Section of Metabolic Tissue Engineering
«Based on applied matrix biology and biophysics (macromolecular crowding, supramolecular aggregates) we develop metabolically active human models like fatty tissue and skeleton muscle.»
The focus of our research is the construction of three-dimensional tissue cultures using human primary cells. We have been applying the methods of tissue engineering for over 10 years to various tissue types such as bone, cartilage and intervertebral discs, connective tissue and skin, the liver and the pancreas. These in vitro tissues and the use of various technologies provide the basis for many diverse objectives and applications.
Our developments are used in areas such as
- Cell culture technology: automated processes, consideration of biomechanical aspects and bioprinting
- Biomaterials and implants: development, characterisation, surface modification and in vitro studies
- Medicine: regenerative, cell-based therapies and clinical trials
- Drug development: Cultivation and use of organotypic models for substance evaluation
Our research laboratories provide a modern infrastructure and methodological expertise.
We offer our project partners a wide range of opportunities for cooperation. Customer-specific concerns are the principal focus of Bachelor's and Master's theses, directly funded collaborations, and CTI projects.
Hou, Yanyan; Kitaguchi, Tetsuya; Kriszt, Rókus; Tseng, Yu-Hua; Raghunath, Michael; Suzuki, Madoka,
6(8), pp. 797-808.
Available from: https://doi.org/10.1016/j.molmet.2017.05.013
Coentro, João Quintas; Capella-Monsonís, Héctor; Graceffa, Valeria; Wu, Zhuning; Mullen, Anne Maria; Raghunath, Michael; Zeugolis, Dimitrios I.,
Methods in Molecular Biology ; 1627.
Available from: https://doi.org/10.1007/978-1-4939-7113-8_22
Samsonraj, Rebekah M.; Raghunath, Michael; Nurcombe, Victor; Hui, James H.; van Wijnen, Andre J.; Cool, Simon M.,
Stem Cells Translational Medicine.
6(12), pp. 2173-2185.
Available from: https://doi.org/10.1002/sctm.17-0129
Patrikoski, Mimmi; Hui Ching Lee, Michelle; Mäkinen, Laura; Ang, Xiu Min; Mannerström, Bettina; Raghunath, Michael; Miettinen, Susanna,
Stem Cells International.
Available from: https://doi.org/10.1155/2017/6909163
Benny, Paula; Raghunath, Michael,
Making microenvironments : a look into incorporating macromolecular crowding into in vitro experiments, to generate biomimetic microenvironments which are capable of directing cell function for tissue engineering applications.
Journal of Tissue Engineering.
Available from: https://doi.org/10.1177/2041731417730467