Competence Center for Drug Discovery
The Competence Center for Drug Discovery (CC Drug Discovery) is dedicated to the discovery and development of new drugs for innovative therapies against serious diseases.
Translational drug discovery
The Competence Center for Drug Discovery at the ZHAW works on a national and international level with partners from industry and academia to develop new clinical drug candidates. Our mission is to address therapeutic issues in an interdisciplinary environment and to promote the synergy of biological, chemical and medical expertise. Our core competence in medicinal chemistry enables us to work with our partners on a range of indications (e.g. cancer, infectious diseases, metabolic diseases) for the benefit of patients.
2nd edition "Competencies in Drug Discovery"
The second edition of our symposium “Competencies in Drug Discovery”, brought together 160 international experts from industry and academia, providing both experienced scientists and young researchers with the opportunity for fruitful exchanges and discussions on the future of drug discovery.
Sponsors
1st edition "Competencies in Drug Discovery"
In June 2022, the first symposium “Competencies in Drug Discovery" took place at the ZHAW Wädenswil. During the symposium, projects from various therapeutic indications were discussed in an interdisciplinary environment to promote the synergy of biological, chemical and medical competencies.
Sponsors
Competencies
We cover the entire chemistry driven value chain of small molecule and peptide drug discovery:
- Medicinal Chemistry
- Organic Chemistry
- Computer aided drug design
- Natural Products
- Parallel and automated organic synthesis
- Microwave assisted organic synthesis
- NMR binding studies of small molecules
- Cheminformatics
- Recombinant protein production in different expression systems
- Protein characterization
- Microbial and cellular test methods
- Culture Collection of Switzerland (www.ccos.ch)
Projects
-
Therapie für den NRAS-Melanom-Subtyp
Das Melanom ist die fünfthäufigste Krebsart in der Schweiz und der tödlichste Hautkrebs. Das NRAS (neuroblastoma ras viral oncogene homolog)-mutierte Melanom ist der aggressivste Subtyp, für den es nach Versagen der Immuntherapie keine wirksame Therapie gibt. Das Ziel dieses Projektes ist es, die erste ...
-
Plattform zur Identifizierung von Wirkstofftargets
Ein grosses Problem bei Projekten der medizinischen Chemie und der Arzneimittelentwicklung ist die unbekannte Identität des molekularen biologischen Ziels, selbst wenn sehr potente Liganden zur Verfügung stehen, wie z. B. solche, die in einem phänotypischen Screening entdeckt wurden. Daher werden Methoden ...
-
Protease-Inhibitoren gegen SARS-CoV-2
Bisher sind zur Bekämpfung der Covid-19 Pandemie Impfstoffe verfügbar, welche vor einem schweren Verlauf schützen können. Ein Teil der Gesellschaft will sich jedoch nicht impfen lassen oder kann dies aufgrund von Vorerkrankungen nicht. Mit einem Wirkstoff, der das Virus im Organismus bekämpfen kann, würde ...
-
Extrazelluläre Vesikel für den Transport von antimikrobiellen Proteinen zum Zielgewebe
Bakterielle Infektionen gehören auch heute noch zu den weltweit häufigsten Todesursachen und sind eine grosse Herausforderung für unser Gesundheitssystem. Obschon Antibiotika erfolgreich zur Bekämpfung von bakteriellen Infektionen eingesetzt werden, haben bestimmte, pathogene Bakterien Resistenzen gegenüber ...
Selected publications
- Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action / M. Brand, L. Wang, S. Agnello, S. Gazzola, F. M. Gall, L. Raguž, M. Kaiser, R. S. Schmidt, A. Ritschl, J. Jelk, A. Hemphill, P. Mäser, P. Bütikofer, M. Adams, R. Riedl, Angew. Chem. Int. Ed. 2021, 60, 15613.
- Drug Design Inspired by Nature: Crystallographic Detection of an Auto‐Tailored Protease Inhibitor Template / F. M. Gall, D. Hohl, D. Frasson, T. Wermelinger, P. R. E. Mittl, M. Sievers, R. Riedl, Angew. Chem. Int. Ed. 2019, 58, 4051.
- A Structural View on Medicinal Chemistry Strategies against Drug Resistance / S. Agnello, M. Brand, M. F. Chellat, S. Gazzola, R. Riedl, Angew. Chem. Int. Ed. 2019, 58, 3300.
- Pseudouridimycin: The First Nucleoside Analogue That Selectively Inhibits Bacterial RNA Polymerase / M. F. Chellat, R. Riedl, Angew. Chem. Int. Ed. 2017, 56, 13184.
- Targeting Antibiotic Resistance / Chellat, Mathieu; Raguž, Luka; Riedl, Rainer - Angew. Chem. Int. Ed. 2016, 55, 6600-6626; Angew.Chem. 2016, 128, 6710–6738.
- Molecular recognition of the catalytic zinc (II) ion in MMP-13: Structure-based evolution of an allosteric inhibitor to dual binding mode inhibitors with improved lipophilic ligand efficiencies / Fischer, Thomas; Riedl, Rainer - invited article for the Special Issue "Enzyme-Inhibitor Interaction as Examples of Molecular Recognition" Int. J. Mol. Sci. 2016, 17, 314. Front cover story 3/2016.
- Merging Allosteric and Active Site Binding Motifs: De novo Generation of Target Selectivity and Potency via Natural-Product-Derived Fragments / Lanz, Jan; Riedl, Rainer - ChemMedChem. 2015, 10, 451–454. Front cover story 3/2015.
Complete List of Publications
-
Lardos, Andreas; Patmore, Kristina; Allkin, Robert; Lazarou, Rebecca; Nesbitt, Mark; Scott, Andrew C.; Zipser, Barbara,
2023.
Journal of Ethnopharmacology.
322(117622).
Verfügbar unter: https://doi.org/10.1016/j.jep.2023.117622
-
2023.
Development of small-molecule drugs for the treatment of leukemia.
Transfer.
2023(1), S. 7.
Verfügbar unter: https://doi.org/10.21256/zhaw-30047
-
Kalbermatter, David; Jeckelmann, Jean-Marc; Wyss, Marianne; Shrestha, Neeta; Pliatsika, Dimanthi; Riedl, Rainer; Lemmin, Thomas; Plattet, Philippe; Fotiadis, Dimitrios,
2023.
Structure and supramolecular organization of the canine distemper virus attachment glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America.
120(6), S. e2208866120.
Verfügbar unter: https://doi.org/10.1073/pnas.2208866120
-
Sabani, Besmira; Brand, Michael; Albert, Ina; Inderbitzin, Joelle; Eichenseher, Fritz; Schmelcher, Mathias; Rohrer, Jack; Riedl, Rainer; Lehmann, Steffi,
2023.
Nanomedicine: Nanotechnology, Biology and Medicine.
47(102607).
Verfügbar unter: https://doi.org/10.1016/j.nano.2022.102607