Dr.-Ing. Jan Ott

ZHAW Life Sciences und Facility Management
Fachgruppe Zellkulturtechnik
Grüentalstrasse 14
8820 Wädenswil

+41 (0) 58 934 53 48
jan.ott@zhaw.ch

Arbeit an der ZHAW

Tätigkeit

Dozent

Arbeits- und Forschungsschwerpunkte

Zellkulturtechnik
Prozessintensivierung
Entwicklung von Biopharmazeutika-Produktionsprozessen
Single-Use Technologie
Scale-Up und Scale-Down

Berufserfahrung

Dozent
ZHAW
03 / 2025 - heute
Wissenschaftlicher Mitarbeiter
ZHAW
03 / 2024 - 02 / 2025
Wissenschaftlicher Assistent
ZHAW
03 / 2019 - 02 / 2024
Studentische Hilfskraft (Duales Studium)
Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
10 / 2013 - 09 / 2016

Aus- und Weiterbildung

Ausbildung

Doktor der Ingenieurwissenschaften (Dr.-Ing.) / Biotechnologie
Technische Universität Berlin
2022 - 2024
Master of Science / Biotechnologie
Hochschule Anhalt
2016 - 2019
Bachelor of Science, Ingenieur / Biotechnologie
Hochschule Anhalt
2013 - 2016

Netzwerk

Mitglied in Netzwerken

ORCID digital identifier

ORCID ID: 0000-0003-2854-9604

Projekte

Publikationen

Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed

Ott, V., Ott, J., Mannone, A. D., & Eibl, R. (2025). Perfusion-based antibody production in the Ambr® 250 Modular. Chimia, 79(5), 330–338. https://doi.org/10.2533/chimia.2025.330
Ott, V., Ott, J., Eibl, D., & Eibl-Schindler, R. (2024). Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors. Processes, 12(4), 806. https://doi.org/10.3390/pr12040806
Ott, J., Ott, V., Neubauer, P., Eibl, D., & Eibl-Schindler, R. (2024). Process intensification by inoculating antibody production bioreactors directly from cryovials . Chemie Ingenieur Technik, 96(4), 453–461. https://doi.org/10.1002/cite.202300189
Müller, J., Ott, V., Eibl, D., & Eibl-Schindler, R. (2022). Seed train intensification using an ultra-high cell density cell banking process. Processes, 10(5), 911. https://doi.org/10.3390/pr10050911
Ott, V., Müller, J., Schirmer, C., Weiss, N., Göhmann, R., Biewald, A., Michel, A., Eibl, D., & Eibl-Schindler, R. (2022). Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production. Chemie Ingenieur Technik, 94(12), 1936–1943. https://doi.org/10.1002/cite.202200096
Müller, J., Ott, V., Weiss, N., Neubauer, P., Eibl, D., & Eibl, R. (2022). Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes. Chemie Ingenieur Technik, 94(12), 1977–1984. https://doi.org/10.1002/cite.202200097
Möller, J., Hernández Rodríguez, T., Müller, J., Arndt, L., Kuchemüller, K. B., Frahm, B., Eibl-Schindler, R., Eibl, D., & Pörtner, R. (2019). Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering, 134, 106693. https://doi.org/10.1016/j.compchemeng.2019.106693

Bücher, peer-reviewed

Müller, J. (2024). Upstream process intensification using an ultra-high cell density Chinese hamster ovary cell bank [Doctoral dissertation, Technische Universität Berlin]. https://doi.org/10.14279/depositonce-21615

Buchbeiträge, peer-reviewed

Müller, J., Teale, M., Steiner, S., Junne, S., Neubauer, P., Eibl, D., & Eibl-Schindler, R. (2021). Intensified and continuous mAb production with single-use systems. In R. Pörtner (Ed.), Cell Culture Engineering and Technology (pp. 401–429). Springer. https://doi.org/10.1007/978-3-030-79871-0_13
Schirmer, C., Müller, J., Steffen, N., Werner, S., Eibl-Schindler, R., & Eibl, D. (2020). How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale. In R. Pörtner (Ed.), Animal cell biotechnology : methods and protocols (pp. 169–186). Springer. https://doi.org/10.1007/978-1-0716-0191-4_10

Schriftliche Konferenzbeiträge, peer-reviewed

Ott, J., Ott, V., Brau, C., Beyer, S., Eibl, D., & Eibl-Schindler, R. (2024, June). Seed train intensification and production process automation for pilot-scale fed-batch and perfusion processes. 28th ESACT Meeting, Edinburgh, United Kingdom, 23-26 June 2024.
Schirmer, C., Ott, V., Müller, J., Göhmann, R., Biewald, A., Eibl-Schindler, R., & Eibl, D. (2022, June). Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale. 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.
Müller, J., Ott, V., Weiss, N., Eibl, D., & Eibl-Schindler, R. (2022, June). Ultra-high cell density cell bank-based IgG production with CHO cells. 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.
Müller, J., Grün, M., Magos, S., Eibl-Schindler, R., & Eibl, D. (2019, July). Scale-up strategy for a CHO cell-based IgG production process in stirred bioreactors. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

Weitere Publikationen

Ott, J., Jossen, V., Eibl, R., & Eibl, D. (2022, March). In-line monitoring and control of glucose concentration with single-use sensors in CHO and stem cell applications. ECI: Single-Use Technologies V: Building the Future, Marseille, France, 20-23 March 2022.
Ott, V., Müller, J., Eibl-Schindler, R., Eibl, D., Schirmer, C., Göhmann, R., & Biewald, A. (2022, March). A new single-use disk stack separator for pilot scale CHO cell-based antibody productions. ECI: Single-Use Technologies V: Building the Future, Marseille, France, 20-23 March 2022.
Werner, S., Schirmer, C., Steffen, N., Müller, J., Becheau, O., Cameau, E., Welsh, J. H., Jones, K., Capone, J., & Collignon, M.-L. (2019). Performance comparison of CHO-S cell cultivation and mAb production in the Allegro™ STR 200 single-use bioreactor and in conventional single-use bioreactor. 26th ESACT Meeting, Copenhagen, Denmark, 5-8 May 2019. https://www.pall.com/en/biotech/posters-presentations/performance-comparison-cho-s-cell-cultivation-mab-production-allegro-str-200-single-use-bioreactor-conventional-single-use-bioreactor.html

Mündliche Konferenzbeiträge und Abstracts

Ott, J. (2025, March). Increasing process efficiency in mAb production through perfusion-based approaches. 8th Annual Bioprocessing Summit Europe, Barcelona, Spain, 18-20 March 2025.
Ott, J., & Grün, M. (2024, April). Intensifying upstream processes and scaling to 50 L DynaDrive. BioProcess International Europe, Vienna, Austria, 9-12 April 2024.
Ott, J. (2024, April 16). Single-use devices for alternating tangential-flow filtration : highly efficient perfusion processes over 50 days. BioProcess International. https://www.bioprocessintl.com/sponsored-content/highly-efficient-perfusion-processes-using-xcell-atf-2-and-atf-6-single-use-devices-for-50-days
Müller, J. (2022, September). Development, scale-up, and intensification of antibody production processes. A3P Switzerland Forum, Lausanne, Switzerland, 27 September 2022.
Müller, J., Eibl, D., & Eibl-Schindler, R. (2021, March). N-1 perfusion-based IgG productions in stirred single-use bioreactors. 6th BioProScale Symposium, Berlin, Germany, 29-31 March 2021.
Möller, J., & Müller, J. (2019, July). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

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