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Extracellular vesicles for targeted delivery of new antimicrobials

At a glance


Infectious disease caused by bacteria constitutes a major threat to human health. Although antibiotics control bacterial infections, their efficacy is mitigated by the rise of antibiotic resistance. Further challenging elimination of pathogenic bacteria, some species such as Staphylococcus aureus, responsible for a broad variety of infections, escape antibiotics by persisting inside host cells. Here we will establish functionalized extracellular vesicles as a novel drug delivery system for target-specific, intracellular delivery of novel antimicrobials with proven efficacy against S. aureus.