Thomas Fischer

Projekte

• Targeting the innate immune system for Multiple Sclerosis / Teammitglied / laufend
• Protease-Inhibitoren gegen SARS-CoV-2 / Teammitglied / abgeschlossen
• Entwicklung neuer Therapieansätze zur Behandlung von Krebs / Teammitglied / abgeschlossen
• Modulatoren der MMP-Hemopexin-Domäne / Teammitglied / abgeschlossen
• Neue Antibiotika: RNA-Polymerase-Inhibitoren / Teammitglied / abgeschlossen
• Dynamic combinatorial chemistry in drug discovery / Teammitglied / abgeschlossen
• Kinetische Struktur-Aktivitäts-Beziehungen und röntgenkristallographische Bestimmung des Bindungsmodus von niedermolekularen Wirkstoffmolekülen / Teammitglied / abgeschlossen

Publikationen

Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed

• Fischer, T. et al. (2024) 'Phthalimide derivatives as a new class of papain‐like protease inhibitors in SARS‐CoV‐2', Archiv der Pharmazie, 358(1), p. e2400714. doi: 10.1002/ardp.202400714.
• Fischer, T. et al. (2024) 'Phthalimide derivatives as a new class of papain-like protease inhibitors in SARS-CoV-2', Archiv der Pharmazie, 358(1), p. e2400714. doi: 10.1002/ardp.202400714.
• Fischer, T. and Riedl, R. (2022) 'Paracelsus" legacy in the faunal realm : drugs deriving from animal toxins', Drug Discovery Today, 27(2), pp. 567–575. doi: 10.1016/j.drudis.2021.10.003.
• Zizzari, A. T. et al. (2021) 'New perspectives in oral peptide delivery', Drug Discovery Today, 26(4), pp. 1097–1105. doi: 10.1016/j.drudis.2021.01.020.
• Fischer, T. and Riedl, R. (2020) 'Challenges with matrix metalloproteinase inhibition and future drug discovery avenues', Expert Opinion on Drug Discovery, 16(1), pp. 75–88. doi: 10.1080/17460441.2020.1819235.
• Fischer, T. and Riedl, R. (2019) 'Inhibitory antibodies designed for matrix metalloproteinase modulation', Molecules, 24(12), p. 2265. doi: 10.3390/molecules24122265.
• Fischer, T. et al. (2019) 'High consistency of structure-based design and x-ray crystallography : design, synthesis, kinetic evaluation and crystallographic binding mode determination of biphenyl-N-acyl-β-D-glucopyranosylamines as glycogen phosphorylase inhibitors', Molecules, 24(7), p. 1322. doi: 10.3390/molecules24071322.
• Fischer, T., Gazzola, S. and Riedl, R. (2019) 'Approaching target selectivity by de novo drug design', Expert Opinion on Drug Discovery, 14(8), pp. 791–803. doi: 10.1080/17460441.2019.1615435.
• Fischer, T., Senn, N. and Riedl, R. (2019) 'Design and structural evolution of matrix metalloproteinase inhibitors', Chemistry – A European Journal, 25(34), pp. 7960–7980. doi: 10.1002/chem.201805361.
• Fischer, T. and Riedl, R. (2017) 'Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor', Molecules, 22(9). doi: 10.3390/molecules22091548.
• Fischer, T. and Riedl, R. (2017) 'Cover profile : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor', ChemistryOpen, 6(2), p. 167. doi: 10.1002/open.201700042.
• Fischer, T. and Riedl, R. (2017) 'Targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor', ChemistryOpen, 6(2), pp. 192–195. doi: 10.1002/open.201600158.
• Fischer, T. and Riedl, R. (2017) 'Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017)', ChemistryOpen, 6(2), p. 165. doi: 10.1002/open.201700043.
• Fischer, T. and Riedl, R. (2016) 'Molecular recognition of the catalytic zinc(II) ion in MMP-13 : structure-based evolution of an allosteric inhibitor to dual binding mode inhibitors with improved lipophilic ligand efficiencies', International Journal of Molecular Sciences, 17(3/314). doi: 10.3390/ijms17030314.
• Fischer, T. and Riedl, R. (2013) 'Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors', ChemMedChem, 8(9), pp. 1457–1461. doi: 10.1002/cmdc.201300278.

Weitere Publikationen

• Fischer, T. and Riedl, R. (2012) 'Design, synthesis and biological testing of novel MMP-inhibitors', in Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 13 September 2012.
• Riedl, R. and Fischer, T. (2012) 'Structure based design and synthesis of novel MMP inhibitors', in 19th EuroQSAR: «Knowledge Enabled Ligand Design», Vienna, Austria, 26-30 August 2012.
• Riedl, R. et al. (2011) 'Structure based design and synthesis of novel MMP inhibitors', in Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.
• Riedl, R. and Fischer, T. (2010) 'Fragment based scaffold hopping in drug discovery', in Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 16 September 2010.

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