Section Bioanalytics
«We realize R&D projects in cooperation with industry partners and universities. Our focus are vaccines and diverse proteins for therapeutic and diagnostic applications.»
Expertise
- Expression and Downstream Processing of soluble and membrane-spanning proteins from prokaryotes and eukaryotes
- Bioanalytic methods (mass spectrometry, interaction analytics,…)
- High-throughput applications
- Protein engineering (site-directed mutagenesis, molecular probes, fusions, cross-linking,…)
Focus areas
- Characterization of the structure-activity relationship (SAR) in bacteriophage tail spike proteins
- Bioanalytics of repeat proteins (antibody mimetics), glycoprotein vaccines, membrane proteins
- Protein extraction, characterization, quantification and modification
- Development of novel enzymes for proteomics and glycan analytics (proteases and N-glycanases)
selected projects:
Molecular mechanism of bacteriophage tail spike proteins in bacterial infection
Team
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Head, Bioanalytics Group
Lecturer in Bioanalytics and Biochemistry
Students
Jon Grolimund (MSc)