Prof. Dr. Dieter Eibl

Personal profile

Position at the ZHAW

www.zhaw.ch/icbt/bioverfahrenstechnik

Membership of networks

• DECHEMA
• ISPE
• APV
• SGLWT

Projects

• Muscle generator – The key to unlock scalable and affordable cultivated meat production / Project co-leader / Project ongoing
• Prozesstransfer einer Kultivierungsstrategie für eine CHO-Zelllinie in einem wellendurchmischten Bioreaktor / Deputy project leader / Project completed
• Process development and biomass production of S. cerevisiae spiked with heavy water / Deputy project leader / Project completed
• Evaluation of cell separation using the GEA kytero® Single Use Pharma Separator with disk stack technology / Deputy project leader / Project completed
• CFD industrial scale protein extraction / Deputy project leader / Project completed
• Intellishaker / Project leader / Project completed
• Microbiome therapeutics / Project leader / Project completed
• Biocatalytic Production - Engineering of terpene cyclases for the production of R-alpha-Ionone / Deputy project leader / Project completed

Publications

• Seidel, Stefan; Eibl-Schindler, Regine; Eibl, Dieter,

  2022.

  Laboratory-independent exploration of stirred bioreactors and their fluid dynamics.

  Education for Chemical Engineers.

  42, pp. 80-87.

  Available from: https://doi.org/10.1016/j.ece.2022.10.001

• Kaiser, Stephan C.; Decaria, Paula N.; Seidel, Stefan; Eibl, Dieter,

  2022.

  Scaling‐up of an insect cell‐based virus production process in a novel single‐use bioreactor with flexible agitation.

  Chemie Ingenieur Technik.

  94(12), pp. 1950-1961.

  Available from: https://doi.org/10.1002/cite.202200103

• Seidel, Stefan; Maschke, Rüdiger; Kraume, Matthias; Eibl-Schindler, Regine; Eibl, Dieter,

  2022.

  CFD modelling of a wave-mixed bioreactor with complex geometry and two degrees of freedom motion.

  Frontiers in Chemical Engineering.

  4(1021416).

  Available from: https://doi.org/10.3389/fceng.2022.1021416

• Müller, Jan; Ott, Vivian; Weiss, Noémi; Neubauer, Peter; Eibl, Dieter; Eibl, Regine,

  2022.

  Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes.

  Chemie Ingenieur Technik.

  94(12), pp. 1977-1984.

  Available from: https://doi.org/10.1002/cite.202200097

• Maschke, Rüdiger; John, Gernot T.; Eibl, Dieter,

  2022.

  Monitoring of oxygen, pH, CO2, and biomass in smart single‐use shake flasks.

  Chemie Ingenieur Technik.

  94(12), pp. 1995-2001.

  Available from: https://doi.org/10.1002/cite.202200094

• Maschke, Rüdiger; Pretzner, Barbara; John, Gernot T.; Herwig, Christoph; Eibl, Dieter,

  2022.

  Improved time resolved KPI and strain characterization of multiple hosts in shake flasks using advanced online analytics and data science.

  Bioengineering.

  9(8), pp. 339.

  Available from: https://doi.org/10.3390/bioengineering9080339

• Maschke, Rüdiger W.; Seidel, Stefan; Bley, Thomas; Eibl, Regine; Eibl, Dieter,

  2022.

  Determination of culture design spaces in shaken disposable cultivation systems for CHO suspension cell cultures.

  Biochemical Engineering Journal.

  177, pp. 108224.

  Available from: https://doi.org/10.1016/j.bej.2021.108224

• Ott, Vivian; Müller, Jan; Schirmer, Cedric; Weiss, Noémi; Göhmann, Rüdiger; Biewald, Andreas; Michel, Andrej; Eibl, Dieter; Eibl-Schindler, Regine,

  2022.

  Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production.

  Chemie Ingenieur Technik.

  94(12), pp. 1936-1943.

  Available from: https://doi.org/10.1002/cite.202200096

• Müller, Jan; Ott, Vivian; Eibl, Dieter; Eibl-Schindler, Regine,

  2022.

  Seed train intensification using an ultra-high cell density cell banking process.

  Processes.

  10(5), pp. 911.

  Available from: https://doi.org/10.3390/pr10050911

• Schirmer, Cedric; Eibl-Schindler, Regine; Maschke, Rüdiger; Mozaffari, Fruhar; Junne, Stefan; Daumke, Ralph; Ottinger, Melanie; Göhmann, Rüdiger; Ott, Christian; Wenk, Irina; Kubischik, Jens; Eibl, Dieter,

  2022.

  Single‐use technology for the production of cellular agricultural products : where are we today?.

  Chemie Ingenieur Technik.

  94(12), pp. 2018-2025.

  Available from: https://doi.org/10.1002/cite.202200092

• Seidel, Stefan; Eibl, Dieter,

  2021.

  Influence of interfacial force models and population balance models on the kLa value in stirred bioreactors.

  Processes.

  9(7), pp. 1185.

  Available from: https://doi.org/10.3390/pr9071185

• Schirmer, Cedric; Maschke, Rüdiger; Pörtner, Ralf; Eibl, Dieter,

  2021.

  An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes.

  Applied Microbiology and Biotechnology.

  Available from: https://doi.org/10.1007/s00253-021-11180-7

• Eibl, Regine; Senn, Yannick; Gubser, Géraldine; Jossen, Valentin; van den Bos, Christian; Eibl, Dieter,

  2021.

  Cellular agriculture : opportunities and challenges.

  Annual Review of Food Science and Technology.

  12, pp. 51-73.

  Available from: https://doi.org/10.1146/annurev-food-063020-123940

• Gubser, Geraldine; Vollenweider, Sabine; Eibl, Dieter; Eibl, Regine,

  2021.

  Food ingredients and food made with plant cell and tissue cultures : state‐of‐the art and future trends.

  Engineering in Life Sciences.

  21(3-4), pp. 87-98.

  Available from: https://doi.org/10.1002/elsc.202000077

• Eibl, Dieter; Sievers, Martin; Eibl, Regine; Bachmann, Martin; Walton, Senta; Keel, Nik; Richner, Gilles; Stübinger, Stefan; Hirsch, Sven; Yeretzian, Chahan; Opitz, Sebastian E.W.; Heldal, Trond; Adlhart, Christian,

  2021.

  Keeping SARS-CoV-2 out : vaccines, filters, and self-disinfecting textiles.

  Chimia.

  75(3), pp. 215-218.

  Available from: https://doi.org/10.2533/chimia.2021.215

• Seidel, Stefan; Maschke, Rüdiger; Werner, Sören; Jossen, Valentin; Eibl, Dieter,

  2020.

  Oxygen mass transfer in biopharmaceutical processes : numerical and experimental approaches .

  Chemie Ingenieur Technik.

  93(1-2).

  Available from: https://doi.org/10.1002/cite.202000179

• Möller, Johannes; Hernández Rodríguez, Tanja; Müller, Jan; Arndt, Lukas; Kuchemüller, Kim B.; Frahm, Björn; Eibl-Schindler, Regine; Eibl, Dieter; Pörtner, Ralf,

  2019.

  Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes.

  Computers & Chemical Engineering.

  134, pp. 106693.

  Available from: https://doi.org/10.1016/j.compchemeng.2019.106693

• Jossen, Valentin; Eibl-Schindler, Regine; Kraume, Matthias; Eibl, Dieter,

  2018.

  Growth behavior of human adipose tissue-derived stromal/stem cells at small scale : numerical and experimental investigations.

  Bioengineering.

  5(4), pp. 106.

  Available from: https://doi.org/10.3390/bioengineering5040106

• Eibl-Schindler, Regine; Jossen, Valentin; Eibl, Dieter,

  2018.

  Einweg-Bioreaktoren : therapeutische Antikörper.

  Chemie in unserer Zeit.

  52(4), pp. 230-237.

  Available from: https://doi.org/10.1002/ciuz.201800803

• Jossen, Valentin; van den Bos, Christian; Eibl-Schindler, Regine; Eibl, Dieter,

  2018.

  Manufacturing human mesenchymal stem cells at clinical scale : process and regulatory challenges.

  Applied Microbiology and Biotechnology.

  102(9), pp. 3981-3994.

  Available from: https://doi.org/10.1007/s00253-018-8912-x

• Eibl-Schindler, Regine; Meier, Philipp; Stutz, Irène Kathrin; Schildberger, David; Hühn, Tilo; Eibl, Dieter,

  2018.

  Plant cell culture technology in the cosmetics and food industries : current state and future trends.

  Applied Microbiology and Biotechnology.

  102(20), pp. 8661-8675.

  Available from: https://doi.org/10.1007/s00253-018-9279-8

• Kaiser, Stephan C.; Werner, Sören; Jossen, Valentin; Blaschczok, Katharina; Eibl, Dieter,

  2018.

  Power input measurements in stirred bioreactors at laboratory scale.

  Journal of Visualized Experiments.

  (135), pp. e56078.

  Available from: https://doi.org/10.3791/56078

• Schirmer, Cedric; Blaschczok, Katharina; Husemann, Ute; Leupold, Marco; Zahnow, Christian; Rupprecht, Jens; Glöckler, Rainer; Greller, Gerhard; Pörtner, Ralf; Eibl-Schindler, Regine; Eibl, Dieter,

  2017.

  Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes.

  Chemie Ingenieur Technik.

  89(12).

  Available from: https://doi.org/10.1002/cite.201700039

• Kaiser, Stephan C.; Werner, Sören; Jossen, Valentin; Kraume, Matthias; Eibl, Dieter,

  2017.

  Development of a method for reliable power input measurements in conventional and single-use stirred bioreactors at laboratory scale.

  Engineering in Life Sciences.

  17(5), pp. 500-511.

  Available from: https://doi.org/10.1002/elsc.201600096

• Eibl, Dieter; Eibl-Schindler, Regine,

  2017.

  Flexible biomanufacturing for the production of biotherapeutics.

  Pharmaceutical Biomanufacturing.

  5(1).

• Demuth, Caspar; Varonier, Joel; Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

  2016.

  Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale.

  Applied Microbiology and Biotechnology.

  100(9), pp. 3853-3863.

  Available from: https://doi.org/10.1007/s00253-016-7412-0

• Kaiser, Stephan; Kraume, Matthias; Eibl, Dieter,

  2016.

  Development of the travelling wave bioreactor. Part I : design studies based on numerical models.

  Chemie Ingenieur Technik.

  88(1-2), pp. 77-85.

  Available from: https://doi.org/10.1002/cite.201500092

• Kaiser, Stephan; Perepelitsa, Nadja; Kraume, Matthias; Eibl, Dieter,

  2016.

  Development of the travelling wave bioreactor. Part II : engineering characteristics and cultivation results.

  Chemie Ingenieur Technik.

  88(1-2), pp. 86-92.

  Available from: https://doi.org/10.1002/cite.201500091

• Fries, Tobias; Dittler, Ina; Blaschczok, Katharina; Löffelholz, Christian; Dornfeld, Wolfgang; Schöb, Reto; Drews, Anja; Eibl, Dieter,

  2016.

  Quantifizierung der hydrodynamischen Beanspruchung von Pumpen auf tierische Zellen mittels des nicht-biologischen Modellsystems Emulsion.

  Chemie Ingenieur Technik.

  88(1-2), pp. 177-182.

  Available from: https://doi.org/10.1002/cite.201500126

• Jossen, Valentin; Schirmer, Cedric; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  Theoretical and practical issues that are relevant when scaling up hMSC microcarrier production processes.

  Stem Cells International.

  2016(4760414).

  Available from: https://doi.org/10.1155/2016/4760414

• Kaiser, Stephan; Perepelitsa, Nadja; Dittler, Ina; Eibl, Dieter,

  2015.

  Experiences with a benchtop-scale glass bioreactor : engineering data and cultivation results.

  BioProcess International.

  13(10), pp. 46-52.

  Available from: http://www.bioprocessintl.com/upstream-processing/bioreactors/experiences-with-a-benchtop-scale-glass-bioreactor-engineering-data-and-cultivation-results/

• Kaiser, Stephan C.; Blaschczok, Katharina; Eibl, Dieter,

  2015.

  Cultivation of CHO suspension cells and SEAP expression in the finesse glass bioreactor.

  BioProcess International.

  Available from: http://www.bioprocessintl.com/sponsored-content/cultivation-of-cho-suspension-cells-and-seap-expression-in-the-finesse-glass-bioreactor

• Dittler, Ina; Dornfeld, Wolfgang; Schöb, Reto; Cocke, Jared; Rojahn, Jürgen; Kraume, Matthias; Eibl, Dieter,

  2015.

  A cost effective and reliable method to predict mechanical stress in single-use and standard pumps.

  Journal of Visualized Experiments.

  Available from: https://doi.org/10.3791/53052

• Werner, Sören; Greulich, Judith; Geipel, Katja; Steingroewer, Juliane; Bley, Thomas; Eibl, Dieter,

  2014.

  Mass propagation of Helianthus annuus suspension cells in orbitally shaken bioreactors : improved growth rate in single-use bag bioreactors.

  Engineering in Life Sciences.

  14(6), pp. 676-684.

  Available from: https://doi.org/10.1002/elsc.201400024

• Klöckner, Wolf; Lattermann, Clemens; Pursche, Franz; Büchs, Jochen; Werner, Sören; Eibl, Dieter,

  2014.

  Time efficient way to calculate oxygen transfer areas and power input in cylindrical disposable shaken bioreactors.

  Biotechnology Progress.

  30(6), pp. 1441-1456.

  Available from: https://doi.org/10.1002/btpr.1977

• Imseng, Nicole; Steiger, Nina; Frasson, David; Sievers, Martin; Tappe, Alexander; Greller, Gerhard; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Single-use wave-mixed versus stirred bioreactors for insect-cell/BEVS-based protein expression at benchtop scale.

  Engineering in Life Sciences.

  14(3), pp. 264-271.

  Available from: https://doi.org/10.1002/elsc.201300131

• Dittler, Ina; Kaiser, Stephan; Blaschczok, Katharina; Löffelholz, Christian; Bösch, Pascal; Dornfeld, Wolfgang; Schöb, Reto; Rojahn, Jürgen; Kraume, Matthias; Eibl, Dieter,

  2014.

  A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps.

  Engineering in Life Sciences.

  14(3), pp. 311-317.

  Available from: https://doi.org/10.1002/elsc.201300068

• Blaschczok, Katharina; Löffelholz, Christian; Eibl-Schindler, Regine; Eibl, Dieter,

  2014.

  Combining single-use stirred bioreactor with standard cross-flow technology in biphasic protein production processes at pilot scale.

  Engineering in Life Sciences.

  14(3), pp. 327-331.

  Available from: https://doi.org/10.1002/elsc.201300069

• Schirmaier, Carmen; Jossen, Valentin; Kaiser, Stephan C.; Jüngerkeks, Frank; Silke, Brill; Safavi-Nab, Agnieszka; Siehoff, Ann; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions.

  Engineering in Life Sciences.

  14(3), pp. 292-303.

  Available from: https://doi.org/10.1002/elsc.201300134

• Werner, Sören; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter,

  2014.

  Computational fluid dynamics as a modern tool for engineering characterization of bioreactors.

  Pharmaceutical Bioprocessing.

  2(1), pp. 85-99.

• Jossen, Valentin; Kaiser, Stephan C.; Schirmaier, Carmen; Hermann, Jacqueline; Tappe, Alexander; Eibl, Dieter; Siehoff, Ann; van den Bos, Christian; Eibl-Schindler, Regine,

  2014.

  Modification and qualification of a stirred single-use bioreactor for the improved expansion of human mesenchymal stem cells at benchtop scale.

  Pharmaceutical Bioprocessing.

  2(4), pp. 311-322.

• Kaiser, Stephan; Blaschczok, Katharina; Eibl, Dieter,

  2013.

  Cultivation of CHO suspension cells and SEAP expression in the finesse glass bioreactor.

  BioProcess International.

  11(7).

• Werner, Sören; Olownia, Johanna; Egger, Daniel; Eibl, Dieter,

  2013.

  An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors.

  Chemie Ingenieur Technik.

  85(1-2), pp. 118-126.

  Available from: https://doi.org/10.1002/cite.201200153

• Löffelholz, Christian; Husemann, Ute; Greller, Gerhard; Meusel, Wolfram; Kauling, Jörg; Ay, Peter; Kraume, Matthias; Eibl-Schindler, Regine; Eibl, Dieter,

  2013.

  Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods.

  Chemie Ingenieur Technik.

  85(1-2), pp. 40-56.

  Available from: https://doi.org/10.1002/cite.201200125

• Kaiser, Stephan; Jossen, Valentin; Schirmaier, Carmen; Eibl, Dieter; Brill, Silke; van den Bos, Christian; Eibl-Schindler, Regine,

  2013.

  Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors.

  Chemie Ingenieur Technik.

  85(1-2), pp. 95-102.

  Available from: https://doi.org/10.1002/cite.201200180

• Blaschczok, Katharina; Kaiser, Stephan C.; Löffelholz, Christian; Imseng, Nicole; Burkart, Jürg; Bösch, Pascal; Dornfeld, Wolfgang; Eibl-Schindler, Regine; Eibl, Dieter,

  2013.

  Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps.

  Chemie Ingenieur Technik.

  85(1-2), pp. 144-152.

  Available from: https://doi.org/10.1002/cite.201200135

• Lehmann, Nicolai; Rischer, Heiko; Eibl, Dieter; Eibl-Schindler, Regine,

  2013.

  Wave-mixed and orbitally shaken single-use photobioreactors for diatom algae propagation.

  Chemie Ingenieur Technik.

  85(1-2), pp. 197-201.

  Available from: https://doi.org/10.1002/cite.201200137

• Kaiser, Stephan; Kraume, M.; Eibl, Dieter,

  2013.

  Development of the travelling wave bioreactor : a concept study.

  Chemie Ingenieur Technik.

  85(1-2), pp. 136-143.

  Available from: https://doi.org/10.1002/cite.201200127

• Bogli, Nicole C.; Ries, Christoph; Adams, Thorsten; Greller, Gerhard; Eibl, Dieter; Eibl-Schindler, Regine,

  2012.

  Large-scale, insect-cell-based vaccine development.

  BioProcess International.

  10(2).

  Available from: http://www.bioprocessintl.com/upstream-processing/upstream-single-use-technologies/large-scale-insect-cellbased-vaccine-development-330217/?pageNum=3

• Rothe, Sebastian; Ries, Christoph; Eibl, Dieter; Walsh, Kieron; Hohenauer, Wolfgang,

  2012.

  Method for preserving cell density and viability in two-phase, fed-batch CHO culture.

  BioProcess International.

  10(4).

  Available from: http://www.bioprocessintl.com/wp-content/uploads/bpi-content/BPI_A_121004AR10_O_178001a.pdf

• Kaiser, Stephan; Eibl-Schindler, Regine; Eibl, Dieter,

  2011.

  Engineering characteristics of a single-use stirred bioreactor at benchtop scale : the Mobius CellReady 3 L bioreactor as case study.

  Engineering in Life Sciences.

  11(4), pp. 359-368.

  Available from: https://doi.org/10.1002/elsc.201000171

• Werner, Sören; Eibl-Schindler, Regine; Lettenbauer, Christine; Röll, Marcel; Eibl, Dieter; De Jesus, Maria; Zhang, Xiaowei; Stettler, Matthieu; Tissot, Stephanie; Bürkie, Cedric; Broccard, Gilles; Kühner, Markus; Tanner, Rolf; Baldi, Lucia; Hacker, David; Wurm, Florian M.,

  2010.

  Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution.

  Chimia.

  64(11), pp. 819-823.

  Available from: https://doi.org/10.2533/chimia.2010.819

• Kaiser, Stephan; Löffelholz, Christian; Werner, Sören; Eibl, Dieter,

  2010.

  Numerische Fluiddynamik in der Biotechnologie.

  Nachrichten aus der Chemie.

  58(9), pp. 897-899.

  Available from: https://doi.org/10.1002/nadc.201075806

• Eibl-Schindler, Regine; Kaiser, Stephan; Lombriser, Renate; Eibl, Dieter,

  2010.

  Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology.

  Applied Microbiology and Biotechnology.

  86(1), pp. 41-49.

  Available from: https://doi.org/10.1007/s00253-009-2422-9

• Ries, Christoph; John, Gernot; John, Corinne; Eibl-Schindler, Regine; Eibl, Dieter,

  2010.

  A shaken disposable bioreaktor system for controlled insect cell cultivations at millilitre-scale.

  Engineering in Life Sciences.

  10(1), pp. 75-79.

  Available from: https://doi.org/10.1002/elsc.200900040

• Eibl-Schindler, Regine; Werner, Sören; Eibl, Dieter,

  2009.

  Disposable bioreactors for plant liquid cultures at litre-scale.

  Engineering in Life Sciences.

  9(3), pp. 156-164.

  Available from: https://doi.org/10.1002/elsc.200800102

• Eibl-Schindler, Regine; Eibl, Dieter,

  2009.

  Disposable bioreactors in cell culture-based upstream processing.

  BioProcess International.

  7(1), pp. 18-23.

  Available from: http://www.bioprocessintl.com/upstream-processing/cell-culture-media/disposable-bioreactors-in-cell-culture-based-upstream-processing-184055/

• Eibl-Schindler, Regine; Eibl, Dieter,

  2007.

  Design of bioreactors suitable for plant cell and tissue cultures.

  Phytochemistry Reviews.

  7(3), pp. 593-598.

  Available from: https://doi.org/10.1007/s11101-007-9083-z

• Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  2019.

  Single-use technology in biopharmaceutical manufacture.

  2nd Edition.

  Wiley.

  ISBN 978-1-119-47783-9.

  Available from: https://doi.org/10.1002/9781119477891

• Eibl, Dieter; Eibl-Schindler, Regine, eds.,

  2013.

  Disposable bioreactors II.

  Berlin:

  Springer.

  Advances in Biochemical Engineering/Biotechnology ; 138.

  ISBN 978-3-642-45157-7.

  Available from: https://doi.org/10.1007/978-3-642-45158-4

• Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  2011.

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  ISBN 978-0-470-43351-5.

  Available from: https://doi.org/10.1002/9780470909997

• Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  2010.

  Disposable bioreactors.

  Berlin:

  Springer.

  Advances in Biochemical Engineering/Biotechnology.

  ISBN 978-3-642-01871-8.

  Available from: https://doi.org/10.1007/978-3-642-01872-5

• Müller, Jan; Teale, Misha; Steiner, Sandra; Junne, Stefan; Neubauer, Peter; Eibl, Dieter; Eibl-Schindler, Regine,

  2021.

  Intensified and continuous mAb production with single-use systems

  .

  In:

  Pörtner, Ralf, ed.,

  Cell Culture Engineering and Technology.

  Cham:

  Springer.

  pp. 401-429.

  Cell Engineering ; 10.

  Available from: https://doi.org/10.1007/978-3-030-79871-0_13

• Jossen, Valentin; Eibl, Dieter; Eibl, Regine,

  2020.

  Numerical methods for the design and description of in vitro expansion processes of human mesenchymal stem cells

  .

  In:

  Digital Twins.

  Berlin:

  Springer.

  pp. 185-228.

  Advances in Biochemical Engineering / Biotechnology ; 177.

  Available from: https://doi.org/10.1007/10_2020_147

• Schirmer, Cedric; Müller, Jan; Steffen, Nina; Werner, Sören; Eibl-Schindler, Regine; Eibl, Dieter,

  2020.

  How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale

  .

  In:

  Pörtner, Ralf, ed.,

  Animal cell biotechnology : methods and protocols.

  New York:

  Springer.

  pp. 169-186.

  Methods in Molecular Biology ; 2095.

  Available from: https://doi.org/10.1007/978-1-0716-0191-4_10

• Schirmer, Cedric; Rothe, Sebastian; Jenness, Ernest; Eibl, Dieter,

  2019.

  Systems for coupling and sampling

  .

  In:

  Eibl, Regine; Eibl, Dieter, eds.,

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  pp. 53-68.

  Available from: https://doi.org/10.1002/9781119477891.ch5

• Werner, Sören; Maschke, Rüdiger W.; Eibl, Dieter; Eibl, Regine,

  2018.

  Bioreactor technology for sustainable production of plant cell-derived products

  .

  In:

  Pavlov, Atanas; Bley, Thomas, eds.,

  Bioprocessing of Plant In Vitro Systems.

  Cham:

  Springer.

  pp. 413-432.

  Reference Series in Phytochemistry.

  Available from: https://doi.org/10.1007/978-3-319-54600-1_6

• Schirmer, Cedric; Nussbaumer, Thomas; Schöb, Reto; Pörtner, Ralf; Eibl-Schindler, Regine; Eibl, Dieter,

  2018.

  Development, engineering and biological characterization of stirred tank bioreactors

  .

  In:

  Yeh, Ming-Kung; Chen, Yuan-Chuan, eds.,

  Biopharmaceuticals.

  London:

  IntechOpen.

  pp. 87-107.

  Available from: https://doi.org/10.5772/intechopen.79444

• Jossen, Valentin; Eibl-Schindler, Regine; Pörtner, Ralf; Kraume, Matthias; Eibl, Dieter,

  2017.

  Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes

  .

  In:

  Current Developments in Biotechnology and Bioengineering.

  Elsevier.

  pp. 179-215.

  Available from: https://doi.org/10.1016/B978-0-444-63663-8.00007-0

• Löffelholz, Christian; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up

  .

  In:

  Eibl, Dieter; Eibl-Schindler, Regine, eds.,

  Disposable bioreactors II.

  Berlin:

  Springer.

  pp. 1-41.

  Advances in Biochemical Engineering/Biotechnology ; 138.

  Available from: https://doi.org/10.1007/10_2013_187

• Eibl-Schindler, Regine; Steiger, Nina; Wellnitz, Sabine; Vicente, Tiago; John, Corinne; Eibl, Dieter,

  2014.

  Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study

  .

  In:

  Eibl, Dieter; Eibl-Schindler, Regine, eds.,

  Disposable bioreactors II.

  Berlin:

  Springer.

  pp. 99-125.

  Advances in Biochemical Engineering/Biotechnology ; 138.

  Available from: https://doi.org/10.1007/10_2013_186

• Werner, Sören; Kraume, Matthias; Eibl, Dieter,

  2011.

  Bag mixing system for single-use

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  pp. 21-32.

  Available from: https://doi.org/10.1002/9780470909997.ch3

• Eibl-Schindler, Regine; Löffelholz, Christian; Eibl, Dieter,

  2011.

  Single-use bioreactors : an overview

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  pp. 145-158.

  Available from: https://doi.org/10.1002/9780470909997.ch4

• Löffelholz, Christian; Kaiser, Stephan; Werner, Sören; Eibl, Dieter,

  2011.

  CFD as tool in order to characterize single-use bioreactors

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  pp. 263-280.

  Available from: https://doi.org/10.1002/9780470909997.ch22

• Eibl-Schindler, Regine; Werner, Sören; Eibl, Dieter,

  2010.

  Bag bioreactor based on wave-induced motion : characteristics and applications

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Disposable Bioreactors.

  Berlin:

  Springer.

  pp. 55-87.

  Advances in Biochemical Engineering / Biotechnology ; 115.

  Available from: https://doi.org/10.1007/10_2008_15

• Eibl-Schindler, Regine; Eibl, Dieter,

  2009.

  Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents

  .

  In:

  Kasper, Cornelia; van Griensven, Martijn; Pörtner, Ralf, eds.,

  Bioreactor systems for tissue engineering.

  Berlin:

  Springer.

  pp. 183-207.

  Advances in Biochemical Engineering/Biotechnology ; 112.

  Available from: https://doi.org/10.1007/10_2008_23

• Schirmer, Cedric; Ott, Vivian; Müller, Jan; Göhmann, Rüdiger; Biewald, Andreas; Eibl-Schindler, Regine; Eibl, Dieter,

  2022.

  Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale [poster].

  In:

  27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.

  ESACT, European Association for Animal Cell Technology.

• Maschke, Rüdiger; Pretzner, Barbara; John, Gernot T.; Herwig, Christoph; Eibl, Dieter,

  2022.

  Automated cell line characterization in shake flasks for multiple organisms [poster].

  In:

  7th BioProScale Symposium, Berlin, Germany, 28-31 March 2022.

• Maschke, Rüdiger; Werner, Sören; Stalder, Mischa; Jossen, Valentin; Eibl, Dieter,

  2016.

  Nutzung von Sensor Spots zur Bestimmung der Gelöstsauerstoffkonzentration in Single-use Systemen im Labormassstab [poster].

  In:

  Institut für Bioprozess- und Analysenmesstechnik, ed.,

  Tagungsband.

  18. Heiligenstädter Kolloquium "Technische Systeme für die Lebenswissenschaft", Heilbad Heiligenstadt, 19.-21. September 2016.

  Winterthur:

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Available from: https://doi.org/10.21256/zhaw-1152

• Meister, Jolanda; Maschke, Rüdiger; Werner, Sören; Abellan, Eric; Stichling, Nicole; Egger, Daniel; Eibl, Dieter,

  2016.

  Cultivation of CHO Cells in Thomson Optimum Growth™ Shake Flasks and Scale-up [poster].

  In:

  Biotech 2016: Biopharmaceutical Manufacturing and Single-Use Technologies.

  Wädenswil:

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Available from: https://doi.org/10.21256/zhaw-1151

• Maschke, Rüdiger; Werner, Sören; Meister, Jolanda; Rohr, Adrian; Abellan, Eric; Eibl, Dieter; Bley, Thomas,

  2016.

  Engineering characterization of Thomson Optimum Growth™ shake flasks with optimized geometry [poster].

  In:

  DECHEMA Himmelfahrtstagung: New Frontiers for Biotech-Processes, Koblenz, Deutschland, 2.-4. Mai 2016.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Available from: https://doi.org/10.21256/zhaw-1141

• Ott, Vivian; Müller, Jan; Eibl-Schindler, Regine; Eibl, Dieter; Schirmer, Cedric; Göhmann, Rüdiger; Biewald, Andreas,

  2022.

  A new single-use disk stack separator for pilot scale CHO cell-based antibody productions [poster].

  In:

  ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.

  Available from: https://dc.engconfintl.org/sut_v/11/

• Seidel, Stefan; Werner, Sören; Eibl, Dieter,

  2020.

  CFD for stirred bioreactors : analysis of different multiphase models to determine oxygen mass transfer [poster].

  In:

  Special Issue : 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020.

  10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 : Processes for Future, Web-Konferenz, 21.-24. September 2020.

  Wiley.

  pp. 1324.

  Available from: https://doi.org/10.1002/cite.202055288

• Bayer, Marcus; Castan, Andreas; Eibl, Regine; Eibl, Dieter; Eisenkrätzer, Detlef; Fritz, Christina; Glaser, Robert; Glenz, Martin; Greller, Gerhard; Hug, Michelle; Kleebank, Sebastian; Kampmann, Markus; Krättli, Martin; Manser, Britta; Matuszczyk, Jens; Ottinger, Melanie; Schleper, Stefan; Schreiber, Marko; Seidel, Stefan; Selzer, Sebastian; Tanner, Markus; Teale, Misha; Tiemann, Karin,

  2020.

  Technical state-of-the-art and risk analysis on single-use equipment in continuous processing steps.

  Frankfurt am Main:

  DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V..

  ISBN 978-3-89746-226-7.

  Available from: https://doi.org/10.21256/zhaw-26357

• Maschke, Rüdiger; Pretzner, Barbara; John, Gernot T.; Eibl, Dieter,

  2020.

  Characterizing CHO cell lines with SFR vario : what online measured data can tell about your cell culture.

  PreSens Publications.

  Available from: https://www.presens.de/knowledge/publications/application-note/characterizing-cho-cell-lines-with-sfr-vario-1723

• Schirmer, Cedric; Ott, Vivian; John, Gernot T.; Eibl, Dieter,

  2020.

  Integration of chemical-optical oxygen and pH sensors in existing control units : cultivation monitoring in a glass bioreactor system with subsequently integrated sensor spots.

  PreSens Publications.

  Available from: https://www.presens.de/knowledge/publications/application-note/integration-of-chemical-optical-oxygen-and-ph-sensors-in-existing-control-units-1692

• Maschke, Rüdiger; Pretzner, Barbara; John, Gernot; Eibl, Dieter,

  2020.

  Interpreting SFR vario online data gathered in plant cell suspension culture : characterization of plant cell lines for successful production processes.

  PreSens Publications.

  Available from: https://www.presens.de/knowledge/publications/application-note/characterizing-plant-cell-suspension-culture-with-sfr-vario-1725

• Schirmer, Cedric; Dreher, Thomas; Leupold, Marco; Glaser, Robert; Castan, Andreas; Brown, Jason; Eibl, Dieter; Glöckler, Rainer,

  2019.

  Recommendation for biological evaluation of bioreactor performance for microbial processes.

  2. revised edition.

  Frankfurt am Main:

  DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V..

  ISBN 978-3-89746-222-9.

  Available from: https://dechema.de/dechema_media/Downloads/Positionspapiere/SingleUse_Microbial_ezl+2Ed+Sept2019-p-20005491.pdf

• Schirmer, Cedric; Nussbaumer, Thomas; Schöb, Reto; Pörtner, Ralf; Eibl, Dieter,

  2019.

  Development of an universally useable single-use bioreactor for the benchtop scale [poster].

  In:

  BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

• Rossi, Lia; Schirmer, Cedric; Teale, Misha; Kurt, Fabienne; Rosenthal, Florian; Eibl, Dieter,

  2019.

  Proof of concept study for cultivation of strict anaerobes in a single-use wave-mixed bioreactor [poster].

  In:

  BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

• Jossen, Valentin; Eberle, Sebastian; Muoio, Francesco; Panella, Stefano; Tallone, Tiziano; Moccetti, Tiziano; Lindner, Matias; Müller, Michele; Eibl, Dieter; Eibl-Schindler, Regine; et al.,

  2019.

  Serum-free hMSC expansion in stirred single-use cultivation systems [poster].

  In:

  BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

• Schirmer, Cedric; Nussbaumer, Thomas; Schöb, Reto; Pörtner, Ralf; Eibl, Dieter,

  2019.

  A universal stirred bioreactor for the development of biotherapeutics [poster].

  In:

  DECHEMA Himmelfahrtstagung: Intensification and digitalisation for integral bioprocessing, Hamburg, Germany, 27-29 May 2019.

  DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie.

• van den Bos, Christian; Jossen, Valentin; Eibl, Dieter; Eibl-Schindler, Regine,

  2019.

  Advanced therapy medicinal products (ATMPs) & GMP : 10 years after.

  Die Pharmazeutische Industrie : pharmind.

  81(4), pp. 508-513.

• Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

  2019.

  Single‐use bioreactors : an overview

  .

  In:

  Single‐Use Technology in Biopharmaceutical Manufacture.

  Wiley.

  pp. 37-52.

  Available from: https://doi.org/10.1002/9781119477891.ch4

• Jossen, Valentin; Eibl-Schindler, Regine; Kraume, Matthias; Eibl, Dieter,

  2018.

  Growth behavior of human adipose tissue-derived stromal/stem cells in single-use spinner flasks : numerical and experimental investigations [poster].

  In:

  ECI: Single Use Technologies III: Scientific and Technological Advancements, Utah, USA, 23-26 September 2018.

• Schildberger, David; Stutz, Irene; Weber, Carlo; Pedan, Vasilisa; Schlüter, Ansgar; Huber, Petra; Chatelain, Karin; Chetschik, Irene; Eibl, Dieter; Hühn, Tilo; Eibl-Schindler, Regine,

  2018.

  Cast off! Chocolate from cacao cell cultures [poster].

  In:

  New Harvest 2018 Conference, Cambridge, USA, 20-21 July 2018.

• Schirmer, Cedric; Eibl, Dieter,

  2017.

  Rührwerk für moderne Bioreaktoren.

  Transfer.

  2017(2), pp. 4.

  Available from: https://doi.org/10.21256/zhaw-19304

• Eibl-Schindler, Regine; Eibl, Dieter,

  2017.

  Single-Use-Systeme in der biopharmazeutischen Produktion : Chancen und Herausforderungen.

  Die Pharmazeutische Industrie : pharmind.

  79, pp. 719-724.

• von Blarer, Damian; Senn, Yannick; Kienle, Klaus; Schirmer, Cedric; Blaschczok, Katharina; Husemann, Ute; Greller, Gerhard; Leupold, Marco; Rupprecht, Jens; Glöckler, Rainer; Eibl, Dieter,

  2016.

  Biological bioreactor characterization by means of an Escherichia coli model process [poster].

  In:

  BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.

• Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  Expansion of human adipose tissue-derived stromal/stem cells in a wave-mixed single-use bioreactor : a proof-of-concept [poster].

  In:

  BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.

• Meister, Jolanda; Maschke, Rüdiger; Werner, Sören; Eibl, Dieter; John, Gernot T.,

  2016.

  How to efficiently shake viscous culture broths.

  Genetic Engineering & Biotechnology News.

  36(15).

  Available from: https://www.genengnews.com/magazine-issues/how-to-efficiently-shake-viscous-culture-broths/

• Jossen, Valentin; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  Impact of shear stress on cell growth and microcarrier-cell-agglomerate formation in microcarrier-based cultivations of adipose tissue-derived stromal/stem cells [poster].

  In:

  BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.

• Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  How to successfully scale up a microcarrier based expansion process of human mesenchymal stem cells from adipose tissue [poster].

  In:

  4th BioProScale Symposium 2016, Berlin, Germany, 6-8 April 2016.

• Eibl, Dieter,

  2016.

  Einwegsysteme : Stand der Technik und sich abzeichnende Entwicklungen.

  GMP Journal.

  38, pp. 11-12.

• Jossen, Valentin; Eibl, Dieter,

  2015.

  Fluid flow modelling through a porous scaffold for the evaluation of co-culture model of human mesenchymal stromal cells and human dermal microvascular endothelial cells for bone tissue engineering [poster].

  In:

  24th European Society for Animal Cell Techonology (ESACT) Meeting, Barcelona, Spain, 31 May - 3 June 2015.

• Jossen, Valentin; Schirmaier, Carmen; John, Gernot T.; Eibl, Dieter; Eibl-Schindler, Regine,

  2015.

  On-line-pH- und -DO-Messungen in Mikrocarrier-basierter hMSC Kultur.

  BIOspektrum.

  21(4), pp. 422-424.

  Available from: https://doi.org/10.1007/s12268-015-0597-4

• Eibl-Schindler, Regine; Eibl, Dieter,

  2015.

  Single-use (disposable) systems in biopharmaceutical processing : quo vadis?.

  ACHEMA Trend Reports.

  13.

• Jossen, Valentin; Pörtner, Ralf; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Mass production of mesenchymal stem cells — impact of bioreactor design and flow conditions on proliferation and differentiation

  .

  In:

  Eberli, Daniel, ed.,

  Cells and Biomaterials in Regenerative Medicine.

  InTech.

  pp. 119-172.

  Tissue Engineering and Regenerative Medicine.

  Available from: https://doi.org/10.5772/59385

• Jossen, Valentin; Schirmaier, Carmen; John, Gernot; Siehoff, Ann; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Online pH and DO measurement in microcarrier-based hMSC cultivations performed in single-use spinner flask [poster].

  In:

  BioTech 2014, Wädenswil, Switzerland, 4-5 September 2014.

• Jossen, Valentin; Ott, Anita; Kaiser, Stephan; Brill, Silke; Spicker, Sonja; Safavi-nab, Agnieszka; Jüngerkes, Frank; Siehoff, Ann; Rosenbaum, Claudia; Reinisch, Barbara; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine; et al.,

  2014.

  Microcarrier-based expansion of adipose tissue and bone marrow derived human mesenchymal stem cells in therapeutically relevant doses [poster].

  In:

  4th Lugano Stem Cell Meeting, Lugano, Switzerland, 23-24 June 2014.

• Olownia, Johanna; Werner, Sören; Eibl, Dieter,

  2013.

  Plant and animal suspension cell cultures : scale-up of geometrically dissimilar orbitally shaken single-use bioreactor.

  Genetic Engineering & Biotechnology News.

  33(21), pp. 38-39.

  Available from: https://doi.org/10.1089/gen.33.21.17

• Kaiser, Stephan; Blaschczok, Katharina; Eibl, Dieter,

  2013.

  Novel CHO suspension cell cultivation : studying cellular growth and SEAP expression in the Finesse SmartGlass Bioreactor.

  Genetic Engineering & Biotechnology News.

  33(14), pp. 32-33.

  Available from: https://doi.org/10.1089/gen.33.14.17

• Jossen, Valentin; Kaiser, Stephan; Schirmaier, Carmen; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine,

  2013.

  Investigations of fluif flow and microcarrier suspension for hMSC expansion in single-use stirred bioreactors [poster].

  In:

  BioTech 2013, Wädenswil, Switzerland, 3-5 June 2013.

• Backoff, Tobias; Malig, Jennifer; Sören, Werner; Eibl, Dieter; John, Gernot T.,

  2013.

  Where does the oxygen go? : kLa measurement in bioreactors.

  G.I.T. Laboratory Journal.

  9(10), pp. 20-21.

  Available from: http://www.laboratory-journal.com/applications/biological-methods/where-does-oxygen-go

• Kaiser, Stephan; Eibl, Dieter,

  2013.

  Single-use Pumpen in der Prozesstechnologie.

  ChemieXtra.

  2013(10), pp. 30-31.

• Löffelholz, Christian; Kaiser, Stephan; Werner, Sören; Eibl, Dieter,

  2012.

  Beitrag zur Charakterisierung und zum Einsatz des 50 L Single-Use Bioreactor (S.U.B.) in der biopharmazeutischen Industrie [paper].

  In:

  Heiser, Martin; Sperling, Reinhard, eds.,

  Vortragssammlung / 14. Köthener Rührer-Kolloquium 2011.

  14. Köthener-Rührer-Kolloquium, Köthen, 16. Juni 2011.

  pp. 52-67.

• Eibl-Schindler, Regine; Eibl, Dieter,

  2011.

  Single-use cell culture systems arrive : tracking the evolution and development of an increasingly used technology.

  Genetic Engineering & Biotechnology News.

  31(17), pp. 59-61.

  Available from: https://doi.org/10.1089/gen.31.17.15

• Kaiser, Stephan; Löffelholz, Christian; Werner, Sören; Eibl, Dieter,

  2011.

  CFD for characterizing standard and single-use stirred cell culture bioreactors

  .

  In:

  Minin, Igor V.; Minin, Oleg V., eds.,

  Computational fluid dynamics : technologies and applications.

  Rijeka, Croatia:

  InTech.

  pp. 97-122.

  Available from: https://doi.org/10.5772/23496

• Löffelholz, Christian; Werner, Sören; Eibl, Dieter; Ay, Peter,

  2010.

  Untersuchungen zum Strömungsverhalten des Einweg-Vibromix-Bioreaktors [paper].

  In:

  Egbers, Christoph; Leder, Alfred; Ruck, Bodo; Dopheide, Dietrich, eds.,

  Proceedings der 18. GALA-Fachtagung "Lasermethoden in der Strömungsmesstechnik".

  18. Fachtagung "Lasermethoden in der Strömungsmesstechnik", Cottbus, 7.-9. September 2010.

  Deutsche Gesellschaft für Laser-Anemometrie GALA.

  18.

• Eibl, Regine; Eibl, Dieter; Pörtner, Ralf; Catapano, Gerardo; Czermak, Peter, eds.,

  2009.

  Cell and tissue reaction engineering.

  Berlin:

  Springer.

  Principles and Practice.

  ISBN 978-3-540-68175-5.

  Available from: https://doi.org/10.1007/978-3-540-68182-3

• Löffelholz, Christian; Werner, Sören; Eibl, Dieter,

  2009.

  Einsatz von Computational Fluid Dynamics.

  Transfer.

  2009(2), pp. 8.

  Available from: https://doi.org/10.21256/zhaw-4286

• Eibl-Schindler, Regine; Eibl, Dieter,

  2007.

  Disposable bioreactors for cell culture based-processing.

  Achema Worldwide News.

  2, pp. 8-10.

• Eibl, Dieter; Eibl-Schindler, Regine,

  2007.

  Einwegbioreaktoren für Zellkulturen : Status quo und Trends.

  Pharma-Tec.

  4, pp. 14-15.

• Eibl-Schindler, Regine; Eibl, Dieter,

  2005.

  Einwegkultivierungstechnologie für biotechnische Pharma-Produktionen.

  BioWorld.

  3.

• Zuchuat, F.; Luisier, A.C.; Crelier, S.; Eibl, Dieter; Müller, J.,

  2005.

  Starterkulturen und Schutzhüllen für bioaktive Stoffe.

  BioWorld.

  4.

• Eibl-Schindler, Regine; Rutschmann, K.; Lisica, Lidija; Eibl, Dieter,

  2003.

  Kostenreduktion bei der Säugerzellkultivierung durch Einwegbioreaktoren?.

  BioWorld.

  5, pp. 22-23.

• Eibl-Schindler, Regine; Brändli, Johanna; Lettenbauer, C.; Eibl, Dieter,

  2000.

  Kultivierung pflanzlicher und animaler Zellkulturen.

  BioWorld.

  5, pp. 48-50.

• Eibl-Schindler, Regine; Lettenbauer, C.; Eibl, Dieter; Röllin, Markus,

  1999.

  Experiences in the application of the wave bioreactor.

  BioForum Europe.

  3, pp. 110-112.

• Eibl, Dieter,

  1999.

  Konstruktive und hygienetechnische Anforderungen an Anlagen der Lebensmittelindustrie und Biotechnologie.

  Lebensmittel-Technologie.

  32(9), pp. 266-268.

• Eibl-Schindler, Regine; Hans, Daniel; Warlies, S.; Lettenbauer, C.; Eibl, Dieter,

  1999.

  Zellkulturtechnik : Einsatz eines Taumelreaktorsystems mit interner Beleuchtung.

  BioWorld.

  2, pp. 10-12.

• Eibl, Dieter; Jenny, D.; Meier, H.P.,

  1996.

  Einsatz eines Magnetrührwerkes in der Lebensmittel- und Pharmaindustrie.

  BioWorld.

  5, pp. 53-55.

• Eibl, Dieter; Feller, H.; Kühne, B.,

  1995.

  CIP-Reinigung und Einsatz von Additiven in der Milchindustrie, Teil 1.

  Lebensmittel-Technologie.

  28(4), pp. 95-101.

• Eibl, Dieter; Feller, H.; Kühne, B.,

  1995.

  CIP-Reinigung und Einsatz von Additiven in der Milchindustrie, Teil 2.

  Lebensmittel-Technologie.

  28(5), pp. 150-156.

• Eibl, Dieter; Imhof, R.; Feller, H.; Kühne, B.,

  1995.

  CIP-Reinigung und Einsatz von Additiven in der Milchindustrie, Teil 3.

  Lebensmittel-Technologie.

  28(7-8), pp. 258-262.

• Eibl, Dieter,

  1993.

  Biotechnologie in der Lebensmittelproduktion.

  Lebensmittel-Technologie.

  26(7-8), pp. 199-206.

• Seidel, Stefan; Schirmer, Cedric; Eibl, Dieter,

  2022.

  Integration of a drive system based on magnetic levitation technology to power a stirred bioreactor.

  In:

  Levitronix Bioprocessing Conference, Boston, USA, 2 June 2022.

  Available from: https://www.levitronix.com/app/uploads/2022/06/Stefan-2_1.mp4

• Seidel, Stefan; Werner, Sören; Eibl, Dieter,

  2020.

  Analysis of different multiphase CFD models for aerated stirred bioreactors.

  In:

  8th OpenFOAM Conference, virtual, 13-15 October 2020.

• Seidel, Stefan; Werner, Sören; Eibl, Dieter,

  2020.

  CFD for process engineering characterization.

  In:

  Levitronix Bioprocessing Conference, Webinar Part 3, 10 June 2020.

• Maschke, Rüdiger; John, Gernot T.; Pretzner, Barbara; Eibl, Dieter,

  2019.

  Small scale bioprocess optimization using soft sensors.

  In:

  BioProcess International Europe, Vienna, Austria, 2-4 April 2019.

  Available from: https://lifesciences.knect365.com/bpieurope/agenda/3#cell-culture-and-upstream-process-development_small-scale-bioprocess-optimization-using-soft-sensors

• Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

  2018.

  Multiphase CFD simulations for supporting MC-based hMSC process development.

  In:

  5th BioProScale Symposium, Berlin, Germany, 20-22 March 2018.

• Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

  2017.

  How to use Computational Fluid Dynamics in the development of cell therapeutics.

  In:

  ECI: Scale-up and Manufacturing of Cell-based Therapies V, San Diego, USA, 15-19 January 2017.

• Maschke, Rüdiger; Stalder, Mischa; Werner, Sören; Abellan, Eric; Eibl, Dieter,

  2017.

  Multivariate process transfer and scale-up models for mammalian cell cultures.

  In:

  DECHEMA Himmelfahrtstagung: Models for Developing and Optimising Biotech Production, Neu-Ulm, Deutschland, 22. Mai 2017.

• Jossen, Valentin; Eibl, Dieter,

  2016.

  Fluid flow simulations in a porous scaffold to improve co-cultivation of human mesenchymal stem cells and human microvascular endothelial cells for bone tissue engineering.

  In:

  BMT Dreiländertagung, Basel, Switzerland, 4-6 October 2016.

• Maschke, Rüdiger; John, Gernot; Eibl, Dieter,

  2016.

  Potential von Sensor Spots für Single-Use Systeme im Labormassstab.

  In:

  18. Heiligenstädter Kolloquium "Technische Systeme für die Lebenswissenschaft", Heilbad Heiligenstadt, 19.-21. September 2016.

• Schirmer, Cedric; Jossen, Valentin; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Böttcher, Lars; Eibl, Dieter,

  2016.

  Standardized expansion of human mesenchymal stem cells in wave-mixed single-use bioreactors.

  In:

  ILMAC, Basel, 2016.

• Jossen, Valentin; Eibl, Dieter; Eibl-Schindler, Regine,

  2015.

  How can Computational Fluid Dynamics be used in order to rapidly expand bone marrow derived hMSCs in clinically relevant numbers.

  In:

  DECHEMA Himmelfahrtstagung, Hamburg, Germany, 11-13 May 2015.

• Eibl-Schindler, Regine; Jossen, Valentin; Eibl, Dieter,

  2015.

  Mass production of hMSCs : an approach based on stirred single-use bioreactors.

  In:

  ECI: Scale-up and Manufacturing of Cell-based Therapies III, 18-22 January 2015.

• Jossen, Valentin; Kaiser, Stephan; Siehoff, Ann; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  A successful approach in order to rapidly scaling-up microcarrier-based expansion of human mesenchymal stem cells for allogeneic therapies.

  In:

  3rd International Conference on Tissue Science & Regenerative Medicine, Valencia, Spain, 24-26 September 2014.

• Jossen, Valentin; Kaiser, Stephan; Eibl-Schindler, Regine; Eibl, Dieter,

  2014.

  Numerische Strömungsuntersuchungen für die Massstabsübertragung der Expansion von humanen mesenchymalen Stammzellen in gerührten Single-Use Bioreaktoren.

  In:

  17. Köthener-Rührer-Kolloquium, Köthen, Deutschland, 26. Juni 2014.

• Jossen, Valentin; Kaiser, Stephan; Ott, Anita; Siehoff, Ann; Brill, Silke; Greller, Gerhard; Tappe, Alexander; Eibl-Schindler, Regine; Eibl, Dieter; et al.,

  2014.

  Optimization of a benchtop single-use bioreactor for the expansion of adipose-tissue and bone marrow derived human mesenchymal stem cells.

  In:

  41st Annual European Society for Artificial Organs Congress, Rome, Italy, 17-20 September 2014.

• Löffelholz, Christian; Werner, Sören; Kaiser, Stephan; Husemann, Ute; Tappe, Alexander; Greller, Gerhard; Eibl, Dieter,

  2013.

  Comparative studies of single-use stirred bioreactors by means of traditional methods, CFD and cultivation experiments.

  In:

  ACHEMA Kongress, Frankfurt, Deutschland, 20. Juni 2013.

• Löffelholz, Christian; Eibl, Dieter,

  2011.

  Characterization and scalability of the S.U.B. systems.

  In:

  Single-Use Technology Seminar - Thermo Fisher Scientific, Kopenhagen, Denmark, 26 Oktober 2011.

go back