Dr. Epifania Bono

ZHAW School of Life Sciences and Facility Management
Section for Research Group 3D Tissues and Biofabrication
Einsiedlerstrasse 31
8820 Wädenswil

+41 (0) 58 934 55 32
epifania.bono@zhaw.ch

Personal profile

Position at the ZHAW

www.zhaw.ch/icbt/3d-tissues-and-biofabrication/

Projects

Towards mechanically biocompatible implant materials for pelvic floor repair / Team member / Project ongoing
Bioprinting of biofilms / Team member / Project completed

Publications

Articles in scientific journal, peer-reviewed

Zumofen, Livia; Kopanska, Katarzyna S.; Bono, Epifania; Kirchheim, Andreas; De Haller, Emmanuel B.; Graf-Hausner, Ursula,

2022.

Properties of additive-manufactured open porous titanium structures for patient-specific load-bearing implants.

Frontiers in Mechanical Engineering.

7(830126).

Available from: https://doi.org/10.3389/fmech.2021.830126
Alave Reyes-Furrer, Angela; De Andrade, Sonia; Bachmann, Dominic; Jeker, Heidi; Steinmann, Martin; Accart, Nathalie; Dunbar, Andrew; Rausch, Martin; Bono, Epifania; Rimann, Markus; Keller, Hansjörg,

2021.

Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses.

Communications Biology.

4(1), pp. 1183.

Available from: https://doi.org/10.1038/s42003-021-02691-0
Hendrawan, Siufui; Bono, Epifania; Hutter, Albert; Weber, Ursula; Lheman, Jennifer; Baer, Hans U.,

2020.

Evaluation of 3D PLLA scaffolds coated with nano‐thick collagen as carrier for hepatocytes.

Journal of Biomedical Materials Research Part B : Applied Biomaterials.

109(5), pp. 723-732.

Available from: https://doi.org/10.1002/jbm.b.34738
Hirsch, Cordula; Striegl, Britta; Mathes, Stephanie; Adlhart, Christian; Edelmann, Michael; Bono, Epifania; Gaan, Sabyasachi; Salmeia, Khalifah A.; Hölting, Lise; Krebs, Alice; Nyffeler, Johanna; Pape, Regina; Bürkle, Alexander; Leist, Marcel; Wick, Peter; Schildknecht, Stefan,

2017.

Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants.

Archives of Toxicology.

91(1), pp. 407-425.

Available from: https://doi.org/10.1007/s00204-016-1680-4
Rimann, Markus; Bono, Epifania; Annaheim, Helene; Bleisch, Matthias; Graf-Hausner, Ursula,

2015.

Standardized 3D bioprinting of soft tissue models with human primary cells.

SLAS Technology: Translating Life Sciences Innovation.

21(4), pp. 496-509.

Available from: https://doi.org/10.1177/2211068214567146
Bono, Epifania; Mathes, Stephanie H; Franscini, Nicola; Graf-Hausner, Ursula,

2010.

Tissue Engineering - the gateway to regenerative medicine.

Chimia.

64(11), pp. 808-812.

Available from: https://doi.org/10.2533/chimia.2010.808
Mauth, C; Bono, Epifania; Haas, S; Paesold, G.; Wiese, H.; Maier, G.; Boos, N.; Graf-Hausner, Ursula,

2009.

Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration.

European Cells & Materials.

18, pp. 27-39.

Available from: https://doi.org/10.22203/eCM.v018a03

Conference contributions, peer-reviewed

Jung, C; Mathes, Stephanie; Bono, Epifania; Walker, C; Kessler, A; Straumann, L; de Wild, M; de Haller, EB,

2015.

Cell viability on titanium implant surfaces modified with antibacterial copper [poster].

In:

Swiss Society for Biomaterials.

pp. 24.

Available from: https://doi.org/10.21256/zhaw-1761

Other publications

Bono, Epifania; Sheard, Jonathan; Mikkonen, Piia; Rimann, Markus,

2022.

Automation of 3D cell culture using cellulose-based scaffolds [poster].

In:

Biointerfaces International Conference (BIC), Zurich, Switzerland, 12-15 September 2022.

Winterthur:

ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

Available from: https://doi.org/10.21256/zhaw-25998
Bono, Epifania,

2020.

Automated 3D cell culture using Corning® 96-well spheroid microplates on the Fluent® automation workstation.

Tecan.
Bono, Epifania; Evers, Christoph; Schmid, Franca; Graf-Hausner, Ursula; Rimann, Markus,

2017.

In vitro characterization of a new composite material for biomedical applications and 3D (bio)printing [poster].

In:

TEDD Annual Meeting, Wädenswil, 8-9 November 2017.

ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

Available from: https://doi.org/10.21256/zhaw-3587
Rimann, Markus; Bono, Epifania; Picenoni, Armin; Felley-Bosco, Emanuela; Meyer, Andreas; Pelleaux, René; Hund, Corinna,

2017.

Development of a matrix-based technology platform for the high throughput analysis of 3D cell cultures [poster].

In:

Swiss Medtech Day, Bern, 13 June 2017.

ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

Available from: https://doi.org/10.21256/zhaw-3588
Bono, Epifania; Mathes, Stephanie; Rimann, Markus,

2017.

Evaluation of 3D hepatic tissue models for bioprinting [poster].

In:

TERMIS-EU 2017 Conference, Davos, 26-30 June 2017.

ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

Available from: https://doi.org/10.21256/zhaw-3590
Bono, Epifania; Hutter, Albert; Hendrawan, Siufui; Sutedja, Barlian; Baer, Hans Ulrich; Mathes, Stephanie,

2016.

3D PLLA-collagen matrices as carriers for hepatocytes [poster].

In:

Swiss Medtech Day, Bern, 7 June 2016.
Mathes, Stephanie; Bono, Epifania; Striegl, Britta; Hettwer, Stefan; Bänziger, Stefan; Suter, Brigit; Spezzaneve, Donato,

2016.

Development of an immune responsive in vitro 3D skin model for the examination of the immune suppressive and collagen stimulating activity of cosmetic actives [poster].

In:

Swiss Medtech Day, Bern, 7 June 2016.
Bono, Epifania; Cloes, Nastasia; Merk, Markus; Mathes, Stephanie,

2016.

In vitro models of human skin models featuring a glycated dermis [poster].

In:

4th International Cosmetic Innovation Days «Cosminnov», Orléans, France, 24-25 May 2016.
Bono, Epifania; Hutter, Albert; Hendrawan, Siufui; Sutedja, Barlian; Baer, Hans Ulrich; Mathes, Stephanie,

2016.

3D PLLA-collagen matrices as carriers for hepatocytes [poster].

In:

3D Cell Culture 2016, Freiburg, Germany, 19-21 April 2016.
Bono, Epifania; Hutter, Albert; Hendrawan, Siufui; Sutedja, Barlian; Baer, Hans Ulrich; Weber, Ursula; Mathes, Stephanie,

2016.

3D PLLA-collagen matrices as carrier for hepatocytes (type Chen-Baermed) an in vitro study [poster].

In:

Sponsorenanlass Klinik Hirslanden, Zürich, 2016.
Rimann, Markus; Laternser, Sandra; Bono, Epifania; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Hartmann, Lilian; Alave-Reyes, Angela; Thurner, Marc; Scheidegger, Andreas; Graf-Hausner, Ursula,

2016.

A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues [poster].

In:

Swiss Medtech Day, Bern, 7 June 2016.
Graf-Hausner, Ursula; Rimann, Markus; Bono, Epifania; Laternser, Sandra; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Richter, Jens; Alave, Angela; Thurner, Marc; Scheidegger, Andreas,

2015.

A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues [poster].

In:

CTI Medtech Event, Bern, 8. September 2015.
Jung, C.; Mathes, Stephanie; Bono, Epifania,

2015.

Cell viability on titanium implant surfaces modified with antibacterial copper [poster].

In:

Medical Cluster [MEET THE EXPERTS] – Technologies and Innovation for Cost Reduction, Interlaken, Switzerland, 7–8 May 2015.
Rimann, Markus; Laternser, Sandra; Bono, Epifania; Keller, Hansjörg; Leupin, Olivier; Fässler, Thomas; Eggmann, Kurt; Thurner, Marc; Graf-Hausner, Ursula,

2015.

Bioprinted muscle/tendon for drug assessment [poster].

In:

NTN Swiss Biotech Innovation Day: The potential of industry-academia collaborations, Zug, 19 August 2015.
Graf-Hausner, Ursula; Rimann, Markus; Bono, Epifania; Laternser, Sandra; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Munz, Peter; Hauer, Matthias; Keller, Hansjörg; Richter, Jens; Alave, Angela; Leupin, Olivier; Thurner, Marc; Scheidegger, Andreas,

2014.

A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues [poster].

In:

CTI Medtech Event, Bern, 2. September 2014.
Pörtner, Ralf; Wagner, Ilka; Atanasova, Tamara; Gautam, Richa; Gattlen, Jasmin; Rimann, Markus; Bono, Epifania; Graf-Hausner, Ursula; Marx, Uwe,

2014.

Aktuelle Trends bei der in vitro-Substanztestung in Deutschland und in der Schweiz.

BIOspektrum.

20(4), pp. 470-472.

Available from: https://doi.org/10.1007/s12268-014-0466-6
Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Meier, Christoph; Bossen, Anke; Graf-Hausner, Ursula,

2014.

Skin bioprinting : an innovative approach to produce standardized skin models on demand [poster].

In:

Swiss Biotech Innovation Day 2014 «the Potential of Industry-Academia Collaborations», Basel, 28 August 2014.
Striegl, Britta; Grad, S.; Eglin, D; Benneker, L.; Peroglio, M.; Alini, Mauro; Graf-Hausner, Ursula; Bono, Epifania,

2012.

Cell-seeded thermoreversible hydrogel-polyurethane composites for nucleus pulposus augmentation [poster].

In:

Proceedings of the 3D Cell Culture 2012 congress.

3D Cell Culture 2012: Zurich, 14-16 March 2012.

Dechema Biotechnologie.

Available from: https://doi.org/10.21256/zhaw-1752
Striegl, Britta; Grad, S.; Eglin, D.; Benneker, L.; Bono, Epifania; Alini, Mauro; Graf-Hausner, Ursula; Peroglio, M.,

2012.

Human disc cells and mesenchymal stem cells differentiation in a thermoreversible hydrogel : an in vitro and ex-vivo study [poster].

In:

Orthopaedic Research Society Congress, San Francisco, USA, 4-7 February 2012.
Santini, Diego; Bono, Epifania; Schmid, Daniel; Mathes, Stephanie; Graf-Hausner, Ursula,

2012.

Tissue engineering for drug development : defined organotypic skin models [poster].

In:

3D Cell Culture 2012: Zurich, 14-16 March 2012.

Dechema Biotechnologie.

Available from: https://doi.org/10.21256/zhaw-1753
Striegl, Britta; Grad, Sibylle; Eglin, David; Benneker, Lorin; Bono, Epifania; Alini, Mauro; Graf-Hausner, Ursula; Peroglio, Marianna,

2011.

Ex-vivo evaluation of thermoreversible hylauronan-based hydrogel as mesenchymal stem cells carrier for nucleus pulposus repair [poster].

In:

Proceedings of the New Horizons in Intervertebral Disc Research Conference.

New Horizons in Intervertebral Disc Research, Philadelphia, USA, 2011.
Graf-Hausner, Ursula; Schmid, Daniel; Bono, Epifania,

2011.

Plant extracts to overcome negative effects of glycation in human skin [poster].

In:

CTI Medtech Event 2011, Bern, 23. August 2011.

ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

Available from: https://doi.org/10.21256/zhaw-1750
Mauth, Corinna; Bono, Epifania; De Wild, Michel; Molenberg, Aart; Farine, Herve; Dard, Michel; Graf-Hausner, Ursula,

2010.

Development of a smart biomaterial for osseointegration in oral defects [poster].

In:

Tissue Engineering and Regenerative Medicine International Societym, Galway, Ireland, 13 June 2010.
Franscini, Nicola; Bono, Epifania; Durner, Roland; Wuertz, Karin; Boos, Norbert; Graf-Hausner, Ursula,

2010.

Disc regeneration : automation for a new cell-based approach [poster].

In:

eCM XI «Cartilage & Disc: Repair and Regeneration», Davos, 28-30 June 2010.
Mauth, Corinna; Bono, Epifania; Gruber, R.; Goebel, E.; Molenberg, Aart; De Wild, M.; Schiephake, H.; Dard, Michel; Graf-Hausner, Ursula,

2010.

SMART biomaterial : bioactive synthetic bone repair material for large oral bone defects [poster].

In:

CTI Medtech Event, Bern, 31. August 2010.
Franscini, Nicola; Bono, Epifania; Würtz, Karin; Patocchi-Tenzer, Isabel; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula,

2009.

Automation and standardization of tissue culture processes for regenerative medicine [poster].

In:

CTI Medtech Event, Bern, 1. September 2009.
Mauth, Corinna; Molenberg, Aart; Dard, Michel; Farine, Herve; Bono, Epifania; Steinhoff, Dirk; Graf-Hausner, Ursula,

2009.

Bioactive synthetic bone repair material for large oral bone defects [paper].

In:

CTI Medtech Event, Bern, 1. September 2009.
Franscini, Nicola; Bono, Epifania; Patocchi - Tenzer, Isabel; Durner, Roland; Wuertz, Karin; Boos, Norbert; Graf-Hausner, Ursula,

2009.

Economic production of quality controlled primary cells for cell based assays by automating tissue culture processes [poster].

In:

MipTech - the leading European Event for Drug Discovery, Basel, 13-15 October 2009.
Franscini, Nicola; Bono, Epifania; Würtz, Karin; Patocchi-Tenzer, Isabel; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula,

2009.

Intervertebral disc degeneration : automation of tissue culture processes for regenerative medicine [poster].

In:

Annual Meeting European Society for Artificial Organs, Compiègne, France, 2-5 September 2009.
Franscini, Nicola; Bono, Epifania; Würtz, Karin; Patocchi-Tenzer, Isabel; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula,

2008.

Automation and standardization of tissue culture processes for regenerative medicine [poster].

In:

CTI Medtech Event, Bern, 2. September 2008.
Mauth, Corinna; Molenberg, Aart; Dard, Michael; Farine, Herve; Bono, Epifania; Steinhoff, Dirk; Graf-Hausner, Ursula,

2008.

Biomaterial : bioactive synthetic bone repair material for large oral bone [poster].

In:

CTI Medtech Event, Bern, 2. September 2008.

Oral conference contributions and abstracts

Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula; Raghunath, Michael,

2017.

3D bioprinted tissue models for substance testing.

In:

International Conference and Exhibition - Society for Laboratory Automation and Screening (SLAS 2017), Washington, USA, 4–8 February 2017.
Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Graf-Hausner, Ursula,

2016.

Standardized 3D bioprinting of skin models for drug development.

In:

4th International Cosmetic Innovation Days «Cosminnov», Orléans, France, 24-25 May 2016.
Rimann, Markus; Laternser, Sandra; Bono, Epifania; Nosswitz, Michael; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

2016.

Bioprinted tissues for substance testing.

In:

3D Cell Culture 2016, Freiburg, Germany, 19-21 April 2016.
Rimann, Markus; Mathes, Stephanie; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Graf-Hausner, Ursula,

2016.

3D models for compound testing.

In:

3rd 3D Models & Drug Screening Conference, Berlin, Germany, 11-12 May 2016.
Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

2016.

3D tissue models : new perspectives in medicine.

In:

2016 Conference and Exhibition for Cutting-Edge Medicine (CLINAM 9), Basel, 26-29 June 2016.
Graf-Hausner, Ursula; Rimann, Markus; Laternser, Sandra; Bono, Epifania; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Hartmann, Lilian; Alave-Reyes, Angela; Thurner, Marc; Scheidegger, Andreas,

2016.

A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues.

In:

Swiss Medtech Day, Bern, 7 June 2016.
Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

2016.

Bioprinted tissue models for substance evalution.

In:

Basel Life Science Week 2016, Basel, 19-23 September 2016.
Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula; Raghunath, Michael,

2016.

Bioprinted tissues for substance evaluation.

In:

Biointerfaces International 2016 Conference, Zurich, 23-25 August 2016.
Rimann, Markus; Bono, Epifania; Laternser, Sandra; Keller, Hansjörg; Leupin, Olivier; Graf-Hausner, Ursula,

2015.

Bioprinted soft tissue models for compound testing.

In:

International Conference on Biofabrication (Biofabrication 2015), Utrecht, Netherlands, 7-9 November 2015.
Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

2015.

Soft tissue bioprinting in tissue engineering for drug development.

In:

Olten Meeting 2015: Antibiotics and Bioprinting - for a better life, Biotechnet Switzerland, Olten, 18 November 2015.
Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Meier, Christoph; Bossen, Anke; Graf-Hausner, Ursula,

2014.

Skin bioprinting : an approach to produce standardized skin models on demand.

In:

DECHEMA - 3D Cell Culture 2014, Freiburg, Germany, 25-27 June 2014.
Striegl, Britta; Grad, S.; Benneker, L. M.; Bono, Epifania; Alini, Mauro; Graf-Hausner, Ursula; Peroglio, M.,

2012.

In vitro evaluation of a thermoreversible hyaluronan-based hydrogel loaded with cell-seeded polyurethane particles for nucleus pulposus repair.

In:

World Forum for Spine Research, Helsinki, Finland, 18-21 June 2012.

AOSpine.
Bono, Epifania; Mauth, Corinna; Molenberg, Aart; Farine, Herve; Dard, Michel; Graf-Hausner, Ursula,

2010.

Oral large bone defects : the suitability of a new biomaterial combination.

In:

23rd European Conference on Biomaterials (ESB 2010), Tampere, 11-15 September 2010.
Franscini, Nicola; Bono, Epifania; Patocchi - Tenzer, Isabel; Durner, Roland; Wuertz, Karin; Boos, Norbert; Graf-Hausner, Ursula,

2009.

Intervertebral disc degeneration : automation of tissue culture processes for regenerative medicine applications.

In:

Deutscher Wirbelsäule Kongress, München, Deutschland, 10.-12. Dezember 2009.
Bono, Epifania; Mauth, Corinna; Franscini, Nicola; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula,

2009.

Intervertebral disc regeneration : small and large scale systems.

In:

12th Annual Seminar & Meeting - Ceramics, Cells and Tissues, Faenza, Italy, 1 May 2009.
Bono, Epifania,

2008.

Intervertebral disc augmentation : an alternative.

In:

International Summer School in Advanced Biotechnology, Palermo, Italy, 2008.
Bono, Epifania,

2008.

Intervertebral disc augmentation : an alternative.

In:

Annual Meeting European Society for Artificial Organs, Geneva, 3.-6. September 2008.
Bono, Epifania,

2008.

Tissue engineering of intervertebral discs : small and large scale options.

In:

Swiss-Japanese Meeting on Spine Research, Zurich, 2008.

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