Prof. Dr. Jack Rohrer

Prof. Dr. Jack Rohrer
ZHAW
School of Life Sciences and Facility Management
Fachgruppe Cell physiology and cell engineering
Einsiedlerstrasse 31
8820 Wädenswil
Work at ZHAW
Management role
Head, Cell Physiology and Cellular Engineering Group
Position at the ZHAW
Head of the group Cell Physiology and Cellular Engineering, special expertise in: glycobiology, recombinant protein expression, development of cell based assays, induced pluripotent stem cells, subcellular drug delivery, lysosomal biogenesis and molecular mechanisms of intracellular protein trafficking in general.
www.zhaw.ch/de/lsfm/institute-zentren/icbt/zellbiologie-und-tissue-engineering/zellphysiologie-und-zell-engineering/
Education and Continuing education
Expertise and research interests
Specific technical know-how covers microscopy (including confocal microscopy and life imaging) as well as a multitude of methods from molecular biology, biochemistry, cell biology and immunology. The main research subjects include induced pluripotent stem cells, development of novel antibodies against complex proteins, the development of cell based assays, and subcellular drug delivery.
Professional milestones
1997-2002 Establishing my own research group as a Prof. Dr. Max Cloetta fellow at the Friedrich Miescher Institute of the Novartis Research Foundation.
1999 Appointed by the Faculty of Natural Sciences of the University of Basel as 'Privatdozent' for Cell Biology.
2004 Appointed by the Medical Faculty of the University of Zürich as 'Privatdozent' for Physiology and Cell Biology.
2007 Appointed by the Medical Faculty of the University of Zürich as 'Titularprofessor'
2008 Professor of the Section Biotechnology of the Zurich University of Applied Sciences
Educational background
Study of Biology II at the University of Basel (1984-1988).
PhD thesis at the Department of Biochemistry, Biozentrum of the University of Basel (1988-1992).
PostDoc at the Division Hematology/Oncology, Washington University School of Medicine, St Louis, USA (1992-1995).
PostDoc at the Department of Biochemistry, Biozentrum of the University of Basel (1996).
Prof. Dr. Max Cloëtta-Fellow at the Friedrich Miescher Institute, Novartis Research Foundation, Basel (1997-2002).
'Oberassistent' at the Institute of Physiology, University of Zürich (2002-2008).
Membership of networks
Projects
- Bestenförderung von Lernenden / Project leader / Project ongoing
- Forschung und Entwicklung Zellphysiologie / Project leader / Project completed
- A platform enabling efficient and effective delivery and packaging of therapeutic molecules / Project leader / Project completed
- Novel cell-based immunization technology and functional validation of resulting antibodies / Project leader / Project completed
- Antibody discovery for therapy of pain / Project leader / Project completed
Publications
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Sabani, Besmira; Brand, Michael; Albert, Ina; Inderbitzin, Joelle; Eichenseher, Fritz; Schmelcher, Mathias; Rohrer, Jack; Riedl, Rainer; Lehmann, Steffi,
2023.
Nanomedicine: Nanotechnology, Biology and Medicine.
47(102607).
Available from: https://doi.org/10.1016/j.nano.2022.102607
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Kozono, Takuma; Sato, Hiroyuki; Okumura, Wataru; Jogano, Chifuyu; Tamura-Nakano, Miwa; Kawamura, Yuki I.; Rohrer, Jack; Tonozuka, Takashi; Nishikawa, Atsushi,
2021.
Scientific Reports.
11(753).
Available from: https://doi.org/10.1038/s41598-020-80258-5
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Luginbühl, Vera; Meier, Nicolas; Kovar, Karin; Rohrer, Jack,
2018.
Biotechnology Advances.
36(3), pp. 613-623.
Available from: https://doi.org/10.1016/j.biotechadv.2018.02.005
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Peanne, Romain; Legrand, Dominique; Duvet, Sandrine; Mir, Anne-Marie; Matthijs, Gert; Rohrer, Jack; Foulquier, Francois,
2011.
Glycobiology.
21(7), pp. 864-876.
Available from: https://doi.org/10.1093/glycob/cwq176
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Schaub, Beat E.; Berger, Eric G.; Rohrer, Jack,
2008.
Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition.
Cellular and Molecular Life Sciences.
65(22), pp. 3677-3687.
Available from: https://doi.org/10.1007/s00018-008-8446-y
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Schaub, Beat E.; Berger, Bea; Berger, Eric G.; Rohrer, Jack,
2006.
Molecular Biology of the Cell.
17(12), pp. 5153-5162.
Available from: https://doi.org/10.1091/mbc.e06-08-0665
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Nair, Prashant; Schaub, Beat E.; Huang, Kai; Chen, Xiang; Murphy, Robert F.; Griffith, Janice M.; Geuze, Hans J.; Rohrer, Jack,
2005.
Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme.
Journal of Cell Science.
118(13), pp. 2949-2956.
Available from: https://doi.org/10.1242/jcs.02434
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Pulipparacharuvil, Suprabha; Akbar, Mohammed; Ray, Sanchali; Sevrioukov, Evgueny A.; Haberman, Adam S.; Rohrer, Jack; Krämer, Helmut,
2005.
Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules.
Journal of Cell Science.
118(16), pp. 3663-3673.
Available from: https://doi.org/10.1242/jcs.02502
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Müntener, Kathrin; Zwicky, Roman; Csucs, Gabor; Rohrer, Jack; Baici, Antonio,
2004.
Exon skipping of cathepsin B : mitochondrial targeting of a lysosomal peptidase provokes cell death.
Journal of Biological Chemistry.
279(39), pp. 41012-41017.
Available from: https://doi.org/10.1074/jbc.M405333200
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Stöckli, Jacqueline; Höning, Stefan; Rohrer, Jack,
2004.
Journal of Biological Chemistry.
279(22), pp. 23542-23549.
Available from: https://doi.org/10.1074/jbc.M313525200
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Stöckli, Jacqueline; Rohrer, Jack,
2004.
Molecular Biology of the Cell.
15(6), pp. 2617-2626.
Available from: https://doi.org/10.1091/mbc.e03-11-0808
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Nair, Prashant; Schaub, Beat E; Rohrer, Jack,
2003.
Journal of Biological Chemistry.
278(27), pp. 24753-24758.
Available from: https://doi.org/10.1074/jbc.M300174200
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Berger, Eric G.; Rohrer, Jack,
2003.
Galactosyltransferase — still up and running.
Biochimie.
85(3-4), pp. 261-274.
Available from: https://doi.org/10.1016/S0300-9084(03)00008-7
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Crottet, Pascal; Meyer, Daniel M.; Rohrer, Jack; Spiess, Martin,
2002.
Molecular Biology of the Cell.
13(10), pp. 3672-3682.
Available from: https://doi.org/10.1091/mbc.e02-05-0309
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Mathews, Paul M.; Guerra, Carolyn B.; Jiang, Ying; Grbovic, Olivera M.; Kao, Benjamin H.; Schmidt, Stephen D.; Dinakar, Ravi; Mercken, Marc; Hille-Rehfeld, Annette; Rohrer, Jack; Mehta, Pankaj; Cataldo, Anne M.; Nixon, Ralph A.,
2002.
Journal of Biological Chemistry.
277(7), pp. 5299-5307.
Available from: https://doi.org/10.1074/jbc.M108161200
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Lee, Wang-Sik; Rohrer, Jack; Kornfeld, Rosalind; Kornfeld, Stuart,
2002.
Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme.
Journal of Biological Chemistry.
277(5), pp. 3544-3551.
Available from: https://doi.org/10.1074/jbc.M108531200
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Rohrer, Jack; Kornfeld, Rosalind,
2001.
Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.
Molecular Biology of the Cell.
12(6), pp. 1623-1631.
Available from: https://doi.org/10.1091/mbc.12.6.1623
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Schweizer, Anja; Stahl, Philip D.; Rohrer, Jack,
2000.
A di-aromatic motif in the cytosolic tail of the mannose receptor mediates endosomal sorting.
Journal of Biological Chemistry.
275(38), pp. 29694-29700.
Available from: https://doi.org/10.1074/jbc.M000571200
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Schweizer, Anja; Valdenaire, Olivier; Köster, Anja; Lang, Yolande; Schmitt, Georg; Lenz, Barbara; Bluethmann, Horst; Rohrer, Jack,
1999.
Journal of Biological Chemistry.
274(29), pp. 20450-20456.
Available from: https://doi.org/10.1074/jbc.274.29.20450
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Schweizer, Anja; Löffler, Bernd-Michael; Rohrer, Jack,
1999.
Palmitoylation of the three isoforms of human endothelin-converting enzyme-1.
Biochemical Journal.
340(3), pp. 649-656.
Available from: https://doi.org/10.1042/bj3400649
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Olayioye, Monilola A.; Graus-Porta, Diana; Beerli, Roger R.; Rohrer, Jack; Gay, Brigitte; Hynes, Nancy E.,
1998.
ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.
Molecular and Cellular Biology.
18(9), pp. 5042-5051.
Available from: https://doi.org/10.1128/MCB.18.9.5042
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Schweizer, Anja; Kornfeld, Stuart; Rohrer, Jack,
1997.
Proceedings of the National Academy of Sciences of the United States of America.
94(26), pp. 14471-14476.
Available from: https://doi.org/10.1073/pnas.94.26.14471
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Hicke, Linda; Zanolari, Bettina; Pypaert, Marc; Rohrer, Jack; Riezman, Howard,
1997.
Molecular Biology of the Cell.
8(1), pp. 13-31.
Available from: https://doi.org/10.1091/mbc.8.1.13
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Schweizer, Anja; Kornfeld, Stuart; Rohrer, Jack,
1996.
Journal of Cell Biology.
132(4), pp. 577-584.
Available from: https://doi.org/10.1083/jcb.132.4.577
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Rohrer, Jack; Schweizer, Anja; Russel, David; Kornfeld, Stuart,
1996.
Journal of Cell Biology.
132(4), pp. 565-576.
Available from: https://doi.org/10.1083/jcb.132.4.565
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Rohrer, Jack; Schweizer, Anja; Johnson, Karl F.; Kornfeld, Stuart,
1995.
Journal of Cell Biology.
130(6), pp. 1297-1306.
Available from: https://doi.org/10.1083/jcb.130.6.1297
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Schweizer, Anja; Rohrer, Jack; Kornfeld, Stuart,
1995.
Determination of the structural requirements for palmitoylation of p63.
Journal of Biological Chemistry.
270(16), pp. 9638-9644.
Available from: https://doi.org/10.1074/jbc.270.16.9638
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Schweizer, Anja; Rohrer, Jack; Slot, Jan W.; Geuze, Hans J.; Kornfeld, Stuart,
1995.
Reassessment of the subcellular localization of p63.
Journal of Cell Science.
108, pp. 2477-2485.
Available from: http://jcs.biologists.org/content/108/6/2477
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Schweizer, Anja; Rohrer, Jack; Hauri, Hanspeter; Kornfeld, Stuart,
1994.
Journal of Cell Biology.
126(1), pp. 25-39.
Available from: https://doi.org/10.1083/jcb.126.1.25
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Rohrer, Jack; Bénédetti, Hélène; Zanolari, Bettina; Riezman, Howard,
1993.
Molecular Biology of the Cell.
4(5), pp. 511-521.
Available from: https://doi.org/10.1091/mbc.4.5.511
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Schweizer, Anja; Rohrer, Jack; Jenö, Paul; DeMaio, Antonio; Buchman, Timothy G.; Hauri, Hans-Peter,
1993.
Journal of Cell Science.
104, pp. 685-694.
Available from: http://jcs.biologists.org/content/104/3/685.short
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Raths, Susan; Rohrer, Jack; Crausaz, Fabienne; Riezman, Howard,
1993.
Journal of Cell Biology.
120(1), pp. 55-65.
Available from: https://doi.org/10.1083/jcb.120.1.55
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Rohrer, Jack; Kuhn, Andreas,
1990.
The function of a leader peptide in translocating charged amino acyl residues across a membrane.
Science.
250(4986), pp. 1418-1421.
Available from: https://doi.org/10.1126/science.2124001
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Kuhn, Andreas; Rohrer, Jack; Gallusser, Andreas,
1990.
Bacteriophages M13 and Pf3 tell us how proteins insert into the membrane.
Journal of Structural Biology.
104(1-3), pp. 38-43.
Available from: https://doi.org/10.1016/1047-8477(90)90055-H
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Rimann, Markus; Mathes, Stephanie; Raghunath, Michael; Rohrer, Jack,
2016.
Zurich university of applied sciences : center for cell biology and tissue engineering [poster].
In:
Roche Symposium, Basel, 2016.
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Raghunath, Michael; Rimann, Markus; Mathes, Stephanie; Rohrer, Jack,
2016.
Zurich University of Applied Sciences : center for cell biology and tissue engineering [poster].
In:
Roche Symposium, Basel, 2016.
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Schaub, Beat E; Nair, Prashant; Rohrer, Jack,
2005.
Analysis of protein transport to lysosomes.
Current Protocols in Cell Biology.
27(1).
Available from: https://doi.org/10.1002/0471143030.cb1508s27