New drugs for the treatment of protozoal infections derived from natural products

Beschreibung

Development of natural product derived drug for the treatment of protozoal infections, and optimisation of its active principle.

Projektleitung

Prof. Dr. Rainer Riedl

Projektteam

Dr. Stefano Agnello, Luka Raguz, Dr. Hector Torres

Projektpartner

BACOBA AG

Projektstatus

abgeschlossen, 08/2015 - 07/2016

Institut/Zentrum

Institut für Chemie und Biotechnologie (ICBT)

Drittmittelgeber

KTI-Projekt / Projekt Nr. 16445.1 PFLS-LS

Projektvolumen

1'403'094 CHF

Dissecting structural requirements of leucinostatin A derivatives for antiprotozoal activity and mammalian toxicity

2025 Rimle, Lukas; Pliatsika, Dimanthi; Arnold, Noëlle; Kurth, Sandra; Kaiser, Marcel; Mäser, Pascal; Kemmler, Michael; Adams, Michael; Riedl, Rainer; von Ballmoos, Christoph
Antiprotozoische Struktur‐Aktivitäts‐Beziehungen von synthetischen Leucinostatin‐Derivaten und Aufklärung ihres Wirkprinzips

2021 Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer
Antiprotozoal structure–activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action

2021 Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer