Dr. Victor Garcia

Dr. Victor Garcia
ZHAW
Life Sciences und Facility Management
FS Bioinformatics
Schloss 1
8820 Wädenswil
Arbeit an der ZHAW
Tätigkeit an der ZHAW
PostDoc
www.zhaw.ch/de/lsfm/institute-zentren/ias/
Aus- und Weiterbildung
Arbeits- und Forschungsschwerpunkte, Spezialkenntnisse
bioinformatics, human immunodeficiency virus (HIV), sexually transmitted diseases, population genetics, theoretical biology
Beruflicher Werdegang
07.2016 – 12.2016 University of Bern
Postdoc in Immuno-Epidemiology (Low and Althaus groups)
- Development of a model for Mycoplasma genitalium transmission, accounting for resistance emergence as well as symptomatic and asymptomatic infection phenotypes
- Quantification of the impact of sexual age mixing patterns on Chlamydia trachomatis prevalence
- Collaboration on project on the impact of regionally heterogeneous vaccination on human papillomavirus (HPV) transmission in Switzerland
11.2015 – 06.2016 Stanford University
Postdoc (Lab of M.W. Feldman)
- Awarded SNF Early.Postdoc Fellowship
- Quantified estimation biases stemming from a standard aggregation procedure performed on escape rates of human immunodeficiency virus (HIV) with stochastic population genetics models (C#)
- Described oscillatory multilocus linkage disequilibrium in systems with tight linkage evolving under strong selection
08.2015 – 10.2015 University of Bern
Postdoc in Immuno-Epidemiology (Low and Althaus groups)
- Development of a generic model for sexually transmitted diseases for Bayesian inference
03.2015 – 07.2015 Zurich University of Applied Sciences, ZHAW
Internship in Bioinformatics (Anisimova group), (50%)
- Initiated project to recalculate codon bias indices while accounting for programmed ribosomal frameshifting (slippery sites) in yeast
02.2015 – 07.2015 Swiss Federal Institute of Technology Zurich, ETH PostDoc in Theoretical Biology (Bonhoeffer group), (50%)
- Investigated efficacy of cancer immunotherapy (stochastic ODE, mathematical analysis)
11.2010 – 12.2010 AXA Leben AG, Winterthur, Switzerland
- Projects in product-management and pricing
06.2010 – 11.2010 Quant-Team AXA Investment Managers, London and Zurich
- Generated of key risk indicator reports, programming in VBA
06.2009 – 06.2010 Product-Management and Pricing at AXA Leben AG, Winterthur
- Designed and programmed insurance products in C#
Aus- und Fortbildung
02.2011 – 01.2015 Swiss Federal Institute of Technology Zurich, ETH
PhD in Theoretical Biology (Bonhoeffer group)
- Simulated within-host evolutionary dynamics of HIV (stochastic ODE)
- Collaborated on interdisciplinary project on stabilization of cooperative virulence (second-author, published in Nature)
- Estimated killing efficacies of killer T cells with statistical methods
09.2013 – 06.2014 Stanford University
Visiting Research Scholar (Lab of M.W. Feldman)
- Awarded Doc.Mobility fellowship of SNF
- Identified multidimensional association patterns in genetic data of HIV during early infection phase
- Collaborated on two projects on stochastic gene regulatory networks dynamics
10.2003 – 08.2008 Swiss Federal Institute of Technology Zurich, ETH
Diploma in Theoretical Physics
- Diploma thesis title “Brownian Agents and Bacterial Motility”: top mark
- Semester work “Simulation of a Khepera robot” at INI: top mark
10.2005 – 03.2006 Exchange Semester at Universidad Complutense de Madrid, Spain
Mitglied in Netzwerken
Swiss Institute of Bioinformatics
Projekte
- A top-down indicator of lean-green alignment in small and medium-sized enterprises / Stellv. ProjektleiterIn / Projekt abgeschlossen
- Die Exploration der Gen-Harmonisierung / Stellv. ProjektleiterIn / Projekt abgeschlossen
- Digitale Werkzeuge zur Codonoptimierung / ProjektleiterIn / Projekt abgeschlossen
- Dynamik Knowledge Platform / Co-ProjektleiterIn / Projekt abgeschlossen
- The effect of programmed ribosomal frameshifting on codon usage bias / Teammitglied / Projekt abgeschlossen
- Exploring the silent fitness landscape / Teammitglied / Projekt abgeschlossen
Publikationen
-
Garcia, Victor; Horn, Claus; Ott, Thomas,
2022.
The sciences of data – moving towards a comprehensive systems perspective.
Archives of Data Science, Series A.
8(2).
Verfügbar unter: https://doi.org/10.5445/IR/1000150241
-
Zrimec, Jan; Buric, Filip; Kokina, Mariia; Garcia, Victor; Zelezniak, Aleksej,
2021.
Learning the regulatory code of gene expression.
Frontiers in Molecular Biosciences.
8(673363).
Verfügbar unter: https://doi.org/10.3389/fmolb.2021.673363
-
Cadosch, Dominique; Garcia, Victor; Jensen, Jørgen S.; Low, Nicola; Althaus, Christian L.,
2020.
Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium.
PeerJ.
8.
Verfügbar unter: https://doi.org/10.7717/peerj.8913
-
Garcia, Victor; Bonhoeffer, Sebastian; Fu, Feng,
2020.
Journal of Theoretical Biology.
492(110185).
Verfügbar unter: https://doi.org/10.1016/j.jtbi.2020.110185
-
Garcia, Victor; Zoller, Stefan; Anisimova, Maria,
2018.
Accounting for programmed ribosomal frameshifting in the computation of codon usage bias indices.
G3 - Genes, Genomes, Genetics.
8(10), S. 3173-3183.
Verfügbar unter: https://doi.org/10.1534/g3.118.200185
-
Smid, Joost H.; Garcia, Victor; Low, Nicola; Mercer, Catherine H.; Althaus, Christian L.,
2018.
Epidemics.
24, S. 60-66.
Verfügbar unter: https://doi.org/10.1016/j.epidem.2018.03.004
-
Garcia, Victor; Glassberg, Emily C.; Harpak, Arbel; Feldman, Marcus W.,
2018.
Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium.
Journal of the Royal Society Interface.
15(140).
Verfügbar unter: https://doi.org/10.1098/rsif.2017.0921
-
Riesen, Maurane; Garcia, Victor; Low, Nicola; Althaus, Christian L.,
2017.
Vaccine.
35(52), S. 7312-7321.
Verfügbar unter: https://doi.org/10.1016/j.vaccine.2017.10.103
-
Garcia, Victor; Feldman, Marcus W.,
2017.
Within-epitope interactions can bias CTL escape estimation in early HIV infection.
Frontiers in Immunology.
8(423).
Verfügbar unter: https://doi.org/10.3389/fimmu.2017.00423
-
Garcia, Victor; Feldman, Marcus W.; Regoes, Roland R.,
2016.
PLOS Computational Biology.
12(2), S. 1-23.
Verfügbar unter: https://doi.org/10.1371/journal.pcbi.1004721
-
Garcia, Victor; Richter, Kirsten; Graw, Frederik; Oxenius, Annette; Regoes, Roland R.,
2015.
PLOS Computational Biology.
11(5), S. 1-13.
Verfügbar unter: https://doi.org/10.1371/journal.pcbi.1004178
-
Garcia, Victor; Zoller, Stefan; Anisimova, Maria,
2018.
Programmed ribosomal frameshifting and codon usage bias [Poster].
In:
Hirsch, Sven, Hrsg.,
Life in Numbers 4.0.
Life in Numbers 4, Wädenswil, 4 October 2018.
ZHAW Zürcher Hochschule für Angewandte Wissenschaften.
Verfügbar unter: https://doi.org/10.21256/zhaw-4023
-
Garcia, Victor; Zoller, Stefan; Anisimova, Maria,
2018.
Accounting for programmed ribosomal frameshifting in the computation of codon usage bias indices [Poster].
In:
Symposium on Quantitative Network Biology, Kandersteg, 19-20 November 2018.
-
Baumann, Isabel; Garcia, Victor; Metz, Florence,
2018.
.
Swiss Political Science Review.
25(1), S. 95-100.
Verfügbar unter: https://doi.org/10.1111/spsr.12336
Publikationen vor Tätigkeit an der ZHAW
- Victor Garcia, Marcus W. Feldman, Roland Regoes, Interference between multiple CD8+ T cell escape mutation in early HIV infection, PLoS Computational Biology, 12(2): e1004721, doi: 10.1371/journal.pcbi.1004721, 2016
- Victor Garcia, Kirsten Richter, Frederik Graw, Annette Oxenius, Roland Regoes, Estimating the in vivo killing efficacy of cytotoxic T lymphocytes across different MHC-peptide complex densities, PLoS Computational Biology, 11(5): e1004178, doi: 10.1371/journal.pcbi.1004178, 2015
- Ricardo Pinho*, Victor Garcia*, Marcus W. Feldman (* = equal contribution),
Phenotype accessibility and noise in gene regulatory networks, PLoS One, 10(4): e0119972, doi:10.1371/journal.pone.0119972, 2015
- Victor Garcia, Roland Regoes, The effect of clonal interference on the CD8+ T cell escape rates in HIV, Frontiers in Immunology, doi: 10.3389/fimmu.2014.00661, 2015
- Mederic Diard, Victor Garcia, Lisa Maier, Mitja N. P. Remus-Emsermann, Roland R. Regoes, Martin Ackermann, and Wolf-Dietrich Hardt. Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature, 494(7437):353–356, 02 21, 2013.
- Ricardo Pinho, Victor Garcia, Manuel Irimia, Marcus W. Feldman, Stability depends on autoregulation in Boolean gene regulatory networks, PLoS Computational Biology, 10(11): e1003916. doi: 10.1371/journal.pcbi.1003916, 2014
- Victor Garcia, Mirko Birbaumer, and Frank Schweitzer. Testing an agent-based model of bacterial cell motility: How nutrient concentration affects speed distribution. The European Physical Journal B-Condensed Matter and Complex Systems, 82(3):235– 244, 2011.