Prof. Dr. Regine Eibl-Schindler

www.zhaw.ch/icbt/bioverfahrenstechnik

Membership of networks

• Swiss Biotechnet
• DECHEMA
• ISPE

• A platform enabling efficient and effective delivery and packaging of therapeutic molecules / Project co-leader / Project completed

Articles in scientific journal, peer-reviewed

• Jossen, Valentin; van den Bos, Christian; Eibl-Schindler, Regine; Eibl, Dieter,

  2018.

  Manufacturing human mesenchymal stem cells at clinical scale : process and regulatory challenges.

  Applied microbiology and biotechnology.

  102(9),

  pp. 3981-3994.

  Available from: https://doi.org/10.21256/zhaw-3135

• Eibl-Schindler, Regine; Meier, Philipp; Stutz, Irène Kathrin; Schildberger, David; Hühn, Tilo; Eibl, Dieter,

  2018.

  Plant cell culture technology in the cosmetics and food industries : current state and future trends.

  Applied microbiology and biotechnology.

  102(20),

  pp. 8661-8675.

  Available from: https://doi.org/10.21256/zhaw-3136

• Schirmer, Cedric; Blaschczok, Katharina; Husemann, Ute; Leupold, Marco; Zahnow, Christian; Rupprecht, Jens; Glöckler, Rainer; Greller, Gerhard; Pörtner, Ralf; Eibl-Schindler, Regine; Eibl, Dieter,

  2017.

  Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes.

  Chemie - Ingenieur - Technik.

  89(12).

  Available from: https://doi.org/10.1002/cite.201700039

• Demuth, Caspar; Varonier, Joel; Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

  2016.

  Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale.

  Applied microbiology and biotechnology.

  100(9),

  pp. 3853-3863.

  Available from: https://doi.org/10.21256/zhaw-1584

• Jossen, Valentin; Schirmer, Cedric; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  Theoretical and practical issues that are relevant when scaling up hMSC microcarrier production processes.

  Stem cells international.

  2016(4760414).

  Available from: https://doi.org/10.21256/zhaw-1592

• Imseng, Nicole; Steiger, Nina; Frasson, David; Sievers, Martin; Tappe, Alexander; Greller, Gerhard; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Single-use wave-mixed versus stirred bioreactors for insect-cell/BEVS-based protein expression at benchtop scale.

  Engineering in life sciences.

  14(3),

  pp. 264-271.

  Available from: https://doi.org/10.1002/elsc.201300131

• Blaschczok, Katharina; Löffelholz, Christian; Eibl-Schindler, Regine; Eibl, Dieter,

  2014.

  Combining single-use stirred bioreactor with standard cross-flow technology in biphasic protein production processes at pilot scale.

  Engineering in life sciences.

  14(3),

  pp. 327-331.

  Available from: https://doi.org/10.1002/elsc.201300069

• Schirmaier, Carmen; Jossen, Valentin; Kaiser, Stephan C.; Jüngerkeks, Frank; Silke, Brill; Safavi-Nab, Agnieszka; Siehoff, Ann; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions.

  Engineering in life sciences.

  14(3),

  pp. 292-303.

  Available from: https://doi.org/10.1002/elsc.201300134

• Vasilev, Nikolay; Schmitz, Christian; Dong, Lemeng; Ritala, Anneli; Imseng, Nicole; Häkkinen, Suvi T.; van der Krol, Sander; Eibl-Schindler, Regine; Oksman-Caldentey, Kirsi-Marja; Bouwmeester, Harro; Fischer, Rainer; Schillberg, Stefan,

  2014.

  Comparison of plant-based expression platforms for the heterologous production of geraniol.

  Plant cell, tissue and organ culture.

  117(3),

  pp. 373-380.

  Available from: https://doi.org/10.21256/zhaw-3500

• Ritala, Anneli; Dong, Lemeng; Imseng, Nicole; Seppänen-Laakso, Tuulikki; Vasilev, Nikolay; van der Krol, Sander; Rischer, Heiko; Maaheimo, Hannu; Virkki, Arho; Brändli, Johanna; Schillberg, Stefan; Eibl-Schindler, Regine; Bouwmeester, Harro; Oksman-Caldentey, Kirsi-Marja,

  2014.

  Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway.

  Journal of biotechnology.

  176,

  pp. 20-28.

  Available from: https://doi.org/10.1016/j.jbiotec.2014.01.031

• Jossen, Valentin; Kaiser, Stephan C.; Schirmaier, Carmen; Hermann, Jacqueline; Tappe, Alexander; Eibl, Dieter; Siehoff, Ann; van den Bos, Christian; Eibl-Schindler, Regine,

  2014.

  Modification and qualification of a stirred single-use bioreactor for the improved expansion of human mesenchymal stem cells at benchtop scale.

  Pharmaceutical Bioprocessing.

  2(4),

  pp. 311-322.

• Löffelholz, Christian; Husemann, Ute; Greller, Gerhard; Meusel, Wolfram; Kauling, Jörg; Ay, Peter; Kraume, Matthias; Eibl-Schindler, Regine; Eibl, Dieter,

  2013.

  Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods.

  Chemie - Ingenieur - Technik.

  85(1-2),

  pp. 40-56.

  Available from: https://doi.org/10.1002/cite.201200125

• Kaiser, Stephan; Jossen, Valentin; Schirmaier, Carmen; Eibl, Dieter; Brill, Silke; van den Bos, Christian; Eibl-Schindler, Regine,

  2013.

  Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors.

  Chemie - Ingenieur - Technik.

  85(1-2),

  pp. 95-102.

  Available from: https://doi.org/10.1002/cite.201200180

• Blaschczok, Katharina; Kaiser, Stephan C.; Löffelholz, Christian; Imseng, Nicole; Burkart, Jürg; Bösch, Pascal; Dornfeld, Wolfgang; Eibl-Schindler, Regine; Eibl, Dieter,

  2013.

  Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps.

  Chemie - Ingenieur - Technik.

  85(1-2),

  pp. 144-152.

  Available from: https://doi.org/10.1002/cite.201200135

• Lehmann, Nicolai; Rischer, Heiko; Eibl, Dieter; Eibl-Schindler, Regine,

  2013.

  Wave-mixed and orbitally shaken single-use photobioreactors for diatom algae propagation.

  Chemie - Ingenieur - Technik.

  85(1-2),

  pp. 197-201.

  Available from: https://doi.org/10.1002/cite.201200137

• Stefanache, Camelia Paula; Imseng, Nicole; Meier, Beat; Tanase, Catalin; Eibl-Schindler, Regine; Peter, Samuel; Wolfram, Evelyn,

  2013.

  Arnica montana L. cell suspension culture as a biotechnological approach for the production of bioactive secondary metabolites.

  Planta medica.

  79(13).

  Available from: https://doi.org/10.1055/s-0033-1352447

• Georgiev, Milen I.; Eibl-Schindler, Regine; Zhong, Jian-Jiang,

  2013.

  Hosting the plant cells in vitro : recent trends in bioreactors.

  Applied microbiology and biotechnology.

  97(9),

  pp. 3787-3800.

  Available from: https://doi.org/10.21256/zhaw-1554

• Steiger, Nina; Eibl-Schindler, Regine,

  2013.

  Interlaboratory test for detection of cytotoxic leachables arising from single-use bags.

  Chemie - Ingenieur - Technik.

  85(1-2),

  pp. 26-28.

  Available from: https://doi.org/10.1002/cite.201200171

• Bogli, Nicole C.; Ries, Christoph; Adams, Thorsten; Greller, Gerhard; Eibl, Dieter; Eibl-Schindler, Regine,

  2012.

  Large-scale, insect-cell-based vaccine development.

  BioProcess international.

  10(2).

  Available from: http://www.bioprocessintl.com/upstream-processing/upstream-single-use-technologies/large-scale-insect-cellbased-vaccine-development-330217/?pageNum=3

• Kaiser, Stephan; Eibl-Schindler, Regine; Eibl, Dieter,

  2011.

  Engineering characteristics of a single-use stirred bioreactor at benchtop scale : the Mobius CellReady 3 L bioreactor as case study.

  Engineering in life sciences.

  11(4),

  pp. 359-368.

  Available from: https://doi.org/10.1002/elsc.201000171

• Werner, Sören; Eibl-Schindler, Regine; Lettenbauer, Christine; Röll, Marcel; Eibl, Dieter; De Jesus, Maria; Zhang, Xiaowei; Stettler, Matthieu; Tissot, Stephanie; Bürkie, Cedric; Broccard, Gilles; Kühner, Markus; Tanner, Rolf; Baldi, Lucia; Hacker, David; Wurm, Florian M.,

  2010.

  Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution.

  Chimia.

  64(11),

  pp. 819-823.

  Available from: https://doi.org/10.2533/chimia.2010.819

• Eibl-Schindler, Regine; Kaiser, Stephan; Lombriser, Renate; Eibl, Dieter,

  2010.

  Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology.

  Applied microbiology and biotechnology.

  86(1),

  pp. 41-49.

  Available from: https://doi.org/10.21256/zhaw-1581

• Ries, Christoph; John, Gernot; John, Corinne; Eibl-Schindler, Regine; Eibl, Dieter,

  2010.

  A shaken disposable bioreaktor system for controlled insect cell cultivations at millilitre-scale.

  Engineering in life sciences.

  10(1),

  pp. 75-79.

  Available from: https://doi.org/10.1002/elsc.200900040

• Eibl-Schindler, Regine; Werner, Sören; Eibl, Dieter,

  2009.

  Disposable bioreactors for plant liquid cultures at litre-scale.

  Engineering in life sciences.

  9(3),

  pp. 156-164.

  Available from: https://doi.org/10.1002/elsc.200800102

• Eibl-Schindler, Regine; Eibl, Dieter,

  2009.

  Disposable bioreactors in cell culture-based upstream processing.

  BioProcess international.

  7(1),

  pp. 18-23.

  Available from: http://www.bioprocessintl.com/upstream-processing/cell-culture-media/disposable-bioreactors-in-cell-culture-based-upstream-processing-184055/

• Eibl-Schindler, Regine; Eibl, Dieter,

  2007.

  Design of bioreactors suitable for plant cell and tissue cultures.

  Phytochemistry reviews.

  7(3),

  pp. 593-598.

  Available from: https://doi.org/10.21256/zhaw-1589

• Bonfill, M.; Bentebibel, S.; Moyano, E.; Palazón, J.; Cusidó, R. M.; Eibl-Schindler, Regine; Piñol, M. T.,

  2007.

  Paclitaxel and baccatin III production induced by methyl jasmonate in free and immobilized cells of Taxus baccata.

  Biologia plantarum.

  51(4),

  pp. 647-652.

  Available from: https://doi.org/10.21256/zhaw-1555

• Bentebibel, Salima; Moyano, Elisabet; Palazón, Javier; Cusidó, Rosa M.; Bonfill, Mercedes; Eibl-Schindler, Regine; Piñol, M. Teresa,

  2005.

  Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata.

  Biotechnology and bioengineering.

  89(6),

  pp. 647-655.

  Available from: https://doi.org/10.1002/bit.20321

• Palazón, Javier; Mallol, Anna; Eibl-Schindler, Regine; Lettenbauer, Christine; Cusidó, Rosa M.; Piñol, M. Teresa,

  2003.

  Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor.

  Planta medica.

  69(4),

  pp. 344-349.

  Available from: https://doi.org/10.1055/s-2003-38873

Books and monographs, peer-reviewed

• Eibl, Dieter; Eibl-Schindler, Regine, eds.,

  2013.

  Disposable bioreactors II.

  Berlin:

  Springer.

  Advances in Biochemical Engineering/Biotechnology ; 138.

  ISBN 978-3-642-45157-7.

  Available from: https://doi.org/10.1007/978-3-642-45158-4

• Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  2011.

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  ISBN 978-0-470-43351-5.

  Available from: https://doi.org/10.1002/9780470909997

Book parts, peer-reviewed

• Löffelholz, Christian; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up

  .

  In:

  Eibl, Dieter; Eibl-Schindler, Regine, eds.,

  Disposable bioreactors II.

  Berlin:

  Springer.

  pp. 1-41.

  Advances in Biochemical Engineering/Biotechnology ; 138.

  Available from: https://doi.org/10.1007/10_2013_187

• Eibl-Schindler, Regine; Steiger, Nina; Wellnitz, Sabine; Vicente, Tiago; John, Corinne; Eibl, Dieter,

  2014.

  Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study

  .

  In:

  Eibl, Dieter; Eibl-Schindler, Regine, eds.,

  Disposable bioreactors II.

  Berlin:

  Springer.

  pp. 99-125.

  Advances in Biochemical Engineering/Biotechnology ; 138.

  Available from: https://doi.org/10.1007/10_2013_186

• Eibl-Schindler, Regine; Löffelholz, Christian; Eibl, Dieter,

  2011.

  Single-use bioreactors : an overview

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  pp. 145-158.

  Available from: https://doi.org/10.1002/9780470909997.ch4

• Eibl-Schindler, Regine; Werner, Sören; Eibl, Dieter,

  2010.

  Bag bioreactor based on wave-induced motion : characteristics and applications

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Advances in biochemical engineering/biotechnology.

  Berlin:

  Springer.

  pp. 55-87.

  Advances in Biochemical Engineering/Biotechnology ; 115.

  Available from: https://doi.org/10.1007/10_2008_15

• Eibl-Schindler, Regine; Eibl, Dieter,

  2009.

  Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents

  .

  In:

  Kasper, Cornelia; van Griensven, Martijn; Pörtner, Ralf, eds.,

  Bioreactor systems for tissue engineering.

  Berlin:

  Springer.

  pp. 183-207.

  Advances in Biochemical Engineering/Biotechnology ; 112.

  Available from: https://doi.org/10.1007/10_2008_23

Other publications

• Schildberger, David; Stutz, Irene; Weber, Carlo; Pedan, Vasilisa; Schlüter, Ansgar; Huber, Petra; Chatelain, Karin; Chetschik, Irene; Eibl, Dieter; Hühn, Tilo; Eibl-Schindler, Regine,

  2018.

  Cast off! Chocolate from cacao cell cultures [poster].

  In:

  New Harvest 2018 Conference, Cambridge, Massachusetts, 20.-21. Juli 2018.

• Jossen, Valentin; Schirmaier, Carmen; John, Gernot T.; Eibl, Dieter; Eibl-Schindler, Regine,

  2015.

  On-line-pH- und -DO-Messungen in Mikrocarrier-basierter hMSC Kultur.

  Biospektrum.

  21(4),

  pp. 422-424.

  Available from: https://doi.org/10.21256/zhaw-1590

• Eibl-Schindler, Regine; Eibl, Dieter,

  2015.

  Single-use (disposable) systems in biopharmaceutical processing : quo vadis?.

  Achema trend reports.

  13.

  Available from: https://www.achema.de/fileadmin/user_upload/Bilder/Presse/ACHEMA2015/Trendberichte/TB_13_ACHEMA_2015_Single_use_d.pdf

• Jossen, Valentin; Pörtner, Ralf; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Mass production of mesenchymal stem cells — impact of bioreactor design and flow conditions on proliferation and differentiation

  .

  In:

  Eberli, Daniel, ed.,

  Cells and Biomaterials in Regenerative Medicine.

  InTech.

  pp. 119-172.

  Tissue Engineering and Regenerative Medicine.

  Available from: https://doi.org/10.21256/zhaw-1597

• Brändli, Johanna; Müller, Matthias; Imseng, Nicole; Schillberg, Stefan; Eibl-Schindler, Regine,

  2012.

  Antikörper-Produktion in Pflanzenzellen : Prozessentwicklung und -übertragung vom 50-ml- auf den 10-l-Maßstab.

  Biospektrum.

  18(2),

  pp. 216-217.

  Available from: https://doi.org/10.21256/zhaw-1556

• Eibl-Schindler, Regine; Eibl, Dieter,

  2011.

  Single-use cell culture systems arrive : tracking the evolution and development of an increasingly used technology.

  GEN : genetic engineering & biotechnology news.

  31(17),

  pp. 59-61.

  Available from: https://doi.org/10.1089/gen.31.17.15

• Eibl-Schindler, Regine,

  2011.

  Zellkultivierung in einem wellendurchmischten, DO-regulierten Einwegbioreaktor.

  Bioforum.

  34(1),

  pp. 22-23.

• Ries, Christoph; John, C.; Eibl-Schindler, Regine,

  2009.

  Einwegbioreaktoren für die Prozessentwicklung mit Insektenzellen.

  Bioforum.

  3,

  pp. 11-13.

• Eibl-Schindler, Regine; Eibl, Dieter,

  2007.

  Disposable bioreactors for cell culture based-processing.

  Achema worldwide news.

  2,

  pp. 8-10.

• Eibl, Dieter; Eibl-Schindler, Regine,

  2007.

  Einwegbioreaktoren für Zellkulturen : Status quo und Trends.

  Pharma-Tec.

  4,

  pp. 14-15.

• Cuperus, S.; Eibl-Schindler, Regine; Hühn, Tilo; Amado, R.,

  2007.

  Plant cell culture based platform investigating biochemical processes in wine production.

  BioForum Europe.

  6,

  pp. 2-4.

• Eibl-Schindler, Regine; Eibl, Dieter,

  2005.

  Einwegkultivierungstechnologie für biotechnische Pharma-Produktionen.

  Bio world.

  3.

• Eibl-Schindler, Regine; Rutschmann, K.; Lisica, Lidija; Eibl, Dieter,

  2003.

  Kostenreduktion bei der Säugerzellkultivierung durch Einwegbioreaktoren?.

  Bio world.

  5,

  pp. 22-23.

• Eibl-Schindler, Regine,

  2002.

  Fermentative Herstellung bioaktiver Wirkstoffe.

  Bio world.

  6(Beilage).

• Viviani, A.; Eibl-Schindler, Regine,

  2001.

  Rote Biotechnologie.

  Bio world.

  4(Beilage).

• Eibl-Schindler, Regine; Brändli, Johanna; Lettenbauer, C.; Eibl, Dieter,

  2000.

  Kultivierung pflanzlicher und animaler Zellkulturen.

  Bio world.

  5,

  pp. 48-50.

• Eibl-Schindler, Regine; Lettenbauer, C.; Eibl, Dieter; Röllin, Markus,

  1999.

  Experiences in the application of the wave bioreactor.

  BioForum Europe.

  3,

  pp. 110-112.

• Eibl-Schindler, Regine; Hans, Daniel; Warlies, S.; Lettenbauer, C.; Eibl, Dieter,

  1999.

  Zellkulturtechnik : Einsatz eines Taumelreaktorsystems mit interner Beleuchtung.

  Bio world.

  2,

  pp. 10-12.

• Eibl-Schindler, Regine,

  1996.

  Pflanzenzellkulturtechnik an der Ingenieurschule Wädenswil.

  Bio world.

  5,

  pp. 3-7.

Oral conference contributions and abstracts

• Schirmer, Cedric; Jossen, Valentin; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Böttcher, Lars; Eibl, Dieter,

  2016.

  Standardized expansion of human mesenchymal stem cells in wave-mixed single-use bioreactors.

  In:

  ILMAC, Basel, 2016.

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