Prof. Dr. Ing. Regine Eibl-Schindler

Projects

• Cyclical cake filtration for separating cell cultures / Deputy project leader / ongoing
• Development of a perfusion filter for the continuous production of biopharmaceuticals / Deputy project leader / ongoing
• Mini disc stack separator for cell culture-based production processes / Project leader / ongoing
• Intensification approaches for the production of an antibody with CHO cells / Project leader / ongoing
• Kuhner TOM Adherent: An innovative and cost-effective tool for real-time metabolic assessment of adherently growing (stem) cells / Project leader / ongoing
• Process Analytical Platform for Autologous Cell-Based Therapy Manufacturing / Project leader / ongoing
• Novel Single-Use Mixer and Bioreactor / Project leader / ongoing
• Digital Twin: supporting the optimization of bioreactor operation and automation / Project leader / completed
• Online monitoring of cell health in antibody production processes / Project leader / completed
• Biological characterization of a novel single-use bioreactor through the cultivation of pluripotent stem cells under various conditions / Project leader / completed
• Establishment of a stem cell expansion process with microcarriers / Project leader / completed
• Scale-up of a scaffold-based cultivation process for the production of clean meat / Project leader / completed
• Glucose-Sensor based Optimization of mAb Production Processes / Project leader / completed
• Biological characterization of a novel single-use bioreactor through the cultivation of pluripotent stem cells on microcarriers / Project leader / completed
• Valve qualification / Project leader / completed
• Evaluation perfusion membrane / Co-project leader / completed
• Human Embryonic Kidney cells (50 L) / Deputy project leader / completed
• Evaluation Perfusion / Project leader / completed
• USP Development with CHO Cells / Project leader / completed
• Scalable Stem Cell Platform for the production of iPSCs / Project leader / completed
• A Kuhner TOM system for process developments with stem cells (Kuhner TOM StemCell) / Project leader / completed
• Antibody production / Project leader / completed
• IgG productions with CHO cells / Project leader / completed
• AMBioVessel – 3D-printed, tailor-made bioreactors for pharma and medicine / Deputy project leader / completed
• Process development for COVID-19 VLP vaccine production / Deputy project leader / completed
• Growth performance studies / Deputy project leader / completed
• Organ-on-a-Chip / Project leader / completed
• A platform enabling efficient and effective delivery and packaging of therapeutic molecules / Co-project leader / completed

Publications

Articles in scientific journal, peer-reviewed

• Schneider, S., Gopalakrishnan, A., Teale, M., & Eibl, R. (2025). Cell retention in scalable, perfusion-based mesenchymal stem cell expansion processes : a proof of concept. Frontiers in Bioengineering and Biotechnology, 13(1611703). https://doi.org/10.3389/fbioe.2025.1611703
• Ott, V., Ott, J., Mannone, A. D., & Eibl, R. (2025). Perfusion-based antibody production in the Ambr® 250 Modular. Chimia, 79(5), 330–338. https://doi.org/10.2533/chimia.2025.330
• Teale, M., Schneider, S., Seidel, S., Krasenbrink, J., Poggel, M., Eibl, D., Sousa, M. F. Q., & Eibl, R. (2025). Expansion of induced pluripotent stem cells under consideration of bioengineering aspects : part 2. Applied Microbiology and Biotechnology, 109(38). https://doi.org/10.1007/s00253-024-13373-2
• Schneider, S., Teale, M., Seidel, S., Krasenbrink, J., Poggel, M., Eibl, D., Sousa, M. F. Q., & Eibl, R. (2025). Expansion of induced pluripotent stem cells under consideration of bioengineering aspects : part 1. Applied Microbiology and Biotechnology, 109(37). https://doi.org/10.1007/s00253-024-13372-3
• Ott, V., Ott, J., Eibl, D., & Eibl-Schindler, R. (2024). Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors. Processes, 12(4), 806. https://doi.org/10.3390/pr12040806
• Ott, J., Ott, V., Neubauer, P., Eibl, D., & Eibl-Schindler, R. (2024). Process intensification by inoculating antibody production bioreactors directly from cryovials . Chemie Ingenieur Technik, 96(4), 453–461. https://doi.org/10.1002/cite.202300189
• Teale, M. A., Schneider, S. L., Eibl, D., & Eibl-Schindler, R. (2024). Process intensification in human pluripotent stem cell expansion with microcarriers. Processes, 12(3), 426. https://doi.org/10.3390/pr12030426
• Seidel, S., Mozaffari, F., Maschke, R. W., Kraume, M., Eibl-Schindler, R., & Eibl, D. (2023). Automated shape and process parameter optimization for scaling up geometrically non-similar bioreactors. Processes, 11(9), 2703. https://doi.org/10.3390/pr11092703
• Teale, M. A., Schneider, S., Eibl, D., van den Bos, C., Neubauer, P., & Eibl, R. (2023). Mesenchymal and induced pluripotent stem cell-based therapeutics : a comparison. Applied Microbiology and Biotechnology, 107(14), 4429–4445. https://doi.org/10.1007/s00253-023-12583-4
• Seidel, S., Maschke, R., Mozaffari, F., Eibl-Schindler, R., & Eibl, D. (2023). Improvement of HEK293 cell growth by adapting hydrodynamic stress and predicting cell aggregate size distribution. Bioengineering, 10(4), 478. https://doi.org/10.3390/bioengineering10040478
• Müller, J., Ott, V., Eibl, D., & Eibl-Schindler, R. (2022). Seed train intensification using an ultra-high cell density cell banking process. Processes, 10(5), 911. https://doi.org/10.3390/pr10050911
• Ott, V., Müller, J., Schirmer, C., Weiss, N., Göhmann, R., Biewald, A., Michel, A., Eibl, D., & Eibl-Schindler, R. (2022). Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production. Chemie Ingenieur Technik, 94(12), 1936–1943. https://doi.org/10.1002/cite.202200096
• Schirmer, C., Eibl-Schindler, R., Maschke, R., Mozaffari, F., Junne, S., Daumke, R., Ottinger, M., Göhmann, R., Ott, C., Wenk, I., Kubischik, J., & Eibl, D. (2022). Single‐use technology for the production of cellular agricultural products : where are we today? Chemie Ingenieur Technik, 94(12), 2018–2025. https://doi.org/10.1002/cite.202200092
• Seidel, S., Eibl-Schindler, R., & Eibl, D. (2022). Laboratory-independent exploration of stirred bioreactors and their fluid dynamics. Education for Chemical Engineers, 42, 80–87. https://doi.org/10.1016/j.ece.2022.10.001
• Seidel, S., Maschke, R., Kraume, M., Eibl-Schindler, R., & Eibl, D. (2022). CFD modelling of a wave-mixed bioreactor with complex geometry and two degrees of freedom motion. Frontiers in Chemical Engineering, 4(1021416). https://doi.org/10.3389/fceng.2022.1021416
• Müller, J., Ott, V., Weiss, N., Neubauer, P., Eibl, D., & Eibl, R. (2022). Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes. Chemie Ingenieur Technik, 94(12), 1977–1984. https://doi.org/10.1002/cite.202200097
• Maschke, R. W., Seidel, S., Bley, T., Eibl, R., & Eibl, D. (2022). Determination of culture design spaces in shaken disposable cultivation systems for CHO suspension cell cultures. Biochemical Engineering Journal, 177, 108224. https://doi.org/10.1016/j.bej.2021.108224
• Panella, S., Muoio, F., Jossen, V., Harder, Y., Eibl-Schindler, R., & Tallone, T. (2021). Chemically defined xeno- and serum-free cell culture medium to grow human adipose stem cells. Cells, 10(2), 466. https://doi.org/10.3390/cells10020466
• Eibl, R., Senn, Y., Gubser, G., Jossen, V., van den Bos, C., & Eibl, D. (2021). Cellular agriculture : opportunities and challenges. Annual Review of Food Science and Technology, 12, 51–73. https://doi.org/10.1146/annurev-food-063020-123940
• Muoio, F., Panella, S., Jossen, V., Lindner, M., Harder, Y., Müller, M., Eibl, R., & Tallone, T. (2021). Human adipose stem cells (hASCs) grown on biodegradable microcarriers in serum- and xeno-free medium preserve their undifferentiated status. Journal of Functional Biomaterials, 12(2), 25. https://doi.org/10.3390/jfb12020025
• Gubser, G., Vollenweider, S., Eibl, D., & Eibl, R. (2021). Food ingredients and food made with plant cell and tissue cultures : state‐of‐the art and future trends. Engineering in Life Sciences, 21(3-4), 87–98. https://doi.org/10.1002/elsc.202000077
• Eibl, D., Sievers, M., Eibl, R., Bachmann, M., Walton, S., Keel, N., Richner, G., Stübinger, S., Hirsch, S., Yeretzian, C., Opitz, S. E. W., Heldal, T., & Adlhart, C. (2021). Keeping SARS-CoV-2 out : vaccines, filters, and self-disinfecting textiles. Chimia, 75(3), 215–218. https://doi.org/10.2533/chimia.2021.215
• Muoio, F., Panella, S., Lindner, M., Jossen, V., Harder, Y., Moccetti, T., Eibl-Schindler, R., Müller, M., & Tallone, T. (2021). Development of a biodegradable microcarrier for the cultivation of human adipose stem cells (hASCs) with a defined xeno- and serum-free medium. Applied Sciences, 11(3), 925. https://doi.org/10.3390/app11030925
• Khojasteh, A., Mirjalili, M. H., Alcalde, M. A., Cusido, R. M., Eibl, R., & Palazon, J. (2020). Powerful plant antioxidants : a new biosustainable approach to the production of rosmarinic acid. Antioxidants, 9(12), 1273. https://doi.org/10.3390/antiox9121273
• Jossen, V., Muoio, F., Panella, S., Harder, Y., Tallone, T., & Eibl-Schindler, R. (2020). An approach towards a GMP compliant in-vitro expansion of human adipose stem cells for autologous therapies. Bioengineering, 7(3), 77. https://doi.org/10.3390/bioengineering7030077
• Khojasteh, A., Metón, I., Camino, S., Cusido, R. M., Eibl-Schindler, R., & Palazon, J. (2019). In vitro study of the anticancer effects of biotechnological extracts of the endangered plant species satureja khuzistanica. International Journal of Molecular Sciences, 20(10), 2400. https://doi.org/10.3390/ijms20102400
• Khojasteh, A., Sanchez-Munoz, R., Moyano, E., Bonfill, M., Cusido, R. M., Eibl, R., & Palazon, J. (2019). Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus. Plant Physiology and Biochemistry, 141, 133–141. https://doi.org/10.1016/j.plaphy.2019.05.029
• Möller, J., Hernández Rodríguez, T., Müller, J., Arndt, L., Kuchemüller, K. B., Frahm, B., Eibl-Schindler, R., Eibl, D., & Pörtner, R. (2019). Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering, 134, 106693. https://doi.org/10.1016/j.compchemeng.2019.106693
• Jossen, V., van den Bos, C., Eibl-Schindler, R., & Eibl, D. (2018). Manufacturing human mesenchymal stem cells at clinical scale : process and regulatory challenges. Applied Microbiology and Biotechnology, 102(9), 3981–3994. https://doi.org/10.1007/s00253-018-8912-x
• Eibl-Schindler, R., Jossen, V., & Eibl, D. (2018). Einweg-Bioreaktoren : therapeutische Antikörper. Chemie in unserer Zeit, 52(4), 230–237. https://doi.org/10.1002/ciuz.201800803
• Eibl-Schindler, R., Meier, P., Stutz, I. K., Schildberger, D., Hühn, T., & Eibl, D. (2018). Plant cell culture technology in the cosmetics and food industries : current state and future trends. Applied Microbiology and Biotechnology, 102(20), 8661–8675. https://doi.org/10.1007/s00253-018-9279-8
• Jossen, V., Eibl-Schindler, R., Kraume, M., & Eibl, D. (2018). Growth behavior of human adipose tissue-derived stromal/stem cells at small scale : numerical and experimental investigations. Bioengineering, 5(4), 106. https://doi.org/10.3390/bioengineering5040106
• Eibl, D., & Eibl-Schindler, R. (2017). Flexible biomanufacturing for the production of biotherapeutics. Pharmaceutical Biomanufacturing, 5(1).
• Schirmer, C., Blaschczok, K., Husemann, U., Leupold, M., Zahnow, C., Rupprecht, J., Glöckler, R., Greller, G., Pörtner, R., Eibl-Schindler, R., & Eibl, D. (2017). Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes. Chemie Ingenieur Technik, 89(12). https://doi.org/10.1002/cite.201700039
• Khojasteh, A., Mirjalili, M. H., Palazon, J., Eibl-Schindler, R., & Cusido, R. M. (2016). Methyl jasmonate enhanced production of rosmarinic acid in cell cultures of Satureja khuzistanica in a bioreactor. Engineering in Life Sciences, 16(8), 740–749. https://doi.org/10.1002/elsc.201600064
• Jossen, V., Schirmer, C., Mostafa Sindi, D., Eibl-Schindler, R., Kraume, M., Pörtner, R., & Eibl, D. (2016). Theoretical and practical issues that are relevant when scaling up hMSC microcarrier production processes. Stem Cells International, 2016(4760414). https://doi.org/10.1155/2016/4760414
• Demuth, C., Varonier, J., Jossen, V., Eibl-Schindler, R., & Eibl, D. (2016). Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale. Applied Microbiology and Biotechnology, 100(9), 3853–3863. https://doi.org/10.1007/s00253-016-7412-0
• Vasilev, N., Schmitz, C., Dong, L., Ritala, A., Imseng, N., Häkkinen, S. T., van der Krol, S., Eibl-Schindler, R., Oksman-Caldentey, K.-M., Bouwmeester, H., Fischer, R., & Schillberg, S. (2014). Comparison of plant-based expression platforms for the heterologous production of geraniol. Plant Cell, Tissue and Organ Culture (PCTOC), 117(3), 373–380. https://doi.org/10.1007/s11240-014-0446-z
• Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillberg, S., Eibl-Schindler, R., Bouwmeester, H., & Oksman-Caldentey, K.-M. (2014). Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway. Journal of Biotechnology, 176, 20–28. https://doi.org/10.1016/j.jbiotec.2014.01.031
• Jossen, V., Kaiser, S. C., Schirmaier, C., Hermann, J., Tappe, A., Eibl, D., Siehoff, A., van den Bos, C., & Eibl-Schindler, R. (2014). Modification and qualification of a stirred single-use bioreactor for the improved expansion of human mesenchymal stem cells at benchtop scale. Pharmaceutical Bioprocessing, 2(4), 311–322.
• Schirmaier, C., Jossen, V., Kaiser, S. C., Jüngerkeks, F., Silke, B., Safavi-Nab, A., Siehoff, A., van den Bos, C., Eibl, D., & Eibl-Schindler, R. (2014). Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions. Engineering in Life Sciences, 14(3), 292–303. https://doi.org/10.1002/elsc.201300134
• Blaschczok, K., Löffelholz, C., Eibl-Schindler, R., & Eibl, D. (2014). Combining single-use stirred bioreactor with standard cross-flow technology in biphasic protein production processes at pilot scale. Engineering in Life Sciences, 14(3), 327–331. https://doi.org/10.1002/elsc.201300069
• Imseng, N., Steiger, N., Frasson, D., Sievers, M., Tappe, A., Greller, G., Eibl, D., & Eibl-Schindler, R. (2014). Single-use wave-mixed versus stirred bioreactors for insect-cell/BEVS-based protein expression at benchtop scale. Engineering in Life Sciences, 14(3), 264–271. https://doi.org/10.1002/elsc.201300131
• Steiger, N., & Eibl-Schindler, R. (2013). Interlaboratory test for detection of cytotoxic leachables arising from single-use bags. Chemie Ingenieur Technik, 85(1-2), 26–28. https://doi.org/10.1002/cite.201200171
• Georgiev, M. I., Eibl-Schindler, R., & Zhong, J.-J. (2013). Hosting the plant cells in vitro : recent trends in bioreactors. Applied Microbiology and Biotechnology, 97(9), 3787–3800. https://doi.org/10.1007/s00253-013-4817-x
• Stefanache, C. P., Imseng, N., Meier, B., Tanase, C., Eibl-Schindler, R., Peter, S., & Wolfram, E. (2013). Arnica montana L. cell suspension culture as a biotechnological approach for the production of bioactive secondary metabolites. Planta Medica, 79(13). https://doi.org/10.1055/s-0033-1352447
• Lehmann, N., Rischer, H., Eibl, D., & Eibl-Schindler, R. (2013). Wave-mixed and orbitally shaken single-use photobioreactors for diatom algae propagation. Chemie Ingenieur Technik, 85(1-2), 197–201. https://doi.org/10.1002/cite.201200137
• Kaiser, S., Jossen, V., Schirmaier, C., Eibl, D., Brill, S., van den Bos, C., & Eibl-Schindler, R. (2013). Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors. Chemie Ingenieur Technik, 85(1-2), 95–102. https://doi.org/10.1002/cite.201200180
• Löffelholz, C., Husemann, U., Greller, G., Meusel, W., Kauling, J., Ay, P., Kraume, M., Eibl-Schindler, R., & Eibl, D. (2013). Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods. Chemie Ingenieur Technik, 85(1-2), 40–56. https://doi.org/10.1002/cite.201200125
• Blaschczok, K., Kaiser, S. C., Löffelholz, C., Imseng, N., Burkart, J., Bösch, P., Dornfeld, W., Eibl-Schindler, R., & Eibl, D. (2013). Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps. Chemie Ingenieur Technik, 85(1-2), 144–152. https://doi.org/10.1002/cite.201200135
• Bogli, N. C., Ries, C., Adams, T., Greller, G., Eibl, D., & Eibl-Schindler, R. (2012). Large-scale, insect-cell-based vaccine development. BioProcess International, 10(2). http://www.bioprocessintl.com/upstream-processing/upstream-single-use-technologies/large-scale-insect-cellbased-vaccine-development-330217/?pageNum=3
• Kaiser, S., Eibl-Schindler, R., & Eibl, D. (2011). Engineering characteristics of a single-use stirred bioreactor at benchtop scale : the Mobius CellReady 3 L bioreactor as case study. Engineering in Life Sciences, 11(4), 359–368. https://doi.org/10.1002/elsc.201000171
• Werner, S., Eibl-Schindler, R., Lettenbauer, C., Röll, M., Eibl, D., De Jesus, M., Zhang, X., Stettler, M., Tissot, S., Bürkie, C., Broccard, G., Kühner, M., Tanner, R., Baldi, L., Hacker, D., & Wurm, F. M. (2010). Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution. Chimia, 64(11), 819–823. https://doi.org/10.2533/chimia.2010.819
• Eibl-Schindler, R., Kaiser, S., Lombriser, R., & Eibl, D. (2010). Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology. Applied Microbiology and Biotechnology, 86(1), 41–49. https://doi.org/10.1007/s00253-009-2422-9
• Ries, C., John, G., John, C., Eibl-Schindler, R., & Eibl, D. (2010). A shaken disposable bioreaktor system for controlled insect cell cultivations at millilitre-scale. Engineering in Life Sciences, 10(1), 75–79. https://doi.org/10.1002/elsc.200900040
• Eibl-Schindler, R., Werner, S., & Eibl, D. (2009). Disposable bioreactors for plant liquid cultures at litre-scale. Engineering in Life Sciences, 9(3), 156–164. https://doi.org/10.1002/elsc.200800102
• Eibl-Schindler, R., & Eibl, D. (2009). Disposable bioreactors in cell culture-based upstream processing. BioProcess International, 7(1), 18–23. http://www.bioprocessintl.com/upstream-processing/cell-culture-media/disposable-bioreactors-in-cell-culture-based-upstream-processing-184055/
• Bonfill, M., Bentebibel, S., Moyano, E., Palazón, J., Cusidó, R. M., Eibl-Schindler, R., & Piñol, M. T. (2007). Paclitaxel and baccatin III production induced by methyl jasmonate in free and immobilized cells of Taxus baccata. Biologia Plantarum, 51(4), 647–652. https://doi.org/10.1007/s10535-007-0137-2
• Eibl-Schindler, R., & Eibl, D. (2007). Design of bioreactors suitable for plant cell and tissue cultures. Phytochemistry Reviews, 7(3), 593–598. https://doi.org/10.1007/s11101-007-9083-z
• Bentebibel, S., Moyano, E., Palazón, J., Cusidó, R. M., Bonfill, M., Eibl-Schindler, R., & Piñol, M. T. (2005). Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata. Biotechnology & Bioengineering, 89(6), 647–655. https://doi.org/10.1002/bit.20321
• Palazón, J., Mallol, A., Eibl-Schindler, R., Lettenbauer, C., Cusidó, R. M., & Piñol, M. T. (2003). Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor. Planta Medica, 69(4), 344–349. https://doi.org/10.1055/s-2003-38873

Books, peer-reviewed

• Eibl-Schindler, R., & Eibl, D. (2019). Single-use technology in biopharmaceutical manufacture (2nd Edition). Wiley. https://doi.org/10.1002/9781119477891
• Eibl, D., & Eibl-Schindler, R. (2013). Disposable bioreactors II. Springer. https://doi.org/10.1007/978-3-642-45158-4
• Eibl-Schindler, R., & Eibl, D. (2011). Single-use technology in biopharmaceutical manufacture. Wiley. https://doi.org/10.1002/9780470909997
• Eibl-Schindler, R., & Eibl, D. (2010). Disposable bioreactors. Springer. https://doi.org/10.1007/978-3-642-01872-5

Book chapters, peer-reviewed

• Jossen, V., Eibl, D., & Eibl, R. (2025). Numerische Methoden für das Design und die Beschreibung von In-vitro-Expansionsprozessen humaner mesenchymaler Stammzellen. In C. Herwig, R. Pörtner, & J. Möller (eds.), Digitale Zwillinge : Anwendungen für das Design und die Optimierung von Bioprozessen (pp. 203–249). Springer. https://doi.org/10.1007/978-3-031-75700-6_7
• Jossen, V., Eibl-Schindler, R., Broccard, G., & Eibl, D. (2023). Single-use systems in biopharmaceutical manufacture : state of the art and recent trends. In R. Pörtner (Ed.), Biopharmaceutical Manufacturing : Progress, Trends and Challenges (pp. 3–38). Springer. https://doi.org/10.1007/978-3-031-45669-5_1
• Seidel, S., Schirmer, C., Maschke, R., Rossi, L., Eibl-Schindler, R., & Eibl, D. (2023). Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review. In G. Ji & J. Dong (Eds.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications (pp. 53–82). IntechOpen Limited. https://doi.org/10.5772/intechopen.109848
• Seidel, S., Schirmer, C., Maschke, R., Rossi, L., Eibl-Schindler, R., & Eibl, D. (2023). Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies. In G. Ji & J. Dong (Eds.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications (pp. 83–98). IntechOpen Limited. https://doi.org/10.5772/intechopen.109849
• Müller, J., Teale, M., Steiner, S., Junne, S., Neubauer, P., Eibl, D., & Eibl-Schindler, R. (2021). Intensified and continuous mAb production with single-use systems. In R. Pörtner (Ed.), Cell Culture Engineering and Technology (pp. 401–429). Springer. https://doi.org/10.1007/978-3-030-79871-0_13
• Teale, M., Jossen, V., Eibl, D., & Eibl-Schindler, R. (2021). Chemically defined, xeno-free expansion of human mesenchymal stem cells (hMSCs) on benchtop-scale using a stirred single-use bioreactor. In K. Turksen (Ed.), Bioreactors in Stem Cell Biology : Methods and Protocols (pp. 83–111). Humana. https://doi.org/10.1007/7651_2021_426
• Schirmer, C., Müller, J., Steffen, N., Werner, S., Eibl-Schindler, R., & Eibl, D. (2020). How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale. In R. Pörtner (Ed.), Animal cell biotechnology : methods and protocols (pp. 169–186). Springer. https://doi.org/10.1007/978-1-0716-0191-4_10
• Jossen, V., Eibl, D., & Eibl, R. (2020). Numerical methods for the design and description of in vitro expansion processes of human mesenchymal stem cells. In Digital Twins (pp. 185–228). Springer. https://doi.org/10.1007/10_2020_147
• Werner, S., Maschke, R. W., Eibl, D., & Eibl, R. (2018). Bioreactor technology for sustainable production of plant cell-derived products. In A. Pavlov & T. Bley (Eds.), Bioprocessing of Plant In Vitro Systems (pp. 413–432). Springer. https://doi.org/10.1007/978-3-319-54600-1_6
• Schirmer, C., Nussbaumer, T., Schöb, R., Pörtner, R., Eibl-Schindler, R., & Eibl, D. (2018). Development, engineering and biological characterization of stirred tank bioreactors. In M.-K. Yeh & Y.-C. Chen (Eds.), Biopharmaceuticals (pp. 87–107). IntechOpen. https://doi.org/10.5772/intechopen.79444
• Jossen, V., Eibl-Schindler, R., Pörtner, R., Kraume, M., & Eibl, D. (2017). Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes. In Current Developments in Biotechnology and Bioengineering (pp. 179–215). Elsevier. https://doi.org/10.1016/B978-0-444-63663-8.00007-0
• Löffelholz, C., Kaiser, S. C., Kraume, M., Eibl, D., & Eibl-Schindler, R. (2014). Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up. In D. Eibl & R. Eibl-Schindler (Eds.), Disposable bioreactors II (pp. 1–41). Springer. https://doi.org/10.1007/10_2013_187
• Eibl-Schindler, R., Steiger, N., Wellnitz, S., Vicente, T., John, C., & Eibl, D. (2014). Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study. In D. Eibl & R. Eibl-Schindler (Eds.), Disposable bioreactors II (pp. 99–125). Springer. https://doi.org/10.1007/10_2013_186
• Eibl-Schindler, R., Löffelholz, C., & Eibl, D. (2011). Single-use bioreactors : an overview. In R. Eibl-Schindler & D. Eibl (Eds.), Single-use technology in biopharmaceutical manufacture (pp. 145–158). Wiley. https://doi.org/10.1002/9780470909997.ch4
• Eibl-Schindler, R., Werner, S., & Eibl, D. (2010). Bag bioreactor based on wave-induced motion : characteristics and applications. In R. Eibl-Schindler & D. Eibl (Eds.), Disposable Bioreactors (pp. 55–87). Springer. https://doi.org/10.1007/10_2008_15
• Eibl-Schindler, R., & Eibl, D. (2009). Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents. In C. Kasper, M. van Griensven, & R. Pörtner (Eds.), Bioreactor systems for tissue engineering (pp. 183–207). Springer. https://doi.org/10.1007/10_2008_23

Written conference contributions, peer-reviewed

• Ott, J., Ott, V., Brau, C., Beyer, S., Eibl, D., & Eibl-Schindler, R. (2024, June). Seed train intensification and production process automation for pilot-scale fed-batch and perfusion processes. 28th ESACT Meeting, Edinburgh, United Kingdom, 23-26 June 2024.
• Schirmer, C., Ott, V., Müller, J., Göhmann, R., Biewald, A., Eibl-Schindler, R., & Eibl, D. (2022, June). Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale. 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.
• Müller, J., Ott, V., Weiss, N., Eibl, D., & Eibl-Schindler, R. (2022, June). Ultra-high cell density cell bank-based IgG production with CHO cells. 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.
• Müller, J., Grün, M., Magos, S., Eibl-Schindler, R., & Eibl, D. (2019, July). Scale-up strategy for a CHO cell-based IgG production process in stirred bioreactors. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

Other publications

• Schneider, S., Buchter, L., Mannone, A., Schulte, A., Flitsch, D., Anderlei, T., & Eibl, R. (2025, June 16). Real-time growth monitoring of stem cell cultures using off-gas analysis in T-flasks and spinner flasks. 5th BIOTECH Conference, Freiburg, Germany, 16-18 June 2025. https://doi.org/10.21256/zhaw-35276
• Seidel, S., Maschke, R. W., Kraume, M., Eibl-Schindler, R., & Eibl, D. (2023, September 11). Advanced numerical characterization of a wave-mixed bioreactor used in the biopharmaceutical industry. Engineering Conferences International (ECI), Single Use Technologies VI: Established, Emergent, Agile, Sustainable?, Boston, USA, 10-13 September 2023.
• Seidel, S., Maschke, R. W., Mozaffari, F., Eibl-Schindler, R., & Eibl, D. (2023, May 15). Prediction of the aggregate size distribution of HEK293 cells based on computational fluid dynamics. Himmelfahrtstagung on Bioprocess Engineering 2023 - Novel Production Routes and Processes for Bio-Pharmaceuticals and Industrial Bioeconomy, Weimar, Germany, 15-17 May 2023.
• Ott, J., Jossen, V., Eibl, R., & Eibl, D. (2022, March). In-line monitoring and control of glucose concentration with single-use sensors in CHO and stem cell applications. ECI: Single-Use Technologies V: Building the Future, Marseille, France, 20-23 March 2022.
• Ott, V., Müller, J., Eibl-Schindler, R., Eibl, D., Schirmer, C., Göhmann, R., & Biewald, A. (2022, March). A new single-use disk stack separator for pilot scale CHO cell-based antibody productions. ECI: Single-Use Technologies V: Building the Future, Marseille, France, 20-23 March 2022.
• Bayer, M., Castan, A., Eibl, R., Eibl, D., Eisenkrätzer, D., Fritz, C., Glaser, R., Glenz, M., Greller, G., Hug, M., Kleebank, S., Kampmann, M., Krättli, M., Manser, B., Matuszczyk, J., Ottinger, M., Schleper, S., Schreiber, M., Seidel, S., et al. (2020). Technical state-of-the-art and risk analysis on single-use equipment in continuous processing steps. DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V. https://doi.org/10.21256/zhaw-26357
• Jossen, V., Eibl-Schindler, R., & Eibl, D. (2019). Single‐use bioreactors : an overview. In Single‐Use Technology in Biopharmaceutical Manufacture (pp. 37–52). Wiley. https://doi.org/10.1002/9781119477891.ch4
• van den Bos, C., Jossen, V., Eibl, D., & Eibl-Schindler, R. (2019). Advanced therapy medicinal products (ATMPs) & GMP : 10 years after. Die Pharmazeutische Industrie : Pharmind, 81(4), 508–513.
• Jossen, V., Eberle, S., Muoio, F., Panella, S., Tallone, T., Moccetti, T., Lindner, M., Müller, M., Eibl, D., & Eibl-Schindler, R. (2019, July). Serum-free hMSC expansion in stirred single-use cultivation systems. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.
• Schildberger, D., Stutz, I., Weber, C., Pedan, V., Schlüter, A., Huber, P., Chatelain, K., Chetschik, I., Eibl, D., Hühn, T., & Eibl-Schindler, R. (2018). Cast off! Chocolate from cacao cell cultures. New Harvest 2018 Conference, Cambridge, USA, 20-21 July 2018.
• Jossen, V., Eibl-Schindler, R., Kraume, M., & Eibl, D. (2018, September). Growth behavior of human adipose tissue-derived stromal/stem cells in single-use spinner flasks : numerical and experimental investigations. ECI: Single Use Technologies III: Scientific and Technological Advancements, Utah, USA, 23-26 September 2018.
• Eibl-Schindler, R., & Eibl, D. (2017). Single-Use-Systeme in der biopharmazeutischen Produktion : Chancen und Herausforderungen. Die Pharmazeutische Industrie : pharmind, 79, 719–724.
• Jossen, V., Schirmer, C., Eibl-Schindler, R., Kraume, M., Pörtner, R., & Eibl, D. (2016, September). Expansion of human adipose tissue-derived stromal/stem cells in a wave-mixed single-use bioreactor : a proof-of-concept. BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.
• Jossen, V., Eibl-Schindler, R., Kraume, M., Pörtner, R., & Eibl, D. (2016, September). Impact of shear stress on cell growth and microcarrier-cell-agglomerate formation in microcarrier-based cultivations of adipose tissue-derived stromal/stem cells. BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.
• Jossen, V., Schirmer, C., Eibl-Schindler, R., Kraume, M., Pörtner, R., & Eibl, D. (2016, April). How to successfully scale up a microcarrier based expansion process of human mesenchymal stem cells from adipose tissue. 4th BioProScale Symposium 2016, Berlin, Germany, 6-8 April 2016.
• Jossen, V., Schirmaier, C., John, G. T., Eibl, D., & Eibl-Schindler, R. (2015). On-line-pH- und -DO-Messungen in Mikrocarrier-basierter hMSC Kultur. BIOspektrum, 21(4), 422–424. https://doi.org/10.1007/s12268-015-0597-4
• Eibl-Schindler, R., & Eibl, D. (2015). Single-use (disposable) systems in biopharmaceutical processing : quo vadis? ACHEMA Trend Reports, 13.
• Jossen, V., Pörtner, R., Kaiser, S. C., Kraume, M., Eibl, D., & Eibl-Schindler, R. (2014). Mass production of mesenchymal stem cells — impact of bioreactor design and flow conditions on proliferation and differentiation. In D. Eberli (Ed.), Cells and Biomaterials in Regenerative Medicine (pp. 119–172). InTech. https://doi.org/10.5772/59385
• Jossen, V., Schirmaier, C., John, G., Siehoff, A., Eibl, D., & Eibl-Schindler, R. (2014, September). Online pH and DO measurement in microcarrier-based hMSC cultivations performed in single-use spinner flask. BioTech 2014, Wädenswil, Switzerland, 4-5 September 2014.
• Jossen, V., Ott, A., Kaiser, S., Brill, S., Spicker, S., Safavi-nab, A., Jüngerkes, F., Siehoff, A., Rosenbaum, C., Reinisch, B., van den Bos, C., Eibl, D., & Eibl-Schindler, R. (2014, June). Microcarrier-based expansion of adipose tissue and bone marrow derived human mesenchymal stem cells in therapeutically relevant doses. 4th Lugano Stem Cell Meeting, Lugano, Switzerland, 23-24 June 2014.
• Eibl, D., Eibl, R., Eisenkrätzer, D., & Tiemann, K. (2013). TAK „Single-Use-Technologien in der biopharmazeutischen Produktion“. BIOspektrum, 19(4), 454–455. https://doi.org/10.1007/s12268-013-0334-9
• Jossen, V., Kaiser, S., Schirmaier, C., van den Bos, C., Eibl, D., & Eibl-Schindler, R. (2013, June). Investigations of fluif flow and microcarrier suspension for hMSC expansion in single-use stirred bioreactors. BioTech 2013, Wädenswil, Switzerland, 3-5 June 2013.
• Brändli, J., Müller, M., Imseng, N., Schillberg, S., & Eibl-Schindler, R. (2012). Antikörper-Produktion in Pflanzenzellen : Prozessentwicklung und -übertragung vom 50-ml- auf den 10-l-Maßstab. BIOspektrum, 18(2), 216–217. https://doi.org/10.1007/s12268-012-0166-z
• Eibl-Schindler, R. (2011). Zellkultivierung in einem wellendurchmischten, DO-regulierten Einwegbioreaktor. Bioforum, 34(1), 22–23.
• Eibl-Schindler, R., & Eibl, D. (2011). Single-use cell culture systems arrive : tracking the evolution and development of an increasingly used technology. Genetic Engineering & Biotechnology News, 31(17), 59–61. https://doi.org/10.1089/gen.31.17.15
• Eibl, R., Eibl, D., Pörtner, R., Catapano, G., & Czermak, P. (2009). Cell and tissue reaction engineering. Springer. https://doi.org/10.1007/978-3-540-68182-3
• Ries, C., John, C., & Eibl-Schindler, R. (2009). Einwegbioreaktoren für die Prozessentwicklung mit Insektenzellen. Bioforum, 3, 11–13.
• Eibl-Schindler, R., & Eibl, D. (2007). Disposable bioreactors for cell culture based-processing. Achema Worldwide News, 2, 8–10.
• Eibl, D., & Eibl-Schindler, R. (2007). Einwegbioreaktoren für Zellkulturen : Status quo und Trends. Pharma-Tec, 4, 14–15.
• Cuperus, S., Eibl-Schindler, R., Hühn, T., & Amado, R. (2007). Plant cell culture based platform investigating biochemical processes in wine production. BioForum Europe, 6, 2–4.
• Eibl-Schindler, R., & Eibl, D. (2005). Einwegkultivierungstechnologie für biotechnische Pharma-Produktionen. BioWorld, 3.
• Eibl-Schindler, R., Rutschmann, K., Lisica, L., & Eibl, D. (2003). Kostenreduktion bei der Säugerzellkultivierung durch Einwegbioreaktoren? BioWorld, 5, 22–23.
• Eibl-Schindler, R. (2002). Fermentative Herstellung bioaktiver Wirkstoffe. BioWorld, 6(Beilage).
• Viviani, A., & Eibl-Schindler, R. (2001). Rote Biotechnologie. BioWorld, 4(Beilage).
• Eibl-Schindler, R., Brändli, J., Lettenbauer, C., & Eibl, D. (2000). Kultivierung pflanzlicher und animaler Zellkulturen. BioWorld, 5, 48–50.
• Eibl-Schindler, R., Lettenbauer, C., Eibl, D., & Röllin, M. (1999). Experiences in the application of the wave bioreactor. BioForum Europe, 3, 110–112.
• Eibl-Schindler, R., Hans, D., Warlies, S., Lettenbauer, C., & Eibl, D. (1999). Zellkulturtechnik : Einsatz eines Taumelreaktorsystems mit interner Beleuchtung. BioWorld, 2, 10–12.
• Eibl-Schindler, R. (1996). Pflanzenzellkulturtechnik an der Ingenieurschule Wädenswil. BioWorld, 5, 3–7.

Oral conference contributions and abstracts

• Hausherr, L., Brown, L., Teale, M., & Eibl-Schindler, R. (2025, June 18). Production of food ingredients from plant cell cultures in orbitally shaken single-use bioreactors. 5th BIOTECH Conference, Freiburg, Germany, 16-18 June 2025.
• Müller, J., Eibl, D., & Eibl-Schindler, R. (2021, March). N-1 perfusion-based IgG productions in stirred single-use bioreactors. 6th BioProScale Symposium, Berlin, Germany, 29-31 March 2021.
• Jossen, V., Eibl-Schindler, R., & Eibl, D. (2018, March). Multiphase CFD simulations for supporting MC-based hMSC process development. 5th BioProScale Symposium, Berlin, Germany, 20-22 March 2018.
• Jossen, V., Schirmer, C., Eibl-Schindler, R., Kraume, M., & Pörtner, R. (2017, May). Standardized expansion of human adipose tissue-derived stromal/stem cells (hASCs) in wave-mixed single-use bioreactors with one-dimensional motion. ECI: Single Use Technologies II: Bridging Polymer Science to Bioprocess Applications, Tomar, Portugal, 7–10 May 2017. https://pdfs.semanticscholar.org/9a61/98bcd2e950104f1457e8f0e7c7380323ebf5.pdf
• Jossen, V., Eibl-Schindler, R., & Eibl, D. (2017, January). How to use Computational Fluid Dynamics in the development of cell therapeutics. ECI: Scale-up and Manufacturing of Cell-Based Therapies V, San Diego, USA, 15-19 January 2017.
• Schirmer, C., Jossen, V., Mostafa Sindi, D., Eibl-Schindler, R., Böttcher, L., & Eibl, D. (2016). Standardized expansion of human mesenchymal stem cells in wave-mixed single-use bioreactors. ILMAC, Basel, 2016.
• Jossen, V., Eibl, D., & Eibl-Schindler, R. (2015). How can Computational Fluid Dynamics be used in order to rapidly expand bone marrow derived hMSCs in clinically relevant numbers. DECHEMA Himmelfahrtstagung, Hamburg, Germany, 11-13 May 2015.
• Eibl-Schindler, R., Jossen, V., & Eibl, D. (2015). Mass production of hMSCs : an approach based on stirred single-use bioreactors. ECI: Scale-up and Manufacturing of Cell-Based Therapies III, 18-22 January 2015.
• Jossen, V., Kaiser, S., Ott, A., Siehoff, A., Brill, S., Greller, G., Tappe, A., Eibl-Schindler, R., & Eibl, D. (2014). Optimization of a benchtop single-use bioreactor for the expansion of adipose-tissue and bone marrow derived human mesenchymal stem cells. 41st Annual European Society for Artificial Organs Congress, Rome, Italy, 17-20 September 2014.
• Jossen, V., Kaiser, S., Eibl-Schindler, R., & Eibl, D. (2014). Numerische Strömungsuntersuchungen für die Massstabsübertragung der Expansion von humanen mesenchymalen Stammzellen in gerührten Single-Use Bioreaktoren. 17. Köthener-Rührer-Kolloquium, Köthen, Deutschland, 26. Juni 2014.
• Jossen, V., Kaiser, S., Siehoff, A., van den Bos, C., Eibl, D., & Eibl-Schindler, R. (2014). A successful approach in order to rapidly scaling-up microcarrier-based expansion of human mesenchymal stem cells for allogeneic therapies. 3rd International Conference on Tissue Science & Regenerative Medicine, Valencia, Spain, 24-26 September 2014.

Patents and patent applications

• Eibl, Regine; Eibl, Dieter; Hühn, Tilo,

  2024.

  Methods for the preparation of culture media based on microgreens and related products.

  Patent number WO2024115573 A1

  (2024-06-06)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2024115573A1

• Eibl, Regine; Eibl, Dieter; Hühn, Tilo,

  2024.

  Methods for the preparation of culture media based on saccharified plant extracts and related products.

  Patent number WO2024115572 A1

  (2024-06-06)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2024115572A1

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