Prof. Dr. Rebecca Buller

Projekte

• National Competence Center of Research Catalysis / Projektleiter:in / laufend
• Enzymatic Construction of DNA-Encoded Chemical Libraries / Projektleiter:in / abgeschlossen
• Biocatalytic halogenation for the sustainable development of agrochemicals / Projektleiter:in / abgeschlossen
• NCCR Catalysis / Teammitglied / abgeschlossen
• Strategien zur Reduktion von Mykotoxinen in Getreidenebenproduktströmen / Co-Projektleiter:in / abgeschlossen
• Microbial Epimerases: A Toolbox for the Synthesis of Novel Peptide-Based Drugs / Projektleiter:in / abgeschlossen
• Impulse - Digitalization in biofabrication: Design, recombinant production and testing of innovative Protein scaffolds as inks for 3D bioprinting / Stellv. Projektleiter:in / abgeschlossen
• Biocatalytic oxidation processes with alpha-ketoglutarate dependent enzymes for sustainable chemical synthesis / Projektleiter:in / abgeschlossen
• CAS - Biocatalysis / Stellv. Projektleiter:in / abgeschlossen
• PgB P-14 Engineered Halogenases / Projektleiter:in / abgeschlossen
• Biocatalytic Production - Engineering of terpene cyclases for the production of R-alpha-Ionone / Projektleiter:in / abgeschlossen
• Firmenich CTI 25929.2 / Projektleiter:in / abgeschlossen
• Innovationsraum Biokatalyse P-14 / Projektleiter:in / abgeschlossen

Publikationen

• Özgen, Fatma Feyza; Stockinger, Peter; Komarova, Anastasia O.; Luterbacher, Jeremy; Buller, Rebecca,

  2026.

  Biomass-derived diformylxylose as a renewable solvent for biocatalysis applications.

  ChemSusChem.

  19(4), S. e202502273.

  Verfügbar unter: https://doi.org/10.1002/cssc.202502273

• Schaub, Daniela; Lessing, Alice; von Haugwitz, Gerlis; Meyer, Fabian; Scheuermann, Jörg; Buller, Rebecca,

  2026.

  Toward the chemoenzymatic synthesis of DNA-encoded libraries.

  ACS Central Science.

  12(1), S. 28-39.

  Verfügbar unter: https://doi.org/10.1021/acscentsci.5c01516

• Graber, David; Stockinger, Peter; Meyer, Fabian; Mishra, Siddhartha; Horn, Claus; Buller, Rebecca,

  2025.

  Resolving data bias improves generalization in binding affinity prediction.

  Nature Machine Intelligence.

  7(10), S. 1713-1725.

  Verfügbar unter: https://doi.org/10.1038/s42256-025-01124-5

• Kumar, Ashutosh; Taubitz, Jan; Meyer, Fabian; Imstepf, Nicolas; Peng, Jiaming; Tassano, Erika; Moore, Charles; Lochmann, Thomas; Šnajdrová, Radka; Buller, Rebecca,

  2025.

  Streamlining enzyme discovery and development through data analysis and computation.

  Chem Catalysis.

  5(10), S. 101445.

  Verfügbar unter: https://doi.org/10.1016/j.checat.2025.101445

• Vornholt, Tobias; Stockinger, Peter; Mutný, Mojmír; Jeschek, Markus; Nestl, Bettina M.; Oberdorfer, Gustav; Osuna, Sílvia; Pleiss, Jürgen; Welner, Ditte Hededam; Krause, Andreas; Buller, Rebecca; Ward, Thomas R.,

  2025.

  Of revolutions and roadblocks : the emerging role of machine learning in biocatalysis.

  ACS Central Science.

  11(10), S. 1828-1838.

  Verfügbar unter: https://doi.org/10.1021/acscentsci.5c00949

• Stockinger, Peter; Niederhauser, Cornel; Farnaud, Sebastien; Buller, Rebecca,

  2025.

  Computational analysis reveals temperature-induced stabilization of FAST-PETase.

  Computational and Structural Biotechnology Journal.

  27, S. 969-977.

  Verfügbar unter: https://doi.org/10.1016/j.csbj.2025.03.006

• Hecht, Katrin; Buller, Rebecca,

  2025.

  Industrializing biocatalysis.

  Chimia.

  79(7-8), S. 522-527.

  Verfügbar unter: https://doi.org/10.2533/chimia.2025.522

• Buller, Rebecca; Damborsky, Jiri; Hilvert, Donald; Bornscheuer, Uwe T.,

  2024.

  Structure prediction and computational protein design for efficient biocatalysts and bioactive proteins.

  Angewandte Chemie: International Edition.

  64(2), S. e202421686.

  Verfügbar unter: https://doi.org/10.1002/anie.202421686

• Stockinger, Peter; Buller, Rebecca,

  2024.

  Nature’s toolbox for the hydrolysis of lactams and cyclic imides.

  ACS Catalysis.

  14(21), S. 16055-16073.

  Verfügbar unter: https://doi.org/10.1021/acscatal.4c04474

• Patsch, David; Schwander, Thomas; Voss, Moritz; Schaub, Daniela; Hüppi, Sean; Eichenberger, Michael; Stockinger, Peter; Schelbert, Lisa; Giger, Sandro; Peccati, Francesca; Jiménez-Osés, Gonzalo; Mutný, Mojmír; Krause, Andreas; Bornscheuer, Uwe T.; Hilvert, Donald; Buller, Rebecca M.,

  2024.

  Enriching productive mutational paths accelerates enzyme evolution.

  Nature Chemical Biology.

  20(12), S. 1662-1669.

  Verfügbar unter: https://doi.org/10.1038/s41589-024-01712-3

• Bopp, Charlotte E.; Bernet, Nora M.; Meyer, Fabian; Khan, Riyaz; Robinson, Serina L.; Kohler, Hans-Peter E.; Buller, Rebecca; Hofstetter, Thomas B.,

  2024.

  Elucidating the role of O2 uncoupling for the adaptation of bacterial biodegradation reactions catalyzed by Rieske oxygenases.

  ACS Environmental Au.

  4(4), S. 204-218.

  Verfügbar unter: https://doi.org/10.1021/acsenvironau.4c00016

• André, Amandine; Hecht, Katrin; Mischler, Sandra; Stäheli, Luca; Kerhanaj, Fllanza; Buller, Rebecca; Kinner, Mathias; Freimüller Leischtfeld, Susette; Chetschik, Irene; Miescher Schwenninger, Susanne; Müller, Nadina,

  2024.

  A new physical and biological strategy to reduce the content of zearalenone in infected wheat kernels : the effect of cold needle perforation, microorganisms, and purified enzyme.

  Food Research International.

  186(114364).

  Verfügbar unter: https://doi.org/10.1016/j.foodres.2024.114364

• Honda Malca, Sumire; Stockinger, Peter; Duss, Nadine; Milbredt, Daniela; Iding, Hans; Buller, Rebecca,

  2024.

  Excelzyme : a Swiss university-industry collaboration for accelerated biocatalyst development.

  Chimia.

  78(3), S. 108-117.

  Verfügbar unter: https://doi.org/10.2533/chimia.2024.108

• Honda Malca, Sumire; Duss, Nadine; Meierhofer, Jasmin; Patsch, David; Niklaus, Michael; Reiter, Stefanie; Hanlon, Steven Paul; Wetzl, Dennis; Kuhn, Bernd; Iding, Hans; Buller, Rebecca,

  2024.

  Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor.

  Communications Chemistry.

  7(1), S. 46.

  Verfügbar unter: https://doi.org/10.1038/s42004-024-01130-5

• Buller, R.; Lutz, S.; Kazlauskas, R. J.; Snajdrova, R.; Moore, J. C.; Bornscheuer, U. T.,

  2023.

  From nature to industry : harnessing enzymes for biocatalysis.

  Science.

  382(6673), S. eadh8615.

  Verfügbar unter: https://doi.org/10.1126/science.adh8615

• Giger, Sandro; Buller, Rebecca,

  2023.

  Advances in noncanonical amino acid incorporation for enzyme engineering applications.

  Chimia.

  77(6), S. 395-402.

  Verfügbar unter: https://doi.org/10.2533/chimia.2023.395

• Hegarty, Eimear; Büchler, Johannes; Buller, Rebecca M.,

  2023.

  Halogenases for the synthesis of small molecules.

  Current Opinion in Green and Sustainable Chemistry.

  41(100784).

  Verfügbar unter: https://doi.org/10.1016/j.cogsc.2023.100784

• Patsch, David; Buller, Rebecca,

  2023.

  Improving enzyme fitness with machine learning.

  Chimia.

  77(3), S. 116-121.

  Verfügbar unter: https://doi.org/10.2533/chimia.2023.116

• Patsch, David; Eichenberger, Michael; Voss, Moritz; Bornscheuer, Uwe T.; Buller, Rebecca M.,

  2023.

  LibGENiE : a bioinformatic pipeline for the design of information-enriched enzyme libraries.

  Computational and Structural Biotechnology Journal.

  21, S. 4488-4496.

  Verfügbar unter: https://doi.org/10.1016/j.csbj.2023.09.013

• Eichenberger, Michael; Schwander, Thomas; Hüppi, Sean; Kreuzer, Jan; Mittl, Peer R. E.; Peccati, Francesca; Jiménez-Osés, Gonzalo; Naesby, Michael; Buller, Rebecca M.,

  2023.

  The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis.

  Nature Catalysis.

  6(10), S. 927-938.

  Verfügbar unter: https://doi.org/10.1038/s41929-023-01018-y

• Papadopoulou, Athena; Meyer, Fabian; Buller, Rebecca M.,

  2022.

  Engineering Fe(II)/α-ketoglutarate-dependent halogenases and desaturases.

  Biochemistry.

  62(2), S. 229-240.

  Verfügbar unter: https://doi.org/10.1021/acs.biochem.2c00115

• Büchler, Johannes; Honda Malca, Sumire; Patsch, David; Voss, Moritz; Turner, Nicholas J.; Bornscheuer, Uwe T.; Allemann, Oliver; Le Chapelain, Camille; Lumbroso, Alexandre; Loiseleur, Olivier; Buller, Rebecca,

  2022.

  Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens.

  Nature Communications.

  13(371).

  Verfügbar unter: https://doi.org/10.1038/s41467-022-27999-1

• Büchler, Johannes; Hegarty, Eimear; Schroer, Kirsten; Snajdrova, Radka; Turner, Nicholas J.; Loiseleur, Olivier; Buller, Rebecca; Le Chapelain, Camille,

  2022.

  A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases.

  Helvetica Chimica Acta.

  106(1), S. e202200128.

  Verfügbar unter: https://doi.org/10.1002/hlca.202200128

• Papadopoulou, Athena; Peters, Christin; Borchert, Sonja; Steiner, Kerstin; Buller, Rebecca,

  2022.

  Development of an ene reductase-based biocatalytic process for the production of flavor compounds.

  Organic Process Research & Development.

  26(7), S. 2102-2110.

  Verfügbar unter: https://doi.org/10.1021/acs.oprd.2c00096

• Voss, Moritz; Hüppi, Sean; Schaub, Daniela; Hayashi, Takahiro; Ligibel, Mathieu; Sager, Emine; Schroer, Kirsten; Snajdrova, Radka; Buller, Rebecca,

  2022.

  Enzyme engineering enables inversion of substrate stereopreference of the halogenase WelO5*.

  ChemCatChem.

  14(24), S. e202201115.

  Verfügbar unter: https://doi.org/10.1002/cctc.202201115

• Reiter, Maud; Hevey, Rachel; Buller, Rebecca; Shybeka, Inga,

  2021.

  Swiss women in chemistry – two years later ....

  Chimia.

  75(12), S. 1088-1090.

  Verfügbar unter: https://doi.org/10.2533/chimia.2021.1088

• Papadopoulou, Athena; Meierhofer, Jasmin; Meyer, Fabian; Hayashi, Takahiro; Schneider, Samuel; Sager, Emine; Buller, Rebecca,

  2021.

  Re‐programming and optimization of a L‐proline cis‐4‐hydroxylase for the cis‐3‐halogenation of its native substrate.

  ChemCatChem.

  13(18), S. 3914-3919.

  Verfügbar unter: https://doi.org/10.1002/cctc.202100591

• Meyer, Fabian; Frey, Raphael; Ligibel, Mathieu; Sager, Emine; Schroer, Kirsten; Snajdrova, Radka; Buller, Rebecca,

  2021.

  Modulating chemoselectivity in a Fe(II)/α-ketoglutarate-dependent dioxygenase for the oxidative modification of a non-proteinogenic amino acid.

  ACS Catalysis.

  2021(11).

  Verfügbar unter: https://doi.org/10.1021/acscatal.1c00678

• Eichenberger, Michael; Hüppi, Sean; Patsch, David; Aeberli, Natalie; Berweger, Raphael; Dossenbach, Sandro; Eichhorn, Eric; Flachsmann, Felix; Hortencio, Lucas; Voirol, Francis; Vollenweider, Sabine; Bornscheuer, Uwe T.; Buller, Rebecca,

  2021.

  Asymmetric cation-olefin monocyclization by engineered squalene-hopene cyclases.

  Angewandte Chemie: International Edition.

  60(50), S. 26080-26086.

  Verfügbar unter: https://doi.org/10.1002/anie.202108037

• Voss, Moritz; Küng, Robin; Hayashi, Takahiro; Jonczyk, Magdalena; Niklaus, Michael; Iding, Hans; Wetzl, Dennis; Buller, Rebecca,

  2020.

  Multi‐faceted set‐up of a diverse ketoreductase library enables the synthesis of pharmaceutically‐relevant secondary alcohols.

  ChemCatChem.

  13(6), S. 1538-1545.

  Verfügbar unter: https://doi.org/10.1002/cctc.202001871

• Aregger, David; Peters, Christin; Buller, Rebecca,

  2020.

  Characterization of the novel ene reductase Ppo-Er1 from paenibacillus polymyxa.

  Catalysts.

  10(2).

  Verfügbar unter: https://doi.org/10.3390/catal10020254

• Voss, Moritz; Honda Malca, Sumire; Buller, Rebecca,

  2020.

  Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases.

  Chemistry - A European Journal.

  Verfügbar unter: https://doi.org/10.1002/chem.201905752

• Hecht, Katrin; Meyer, Hans-Peter; Wohlgemuth, Roland; Buller, Rebecca,

  2020.

  Biocatalysis in the Swiss manufacturing environment.

  Catalysts.

  10(12), S. 1420.

  Verfügbar unter: https://doi.org/10.3390/catal10121420

• Büchler, Johannes; Papadopoulou, Athena; Buller, Rebecca,

  2019.

  Recent advances in Flavin-dependent halogenase biocatalysis : sourcing, engineering, and application.

  Catalysts.

  9(12), S. 1030.

  Verfügbar unter: https://doi.org/10.3390/catal9121030

• Hayashi, Takahiro; Ligibel, Mathieu; Sager, Emine; Voss, Moritz; Hunziker, Jürg; Schroer, Kirsten; Snajdrova, Radka; Buller, Rebecca,

  2019.

  Evolved aliphatic halogenases enable regiocomplementary C‐H functionalization of an added‐value chemical.

  Angewandte Chemie: International Edition.

  58(51), S. 18535-18539.

  Verfügbar unter: https://doi.org/10.1002/anie.201907245

• Hayashi, Takahiro; Ligibel, Mathieu; Sager, Emine; Voss, Moritz; Hunziker, Jürg; Schroer, Kirsten; Snajdrova, Radka; Buller, Rebecca,

  2019.

  Evolvierte aliphatische Halogenasen ermöglichen die regiokomplementäre C‐H‐Funktionalisierung einer hochwertigen Chemikalie.

  Angewandte Chemie.

  131(51), S. 18706-18711.

  Verfügbar unter: https://doi.org/10.1002/ange.201907245

• Papadopoulou, Athena; Hecht, Katrin; Buller, Rebecca,

  2019.

  Enzymatic PET degradation.

  Chimia.

  73(9), S. 743-749.

  Verfügbar unter: https://doi.org/10.2533/chimia.2019.743

• Peters, Christin; Frasson, David; Sievers, Martin; Buller, Rebecca,

  2019.

  Novel Old Yellow Enzyme subclasses.

  ChemBioChem.

  Verfügbar unter: https://doi.org/10.1002/cbic.201800770

• Frey, Raphael; Hayashi, Takahiro; Buller, Rebecca,

  2019.

  Directed evolution of carbon–hydrogen bond activating enzymes.

  Current Opinion in Biotechnology.

  60, S. 29-38.

  Verfügbar unter: https://doi.org/10.1016/j.copbio.2018.12.004

• Peters, Christin; Buller, Rebecca,

  2019.

  Industrial application of 2-oxoglutarate-dependent oxygenases.

  Catalysts.

  9(3), S. 221-240.

  Verfügbar unter: https://doi.org/10.3390/catal9030221

• Peters, Christin; Buller, Rebecca,

  2019.

  Linear enzyme cascade for the production of (–)-iso-isopulegol.

  Zeitschrift für Naturforschung C.

  74(3-4).

  Verfügbar unter: https://doi.org/10.1515/znc-2018-0146

• Kries, Hajo; Blomberg, Rebecca; Hilvert, Donald,

  2013.

  De novo enzymes by computational design.

  Current Opinion in Chemical Biology.

  17(2), S. 221-228.

  Verfügbar unter: https://doi.org/10.1016/j.cbpa.2013.02.012

• Blomberg, Rebecca; Kries, Hajo; Pinkas, Daniel M.; Mittl, Peer R. E.; Grütter, Markus G.; Privett, Heidi K.; Mayo, Stephen L.; Hilvert, Donald,

  2013.

  Precision is essential for efficient catalysis in an evolved Kemp eliminase.

  Nature.

  503(7476), S. 418-421.

  Verfügbar unter: https://doi.org/10.1038/nature12623

• Richter, Florian; Blomberg, Rebecca; Khare, Sagar D.; Kiss, Gert; Kuzin, Alexandre P.; Smith, Adam J. T.; Gallaher, Jasmine; Pianowski, Zbigniew; Helgeson, Roger C.; Grjasnow, Alexej; Xiao, Rong; Seetharaman, Jayaraman; Su, Min; Vorobiev, Sergey; Lew, Scott; Forouhar, Farhad; Kornhaber, Gregory J.; Hunt, John F.; Montelione, Gaetano T.; Tong, Liang; Houk, K. N.; Hilvert, Donald; Baker, David,

  2012.

  Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.

  Journal of the American Chemical Society.

  134(39), S. 16197-16206.

  Verfügbar unter: https://doi.org/10.1021/ja3037367

• Privett, H. K.; Kiss, G.; Lee, T. M.; Blomberg, R.; Chica, R. A.; Thomas, L. M.; Hilvert, D.; Houk, K. N.; Mayo, S. L.,

  2012.

  Iterative approach to computational enzyme design.

  Proceedings of the National Academy of Sciences of the United States of America.

  109(10), S. 3790-3795.

  Verfügbar unter: https://doi.org/10.1073/pnas.1118082108

• Chapleau, Richard R.; Blomberg, Rebecca; Ford, Peter C.; Sagermann, Martin,

  2008.

  Design of a highly specific and noninvasive biosensor suitable for real-time in vivo imaging of mercury (II) uptake.

  Protein Science.

  17(4), S. 614-622.

  Verfügbar unter: https://doi.org/10.1110/ps.073358908

• Hecht, Katrin; Buller, Rebecca,

  2019.

  Ene-reductases in pharmaceutical chemistry.

  In:

  Grunwald, Peter, Hrsg.,

  Pharmaceutical biocatalysis : chemoenzymatic synthesis of active pharmaceutical ingredients.

  Singapore:

  Jenny Stanford.

• Buller, Rebecca; Hecht, Katrin; Mirata, Marco Antonio; Meyer, Hans-Peter,

  2017.

  An appreciation of biocatalysis in the Swiss manufacturing environment.

  In:

  Biocatalysis : an industrial perspective.

  Royal Society of Chemistry.

  S. 1-43.

  Catalysis Series ; 29.

  Verfügbar unter: https://doi.org/10.1039/9781782629993-00001

• Graber, David; Stockinger, Peter; Meyer, Fabian; Mishra, Siddhartha; Horn, Claus; Buller, Rebecca,

  2024.

  GEMS : a generalizable GNN framework for protein-ligand binding affinity prediction through robust data filtering and language model integration.

  bioRxiv.

  Verfügbar unter: https://doi.org/10.1101/2024.12.09.627482

• André, Amandine; Hecht, Katrin; Mischler, Sandra; Buller, Rebecca; Chetschik, Irene; Miescher Schwenninger, Susanne; Müller, Nadina,

  2024.

  A new physical and biological strategy to reduce the content of zearalenone in infected wheat kernels : the effect of cold needle perforation, microorganisms, and purified enzyme[Poster].

  In:

  11th Symposium on Recent Advances in Food Analysis (RAFA), Prague, Czech Republic, 5-8 November 2024.

• Buller, Rebecca,

  2021.

  Biocatalysis and biosynthesis.

  In:

  Technology Outlook 2021.

  Swiss Academy of Engineering Sciences SATW.

  S. 71.

  Verfügbar unter: https://www.satw.ch/de/publikationen/technology-outlook-2021

• Buller, Rebecca; Coperét, Christophe; Emsley, Lyndon; Gademann, Karl; Hari, Yvonne; Leo, Merz,

  2021.

  Chemistry roadmap for research infrastructures 2025-2028 by the Swiss chemistry community.

  Swiss Academies Reports

  ; 16(3).

  Swiss Academy of Sciences.

  Verfügbar unter: https://doi.org/10.5281/zenodo.4572642

• André, Amandine; Hecht, Katrin; Mischler, Sandra; Freimüller Leischtfeld, Susette; Kinner, Mathias; Stäheli, Luca; Kerhanaj, Fllanza; Buller, Rebecca; Miescher Schwenninger, Susanne; Chetschik, Irene; Müller, Nadina,

  2023.

  Eine biologische Strategie zur Reduzierung des Zearalenongehalts in infizierten Weizenkörnern.

  In:

  9. D-A-CH-Tagung für angewandte Getreidewissenschaften, Detmold, Deutschland, 5.-6. Oktober 2023.

• André, Amandine; Freimüller Leischtfeld, Susette; Mischler, Sandra; Hecht, Katrin; Stäheli, Luca; Rüegg, Ramona; Kinner, Mathias; Buller, Rebecca; Chetschik, Irene; Miescher Schwenninger, Susanne; Müller, Nadina,

  2022.

  Mycotoxins reduction strategies to reintroduce grain side product streams into the food value chain.

  In:

  20th ICC Conference, Vienna, Austria, 5-7 July 2022.

Forschungsdaten

Özgen, Fatma Feyza; Stockinger, Peter; Komarova, Anastasia; Luterbacher, Jeremy; Buller, Rebecca, 2025. Dataset for biomass-derived diformylxylose as a renewable solvent for biocatalysis applications. Zenodo. Verfügbar unter: https://doi.org/10.5281/zenodo.17286566

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