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Novel cell-based immunization technology and functional validation of resulting antibodies

At a glance

  • Project leader : Prof. Dr. Jack Rohrer
  • Co-project leader : Dr. Philippe Krebs, Prof. Dr. Frank Stenner
  • Deputy of project leader : Dr. Bruno Filippi
  • Project team : Bettina Keller Abu Seda, Jenny Pally, Leopold von Balthazar
  • Project budget : CHF 1'581'835
  • Project status : completed
  • Funding partner : CTI (KTI-Projekt / Projekt Nr. 26019.2 PFLS-LS)
  • Project partner : Memo Therapeutics AG
  • Contact person : Jack Rohrer


Development of a novel immunization method in rabbits that improves the generation of antibodies against the native form of human proteins e.g. cell surface receptors. Subsequent validation of the method through functional characterization of candidate therapeutic antibodies in vitro and in vivo. The aim is the discovery of monoclonal antibodies as novel therapeutics for two different first in class targets in cancer.