Dr.-Ing. Jan Ott

Work at ZHAW

Position

Lecturer

Focus

• Cell Cultivation Techniques
• Process Intensification
• Development of Biopharmaceutical Production Processes
• Single-Use Technology
• Scale-Up and Scale-Down

Experience

• Lecturer
  ZHAW
  03 / 2025 - today
• Research Associate
  ZHAW
  03 / 2024 - 02 / 2025
• Scientific Assistant
  ZHAW
  03 / 2019 - 02 / 2024
• Student Assistant (Dual Studies)
  Leibniz Institute of Plant Genetics and Crop Plant Research
  10 / 2013 - 09 / 2016

Education and Continuing education

Education

• Doktor der Ingenieurwissenschaften (Dr.-Ing.) / Biotechnology
  Technische Universität Berlin
  2022 - 2024
• Master of Science / Biotechnology
  Anhalt University of Applied Sciences
  2016 - 2019
• Bachelor of Science, Ingenieur / Biotechnology
  Anhalt University of Applied Sciences
  2013 - 2016

Network

Membership of networks

• Biotechnet Switzerland
• DECHEMA

ORCID digital identifier

ORCID ID: 0000-0003-2854-9604

Projects

• Cyclical cake filtration for separating cell cultures / Project leader / ongoing
• Development of a perfusion filter for the continuous production of biopharmaceuticals / Project leader / ongoing
• Mini disc stack separator for cell culture-based production processes / Team member / ongoing
• Intensification approaches for the production of an antibody with CHO cells / Deputy project leader / ongoing
• Process Analytical Platform for Autologous Cell-Based Therapy Manufacturing / Team member / ongoing
• Novel Single-Use Mixer and Bioreactor / Deputy project leader / ongoing
• Online monitoring of cell health in antibody production processes / Team member / completed
• Glucose-Sensor based Optimization of mAb Production Processes / Team member / completed
• Evaluation perfusion membrane / Team member / completed
• Human Embryonic Kidney cells (50 L) / Team member / completed
• Evaluation of cell separation using the GEA kytero® Single Use Pharma Separator with disk stack technology / Team member / completed
• IgG productions with CHO cells / Team member / completed
• AMBioVessel – 3D-printed, tailor-made bioreactors for pharma and medicine / Team member / completed
• Process development for COVID-19 VLP vaccine production / Team member / completed

Publications

• Ott, Vivian; Ott, Jan; Mannone, Andry D.; Eibl, Regine,

  2025.

  Perfusion-based antibody production in the Ambr® 250 Modular.

  Chimia.

  79(5), pp. 330-338.

  Available from: https://doi.org/10.2533/chimia.2025.330

• Ott, Vivian; Ott, Jan; Eibl, Dieter; Eibl-Schindler, Regine,

  2024.

  Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors.

  Processes.

  12(4), pp. 806.

  Available from: https://doi.org/10.3390/pr12040806

• Ott, Jan; Ott, Vivian; Neubauer, Peter; Eibl, Dieter; Eibl-Schindler, Regine,

  2024.

  Process intensification by inoculating antibody production bioreactors directly from cryovials .

  Chemie Ingenieur Technik.

  96(4), pp. 453-461.

  Available from: https://doi.org/10.1002/cite.202300189

• Müller, Jan; Ott, Vivian; Weiss, Noémi; Neubauer, Peter; Eibl, Dieter; Eibl, Regine,

  2022.

  Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes.

  Chemie Ingenieur Technik.

  94(12), pp. 1977-1984.

  Available from: https://doi.org/10.1002/cite.202200097

• Ott, Vivian; Müller, Jan; Schirmer, Cedric; Weiss, Noémi; Göhmann, Rüdiger; Biewald, Andreas; Michel, Andrej; Eibl, Dieter; Eibl-Schindler, Regine,

  2022.

  Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production.

  Chemie Ingenieur Technik.

  94(12), pp. 1936-1943.

  Available from: https://doi.org/10.1002/cite.202200096

• Müller, Jan; Ott, Vivian; Eibl, Dieter; Eibl-Schindler, Regine,

  2022.

  Seed train intensification using an ultra-high cell density cell banking process.

  Processes.

  10(5), pp. 911.

  Available from: https://doi.org/10.3390/pr10050911

• Möller, Johannes; Hernández Rodríguez, Tanja; Müller, Jan; Arndt, Lukas; Kuchemüller, Kim B.; Frahm, Björn; Eibl-Schindler, Regine; Eibl, Dieter; Pörtner, Ralf,

  2019.

  Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes.

  Computers & Chemical Engineering.

  134, pp. 106693.

  Available from: https://doi.org/10.1016/j.compchemeng.2019.106693

• Müller, Jan,

  2024.

  Upstream process intensification using an ultra-high cell density Chinese hamster ovary cell bank.

  Berlin:

  Technische Universität Berlin.

  Available from: https://doi.org/10.14279/depositonce-21615

• Müller, Jan; Teale, Misha; Steiner, Sandra; Junne, Stefan; Neubauer, Peter; Eibl, Dieter; Eibl-Schindler, Regine,

  2021.

  Intensified and continuous mAb production with single-use systems.

  In:

  Pörtner, Ralf, ed.,

  Cell Culture Engineering and Technology.

  Cham:

  Springer.

  pp. 401-429.

  Cell Engineering ; 10.

  Available from: https://doi.org/10.1007/978-3-030-79871-0_13

• Schirmer, Cedric; Müller, Jan; Steffen, Nina; Werner, Sören; Eibl-Schindler, Regine; Eibl, Dieter,

  2020.

  How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale.

  In:

  Pörtner, Ralf, ed.,

  Animal cell biotechnology : methods and protocols.

  Springer.

  pp. 169-186.

  Methods in Molecular Biology ; 2095.

  Available from: https://doi.org/10.1007/978-1-0716-0191-4_10

• Ott, Jan; Ott, Vivian; Brau, Christopher; Beyer, Sandra; Eibl, Dieter; Eibl-Schindler, Regine,

  2024.

  Seed train intensification and production process automation for pilot-scale fed-batch and perfusion processes[poster].

  In:

  28th ESACT Meeting, Edinburgh, United Kingdom, 23-26 June 2024.

• Schirmer, Cedric; Ott, Vivian; Müller, Jan; Göhmann, Rüdiger; Biewald, Andreas; Eibl-Schindler, Regine; Eibl, Dieter,

  2022.

  Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale[poster].

  In:

  27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.

  ESACT, European Association for Animal Cell Technology.

• Müller, Jan; Ott, Vivian; Weiss, Noémi; Eibl, Dieter; Eibl-Schindler, Regine,

  2022.

  Ultra-high cell density cell bank-based IgG production with CHO cells[poster].

  In:

  27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.

  ESACT, European Association for Animal Cell Technology.

• Müller, Jan; Grün, Maren; Magos, Simone; Eibl-Schindler, Regine; Eibl, Dieter,

  2019.

  Scale-up strategy for a CHO cell-based IgG production process in stirred bioreactors[poster].

  In:

  BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

• Ott, Vivian; Müller, Jan; Eibl-Schindler, Regine; Eibl, Dieter; Schirmer, Cedric; Göhmann, Rüdiger; Biewald, Andreas,

  2022.

  A new single-use disk stack separator for pilot scale CHO cell-based antibody productions[poster].

  In:

  ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.

• Ott, Jan; Jossen, Valentin; Eibl, Regine; Eibl, Dieter,

  2022.

  In-line monitoring and control of glucose concentration with single-use sensors in CHO and stem cell applications[poster].

  In:

  ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.

• Werner, Sören; Schirmer, Cedric; Steffen, Nina; Müller, Jan; Becheau, Odette; Cameau, Emmanuelle; Welsh, John H.; Jones, Kyle; Capone, Joe; Collignon, Marie-Laure,

  2019.

  Performance comparison of CHO-S cell cultivation and mAb production in the Allegro™ STR 200 single-use bioreactor and in conventional single-use bioreactor[poster].

  In:

  26th ESACT Meeting, Copenhagen, Denmark, 5-8 May 2019.

  Available from: https://www.pall.com/en/biotech/posters-presentations/performance-comparison-cho-s-cell-cultivation-mab-production-allegro-str-200-single-use-bioreactor-conventional-single-use-bioreactor.html

• Ott, Jan,

  2025.

  Increasing process efficiency in mAb production through perfusion-based approaches.

  In:

  8th Annual Bioprocessing Summit Europe, Barcelona, Spain, 18-20 March 2025.

• Ott, Jan,

  2024.

  Single-use devices for alternating tangential-flow filtration : highly efficient perfusion processes over 50 days.

  In:

  BioProcess International Ask the Expert Webcasts, online, 14. April 2024.

  Informa Life Sciences.

  Available from: https://www.bioprocessintl.com/sponsored-content/highly-efficient-perfusion-processes-using-xcell-atf-2-and-atf-6-single-use-devices-for-50-days

• Ott, Jan; Grün, Maren,

  2024.

  Intensifying upstream processes and scaling to 50 L DynaDrive.

  In:

  BioProcess International Europe, Vienna, Austria, 9-12 April 2024.

• Müller, Jan,

  2022.

  Development, scale-up, and intensification of antibody production processes.

  In:

  A3P Switzerland Forum, Lausanne, Switzerland, 27 September 2022.

• Müller, Jan; Eibl, Dieter; Eibl-Schindler, Regine,

  2021.

  N-1 perfusion-based IgG productions in stirred single-use bioreactors.

  In:

  6th BioProScale Symposium, Berlin, Germany, 29-31 March 2021.

• Möller, Johannes; Müller, Jan,

  2019.

  Workflow for model-assisted design and scale-up of biopharmaceutical production processes.

  In:

  BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

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