Quick navigation

Main navigation

Prof. Dr. Sven Hirsch

Prof. Dr. Sven Hirsch

Prof. Dr. Sven Hirsch
ZHAW School of Life Sciences and Facility Management
Fachstelle Biomedical Simulation
Einsiedlerstrasse 31a
8820 Wädenswil

+41 (0) 58 934 54 44

Personal profile

Management role

Head, Biomedical Simulation Lab

Position at the ZHAW

Professor for modeling of complex systems


Expertise and research interests

Biomedical Modeling and Simulation, Digital Health

Medical imaging analysis & diagnostics systems, Modelling of biomedical processing, Data assimilation and machine intelligence, Sensor and time series analysis

Applications fields: tumor growth, blot clotting, formation of aneurysms, flow reconstruction, food safety

multi-physics multi-scale continuum models (CFD, structural mechanics, reaction models, FEM)
system dynamics

foresight methods, market forecast
sector knowledge in the fields: energy, mobility, technologies

model generation & esthetics
Implications of digital media and technology on society

Scientific Advisor in the Board of Foundation Insel Hombroich

Educational background

CAS didactics for higher education (2015)

PhD laser physics, Univ. Dusseldorf (2006)
Postgrad. Master Audiovisual Media (2002)
Diploma Physics, Univ. Heidelberg (1998) - Digital image processing and physiology

Professional milestones

2016 - Professor for Modeling, ZFH
2013 - Group Leader Biomedical Simulation – Institute of applied simulation ZHAW, Wädenswil
2008 - 2013 Group Leader Biomedical Simulation – Computer vision lab (Prof. Székely), ETH Zürich
2008 - Head of Quantification, Senior Foresight Consultant, Z_punkt (http://www.z-punkt.de)
2007 - 2008 Project leader holographic topometry, ViRad Imaging/Uniklinik Düsseldorf/caesar Bonn
2004 - 2006 Assistent holographic facial topometry, Kantonspital Basel
2000 - today artist (a.k.a Sven Mann) in media and sound art

Membership of networks



Peer-reviewed articles/chapters

  • ; ; ; ; ; ; ; ; ().

    PHASES Score for the Management of Intracranial Aneurysm

    : A Cross-Sectional Population-Based Retrospective Study.

    Stroke, 48, 8. 2105-2112. Peer reviewed.

  • ; ; ; ; ().

    Using Shape Descriptors to Categorize Intracranial Aneurysms


    In: CMBE 2017. 5th International Conference on Computational and Mathematical Biomedical Engineering. Pittsburgh, USA: CMBE. Peer reviewed.

  • ; ; ; ; ; ().

    Where does CFD Identify Lesion Instability in Small Aneurysms?


    In: CMBE2017. 5th International Conference on Computational and Mathematical Biomedical Engineering. Pittsburgh, USA: CMBE. Peer reviewed.

  • ; ; ; ; ; ().

    Shape-based modeling of aneurysmal disease status


    In: ECCOMAS 2016. Minisimposium on Aneurysms: Solid Mechanics, fluid mechanics and mechanobiology. Heraklion, Greece: ECCOMAS. Peer reviewed.

  • ; ; ; ().

    What’s ugly? Shape-based analysis of intracranial aneurysms


    In: Latsis Symposium ETH Zürich. On Personalized Medicine. Zürich: Latsis Foundation. Peer reviewed.

  • ; ; ; ; ; ; ().

    A Partial Domain Approach to Enable Aortic Flow Simulation Without Turbulent Modeling

    : MICCAI – Medical Image Computing and Computer-Assisted Intervention.

    Lecture Notes in Computer Science , 9350 544-551. Peer reviewed.

  • ; ; ; ; ; ().

    A robust comparison approach of velocity data between MRI and CFD based on divergence-free space projection


    IEEE International Symposium on Biomedical Imaging, April 16-19, New York. Peer reviewed.

  • ; ; ; ; ; ().

    Computational Framework for Personalized Characterization of Aneurysm Physics and Physiology, as well as Disease Progression Modelling


    European Solid Mechanics Conference Madrid Peer reviewed.

  • ; ().

    Emerging Practices in Foresight and Their Use in STI Policy


    STI Policy Review, 6, 2. 24-53. Peer reviewed.

  • ; ().

    Intracranial aneurysms rupture risk clinical assessment


    European Solid Mechanics Conference Madrid Peer reviewed.

  • ; ; ; ; ().

    Joint 3-D Vessel Segmentation and Centerline Extraction Using Oblique Hough Forests with Steerable Filters


    Medical Image Analysis, 19, 1. 220-49. Peer reviewed.

  • ; ; ; ; ().

    The role of clot maturation inside intracranial aneurysms using a viscoelastic thrombosis model


    European Solid Mechanics Conference Madrid Peer reviewed.

  • ; ; ; ; ().

    2D viscoelastic thrombosis model for stented aneurysms


    World Conference on Biomechanics, Boston, MA, 6-11th July. Peer reviewed.

  • ; ; ; ; ; ; ; ().

    Computational Stent Placement in Transcatheter Aortic Valve Implantation


    In: Lecture Notes in Computer Science. Volume 8789. Cambridge: Springer. Peer reviewed.

  • ; ; ; ; ; ; ; ; ; ().

    Image-Based Mechanical Analysis of Stent Deformation. Concept and Exemplary Implementation for TAVI Stents


    IEEE Transactions on Biomedical Engineering, 60, 1. 4-15. Peer reviewed.

  • ; ; ; ; ().

    TGIF: Topological gap in-fill for correction of vascular connectivity –- A generative physiological modeling approach


    In: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014 (89-96). (17. Aufl.) Peer reviewed.

  • ; ; ; ; ().

    Clinical relevance of mechano-biological transduction in intracranial aneurysms: the mediating role of thrombus formation and inflammatory response expressing as aneurysm shape


    Int Conf Comp Math Biomed Eng 107-110. Peer reviewed.

  • ; ; ().

    Scenario planning with integrated quantification – managing uncertainty in corporate strategy building


    Foresight, 15, 5. 363 - 374. Peer reviewed.

  • ; ; ; ; ; ; ().

    Simulation of Transcatheter Aortic Valve Implantation under Consideration of Leaflet Calcification


    Conf Proc IEEE Eng Med Biol Soc, 711 Peer reviewed.

Non-peer-reviewed articles/chapters

Publications before appointment at the ZHAW

S Hirsch, P Burggraf, C Daheim. Scenario Planning with Integrated Quantification – Managing Uncertainty in Corporate Strategy Building. Foresight (2013)

S Hirsch, C Daheim. The meaning of clean electricity. Yearbook World Future Society (2012)

S Hirsch, P Burggraf. Quantifizierte Szenarien. Zukunftsmanager, online Publikation (2012)

S Hirsch, C Daheim. Zur Zukunft der Stromversorgung. Swissfuture (2011)

Christoph Russ, Simon Sündermann, Sven Hirsch, Volkmar Falk, Gabor Székely, Michael Gessat. On the Effect of Anatomy-based Multi-material Model Simulation of the Aortic Root. 4th International Workshop on Computational Phantoms for Radiation Protection, Imaging and Radiotherapy (2013)

Julien Egger, Ajit S. Mallik, Dominik Szczerba, Daniel A. Rüfenacht, Gabor Székely, Sven Hirsch. Spatial stabilization strategies applied to multiphysics modeling of blood clotting using a modified PTT model. International Conference on Computational Science, ICCS 2013 (2013)

Kulcsár Z, Augsburger L, Reymond P, Pereira VM, Hirsch S, Mallik AS, Millar J, Wetzel SG, Wanke I, Rüfenacht DA. Flow diversion treatment: intra-aneurismal blood flow velocity and WSS reduction are parameters to predict aneurysm thrombosis. Acta Neurochir (Wien) (2012)

Matthias Schneider, Johannes Reichold, Bruno Weber, Gábor Székely, Sven Hirsch. Tissue Metabolism Driven Arterial Tree Generation. Medical Image Analysis (2012)

Sven Hirsch, Johannes Reichold, Matthias Schneider, Gábor Székely, Bruno Weber. Topology and hemodynamics of the cortical cerebrovascular system. J Cereb Blood Flow Metab (2012)

S. Hirsch, B. Lloyd, D. Szczerba, G. Székely. A Multiscale Simulation Framework for Modeling Solid Tumor Growth with an Explicit Vessel Network. Multiscale Cancer Imaging, T. Deisboeck and G. Stamatsakos, Ed., Chapman & Hall /CRC (2010)

Matthias Schneider, Sven Hirsch, Gábor Székely, Bruno Weber, Bjoern H. Menze. Oblique Random Forests for 3-D Vessel Detection Using Steerable Filters and Orthogonal Subspace Filtering. MICCAI Workshop on Medical Computer Vision 2012 (2012)

Matthias Schneider, Sven Hirsch, Bruno Weber, Gábor Székely. Physiologically Based Construction of Optimized 3-D Arterial Tree Models. MICCAI 2011 (2011)

Bryn A. Lloyd, Sven Hirsch, Gabor Székely. Optimization of Case-specific Vascular Tree Models Based on Vessel Size Imaging. Proceedings of the 5th International Symposium on Biomedical Simulation - ISBMS10 (2010)

Sven Hirsch, Dominik Szczerba, Bryn Lloyd, Michael Bajka, Niels Kuster, Gabor Székely. A Mechano-Chemical Model of a Solid Tumor for Therapy Outcome Predictions. Computational Science - ICCS 2009 (2009)

F Prieels, S Hirsch, P Hering. Holographic topometry for a dense visualisation of soft tissue for facial reconstruction. Forensic Science, Medicine and Pathology (2009)

S Hirsch. Holographie als Messtechnik in der Medizin. Das holographische Wissen, Ed. Schröter und Rieger, diaphanes, Berlin, (2009)

A Thelen, S Frey, S Hirsch, P Hering. Improvements in shape-from-focus for holographic reconstructions with regard to focus operators, neighborhood-size, and height value interpolation. IEEE Trans Image Process, Vol.18, No.1 (2009)

S Hirsch. Digital and Analog Hologram Tomography for Medical Applications. Dissertation, Heinrich-Heine Universität Düsseldorf (2007)

S Hirsch et al. Single-Pulsed Digital Holographic Topometry Novel Optical Instrumentation for Biomedical Applications. Proc. SPIE Int. Soc. Opt. Eng. 6631, 66310I (2007)

S Hirsch et al. Ultrafast Holographic 3D Facial Topometry and Digital Reconstruction. In: Buzug et al. (Eds); Facial Reconstruction - Gesichtsrekonstruktion, BKA series: Police and Research 35 (2007)

S Heintz, S Hirsch, A Thelen, P Hering. Three-dimensional surface measurement using digital holography with pulsed lasers. Advances in Medical Engineering, Vol. 114, pp. 435-440 (2007)

S Frey, A Thelen, S Hirsch, P Hering. Generation of digital textured surface models from hologram recordings. Applied Optics, Vol. 46, No. 11, pp. 1986-1993 (2007)

R Bakanas, GA Gudaitis, SJ Zacharovas, DB Ratcliffe, S Hirsch, S Frey, A Thelen, N Ladriere, P Hering. Using a portable holographic camera in cosmetology. Journal of Optical Technology, Vol. 73, No. 7, pp. 457-461 (2006)

S Frey, A Thelen, S Hirsch, P Hering. Shape measurement using pulsed optical holography. Laser Technik Journal, No. 1, pp. 42-45 (2006)

S Hirsch, et. al. Facial topometry using pulsed holography. In: Advances in Display Holography, Proceedings of the 7th International Symposium on Display Holography (2006)

M Hoch, S Mann. Fuzzy-Based Person Tracking in Real-Time. Computer Graphics International, 201-208 (2000)

D Uttenweiler, C Veigel, R Steubing, C Goetz, S Mann, H Haußecker, B Jaehne, & RHA Fink. Motion determination in actin filament !uorescence images with a spatio-temporal orientation analysis method. Biophys. J., 78: 2709-2715 (2000)

D Uttenweiler, C Veigel, R Steubing, C Goetz, S Mann, H Haußecker, B Jaehne, & RHA Fink. A spatio-temporal orientation method for analyzing actin filament sliding velocity in the in vitro motility assay. Biophys. J., 78(1):1474 (2000)

M Hoch, S Mann. Fuzzy-Based Person Tracking in Real-Time. Computer Graphics International, 201-208 (2000)

S Mann. Objektbasierte Bildfolgenanalyse zur Bewegungsbestimmung im in vitro Motility Assay unter Verwendung eines Strukturtensorverfahrens. Diplomarbeit (1998)