Dr.-Ing. Jan Ott
Dr.-Ing. Jan Ott
ZHAW
Life Sciences und Facility Management
Fachgruppe Zellkulturtechnik
Grüentalstrasse 14
8820 Wädenswil
Arbeit an der ZHAW
Tätigkeit
Dozent
Arbeits- und Forschungsschwerpunkte
- Zellkulturtechnik
- Prozessintensivierung
- Entwicklung von Biopharmazeutika-Produktionsprozessen
- Single-Use Technologie
- Scale-Up und Scale-Down
Berufserfahrung
- Dozent
ZHAW
03 / 2025 - heute - Wissenschaftlicher Mitarbeiter
ZHAW
03 / 2024 - 02 / 2025 - Wissenschaftlicher Assistent
ZHAW
03 / 2019 - 02 / 2024 - Studentische Hilfskraft (Duales Studium)
Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
10 / 2013 - 09 / 2016
Aus- und Weiterbildung
Ausbildung
- Doktor der Ingenieurwissenschaften (Dr.-Ing.) / Biotechnologie
Technische Universität Berlin
2022 - 2024 - Master of Science / Biotechnologie
Hochschule Anhalt
2016 - 2019 - Bachelor of Science, Ingenieur / Biotechnologie
Hochschule Anhalt
2013 - 2016
Netzwerk
Mitglied in Netzwerken
ORCID digital identifier
Projekte
- Zyklische Kuchenfiltration für Abtrennung von Zellkulturen / Projektleiter:in / laufend
- Entwicklung eines Perfusionsfilters zur kontinuierlichen Produktion von Biopharmazeutika / Projektleiter:in / laufend
- Minitellerseparator für zellkulturbasierte Produktionsprozesse / Teammitglied / laufend
- Intensivierungsansätze zur Produktion eines Antikörpers mit CHO-Zellen / Stellv. Projektleiter:in / laufend
- Prozessanalytik-Plattform für die Herstellung autologer zellbasierter Therapien / Teammitglied / laufend
- Online-Monitoring der Zellqualität in Antikörperproduktionsprozessen / Teammitglied / abgeschlossen
- Optimierung von Antikörperproduktionsprozessen mithilfe von Glucosesensoren / Teammitglied / abgeschlossen
- Neuer Single-Use Mischer und Bioreaktor / Stellv. Projektleiter:in / abgeschlossen
- Evaluation Perfusionsmembranen / Teammitglied / abgeschlossen
- Humanen embryonale Nierenzellen (50 L) / Teammitglied / abgeschlossen
- Prozesstransfer einer Kultivierungsstrategie für eine CHO-Zelllinie in einem wellendurchmischten Bioreaktor / Teammitglied / abgeschlossen
- Evaluation of cell separation using the GEA kytero® Single Use Pharma Separator with disk stack technology / Teammitglied / abgeschlossen
- IgG Produktionen mit CHO-Zellen / Teammitglied / abgeschlossen
- AMBioVessel – 3D-printed, tailor-made bioreactors for pharma and medicine / Teammitglied / abgeschlossen
- Process development for COVID-19 VLP vaccine production / Teammitglied / abgeschlossen
Publikationen
Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed
- Ott, V. et al. (2025) 'Perfusion-based antibody production in the Ambr® 250 Modular', Chimia, 79(5), pp. 330–338. doi: 10.2533/chimia.2025.330.
- Ott, V. et al. (2024) 'Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors', Processes, 12(4), p. 806. doi: 10.3390/pr12040806.
- Ott, J. et al. (2024) 'Process intensification by inoculating antibody production bioreactors directly from cryovials ', Chemie Ingenieur Technik, 96(4), pp. 453–461. doi: 10.1002/cite.202300189.
- Müller, J. et al. (2022) 'Seed train intensification using an ultra-high cell density cell banking process', Processes, 10(5), p. 911. doi: 10.3390/pr10050911.
- Ott, V. et al. (2022) 'Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production', Chemie Ingenieur Technik, 94(12), pp. 1936–1943. doi: 10.1002/cite.202200096.
- Müller, J. et al. (2022) 'Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes', Chemie Ingenieur Technik, 94(12), pp. 1977–1984. doi: 10.1002/cite.202200097.
- Möller, J. et al. (2019) 'Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes', Computers & Chemical Engineering, 134, p. 106693. doi: 10.1016/j.compchemeng.2019.106693.
Bücher, peer-reviewed
Müller, J. (2024) Upstream process intensification using an ultra-high cell density Chinese hamster ovary cell bank. Doctoral dissertation. Technische Universität Berlin. doi: 10.14279/depositonce-21615.
Buchbeiträge, peer-reviewed
- Müller, J. et al. (2021) 'Intensified and continuous mAb production with single-use systems', in Pörtner, R. (ed.) Cell Culture Engineering and Technology. Cham: Springer, pp. 401–429. doi: 10.1007/978-3-030-79871-0_13.
- Schirmer, C. et al. (2020) 'How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale', in Pörtner, R. (ed.) Animal cell biotechnology : methods and protocols. Springer, pp. 169–186. doi: 10.1007/978-1-0716-0191-4_10.
Schriftliche Konferenzbeiträge, peer-reviewed
- Ott, J. et al. (2024) 'Seed train intensification and production process automation for pilot-scale fed-batch and perfusion processes', in 28th ESACT Meeting, Edinburgh, United Kingdom, 23-26 June 2024.
- Müller, J. et al. (2022) 'Ultra-high cell density cell bank-based IgG production with CHO cells', in 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022. ESACT, European Association for Animal Cell Technology.
- Schirmer, C. et al. (2022) 'Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale', in 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022. ESACT, European Association for Animal Cell Technology.
- Müller, J. et al. (2019) 'Scale-up strategy for a CHO cell-based IgG production process in stirred bioreactors', in BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.
Weitere Publikationen
- Ott, V. et al. (2022) 'A new single-use disk stack separator for pilot scale CHO cell-based antibody productions', in ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.
- Ott, J. et al. (2022) 'In-line monitoring and control of glucose concentration with single-use sensors in CHO and stem cell applications', in ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.
- Werner, S. et al. (2019) 'Performance comparison of CHO-S cell cultivation and mAb production in the Allegro™ STR 200 single-use bioreactor and in conventional single-use bioreactor', in 26th ESACT Meeting, Copenhagen, Denmark, 5-8 May 2019. Available at: https://www.pall.com/en/biotech/posters-presentations/performance-comparison-cho-s-cell-cultivation-mab-production-allegro-str-200-single-use-bioreactor-conventional-single-use-bioreactor.html.
Mündliche Konferenzbeiträge und Abstracts
- Ott, J. (2025) 'Increasing process efficiency in mAb production through perfusion-based approaches', in 8th Annual Bioprocessing Summit Europe, Barcelona, Spain, 18-20 March 2025.
- Ott, J. and Grün, M. (2024) 'Intensifying upstream processes and scaling to 50 L DynaDrive', in BioProcess International Europe, Vienna, Austria, 9-12 April 2024.
- Ott, J. (2024) 'Single-use devices for alternating tangential-flow filtration : highly efficient perfusion processes over 50 days', in BioProcess International. Informa Life Sciences. Available at: https://www.bioprocessintl.com/sponsored-content/highly-efficient-perfusion-processes-using-xcell-atf-2-and-atf-6-single-use-devices-for-50-days.
- Müller, J. (2022) 'Development, scale-up, and intensification of antibody production processes', in A3P Switzerland Forum, Lausanne, Switzerland, 27 September 2022.
- Müller, J., Eibl, D. and Eibl-Schindler, R. (2021) 'N-1 perfusion-based IgG productions in stirred single-use bioreactors', in 6th BioProScale Symposium, Berlin, Germany, 29-31 March 2021.
- Möller, J. and Müller, J. (2019) 'Workflow for model-assisted design and scale-up of biopharmaceutical production processes', in BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.