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Therapy comparison for multiple sclerosis

Long-term effect of a newly developed drug compared with teriflunomide.

At a glance


In this project, the longterm effectiveness (i.e. EDSS progression) of a only clinically tested new drug was compared to Teriflunomide. For this purpose, in a first step, the two data sets (Randomized Clinical Trial Data of the new drug and observational Data for Teriflunomide) were processed for comparability using statistical tools such as Propensity Score Matching. For the effectiveness, Cox regression and various sensitivity analyses were applied.