Prof. Dr. Rebecca Buller
Prof. Dr. Rebecca Buller
ZHAW
School of Life Sciences and Facility Management
Fachstelle Biokatalyse und Prozesstechnologie
Einsiedlerstrasse 31
8820 Wädenswil
Projects
- Biocatalytic Production - Engineering of terpene cyclases for the production of R-alpha-Ionone / Project leader / abgeschlossen
- Biocatalytic oxidation processes with alpha-ketoglutarate dependent enzymes for sustainable chemical synthesis / Project leader / abgeschlossen
- Strategies to reduce mycotoxins in grain side product streams enabling their reintroduction into the food value chain / Co-project leader / abgeschlossen
- Microbial Epimerases: A Toolbox for the Synthesis of Novel Peptide-Based Drugs / Project leader / abgeschlossen
- Biocatalytic halogenation for the sustainable development of agrochemicals / Project leader / abgeschlossen
- Impulse - Digitalization in biofabrication: Design, recombinant production and testing of innovative Protein scaffolds as inks for 3D bioprinting / Deputy project leader / abgeschlossen
- National Competence Center of Research Catalysis / Project leader / laufend
Publications
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André, Amandine; Hecht, Katrin; Mischler, Sandra; Stäheli, Luca; Kerhanaj, Fllanza; Buller, Rebecca; Kinner, Mathias; Freimüller Leischtfeld, Susette; Chetschik, Irene; Miescher Schwenninger, Susanne; Müller, Nadina,
2024.
Food Research International.
186(114364).
Available from: https://doi.org/10.1016/j.foodres.2024.114364
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Buller, R.; Lutz, S.; Kazlauskas, R. J.; Snajdrova, R.; Moore, J. C.; Bornscheuer, U. T.,
2023.
From nature to industry : harnessing enzymes for biocatalysis.
Science.
382(6673), pp. eadh8615.
Available from: https://doi.org/10.1126/science.adh8615
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Giger, Sandro; Buller, Rebecca,
2023.
Advances in noncanonical amino acid incorporation for enzyme engineering applications.
Chimia.
77(6), pp. 395-402.
Available from: https://doi.org/10.2533/chimia.2023.395
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Hegarty, Eimear; Büchler, Johannes; Buller, Rebecca M.,
2023.
Halogenases for the synthesis of small molecules.
Current Opinion in Green and Sustainable Chemistry.
41(100784).
Available from: https://doi.org/10.1016/j.cogsc.2023.100784
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Patsch, David; Buller, Rebecca,
2023.
Improving enzyme fitness with machine learning.
Chimia.
77(3), pp. 116-121.
Available from: https://doi.org/10.2533/chimia.2023.116
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Patsch, David; Eichenberger, Michael; Voss, Moritz; Bornscheuer, Uwe T.; Buller, Rebecca M.,
2023.
LibGENiE : a bioinformatic pipeline for the design of information-enriched enzyme libraries.
Computational and Structural Biotechnology Journal.
21, pp. 4488-4496.
Available from: https://doi.org/10.1016/j.csbj.2023.09.013
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Eichenberger, Michael; Schwander, Thomas; Hüppi, Sean; Kreuzer, Jan; Mittl, Peer R. E.; Peccati, Francesca; Jiménez-Osés, Gonzalo; Naesby, Michael; Buller, Rebecca M.,
2023.
The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis.
Nature Catalysis.
6(10), pp. 927-938.
Available from: https://doi.org/10.1038/s41929-023-01018-y
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Papadopoulou, Athena; Meyer, Fabian; Buller, Rebecca M.,
2022.
Engineering Fe(II)/α-ketoglutarate-dependent halogenases and desaturases.
Biochemistry.
62(2), pp. 229-240.
Available from: https://doi.org/10.1021/acs.biochem.2c00115
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Büchler, Johannes; Honda Malca, Sumire; Patsch, David; Voss, Moritz; Turner, Nicholas J.; Bornscheuer, Uwe T.; Allemann, Oliver; Le Chapelain, Camille; Lumbroso, Alexandre; Loiseleur, Olivier; Buller, Rebecca,
2022.
Nature Communications.
13(371).
Available from: https://doi.org/10.1038/s41467-022-27999-1
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Büchler, Johannes; Hegarty, Eimear; Schroer, Kirsten; Snajdrova, Radka; Turner, Nicholas J.; Loiseleur, Olivier; Buller, Rebecca; Le Chapelain, Camille,
2022.
Helvetica Chimica Acta.
106(1), pp. e202200128.
Available from: https://doi.org/10.1002/hlca.202200128
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Papadopoulou, Athena; Peters, Christin; Borchert, Sonja; Steiner, Kerstin; Buller, Rebecca,
2022.
Development of an ene reductase-based biocatalytic process for the production of flavor compounds.
Organic Process Research & Development.
26(7), pp. 2102-2110.
Available from: https://doi.org/10.1021/acs.oprd.2c00096
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Voss, Moritz; Hüppi, Sean; Schaub, Daniela; Hayashi, Takahiro; Ligibel, Mathieu; Sager, Emine; Schroer, Kirsten; Snajdrova, Radka; Buller, Rebecca,
2022.
Enzyme engineering enables inversion of substrate stereopreference of the halogenase WelO5*.
ChemCatChem.
14(24), pp. e202201115.
Available from: https://doi.org/10.1002/cctc.202201115
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Reiter, Maud; Hevey, Rachel; Buller, Rebecca; Shybeka, Inga,
2021.
Swiss women in chemistry – two years later ....
Chimia.
75(12), pp. 1088-1090.
Available from: https://doi.org/10.2533/chimia.2021.1088
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Papadopoulou, Athena; Meierhofer, Jasmin; Meyer, Fabian; Hayashi, Takahiro; Schneider, Samuel; Sager, Emine; Buller, Rebecca,
2021.
ChemCatChem.
13(18), pp. 3914-3919.
Available from: https://doi.org/10.1002/cctc.202100591
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Meyer, Fabian; Frey, Raphael; Ligibel, Mathieu; Sager, Emine; Schroer, Kirsten; Snajdrova, Radka; Buller, Rebecca,
2021.
ACS Catalysis.
2021(11).
Available from: https://doi.org/10.1021/acscatal.1c00678
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Eichenberger, Michael; Hüppi, Sean; Patsch, David; Aeberli, Natalie; Berweger, Raphael; Dossenbach, Sandro; Eichhorn, Eric; Flachsmann, Felix; Hortencio, Lucas; Voirol, Francis; Vollenweider, Sabine; Bornscheuer, Uwe T.; Buller, Rebecca,
2021.
Asymmetric cation-olefin monocyclization by engineered squalene-hopene cyclases.
Angewandte Chemie: International Edition.
60(50), pp. 26080-26086.
Available from: https://doi.org/10.1002/anie.202108037
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Voss, Moritz; Küng, Robin; Hayashi, Takahiro; Jonczyk, Magdalena; Niklaus, Michael; Iding, Hans; Wetzl, Dennis; Buller, Rebecca,
2020.
ChemCatChem.
13(6), pp. 1538-1545.
Available from: https://doi.org/10.1002/cctc.202001871
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Aregger, David; Peters, Christin; Buller, Rebecca,
2020.
Characterization of the novel ene reductase Ppo-Er1 from paenibacillus polymyxa.
Catalysts.
10(2).
Available from: https://doi.org/10.3390/catal10020254
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Voss, Moritz; Honda Malca, Sumire; Buller, Rebecca,
2020.
Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases.
Chemistry - A European Journal.
Available from: https://doi.org/10.1002/chem.201905752
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Hecht, Katrin; Meyer, Hans-Peter; Wohlgemuth, Roland; Buller, Rebecca,
2020.
Biocatalysis in the Swiss manufacturing environment.
Catalysts.
10(12), pp. 1420.
Available from: https://doi.org/10.3390/catal10121420
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Büchler, Johannes; Papadopoulou, Athena; Buller, Rebecca,
2019.
Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application.
Catalysts.
9(12), pp. 1030.
Available from: https://doi.org/10.3390/catal9121030
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Hayashi, Takahiro; Ligibel, Mathieu; Sager, Emine; Voss, Moritz; Hunziker, Jürg; Schroer, Kirsten; Snajdrova, Radka; Buller, Rebecca,
2019.
Angewandte Chemie: International Edition.
58(51), pp. 18535-18539.
Available from: https://doi.org/10.1002/anie.201907245
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Hayashi, Takahiro; Ligibel, Mathieu; Sager, Emine; Voss, Moritz; Hunziker, Jürg; Schroer, Kirsten; Snajdrova, Radka; Buller, Rebecca,
2019.
Angewandte Chemie.
131(51), pp. 18706-18711.
Available from: https://doi.org/10.1002/ange.201907245
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Papadopoulou, Athena; Hecht, Katrin; Buller, Rebecca,
2019.
Chimia.
73(9), pp. 743-749.
Available from: https://doi.org/10.2533/chimia.2019.743
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Peters, Christin; Frasson, David; Sievers, Martin; Buller, Rebecca,
2019.
Novel Old Yellow Enzyme subclasses.
ChemBioChem.
Available from: https://doi.org/10.1002/cbic.201800770
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Frey, Raphael; Hayashi, Takahiro; Buller, Rebecca,
2019.
Directed evolution of carbon–hydrogen bond activating enzymes.
Current Opinion in Biotechnology.
60, pp. 29-38.
Available from: https://doi.org/10.1016/j.copbio.2018.12.004
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Peters, Christin; Buller, Rebecca,
2019.
Industrial application of 2-oxoglutarate-dependent oxygenases.
Catalysts.
9(3), pp. 221-240.
Available from: https://doi.org/10.3390/catal9030221
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Peters, Christin; Buller, Rebecca,
2019.
Linear enzyme cascade for the production of (–)-iso-isopulegol.
Zeitschrift für Naturforschung C.
74(3-4).
Available from: https://doi.org/10.1515/znc-2018-0146
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Kries, Hajo; Blomberg, Rebecca; Hilvert, Donald,
2013.
De novo enzymes by computational design.
Current Opinion in Chemical Biology.
17(2), pp. 221-228.
Available from: https://doi.org/10.1016/j.cbpa.2013.02.012
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Blomberg, Rebecca; Kries, Hajo; Pinkas, Daniel M.; Mittl, Peer R. E.; Grütter, Markus G.; Privett, Heidi K.; Mayo, Stephen L.; Hilvert, Donald,
2013.
Precision is essential for efficient catalysis in an evolved Kemp eliminase.
Nature.
503(7476), pp. 418-421.
Available from: https://doi.org/10.1038/nature12623
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Richter, Florian; Blomberg, Rebecca; Khare, Sagar D.; Kiss, Gert; Kuzin, Alexandre P.; Smith, Adam J. T.; Gallaher, Jasmine; Pianowski, Zbigniew; Helgeson, Roger C.; Grjasnow, Alexej; Xiao, Rong; Seetharaman, Jayaraman; Su, Min; Vorobiev, Sergey; Lew, Scott; Forouhar, Farhad; Kornhaber, Gregory J.; Hunt, John F.; Montelione, Gaetano T.; Tong, Liang; Houk, K. N.; Hilvert, Donald; Baker, David,
2012.
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.
Journal of the American Chemical Society.
134(39), pp. 16197-16206.
Available from: https://doi.org/10.1021/ja3037367
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Privett, H. K.; Kiss, G.; Lee, T. M.; Blomberg, R.; Chica, R. A.; Thomas, L. M.; Hilvert, D.; Houk, K. N.; Mayo, S. L.,
2012.
Iterative approach to computational enzyme design.
Proceedings of the National Academy of Sciences of the United States of America.
109(10), pp. 3790-3795.
Available from: https://doi.org/10.1073/pnas.1118082108
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Chapleau, Richard R.; Blomberg, Rebecca; Ford, Peter C.; Sagermann, Martin,
2008.
Protein Science.
17(4), pp. 614-622.
Available from: https://doi.org/10.1110/ps.073358908
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Hecht, Katrin; Buller, Rebecca,
2019.
Ene-reductases in pharmaceutical chemistry
.
In:
Grunwald, Peter, ed.,
Pharmaceutical biocatalysis : chemoenzymatic synthesis of active pharmaceutical ingredients.
Singapore:
Jenny Stanford.
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Buller, Rebecca; Hecht, Katrin; Mirata, Marco Antonio; Meyer, Hans-Peter,
2017.
An appreciation of biocatalysis in the Swiss manufacturing environment
.
In:
Biocatalysis : an industrial perspective.
Royal Society of Chemistry.
pp. 1-43.
Catalysis Series ; 29.
Available from: https://doi.org/10.1039/9781782629993-00001
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Buller, Rebecca,
2021.
.
In:
Technology Outlook 2021.
Swiss Academy of Engineering Sciences SATW.
pp. 71.
Available from: https://www.satw.ch/de/publikationen/technology-outlook-2021
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Buller, Rebecca; Coperét, Christophe; Emsley, Lyndon; Gademann, Karl; Hari, Yvonne; Leo, Merz,
2021.
Chemistry roadmap for research infrastructures 2025-2028 by the Swiss chemistry community.
Swiss Academies Reports
; 16(3).
Swiss Academy of Sciences.
Available from: https://doi.org/10.5281/zenodo.4572642
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André, Amandine; Hecht, Katrin; Mischler, Sandra; Freimüller Leischtfeld, Susette; Kinner, Mathias; Stäheli, Luca; Kerhanaj, Fllanza; Buller, Rebecca; Miescher Schwenninger, Susanne; Chetschik, Irene; Müller, Nadina,
2023.
Eine biologische Strategie zur Reduzierung des Zearalenongehalts in infizierten Weizenkörnern.
In:
9. D-A-CH-Tagung für angewandte Getreidewissenschaften, Detmold, Deutschland, 5.-6. Oktober 2023.
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André, Amandine; Freimüller Leischtfeld, Susette; Mischler, Sandra; Hecht, Katrin; Stäheli, Luca; Rüegg, Ramona; Kinner, Mathias; Buller, Rebecca; Chetschik, Irene; Miescher Schwenninger, Susanne; Müller, Nadina,
2022.
Mycotoxins reduction strategies to reintroduce grain side product streams into the food value chain.
In:
20th ICC Conference, Vienna, Austria, 5-7 July 2022.