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New drugs for the treatment of protozoal infections derived from natural products

At a glance

Project leader : Prof. Dr. Rainer Riedl
Project team : Dr. Stefano Agnello, Luka Raguz, Dr. Hector Torres
Project budget : CHF 1'403'094
Project status : completed
Funding partner : CTI (KTI-Projekt / Projekt Nr. 16445.1 PFLS-LS)
Project partner : BACOBA AG
Contact person : Rainer Riedl

Description

Development of natural product derived drug for the treatment of protozoal infections, and optimisation of its active principle.

Publications

Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer,

2021.

Antiprotozoal structure–activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action.

Angewandte Chemie: International Edition.

60(28), pp. 15613-15621.

Available from: https://doi.org/10.1002/anie.202102153
Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer,

2021.

Antiprotozoische Struktur‐Aktivitäts‐Beziehungen von synthetischen Leucinostatin‐Derivaten und Aufklärung ihres Wirkprinzips.

Angewandte Chemie.

133(28), pp. 15741-15749.

Available from: https://doi.org/10.1002/ange.202102153