Dr.-Ing. Jan Ott

Work at ZHAW

Position

Lecturer

Focus

• Cell Cultivation Techniques
• Process Intensification
• Development of Biopharmaceutical Production Processes
• Single-Use Technology
• Scale-Up and Scale-Down

Experience

• Lecturer
  ZHAW
  03 / 2025 - today
• Research Associate
  ZHAW
  03 / 2024 - 02 / 2025
• Scientific Assistant
  ZHAW
  03 / 2019 - 02 / 2024
• Student Assistant (Dual Studies)
  Leibniz Institute of Plant Genetics and Crop Plant Research
  10 / 2013 - 09 / 2016

Education and Continuing education

Education

• Doktor der Ingenieurwissenschaften (Dr.-Ing.) / Biotechnology
  Technische Universität Berlin
  2022 - 2024
• Master of Science / Biotechnology
  Anhalt University of Applied Sciences
  2016 - 2019
• Bachelor of Science, Ingenieur / Biotechnology
  Anhalt University of Applied Sciences
  2013 - 2016

Network

Membership of networks

• Biotechnet Switzerland
• DECHEMA

ORCID digital identifier

ORCID ID: 0000-0003-2854-9604

Projects

• Cyclical cake filtration for separating cell cultures / Project leader / ongoing
• Development of a perfusion filter for the continuous production of biopharmaceuticals / Project leader / ongoing
• Mini disc stack separator for cell culture-based production processes / Team member / ongoing
• Intensification approaches for the production of an antibody with CHO cells / Deputy project leader / ongoing
• Process Analytical Platform for Autologous Cell-Based Therapy Manufacturing / Team member / ongoing
• Online monitoring of cell health in antibody production processes / Team member / completed
• Glucose-Sensor based Optimization of mAb Production Processes / Team member / completed
• Novel Single-Use Mixer and Bioreactor / Deputy project leader / completed
• Evaluation perfusion membrane / Team member / completed
• Human Embryonic Kidney cells (50 L) / Team member / completed
• Evaluation of cell separation using the GEA kytero® Single Use Pharma Separator with disk stack technology / Team member / completed
• IgG productions with CHO cells / Team member / completed
• AMBioVessel – 3D-printed, tailor-made bioreactors for pharma and medicine / Team member / completed
• Process development for COVID-19 VLP vaccine production / Team member / completed

Publications

Articles in scientific journal, peer-reviewed

• Ott, V., Ott, J., Mannone, A. D., & Eibl, R. (2025). Perfusion-based antibody production in the Ambr® 250 Modular. Chimia, 79(5), 330–338. https://doi.org/10.2533/chimia.2025.330
• Ott, V., Ott, J., Eibl, D., & Eibl-Schindler, R. (2024). Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors. Processes, 12(4), 806. https://doi.org/10.3390/pr12040806
• Ott, J., Ott, V., Neubauer, P., Eibl, D., & Eibl-Schindler, R. (2024). Process intensification by inoculating antibody production bioreactors directly from cryovials . Chemie Ingenieur Technik, 96(4), 453–461. https://doi.org/10.1002/cite.202300189
• Müller, J., Ott, V., Eibl, D., & Eibl-Schindler, R. (2022). Seed train intensification using an ultra-high cell density cell banking process. Processes, 10(5), 911. https://doi.org/10.3390/pr10050911
• Ott, V., Müller, J., Schirmer, C., Weiss, N., Göhmann, R., Biewald, A., Michel, A., Eibl, D., & Eibl-Schindler, R. (2022). Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production. Chemie Ingenieur Technik, 94(12), 1936–1943. https://doi.org/10.1002/cite.202200096
• Müller, J., Ott, V., Weiss, N., Neubauer, P., Eibl, D., & Eibl, R. (2022). Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes. Chemie Ingenieur Technik, 94(12), 1977–1984. https://doi.org/10.1002/cite.202200097
• Möller, J., Hernández Rodríguez, T., Müller, J., Arndt, L., Kuchemüller, K. B., Frahm, B., Eibl-Schindler, R., Eibl, D., & Pörtner, R. (2019). Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering, 134, 106693. https://doi.org/10.1016/j.compchemeng.2019.106693

Books, peer-reviewed

Müller, J. (2024). Upstream process intensification using an ultra-high cell density Chinese hamster ovary cell bank [Doctoral dissertation, Technische Universität Berlin]. https://doi.org/10.14279/depositonce-21615

Book chapters, peer-reviewed

• Müller, J., Teale, M., Steiner, S., Junne, S., Neubauer, P., Eibl, D., & Eibl-Schindler, R. (2021). Intensified and continuous mAb production with single-use systems. In R. Pörtner (Ed.), Cell Culture Engineering and Technology (pp. 401–429). Springer. https://doi.org/10.1007/978-3-030-79871-0_13
• Schirmer, C., Müller, J., Steffen, N., Werner, S., Eibl-Schindler, R., & Eibl, D. (2020). How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale. In R. Pörtner (Ed.), Animal cell biotechnology : methods and protocols (pp. 169–186). Springer. https://doi.org/10.1007/978-1-0716-0191-4_10

Written conference contributions, peer-reviewed

• Ott, J., Ott, V., Brau, C., Beyer, S., Eibl, D., & Eibl-Schindler, R. (2024, June). Seed train intensification and production process automation for pilot-scale fed-batch and perfusion processes. 28th ESACT Meeting, Edinburgh, United Kingdom, 23-26 June 2024.
• Müller, J., Ott, V., Weiss, N., Eibl, D., & Eibl-Schindler, R. (2022, June). Ultra-high cell density cell bank-based IgG production with CHO cells. 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.
• Schirmer, C., Ott, V., Müller, J., Göhmann, R., Biewald, A., Eibl-Schindler, R., & Eibl, D. (2022, June). Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale. 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.
• Müller, J., Grün, M., Magos, S., Eibl-Schindler, R., & Eibl, D. (2019, July). Scale-up strategy for a CHO cell-based IgG production process in stirred bioreactors. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

Other publications

• Ott, J., Jossen, V., Eibl, R., & Eibl, D. (2022, March). In-line monitoring and control of glucose concentration with single-use sensors in CHO and stem cell applications. ECI: Single-Use Technologies V: Building the Future, Marseille, France, 20-23 March 2022.
• Ott, V., Müller, J., Eibl-Schindler, R., Eibl, D., Schirmer, C., Göhmann, R., & Biewald, A. (2022, March). A new single-use disk stack separator for pilot scale CHO cell-based antibody productions. ECI: Single-Use Technologies V: Building the Future, Marseille, France, 20-23 March 2022.
• Werner, S., Schirmer, C., Steffen, N., Müller, J., Becheau, O., Cameau, E., Welsh, J. H., Jones, K., Capone, J., & Collignon, M.-L. (2019). Performance comparison of CHO-S cell cultivation and mAb production in the Allegro™ STR 200 single-use bioreactor and in conventional single-use bioreactor. 26th ESACT Meeting, Copenhagen, Denmark, 5-8 May 2019. https://www.pall.com/en/biotech/posters-presentations/performance-comparison-cho-s-cell-cultivation-mab-production-allegro-str-200-single-use-bioreactor-conventional-single-use-bioreactor.html

Oral conference contributions and abstracts

• Ott, J. (2025, March). Increasing process efficiency in mAb production through perfusion-based approaches. 8th Annual Bioprocessing Summit Europe, Barcelona, Spain, 18-20 March 2025.
• Ott, J., & Grün, M. (2024, April). Intensifying upstream processes and scaling to 50 L DynaDrive. BioProcess International Europe, Vienna, Austria, 9-12 April 2024.
• Ott, J. (2024, April 16). Single-use devices for alternating tangential-flow filtration : highly efficient perfusion processes over 50 days. BioProcess International. https://www.bioprocessintl.com/sponsored-content/highly-efficient-perfusion-processes-using-xcell-atf-2-and-atf-6-single-use-devices-for-50-days
• Müller, J. (2022, September). Development, scale-up, and intensification of antibody production processes. A3P Switzerland Forum, Lausanne, Switzerland, 27 September 2022.
• Müller, J., Eibl, D., & Eibl-Schindler, R. (2021, March). N-1 perfusion-based IgG productions in stirred single-use bioreactors. 6th BioProScale Symposium, Berlin, Germany, 29-31 March 2021.
• Möller, J., & Müller, J. (2019, July). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

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