Dr. Victor Garcia

Dr. Victor Garcia

Dr. Victor Garcia
ZHAW Life Sciences und Facility Management

+41 (0) 58 934 56 12
victor.garcia@zhaw.ch

Persönliches Profil

Tätigkeit an der ZHAW als

PostDoc

https://www.zhaw.ch/de/lsfm/institute-zentren/ias/

Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse

bioinformatics, human immunodeficiency virus (HIV), sexually transmitted diseases, population genetics, theoretical biology

Aus- und Fortbildung

02.2011 – 01.2015 Swiss Federal Institute of Technology Zurich, ETH
PhD in Theoretical Biology (Bonhoeffer group)
- Simulated within-host evolutionary dynamics of HIV (stochastic ODE)
- Collaborated on interdisciplinary project on stabilization of cooperative virulence (second-author, published in Nature)
- Estimated killing efficacies of killer T cells with statistical methods

09.2013 – 06.2014 Stanford University
Visiting Research Scholar (Lab of M.W. Feldman)
- Awarded Doc.Mobility fellowship of SNF
- Identified multidimensional association patterns in genetic data of HIV during early infection phase
- Collaborated on two projects on stochastic gene regulatory networks dynamics

10.2003 – 08.2008 Swiss Federal Institute of Technology Zurich, ETH
Diploma in Theoretical Physics
- Diploma thesis title “Brownian Agents and Bacterial Motility”: top mark
- Semester work “Simulation of a Khepera robot” at INI: top mark

10.2005 – 03.2006 Exchange Semester at Universidad Complutense de Madrid, Spain

Beruflicher Werdegang

07.2016 – 12.2016 University of Bern
Postdoc in Immuno-Epidemiology (Low and Althaus groups)
- Development of a model for Mycoplasma genitalium transmission, accounting for resistance emergence as well as symptomatic and asymptomatic infection phenotypes
- Quantification of the impact of sexual age mixing patterns on Chlamydia trachomatis prevalence
- Collaboration on project on the impact of regionally heterogeneous vaccination on human papillomavirus (HPV) transmission in Switzerland

11.2015 – 06.2016 Stanford University
Postdoc (Lab of M.W. Feldman)
- Awarded SNF Early.Postdoc Fellowship
- Quantified estimation biases stemming from a standard aggregation procedure performed on escape rates of human immunodeficiency virus (HIV) with stochastic population genetics models (C#)
- Described oscillatory multilocus linkage disequilibrium in systems with tight linkage evolving under strong selection

08.2015 – 10.2015 University of Bern
Postdoc in Immuno-Epidemiology (Low and Althaus groups)
- Development of a generic model for sexually transmitted diseases for Bayesian inference

03.2015 – 07.2015 Zurich University of Applied Sciences, ZHAW
Internship in Bioinformatics (Anisimova group), (50%)
- Initiated project to recalculate codon bias indices while accounting for programmed ribosomal frameshifting (slippery sites) in yeast

02.2015 – 07.2015 Swiss Federal Institute of Technology Zurich, ETH PostDoc in Theoretical Biology (Bonhoeffer group), (50%)
- Investigated efficacy of cancer immunotherapy (stochastic ODE, mathematical analysis)


11.2010 – 12.2010 AXA Leben AG, Winterthur, Switzerland
- Projects in product-management and pricing

06.2010 – 11.2010 Quant-Team AXA Investment Managers, London and Zurich
- Generated of key risk indicator reports, programming in VBA

06.2009 – 06.2010 Product-Management and Pricing at AXA Leben AG, Winterthur
- Designed and programmed insurance products in C#

Mitglied in Netzwerken

Publikationen

Beiträge, peer-reviewed

; ().

Within-epitope interactions can bias CTL escape estimation in early HIV infection

.

Frontiers in Immunology, 8 423. Peer reviewed.

Publikationen vor Tätigkeit an der ZHAW

- Victor Garcia, Marcus W. Feldman, Roland Regoes, Interference between multiple CD8+ T cell escape mutation in early HIV infection, PLoS Computational Biology, 12(2): e1004721, doi: 10.1371/journal.pcbi.1004721, 2016

- Victor Garcia, Kirsten Richter, Frederik Graw, Annette Oxenius, Roland Regoes, Estimating the in vivo killing efficacy of cytotoxic T lymphocytes across different MHC-peptide complex densities, PLoS Computational Biology, 11(5): e1004178, doi: 10.1371/journal.pcbi.1004178, 2015

- Ricardo Pinho*, Victor Garcia*, Marcus W. Feldman (* = equal contribution),
Phenotype accessibility and noise in gene regulatory networks, PLoS One, 10(4): e0119972, doi:10.1371/journal.pone.0119972, 2015

- Victor Garcia, Roland Regoes, The effect of clonal interference on the CD8+ T cell escape rates in HIV, Frontiers in Immunology, doi: 10.3389/fimmu.2014.00661, 2015

- Mederic Diard, Victor Garcia, Lisa Maier, Mitja N. P. Remus-Emsermann, Roland R. Regoes, Martin Ackermann, and Wolf-Dietrich Hardt. Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature, 494(7437):353–356, 02 21, 2013.

- Ricardo Pinho, Victor Garcia, Manuel Irimia, Marcus W. Feldman, Stability depends on autoregulation in Boolean gene regulatory networks, PLoS Computational Biology, 10(11): e1003916. doi: 10.1371/journal.pcbi.1003916, 2014

- Victor Garcia, Mirko Birbaumer, and Frank Schweitzer. Testing an agent-based model of bacterial cell motility: How nutrient concentration affects speed distribution. The European Physical Journal B-Condensed Matter and Complex Systems, 82(3):235– 244, 2011.