Dr.-Ing. Jan Ott

Work at ZHAW

Position

Lecturer

Focus

• Cell Cultivation Techniques
• Process Intensification
• Development of Biopharmaceutical Production Processes
• Single-Use Technology
• Scale-Up and Scale-Down

Experience

• Lecturer
  ZHAW
  03 / 2025 - today
• Research Associate
  ZHAW
  03 / 2024 - 02 / 2025
• Scientific Assistant
  ZHAW
  03 / 2019 - 02 / 2024
• Student Assistant (Dual Studies)
  Leibniz Institute of Plant Genetics and Crop Plant Research
  10 / 2013 - 09 / 2016

Education and Continuing education

Education

• Doktor der Ingenieurwissenschaften (Dr.-Ing.) / Biotechnology
  Technische Universität Berlin
  2022 - 2024
• Master of Science / Biotechnology
  Anhalt University of Applied Sciences
  2016 - 2019
• Bachelor of Science, Ingenieur / Biotechnology
  Anhalt University of Applied Sciences
  2013 - 2016

Network

Membership of networks

• Biotechnet Switzerland
• DECHEMA

ORCID digital identifier

ORCID ID: 0000-0003-2854-9604

Projects

• Cyclical cake filtration for separating cell cultures / Project leader / ongoing
• Development of a perfusion filter for the continuous production of biopharmaceuticals / Project leader / ongoing
• Intensification approaches for the production of an antibody with CHO cells / Deputy project leader / ongoing
• Mini disc stack separator for cell culture-based production processes / Team member / completed
• Online monitoring of cell health in antibody production processes / Team member / completed
• Process Analytical Platform for Autologous Cell-Based Therapy Manufacturing / Team member / completed
• Glucose-Sensor based Optimization of mAb Production Processes / Team member / completed
• Novel Single-Use Mixer and Bioreactor / Deputy project leader / completed
• Evaluation perfusion membrane / Team member / completed
• Human Embryonic Kidney cells (50 L) / Team member / completed
• Evaluation of cell separation using the GEA kytero® Single Use Pharma Separator with disk stack technology / Team member / completed
• IgG productions with CHO cells / Team member / completed
• AMBioVessel – 3D-printed, tailor-made bioreactors for pharma and medicine / Team member / completed
• Process development for COVID-19 VLP vaccine production / Team member / completed

Publications

Articles in scientific journal, peer-reviewed

• Pynos, C. J.-J. et al. (2026) 'Increasing CHO cell harvest efficiency with cyclical cake filtration', Applied Microbiology and Biotechnology. doi: 10.1007/s00253-026-14021-7.
• Ott, V. et al. (2025) 'Perfusion-based antibody production in the Ambr® 250 Modular', Chimia, 79(5), pp. 330–338. doi: 10.2533/chimia.2025.330.
• Ott, V. et al. (2024) 'Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors', Processes, 12(4), p. 806. doi: 10.3390/pr12040806.
• Ott, J. et al. (2024) 'Process intensification by inoculating antibody production bioreactors directly from cryovials ', Chemie Ingenieur Technik, 96(4), pp. 453–461. doi: 10.1002/cite.202300189.
• Müller, J. et al. (2022) 'Seed train intensification using an ultra-high cell density cell banking process', Processes, 10(5), p. 911. doi: 10.3390/pr10050911.
• Ott, V. et al. (2022) 'Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production', Chemie Ingenieur Technik, 94(12), pp. 1936–1943. doi: 10.1002/cite.202200096.
• Müller, J. et al. (2022) 'Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes', Chemie Ingenieur Technik, 94(12), pp. 1977–1984. doi: 10.1002/cite.202200097.
• Möller, J. et al. (2019) 'Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes', Computers & Chemical Engineering, 134, p. 106693. doi: 10.1016/j.compchemeng.2019.106693.

Books, peer-reviewed

Müller, J. (2024) Upstream process intensification using an ultra-high cell density Chinese hamster ovary cell bank. Doctoral dissertation. Technische Universität Berlin. doi: 10.14279/depositonce-21615.

Book chapters, peer-reviewed

• Müller, J. et al. (2021) 'Intensified and continuous mAb production with single-use systems', in Pörtner, R. (ed.) Cell Culture Engineering and Technology. Cham: Springer, pp. 401–429. doi: 10.1007/978-3-030-79871-0_13.
• Schirmer, C. et al. (2020) 'How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale', in Pörtner, R. (ed.) Animal cell biotechnology : methods and protocols. Springer, pp. 169–186. doi: 10.1007/978-1-0716-0191-4_10.

Written conference contributions, peer-reviewed

• Ott, J. et al. (2024) 'Seed train intensification and production process automation for pilot-scale fed-batch and perfusion processes', in 28th ESACT Meeting, Edinburgh, United Kingdom, 23-26 June 2024.
• Müller, J. et al. (2022) 'Ultra-high cell density cell bank-based IgG production with CHO cells', in 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022. ESACT, European Association for Animal Cell Technology.
• Schirmer, C. et al. (2022) 'Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale', in 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022. ESACT, European Association for Animal Cell Technology.
• Müller, J. et al. (2019) 'Scale-up strategy for a CHO cell-based IgG production process in stirred bioreactors', in BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

Other publications

• Ott, J. et al. (2022) 'In-line monitoring and control of glucose concentration with single-use sensors in CHO and stem cell applications', in ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.
• Ott, V. et al. (2022) 'A new single-use disk stack separator for pilot scale CHO cell-based antibody productions', in ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.
• Werner, S. et al. (2019) 'Performance comparison of CHO-S cell cultivation and mAb production in the Allegro™ STR 200 single-use bioreactor and in conventional single-use bioreactor', in 26th ESACT Meeting, Copenhagen, Denmark, 5-8 May 2019.

Oral conference contributions and abstracts

• Ott, J. (2025) 'Increasing process efficiency in mAb production through perfusion-based approaches', in 8th Annual Bioprocessing Summit Europe, Barcelona, Spain, 18-20 March 2025.
• Ott, J. and Grün, M. (2024) 'Intensifying upstream processes and scaling to 50 L DynaDrive', in BioProcess International Europe, Vienna, Austria, 9-12 April 2024.
• Ott, J. (2024) 'Single-use devices for alternating tangential-flow filtration : highly efficient perfusion processes over 50 days', in BioProcess International. Informa Life Sciences. Available at: https://www.bioprocessintl.com/sponsored-content/highly-efficient-perfusion-processes-using-xcell-atf-2-and-atf-6-single-use-devices-for-50-days.
• Müller, J. (2022) 'Development, scale-up, and intensification of antibody production processes', in A3P Switzerland Forum, Lausanne, Switzerland, 27 September 2022.
• Müller, J., Eibl, D. and Eibl-Schindler, R. (2021) 'N-1 perfusion-based IgG productions in stirred single-use bioreactors', in 6th BioProScale Symposium, Berlin, Germany, 29-31 March 2021.
• Möller, J. and Müller, J. (2019) 'Workflow for model-assisted design and scale-up of biopharmaceutical production processes', in BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

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