New drugs for the treatment of protozoal infections derived from natural products
Description
Development of natural product derived drug for the treatment of protozoal infections, and optimisation of its active principle.
Key data
Projectlead
Project team
Dr. Hector Torres, Dr. Stefano Agnello, Luka Raguz
Project partners
BACOBA AG
Project status
completed, 08/2015 - 07/2016
Institute/Centre
Institute of Chemistry and Biotechnology (ICBT)
Funding partner
KTI-Projekt / Projekt Nr. 16445.1 PFLS-LS
Project budget
1'403'094 CHF
Publications
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Dissecting structural requirements of leucinostatin A derivatives for antiprotozoal activity and mammalian toxicity
2025 Rimle, Lukas; Pliatsika, Dimanthi; Arnold, Noëlle; Kurth, Sandra; Kaiser, Marcel; Mäser, Pascal; Kemmler, Michael; Adams, Michael; Riedl, Rainer; von Ballmoos, Christoph
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Antiprotozoische Struktur‐Aktivitäts‐Beziehungen von synthetischen Leucinostatin‐Derivaten und Aufklärung ihres Wirkprinzips
2021 Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer
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Antiprotozoal structure–activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action
2021 Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer
School of Life Sciences and Facility Management
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