Thomas Fischer

Personal profile

Position at the ZHAW

www.zhaw.ch/icbt/organic-and-medicinal-chemistry/

Projects

• Inhibitors targeting SARS-CoV-2 proteases / Team member / Project ongoing
• Development of new therapeutic approaches for the treatment of cancer / Team member / Project completed
• Modulatoren der MMP-Hemopexin-Domäne / Team member / Project completed
• Neue Antibiotika: RNA-Polymerase-Inhibitoren / Team member / Project completed
• Dynamic combinatorial chemistry in drug discovery / Team member / Project completed
• Kinetische Struktur-Aktivitäts-Beziehungen und röntgenkristallographische Bestimmung des Bindungsmodus von niedermolekularen Wirkstoffmolekülen / Team member / Project completed

Publications

• Fischer, Thomas; Riedl, Rainer,

  2022.

  Paracelsus' legacy in the faunal realm : drugs deriving from animal toxins.

  Drug Discovery Today.

  27(2), pp. 567-575.

  Available from: https://doi.org/10.1016/j.drudis.2021.10.003

• Zizzari, Alessandra Tania; Pliatsika, Dimanthi; Gall, Flavio; Fischer, Thomas; Riedl, Rainer,

  2021.

  New perspectives in oral peptide delivery.

  Drug Discovery Today.

  26(4), pp. 1097-1105.

  Available from: https://doi.org/10.1016/j.drudis.2021.01.020

• Fischer, Thomas; Riedl, Rainer,

  2020.

  Challenges with matrix metalloproteinase inhibition and future drug discovery avenues.

  Expert Opinion on Drug Discovery.

  16(1), pp. 75-88.

  Available from: https://doi.org/10.1080/17460441.2020.1819235

• Fischer, Thomas; Gazzola, Silvia; Riedl, Rainer,

  2019.

  Approaching target selectivity by de novo drug design.

  Expert Opinion on Drug Discovery.

  14(8), pp. 791-803.

  Available from: https://doi.org/10.1080/17460441.2019.1615435

• Fischer, Thomas; Senn, Nicole; Riedl, Rainer,

  2019.

  Design and structural evolution of matrix metalloproteinase inhibitors.

  Chemistry – A European Journal.

  25(34), pp. 7960-7980.

  Available from: https://doi.org/10.1002/chem.201805361

• Fischer, Thomas; Koulas, Symeon M.; Tsagkarakou, Anastasia S.; Kyriakis, Efthimios; Stravodimos, George A.; Skamnaki, Vassiliki T.; Liggri, Panagiota G.V.; Zographos, Spyros E.; Riedl, Rainer; Leonidas, Demetres D.,

  2019.

  High consistency of structure-based design and x-ray crystallography : design, synthesis, kinetic evaluation and crystallographic binding mode determination of biphenyl-N-acyl-β-D-glucopyranosylamines as glycogen phosphorylase inhibitors.

  Molecules.

  24(7), pp. 1322.

  Available from: https://doi.org/10.3390/molecules24071322

• Fischer, Thomas; Riedl, Rainer,

  2019.

  Inhibitory antibodies designed for matrix metalloproteinase modulation.

  Molecules.

  24(12), pp. 2265.

  Available from: https://doi.org/10.3390/molecules24122265

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017).

  ChemistryOpen.

  6(2), pp. 165.

  Available from: https://doi.org/10.1002/open.201700043

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Cover profile : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor.

  ChemistryOpen.

  6(2), pp. 167.

  Available from: https://doi.org/10.1002/open.201700042

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor.

  Molecules.

  22(9).

  Available from: https://doi.org/10.3390/molecules22091548

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor.

  ChemistryOpen.

  6(2), pp. 192-195.

  Available from: https://doi.org/10.1002/open.201600158

• Fischer, Thomas; Riedl, Rainer,

  2016.

  Molecular recognition of the catalytic zinc(II) ion in MMP-13 : structure-based evolution of an allosteric inhibitor to dual binding mode inhibitors with improved lipophilic ligand efficiencies.

  International Journal of Molecular Sciences.

  17(3/314).

  Available from: https://doi.org/10.3390/ijms17030314

• Fischer, Thomas; Riedl, Rainer,

  2013.

  Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors.

  ChemMedChem.

  8(9), pp. 1457-1461.

  Available from: https://doi.org/10.1002/cmdc.201300278

• Fischer, Thomas; Riedl, Rainer,

  2012.

  Design, synthesis and biological testing of novel MMP-inhibitors [poster].

  In:

  Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 13 September 2012.

• Riedl, Rainer; Fischer, Thomas,

  2012.

  Structure based design and synthesis of novel MMP inhibitors [poster].

  In:

  19th EuroQSAR: «Knowledge Enabled Ligand Design», Vienna, Austria, 26-30 August 2012.

• Riedl, Rainer; Fischer, Thomas; Züger, Patrik; Brand, Michael,

  2011.

  Structure based design and synthesis of novel MMP inhibitors [poster].

  In:

  Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.

• Riedl, Rainer; Fischer, Thomas,

  2010.

  Fragment based scaffold hopping in drug discovery [poster].

  In:

  Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 16 September 2010.

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