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Online monitoring of cell health in antibody production processes

Online monitoring of cell health in Chinese Hamster Ovary (CHO)-based antibody production processes in the benchtop bioreactor.

Description

As part of the Innocheque project by Innosuisse, the cell quality of Chinese Hamster Ovary (CHO) cell-based antibody production processes is being investigated.

In a first step, measurement methods are being developed using a flow cytometer to determine the ratio of living and dead cells. In the next step, this method will be automated and transferred to a continuously measuring flow cytometer. Finally, bioreactor cultivations are carried out on a benchtop scale with the CHO cells and the cell quality is monitored continuously and online over the entire cultivation period.

This process makes it possible to gain a direct insight into cell quality and thus also product formation. In future, this method could be used to simplify process development and monitoring.

Key data

Deputy Projectlead

Project team

Project partners

onCyt Microbiology AG

Project status

ongoing, started 02/2025

Institute/Centre

Institute of Chemistry and Biotechnology (ICBT)

Funding partner

Innosuisse Innovationsscheck