abgeschlossen

Publikationen

• Garcia, Victor; Horn, Claus; Ott, Thomas,

  2022.

  The sciences of data – moving towards a comprehensive systems perspective.

  Archives of Data Science, Series A.

  8(2).

  Verfügbar unter: https://doi.org/10.5445/IR/1000150241

• Zrimec, Jan; Buric, Filip; Kokina, Mariia; Garcia, Victor; Zelezniak, Aleksej,

  2021.

  Learning the regulatory code of gene expression.

  Frontiers in Molecular Biosciences.

  8(673363).

  Verfügbar unter: https://doi.org/10.3389/fmolb.2021.673363

• Cadosch, Dominique; Garcia, Victor; Jensen, Jørgen S.; Low, Nicola; Althaus, Christian L.,

  2020.

  Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium.

  PeerJ.

  8.

  Verfügbar unter: https://doi.org/10.7717/peerj.8913

• Garcia, Victor; Bonhoeffer, Sebastian; Fu, Feng,

  2020.

  Cancer-induced immunosuppression can enable effectiveness of immunotherapy through bistability generation : a mathematical and computational examination.

  Journal of Theoretical Biology.

  492(110185).

  Verfügbar unter: https://doi.org/10.1016/j.jtbi.2020.110185

• Garcia, Victor; Zoller, Stefan; Anisimova, Maria,

  2018.

  Accounting for programmed ribosomal frameshifting in the computation of codon usage bias indices.

  G3 - Genes, Genomes, Genetics.

  8(10), S. 3173-3183.

  Verfügbar unter: https://doi.org/10.1534/g3.118.200185

• Smid, Joost H.; Garcia, Victor; Low, Nicola; Mercer, Catherine H.; Althaus, Christian L.,

  2018.

  Age difference between heterosexual partners in Britain : implications for the spread of Chlamydia trachomatis.

  Epidemics.

  24, S. 60-66.

  Verfügbar unter: https://doi.org/10.1016/j.epidem.2018.03.004

• Garcia, Victor; Glassberg, Emily C.; Harpak, Arbel; Feldman, Marcus W.,

  2018.

  Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium.

  Journal of the Royal Society Interface.

  15(140).

  Verfügbar unter: https://doi.org/10.1098/rsif.2017.0921

• Riesen, Maurane; Garcia, Victor; Low, Nicola; Althaus, Christian L.,

  2017.

  Modeling the consequences of regional heterogeneity in human papillomavirus (HPV) vaccination uptake on transmission in Switzerland.

  Vaccine.

  35(52), S. 7312-7321.

  Verfügbar unter: https://doi.org/10.1016/j.vaccine.2017.10.103

• Garcia, Victor; Feldman, Marcus W.,

  2017.

  Within-epitope interactions can bias CTL escape estimation in early HIV infection.

  Frontiers in Immunology.

  8(423).

  Verfügbar unter: https://doi.org/10.3389/fimmu.2017.00423

• Garcia, Victor; Feldman, Marcus W.; Regoes, Roland R.,

  2016.

  Investigating the consequences of interference between multiple CD8+ T cell escape mutations in early HIV infection.

  PLOS Computational Biology.

  12(2), S. 1-23.

  Verfügbar unter: https://doi.org/10.1371/journal.pcbi.1004721

• Garcia, Victor; Richter, Kirsten; Graw, Frederik; Oxenius, Annette; Regoes, Roland R.,

  2015.

  Estimating the in vivo killing efficacy of cytotoxic T lymphocytes across different peptide-MHC complex densities.

  PLOS Computational Biology.

  11(5), S. 1-13.

  Verfügbar unter: https://doi.org/10.1371/journal.pcbi.1004178

• Garcia, Victor; Zoller, Stefan; Anisimova, Maria,

  2018.

  Programmed ribosomal frameshifting and codon usage bias [Poster].

  In:

  Hirsch, Sven, Hrsg.,

  Life in Numbers 4.0.

  Life in Numbers 4, Wädenswil, 4 October 2018.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-4023

• Garcia, Victor; Zoller, Stefan; Anisimova, Maria,

  2018.

  Accounting for programmed ribosomal frameshifting in the computation of codon usage bias indices [Poster].

  In:

  Symposium on Quantitative Network Biology, Kandersteg, 19-20 November 2018.

• Baumann, Isabel; Garcia, Victor; Metz, Florence,

  2018.

  Heat, greed and human need : climate change, capitalism and sustainable wellbeing. Gough, Ian. Cheltenham, Edward Elgar Publishing (2017), 264 p., ISBN 978-1-785-36512-6

  .

  Swiss Political Science Review.

  25(1), S. 95-100.

  Verfügbar unter: https://doi.org/10.1111/spsr.12336

Publikationen vor Tätigkeit an der ZHAW

- Victor Garcia, Marcus W. Feldman, Roland Regoes, Interference between multiple CD8+ T cell escape mutation in early HIV infection, PLoS Computational Biology, 12(2): e1004721, doi: 10.1371/journal.pcbi.1004721, 2016

- Victor Garcia, Kirsten Richter, Frederik Graw, Annette Oxenius, Roland Regoes, Estimating the in vivo killing efficacy of cytotoxic T lymphocytes across different MHC-peptide complex densities, PLoS Computational Biology, 11(5): e1004178, doi: 10.1371/journal.pcbi.1004178, 2015

- Ricardo Pinho*, Victor Garcia*, Marcus W. Feldman (* = equal contribution),
Phenotype accessibility and noise in gene regulatory networks, PLoS One, 10(4): e0119972, doi:10.1371/journal.pone.0119972, 2015

- Victor Garcia, Roland Regoes, The effect of clonal interference on the CD8+ T cell escape rates in HIV, Frontiers in Immunology, doi: 10.3389/fimmu.2014.00661, 2015

- Mederic Diard, Victor Garcia, Lisa Maier, Mitja N. P. Remus-Emsermann, Roland R. Regoes, Martin Ackermann, and Wolf-Dietrich Hardt. Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature, 494(7437):353–356, 02 21, 2013.

- Ricardo Pinho, Victor Garcia, Manuel Irimia, Marcus W. Feldman, Stability depends on autoregulation in Boolean gene regulatory networks, PLoS Computational Biology, 10(11): e1003916. doi: 10.1371/journal.pcbi.1003916, 2014

- Victor Garcia, Mirko Birbaumer, and Frank Schweitzer. Testing an agent-based model of bacterial cell motility: How nutrient concentration affects speed distribution. The European Physical Journal B-Condensed Matter and Complex Systems, 82(3):235– 244, 2011.

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