Chemistry for the Life Sciences
The Master’s thesis is at the heart of your studies. You select modules from Entrepreneurial Skills and Advanced Life Science Skills at an early stage to prepare you for work on your thesis. From the start you are part of a research group at the Institute for Chemistry and Biological Chemistry in Wädenswil or in an external company, organisation or research institute. On the basis of your research you answer specific questions and work out solutions which are relevant for research, business and /or society, often in cooperation with national or international partners. The thesis gives you the opportunity to demonstrate that you can apply the knowledge and competencies you have acquired.
Topics for the Master's thesis
You choose the topic of your Master’s thesis in one of the seven centres shown below. You deepen your experimental abilities in your selected area of research and gain detailed insight into the methodologies needed to carry out demanding research projects.
Centre for Organic and Medicinal Chemistry
Contact: Prof. Dr. Rainer Riedl
- Design and synthesis of novel inhibitors for therapeutically relevant drug targets:
A Structural View on Medicinal Chemistry Strategies against Drug Resistance
S. Agnello, M. Brand, M. F. Chellat, S. Gazzola, R. Riedl, Angew. Chem. Int. Ed. 2019, 58, 3300. Details
Targeting Antibiotic Resistance
M. F. Chellat, L. Raguž, R. Riedl, Angew. Chem. Int. Ed. 2016, 55, 6600. Details
- Linear and cyclic peptides and peptidomimetics as inhibitors of protein-proteininteractions:
Drug Design Inspired by Nature: Crystallographic Detection of an Auto- Tailored Protease Inhibitor Template
F. M. Gall, D. Hohl, D. Frasson, T. Wermelinger, P. R. E. Mittl, M. Sievers, R. Riedl, Angew. Chem. Int. Ed. 2019, 58, 4051. Details
- Computer aided and fragment based drug design:
Merging Allosteric and Active Site Binding Motifs: De novo Generation of Target Selectivity and Potency via Natural-Product-Derived Fragments
Lanz, J. and Riedl, R. (2015), Merging Allosteric and Active Site Binding Motifs: De novo Generation of Target Selectivity and Potency via Natural-Product-Derived Fragments. ChemMedChem, 10: 451-454. Details
Centre for Physical Chemistry
Contact: Prof. Dr. Jürgen Stohner
- Synthesis and characterisation of chiral molecules with infrared spectroscopy.
Mazenauer, Manuel R.; Manov, Stole; Galati, Vanessa M.; Kappeler, Philipp; Stohner, Jürgen, 2017. Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate. RSC Advances. 7(87), p. 55434-55440.
- Enantio-separation of small chiral molecules.
Spenger, Benjamin; Stohner, Jürgen, 2016. Verfahren zur gaschromatischen Trennung eines Enantiomerengemisches. Patentnummer EP3069777 A1 (2016-09-21). Details
- High-resolution rovibrational spectroscopy of small molecules (relevant in atmospheric and environmental chemistry).
Hobi, Fabian; Berger, Robert; Stohner, Jürgen, 2013. Investigation of parity violation in nuclear spin-rotation interaction of fluorooxirane. Molecular physics. 111(14-15), p. 2345-2362.
(Collaboration with ETH Zurich)
- Determination of the absolute configuration of chiral molecules by new spectroscopic techniques.
Pitzer, Martin; Berger, Robert; Stohner, Jürgen; Dörner, Reinhard; Schöffler, Markus, 2018. Investigating absolute stereochemical configuration with coulomb explosion imaging. Chimia. 72(6), p. 384-388.
(Collaboration with University Frankfurt and University Marburg)
- ... mixtures ...
Böselt, Lennard; Sidler, Dominik; Kittelmann, Tobias; Stohner, Jürgen; Zindel, Daniel; Wagner, Trixie; Riniker, Sereina, 2019. Determination of absolute stereochemistry of flexible molecules using a vibrational circular dichroism spectra alignment algorithm. Journal of chemical information and modeling. 59(5), p. 1826-1838.
(Collaboration with Novartis and ETH Zurich)
Centre for Biochemistry
Contact: Prof. Dr. Christiane Zaborosch
- Recombinant Protein Technology and Downstream Processing: Development and optimisation of purifications of recombinant proteins.
- Bioanalytics – Characterization of proteins regarding identity, purity, concentration, biological activity and stability: Determination of kinetic parameters and of affinities of protein-protein interactions using label-free surface plasmon resonance (SPR) measurements on a Biacore T200.
- Bioanalytics – Development of specific assays using immunological methods such as ELISA, development of analytics using mass spectrometry or capillary electrophoresis: Characterization of glycan microheterogeneities of recombinant glycoproteins.
Centre for Tissue Engineering
Kontakt: Prof. Dr. Michael Raghunath
- Stem cell applications: Nutraceutical platform based on human progenitor cells (brown and white adipose tissue); Induced pluripotent stem cells, exosome typing, Reporter assays
- Biofabrication: development of enzymatic bio-ink, bioprinted skeletal muscle, voxelated tissue assembly (cancer models, pancreas, fat)
- Immuno-bioengineering: Immunogenic expression of cell membrane structures; 3D bone marrow models
- 3D epithelial constructs: Skin Photobiology; immuncompetent skin models; renal tubules
Centre for Microbiology and Biofilms
Contact: Prof. Dr. Walter Krebs
- Flow Cytometry: Application and further development of methods for the qualitative and quantitative analysis of microbial communities in complex matrices such as biofilms.
- Susceptibility testing: The established methods are used to examine the susceptibility (sensitivity) "only" with fresh planktonic microbes to antimicrobial agents. In reality, most pathogenic microorganisms live on or with us in mixed cultures as biofilms and are significantly more difficult to combat. Therefore, we try to modify established methods accordingly or to develop new ones.