Prof. Dr. Rainer Riedl

Work at ZHAW

Position

• Head of Competence Center for Drug Discovery
• Head of Organic and Medicinal Chemistry

Network

Membership of networks

• Swiss Academy of Engineering Sciences SATW
• Biotechnet Switzerland
• German Academic Scholarship Foundation
• Swiss Chemical Society
• Alexander von Humboldt Foundation

ORCID digital identifier

ORCID ID: 0000-0003-2534-1963

Social media

linkedin

Projects

• Peptidic active ingredients III / Project leader / ongoing
• Targeting the innate immune system for Multiple Sclerosis / Project leader / ongoing
• Alzheimer's dementia / Project leader / ongoing
• Small molecules targeting CD93-signaling for the treatment of acute myeloid leukemia / Project leader / ongoing
• Peptidic active ingredients II / Project leader / ongoing
• Targeting Gram-negative bacteria / Project leader / ongoing
• Evaluation of the potential of PROTACs / Project leader / completed
• Innovative Immunotherapy Approach / Project leader / completed
• Synthesis of peptidic active ingredients / Project leader / completed
• Therapy for the NRAS melanoma subtype / Project leader / completed
• Platform for drug target identification / Project leader / completed
• Inhibitors targeting SARS-CoV-2 proteases / Project leader / completed
• Extracellular vesicles for targeted delivery of new antimicrobials / Deputy project leader / completed
• Developing novel and effective therapies for treatment of childhood brain cancers / Project leader / completed
• Development of new therapeutic approaches for the treatment of cancer / Project leader / completed
• Developing a gasotransmitter based treatment for pathological skin and tendon calcification / Project leader / completed
• Plants and Minerals in Byzantine Popular Pharmacy. A New Multidisciplinary Approach / Deputy project leader / completed
• Development of small-molecules targeting CD93-signaling for the treatment of leukemia / Project leader / completed
• Inflammasome inhibitors - Development of new inhibitors / Project leader / completed
• Burn Wound Treatment / Project leader / completed
• Silent pathway awakening to discover novel antibacterial compounds from actinomycetes / Deputy project leader / completed
• A topical anti-infective / Project leader / completed
• Morbillivirus cell entry machinery: mechanisms, structures and antiviral drug discovery / Co-project leader / completed
• Identification and characterization of active substances from actinomycetes from Switzerland against pathogenic bacteria / Project leader / completed
• Virus cell entry machinery: antiviral drug discovery / Project leader / completed
• Novel Antimicrobials for Life-Threatening Infections / Project leader / completed
• Dynamic combinatorial chemistry in drug discovery / Project leader / completed
• New antileishmanial and antitrypanosomal drugs / Project leader / completed
• New drugs for the treatment of protozoal infections derived from natural products / Project leader / completed
• Development of high temperature resistant, synergistic biocidal products for protection of PVC against microbial infestation for commercial product applications / Project leader / completed
• HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory Compound (TRIC) that increases antibiotic susceptibility of multidrug resistant staphylococci / Project leader / completed
• Research and development in the field of potential small molecule drugs against diabetes / Project leader / completed
• Prevention of undesired interactions between biocides and additives in synthetic materials to improve efficacy and to reduce the necessary amount of biocides / Project leader / completed
• Development of a software to analyse chemical and biological data: CyBy2 / Project leader / completed
• HIT to LEAD to Candidate development of a Transcription Repressor Inhibitory Compound (TRIC), which switches off bacterial resistance to a broad band antibiotic / Project leader / completed
• Identification of novel targets and drug candidates against multi-drug resistant bacteria / Project leader / completed

Publications

• Rimle, Lukas; Pliatsika, Dimanthi; Arnold, Noëlle; Kurth, Sandra; Kaiser, Marcel; Mäser, Pascal; Kemmler, Michael; Adams, Michael; Riedl, Rainer; von Ballmoos, Christoph,

  2025.

  Dissecting structural requirements of leucinostatin A derivatives for antiprotozoal activity and mammalian toxicity.

  Journal of Medicinal Chemistry.

  68(4), pp. 4237-4258.

  Available from: https://doi.org/10.1021/acs.jmedchem.4c01989

• Fischer, Thomas; Frasson, David; Sievers, Martin; Riedl, Rainer,

  2024.

  Phthalimide derivatives as a new class of papain-like protease inhibitors in SARS-CoV-2.

  Archiv der Pharmazie.

  358(1), pp. e2400714.

  Available from: https://doi.org/10.1002/ardp.202400714

• Pliatsika, Dimanthi; Blatter, Cindy; Riedl, Rainer,

  2024.

  Targeted protein degradation : current molecular targets, localization, and strategies.

  Drug Discovery Today.

  29(11), pp. 104178.

  Available from: https://doi.org/10.1016/j.drudis.2024.104178

• Kalbermatter, David; Jeckelmann, Jean-Marc; Wyss, Marianne; Shrestha, Neeta; Pliatsika, Dimanthi; Riedl, Rainer; Lemmin, Thomas; Plattet, Philippe; Fotiadis, Dimitrios,

  2023.

  Structure and supramolecular organization of the canine distemper virus attachment glycoprotein.

  Proceedings of the National Academy of Sciences of the United States of America.

  120(6), pp. e2208866120.

  Available from: https://doi.org/10.1073/pnas.2208866120

• Sabani, Besmira; Brand, Michael; Albert, Ina; Inderbitzin, Joelle; Eichenseher, Fritz; Schmelcher, Mathias; Rohrer, Jack; Riedl, Rainer; Lehmann, Steffi,

  2023.

  A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging.

  Nanomedicine: Nanotechnology, Biology and Medicine.

  47(102607).

  Available from: https://doi.org/10.1016/j.nano.2022.102607

• Bagatella, Stefano; Haghayegh Jahromi, Neda; Monney, Camille; Polidori, Margherita; Gall, Flavio Max; Marchionatti, Emma; Serra, Fabienne; Riedl, Rainer; Engelhardt, Britta; Oevermann, Anna,

  2022.

  Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors.

  Journal of Neuroinflammation.

  19(304).

  Available from: https://doi.org/10.1186/s12974-022-02653-1

• Kiss, Cedric; Gall, Flavio M.; Dreier, Birgit; Adams, Michael; Riedl, Rainer; Plückthun, Andreas; Mittl, Peer R. E.,

  2022.

  Structure of a hydrophobic leucinostatin derivative determined by host lattice display.

  Acta Crystallographica. Section D: Structural Biology.

  78(12), pp. 1439-1450.

  Available from: https://doi.org/10.1107/S2059798322010762

• Brand, Michael; Bommeli, Elias Benjamin; Rütimann, Marc; Lindenmann, Urs; Riedl, Rainer,

  2022.

  Discovery of a dual SENP1 and SENP2 inhibitor.

  International Journal of Molecular Sciences.

  23(20), pp. 12085.

  Available from: https://doi.org/10.3390/ijms232012085

• Fischer, Thomas; Riedl, Rainer,

  2022.

  Paracelsus' legacy in the faunal realm : drugs deriving from animal toxins.

  Drug Discovery Today.

  27(2), pp. 567-575.

  Available from: https://doi.org/10.1016/j.drudis.2021.10.003

• Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer,

  2021.

  Antiprotozoal structure–activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action.

  Angewandte Chemie: International Edition.

  60(28), pp. 15613-15621.

  Available from: https://doi.org/10.1002/anie.202102153

• Zizzari, Alessandra Tania; Pliatsika, Dimanthi; Gall, Flavio; Fischer, Thomas; Riedl, Rainer,

  2021.

  New perspectives in oral peptide delivery.

  Drug Discovery Today.

  26(4), pp. 1097-1105.

  Available from: https://doi.org/10.1016/j.drudis.2021.01.020

• Shrestha, Neeta; Gall, Flavio; Vesin, Jonathan; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe,

  2021.

  Antiviral screen against canine distemper virus-induced membrane fusion activity.

  Viruses.

  13(1), pp. 128.

  Available from: https://doi.org/10.3390/v13010128

• Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer,

  2021.

  Antiprotozoische Struktur‐Aktivitäts‐Beziehungen von synthetischen Leucinostatin‐Derivaten und Aufklärung ihres Wirkprinzips.

  Angewandte Chemie.

  133(28), pp. 15741-15749.

  Available from: https://doi.org/10.1002/ange.202102153

• Shrestha, Neeta; Gall, Flavio Max; Mathieu, Cyrille; Hierweger, Melanie Michaela; Brügger, Melanie; Alves, Marco P.; Vesin, Jonathan; Banfi, Damiano; Kalbermatter, David; Horvat, Branka; Chambon, Marc; Turcatti, Gerardo; Fotiadis, Dimitrios; Riedl, Rainer; Plattet, Philippe,

  2021.

  Highly potent host-specific small-molecule inhibitor of paramyxovirus and pneumovirus replication with high resistance barrier.

  mBio.

  12(6), pp. e0262121.

  Available from: https://doi.org/10.1128/mBio.02621-21

• Neidhart, Berna; Kowalska, Malwina; Valentin, Jules D. P.; Gall, Flavio; Ren, Qun; Riedl, Rainer; Pot, Simon; Rottmar, Markus,

  2021.

  Tissue inhibitor of metalloproteinase (TIMP) peptidomimetic as an adjunctive therapy for infectious keratitis.

  Biomacromolecules.

  22(2), pp. 629-639.

  Available from: https://doi.org/10.1021/acs.biomac.0c01473

• Fischer, Thomas; Riedl, Rainer,

  2020.

  Challenges with matrix metalloproteinase inhibition and future drug discovery avenues.

  Expert Opinion on Drug Discovery.

  16(1), pp. 75-88.

  Available from: https://doi.org/10.1080/17460441.2020.1819235

• Kalbermatter, David; Shrestha, Neeta; Gall, Flavio; Wyss, Marianne; Riedl, Rainer; Plattet, Philippe; Fotiadis, Dimitrios,

  2020.

  Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain.

  Journal of Structural Biology: X.

  4, pp. 100021.

  Available from: https://doi.org/10.1016/j.yjsbx.2020.100021

• Lindenmann, Urs; Brand, Michael; Gall, Flavio; Frasson, David; Hunziker, Lukas; Kroslakova, Ivana; Sievers, Martin; Riedl, Rainer,

  2020.

  Discovery of a class of potent and selective non‐competitive sentrin‐specific protease 1 inhibitors.

  ChemMedChem.

  15(8), pp. 675-679.

  Available from: https://doi.org/10.1002/cmdc.202000067

• Arn, Fabienne; Frasson, David; Kroslakova, Ivana; Rezzonico, Fabio; Pothier, Joël; Riedl, Rainer; Sievers, Martin,

  2020.

  Isolation and identification of actinomycetes strains from Switzerland and their biotechnological potential.

  Chimia.

  74(5), pp. 382-390.

  Available from: https://doi.org/10.2533/chimia.2020.382

• Höck, Stefan; Riedl, Rainer,

  2019.

  CyBy2 : a strongly typed, purely functional framework for chemical data management.

  Journal of Cheminformatics.

  11(80).

  Available from: https://doi.org/10.1186/s13321-019-0403-2

• Fischer, Thomas; Gazzola, Silvia; Riedl, Rainer,

  2019.

  Approaching target selectivity by de novo drug design.

  Expert Opinion on Drug Discovery.

  14(8), pp. 791-803.

  Available from: https://doi.org/10.1080/17460441.2019.1615435

• Fischer, Thomas; Senn, Nicole; Riedl, Rainer,

  2019.

  Design and structural evolution of matrix metalloproteinase inhibitors.

  Chemistry – A European Journal.

  25(34), pp. 7960-7980.

  Available from: https://doi.org/10.1002/chem.201805361

• Gall, Flavio; Hohl, Deborah; Frasson, David; Wermelinger, Tobias; Mittl, Peer R. E.; Sievers, Martin; Riedl, Rainer,

  2019.

  Drug design inspired by nature : crystallographic detection of an auto‐tailored protease inhibitor template.

  Angewandte Chemie: International Edition.

  58(12), pp. 4051-4055.

  Available from: https://doi.org/10.1002/anie.201812348

• Gall, Flavio; Hohl, Deborah; Frasson, David; Wermelinger, Tobias; Mittl, Peer R. E.; Sievers, Martin; Riedl, Rainer,

  2019.

  Von der Natur inspiriertes Wirkstoffdesign : kristallographische Detektion eines selbstgenerierten Inhibitor‐Grundgerüsts.

  Angewandte Chemie.

  131(12), pp. 4091-4096.

  Available from: https://doi.org/10.1002/ange.201812348

• Fischer, Thomas; Koulas, Symeon M.; Tsagkarakou, Anastasia S.; Kyriakis, Efthimios; Stravodimos, George A.; Skamnaki, Vassiliki T.; Liggri, Panagiota G.V.; Zographos, Spyros E.; Riedl, Rainer; Leonidas, Demetres D.,

  2019.

  High consistency of structure-based design and x-ray crystallography : design, synthesis, kinetic evaluation and crystallographic binding mode determination of biphenyl-N-acyl-β-D-glucopyranosylamines as glycogen phosphorylase inhibitors.

  Molecules.

  24(7), pp. 1322.

  Available from: https://doi.org/10.3390/molecules24071322

• Fischer, Thomas; Riedl, Rainer,

  2019.

  Inhibitory antibodies designed for matrix metalloproteinase modulation.

  Molecules.

  24(12), pp. 2265.

  Available from: https://doi.org/10.3390/molecules24122265

• Kalbermatter, David; Shrestha, Neeta; Ader-Ebert, Nadine; Herren, Michael; Moll, Pascal; Plemper, Richard K.; Altmann, Karl-Heinz; Langedijk, Johannes P.; Gall, Flavio; Lindenmann, Urs; Riedl, Rainer; Fotiadis, Dimitrios; Plattet, Philippe,

  2018.

  Primary resistance mechanism of the canine distemper virus fusion protein against a small-molecule membrane fusion inhibitor.

  Virus Research.

  259, pp. 28-37.

  Available from: https://doi.org/10.1016/j.virusres.2018.10.003

• Agnello, Stefano; Brand, Michael; Chellat, Mathieu; Gazzola, Silvia; Riedl, Rainer,

  2018.

  A Structural view on medicinal chemistry strategies against drug resistance.

  Angewandte Chemie.

  58(11), pp. 3300-3345.

  Available from: https://doi.org/10.1002/anie.201802416

• Agnello, Stefano; Brand, Michael; Chellat, Mathieu; Gazzola, Silvia; Riedl, Rainer,

  2018.

  Eine strukturelle Evaluierung medizinalchemischer Strategien gegen Wirkstoffresistenzen.

  Angewandte Chemie.

  131(11), pp. 3336-3383.

  Available from: https://doi.org/10.1002/ange.201802416

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017).

  ChemistryOpen.

  6(2), pp. 165.

  Available from: https://doi.org/10.1002/open.201700043

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Cover profile : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor.

  ChemistryOpen.

  6(2), pp. 167.

  Available from: https://doi.org/10.1002/open.201700042

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor.

  Molecules.

  22(9).

  Available from: https://doi.org/10.3390/molecules22091548

• Abu Eid, Sameer; Adams, Michael; Scherer, Thomas; Torres-Gómez, Héctor Manuel; Hackl, Martina Theresa; Kaplanian, Mairam; Riedl, Rainer; Luger, Anton; Fürnsinn, Clemens,

  2017.

  Emodin : a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents.

  European Journal of Pharmacology.

  798, pp. 77-84.

  Available from: https://doi.org/10.1016/j.ejphar.2017.01.022

• Chellat, Mathieu F.; Riedl, Rainer,

  2017.

  Pseudouridimycin : das erste Nukleosid-Analogon, das bakterielle RNA-Polymerase selektiv inhibiert.

  Angewandte Chemie.

  129(43), pp. 13364-13366.

  Available from: https://doi.org/10.1002/ange.201708133

• Chellat, Mathieu F.; Riedl, Rainer,

  2017.

  Pseudouridimycin : the first nucleoside analogue that selectively inhibits bacterial RNA polymerase.

  Angewandte Chemie: International Edition.

  56(43), pp. 13184-13186.

  Available from: https://doi.org/10.1002/anie.201708133

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor.

  ChemistryOpen.

  6(2), pp. 192-195.

  Available from: https://doi.org/10.1002/open.201600158

• Senn, Nicole; Ott, Michael; Lanz, Jan; Riedl, Rainer,

  2017.

  Targeted polypharmacology : discovery of a highly potent non-hydroxamate dual matrix metalloproteinase (MMP)-10/-13 inhibitor.

  Journal of Medicinal Chemistry.

  60(23), pp. 9585-9598.

  Available from: https://doi.org/10.1021/acs.jmedchem.7b01001

• Chellat, Mathieu F.; Raguž, Luka; Riedl, Rainer,

  2016.

  Antibiotikaresistenzen gezielt überwinden.

  Angewandte Chemie.

  128(23), pp. 6710-6738.

  Available from: https://doi.org/10.1002/ange.201506818

• Fischer, Thomas; Riedl, Rainer,

  2016.

  Molecular recognition of the catalytic zinc(II) ion in MMP-13 : structure-based evolution of an allosteric inhibitor to dual binding mode inhibitors with improved lipophilic ligand efficiencies.

  International Journal of Molecular Sciences.

  17(3/314).

  Available from: https://doi.org/10.3390/ijms17030314

• Chellat, Mathieu F.; Raguž, Luka; Riedl, Rainer,

  2016.

  Targeting antibiotic resistance.

  Angewandte Chemie: International Edition.

  55(23), pp. 6600-6626.

  Available from: https://doi.org/10.1002/anie.201506818

• Todorova, Milka; Trendafilova, Antoaneta; Danova, Kalina; Simmons, Luke; Wolfram, Evelyn; Meier, Beat; Riedl, Rainer; Evstatieva, Luba,

  2015.

  Highly oxygenated sesquiterpenes in Artemisia alba Turra.

  Phytochemistry.

  110, pp. 140-149.

  Available from: https://doi.org/10.1016/j.phytochem.2014.12.008

• Lanz, Jan; Riedl, Rainer,

  2015.

  Merging allosteric and active site binding motifs : de novo generation of target selectivity and potency via natural-product-derived fragments.

  ChemMedChem.

  10(3), pp. 451-454.

  Available from: https://doi.org/10.1002/cmdc.201402478

• Fischer, Thomas; Riedl, Rainer,

  2013.

  Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors.

  ChemMedChem.

  8(9), pp. 1457-1461.

  Available from: https://doi.org/10.1002/cmdc.201300278

• Höck, Stefan; Riedl, Rainer,

  2012.

  chemf : a purely functional chemistry toolkit.

  Journal of Cheminformatics.

  4(38).

  Available from: https://doi.org/10.1186/1758-2946-4-38

• Höck, Stefan; Riedl, Rainer,

  2012.

  CyBy2 : a structure-based data management tool for chemical and biological data.

  Chimia.

  66(3), pp. 132-134.

  Available from: https://doi.org/10.2533/chimia.2012.132a

• Höck, Stefan; Marti, Roger; Riedl, Rainer; Simeunovic, Marina,

  2010.

  Thermal cleavage of the Fmoc protection group.

  Chimia.

  64(3), pp. 200-202.

  Available from: https://doi.org/10.2533/chimia.2010.200

• Heuser, Stefan; Barrett, David G.; Berg, Martina; Bonnier, Benjamin; Kahl, Astrid; Luz De La Puente, Maria; Oram, Niall; Riedl, Rainer; Roettig, Ulrike; Gil, Gema Sanz; Seger, Erich; Steggles, David J.; Wanner, Jutta; Weichert, Andreas G.,

  2006.

  Synthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators.

  Tetrahedron Letters.

  47(16), pp. 2675-2678.

  Available from: https://doi.org/10.1016/j.tetlet.2006.02.110

• Supekova, Lubica; Pezacki, John Paul; Su, Andrew I.; Loweth, Colin J.; Riedl, Rainer; Geierstanger, Bernhard; Schultz, Peter G.; Wemmer, David E.,

  2002.

  Genomic effects of polyamide/DNA interactions on mRNA expression.

  Chemistry & Biology.

  9(7), pp. 821-827.

  Available from: https://doi.org/10.1016/S1074-5521(02)00174-6

• Berkessel, Albrecht; Riedl, Rainer,

  2000.

  Combinatorial de novo synthesis of catalysts : how much of a hit-structure is needed for activity?.

  Journal of Combinatorial Chemistry.

  2(3), pp. 215-219.

  Available from: https://doi.org/10.1021/cc990073i

• Riedl, Rainer; Tappe, Robert; Berkessel, Albrecht,

  1998.

  Probing the scope of the asymmetric dihydroxylation of polymer-bound olefins : monitoring by HRMAS NMR allows for reaction control and on-bead measurement of enantiomeric excess.

  Journal of the American Chemical Society.

  120(35), pp. 8994-9000.

  Available from: https://doi.org/10.1021/ja980183d

• Berkessel, Albrecht; Riedl, Rainer,

  1997.

  Fluorescence reporters for phosphodiesterase activity.

  Angewandte Chemie: International Edition.

  36(13-14), pp. 1481-1483.

  Available from: https://doi.org/10.1002/anie.199714811

• Berkessel, Albrecht; Riedl, Rainer,

  1997.

  Fluoreszenz-Reporter für Phosphodiesterase-Aktivität.

  Angewandte Chemie.

  109(13-14), pp. 1518-1520.

  Available from: https://doi.org/10.1002/ange.19971091313

• Riedl, Rainer,

  1998.

  Kombinatorische de novo Synthese von künstlichen Phosphorsäurediesterasen : Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Universität zu Köln.

  Köln:

  Universität zu Köln.

  Available from: http://kups.ub.uni-koeln.de/573/

• Riedl, Rainer,

  2023.

  Development of small-molecule drugs for the treatment of leukemia.

  Transfer.

  2023(1), pp. 7.

  Available from: https://doi.org/10.21256/zhaw-30047

• Gall, Flavio; Riedl, Rainer; Sievers, Martin; Wermelinger, Tobias; Frasson, David,

  2019.

  Durch die Natur inspiriertes Wirkstoffdesign.

  Transfer.

  2019(1), pp. 6.

  Available from: https://doi.org/10.21256/zhaw-30046

• Gall, Flavio; Hohl, Deborah; Frasson, David; Wermelinger, Tobias; Mittl, Peer R. E.; Sievers, Martin; Riedl, Rainer,

  2019.

  Cover picture : drug design inspired by nature : crystallographic detection of an auto‐tailored protease inhibitor template (Angew. Chem. Int. Ed. 12/2019).

  Angewandte Chemie: International Edition.

  58(12), pp. 3653.

  Available from: https://doi.org/10.1002/anie.201901671

• Riedl, Rainer,

  2014.

  Fighting the resistance.

  Horizon 2020 Projects.

  2014(4), pp. 130.

• Riedl, Rainer,

  2014.

  Nicht nur Metalloproteasen im Visier.

  Chemie Plus.

  2014(4), pp. 30-31.

• Riedl, Rainer,

  2013.

  Bridging the disciplines : cancer diagnostics & treatment.

  Pan European Networks: Science & Technology.

  7, pp. 240-241.

• Riedl, Rainer; Höck, Stefan,

  2013.

  CyBy² : clevere Handhabung strukturbasierter Datensätze.

  Transfer.

  2013(1), pp. 3.

  Available from: https://doi.org/10.21256/zhaw-2864

• Riedl, Rainer,

  2013.

  Drug discovery through a chemist’s eyes.

  International Innovation - EuroFocus.

  18, pp. 103.

• Riedl, Rainer,

  2013.

  Organic chemistry : the heart and soul of drug discovery.

  International Innovation - EuroFocus.

  18, pp. 104-105.

• Fischer, Thomas; Riedl, Rainer,

  2012.

  Design, synthesis and biological testing of novel MMP-inhibitors[poster].

  In:

  Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 13 September 2012.

• Riedl, Rainer; Höck, Stefan,

  2012.

  Enhancing CyBy2 : visualization of structure activity relationships of large datasets[poster].

  In:

  Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 13 September 2012.

• Riedl, Rainer; Fischer, Thomas,

  2012.

  Structure based design and synthesis of novel MMP inhibitors[poster].

  In:

  19th EuroQSAR: «Knowledge Enabled Ligand Design», Vienna, Austria, 26-30 August 2012.

• Riedl, Rainer; Brand, Michael,

  2012.

  Synthese und medizinalchemische Optimierung von Tetrazyklinanaloga.

  À Jour: SVC - Chemie, Life Sciences & Biotechnologie.

  2012(1), pp. 10-11.

• Riedl, Rainer; Fischer, Thomas; Züger, Patrik; Brand, Michael,

  2011.

  Structure based design and synthesis of novel MMP inhibitors[poster].

  In:

  Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.

• Riedl, Rainer; Brand, Michael; Sephton, Mark,

  2011.

  Synthesis of tetracycline analogues[poster].

  In:

  Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.

• Riedl, Rainer; Höck, Stefan,

  2011.

  CyBy2 : a modular rich client for the chemical and biological information management[poster].

  In:

  Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.

• Riedl, Rainer; Fischer, Thomas,

  2010.

  Fragment based scaffold hopping in drug discovery[poster].

  In:

  Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 16 September 2010.

• Riedl, Rainer; Höck, Stefan; Kunz, Laura,

  2010.

  Profiling H-bond properties of fragments[poster].

  In:

  Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 16 September 2010.

• Riedl, Rainer,

  2024.

  Competencies in drug discovery.

  In:

  tfz Innovation Inside Pharma, Rotkreuz, Switzerland, 23 October 2024.

• Rimle, Lukas; Pliatsika, Dimanthi; Arnold, Noëlle; Kurth, Sandra; Kaiser, Marcel; Mäser, Pascal; Kemmler, Michael; Adams, Michael; Riedl, Rainer; von Ballmoos, Christoph,

  2024.

  Molecular basis for leucinostatin A toxicity in mammals.

  In:

  22nd European Bioenergetics Conference (EBEC), Innsbruck, Austria, 26-31 August 2024.

  Elsevier.

  Available from: https://doi.org/10.1016/j.bbabio.2024.149316

• Riedl, Rainer,

  2024.

  Center of excellence for drug discovery.

  In:

  Competencies in Drug Discovery, Wädenswil, Switzerland, 6 June 2024.

• Bagatella, S.; Haghayegh Jahromi, N.; Monney, C.; Polidori, M.; Gall, F.M.; Serra, F.; Riedl, R.; Engelhardt, B.; Oevermann, A.,

  2022.

  Microglia, rather than bacterial factors, mediate bovine neutrophil chemotaxis in neurolisteriosis.

  In:

  Annual Congress of the European Society of Veterinary Pathology and European College of Veterinary Pathologists, Athens, Greece, September 7‒10, 2022.

  Elsevier.

  pp. 61.

  Available from: https://doi.org/10.1016/j.jcpa.2023.03.073

• Abu Eid, S.; Adams, M.; Scherer, T.; Torres-Gómez, H.; Hackl, M.T.; Riedl, R.; Luger, A.; Fürnsinn, C.,

  2016.

  Emodin, a compound with acclaimed antidiabetic potential, deteriorates glucose tolerance in obese mice.

  In:

  Abstracts of 52nd EASD Annual Meeting.

  52nd EASD Annual Meeting, Munich, Germany, 12–16 September 2016.

  Springer.

  pp. S343.

  Available from: https://doi.org/10.1007/s00125-016-4046-9

• Abu Eud, Sameer; Adams, Michael; Scherer, Thomas; Torres-Gomez, Hector; Riedl, Rainer; Luger, Anton; Fürnsinn, Clemens,

  2015.

  Emodin, eine mutmaßlich anti-diabetisch wirksame Verbindung, beeinträchtigt die Glukosetoleranz adipöser Mäuse.

  In:

  16. Jahrestagung der Österreichischen Adipositas Gesellschaft: „Adipositas 2015, Vision & Wirklichkeit“, Wien, Österreich, 23.–24. Oktober 2015.

  Springer.

  pp. 735.

  Available from: https://doi.org/10.1007/s00508-015-0838-z

• Riedl, Rainer,

  2013.

  Tackling antibiotic resistance.

  In:

  ILMAC 2013, 19. Internationale Fachmesse für Laboratoriums- und Verfahrenstechnik, Messtechnik und Automatik in der Chemie (ILMAC), Basel, 24.-27. September 2013.

• Riedl, Rainer,

  2011.

  Drug discovery in the academic setting.

  In:

  3. Wädenswiler Chemietag «Medizinalchemie - Fokus Wirkstoffentwicklung», Wädenswil, 16. Juni 2011.

• Riedl, Rainer,

  2010.

  Structure activity relationship within a gene switching system.

  In:

  Symposium - Synthetic Biotechnology, Basel, 18.-19. November 2010.

• Riedl, Rainer,

  2010.

  Structure based drug design.

  In:

  Biotech in Medicine - Olten Meeting, Olten, 24. November 2010.

Patents and patent applications

• Riedl, Rainer; Brand, Michael; Bommeli, Elias; Ochsenbein, Adrian; Riether, Carsten,

  2024.

  CD93 inhibitors.

  Patent number WO2024115637 A1

  (2024-06-06)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2024115637A1

• Adams, Michael; Kemmler, Michael; Pliatsika, Dimanthi; Riedl, Rainer,

  2024.

  Topical treatment of skin cancer using oligopeptides.

  Patent number WO2024033418 A1

  (2024-02-15)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2024033418A1

• Knechtle, Philipp; Gombert, Frank Otto; Riedl, Rainer; Lindenmann, Urs; Krebs, Walter; Wipfli, Dennis; Albert, Ina; Wegmann, Sandro; Schmid, Andrina,

  2023.

  Novel antifungal compounds.

  Patent number WO2023001905 A1

  (2023-01-26)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2023001905A1

• So, Alexander; Busso, Natalie; Nasi, Sonia; Brand, Michael; Gall, Flavio Max; Riedl, Rainer; Germann, Stefan,

  2022.

  Methods and compositions for treating conditions associated with hypermineralization.

  Patent number WO2022194953 A1

  (2022-09-22)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022194953A1

• So, Alexander; Busso, Natalie; Nasi, Sonia; Brand, Michael; Gall, Flavio; Riedl, Rainer,

  2022.

  Methods and compositions for treating conditions associated with hypermineralization.

  Patent number EP4059498 A1

  (2022-09-21)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DEP4059498A1

• Adams, Michael; Kemmler, Michael; Riedl, Rainer; Pliatsika, Dimanthi; Imanidis, Georgios; Herzig, Susanne; Kaiser, Marcel; Mäser, Pascal,

  2022.

  Treatment of skin disorders.

  Patent number WO2022167656 A1

  (2022-08-11)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022167656A1

• Agnello, Stefano; Adams, Michael; Kaiser, Marcel; Mäser, Pascal; Urban, Alexander; Raguz, Luka; Riedl, Rainer,

  2018.

  Antiprotozoal compounds.

  Patent number EP3345917 A1

  (2018-07-11)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DEP3345917A1

• Schneider, Peter; Riedl, Rainer; Tigges, Marcel; Gitzinger, Marc; Pieren, Michel; Levi, Assaf; Sephton, Mark; Schellhorn, Birgit; Züger, Patrik; Brand, Michael; Gygax, Daniel; Spies, Peter,

  2015.

  Composition for treatment of pathogens that are resistant to tetracyclines.

  Patent number EP2950793 A1

  (2015-12-09)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DEP2950793A1

• Weichert, Andreas Gerhard; Barrett, David Gene; Heuser, Stefan; Riedl, Rainer; Tebbe, Mark Joseph; Zaliani, Andrea,

  2011.

  Substituted arylcyclopropylacetamides as glucokinase activators.

  Patent number EP1585739 B1

  (2011-04-20)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DEP1585739B1

• Weichert, Andreas; Barrett, David; Heuser, Stefan; Riedl, Rainer; Tebbe, Mark; Zaliani, Andrea,

  2004.

  Heteroaryl compounds.

  Patent number WO2004063194 A1

  (2004-07-29)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2004063194A1

Affiliations

Current Affiliations

• Consulting
  Consulting activities in the field of pharmaceutical drug discovery and drug development for the company Ultimate Medicine AG, founded and registered in Switzerland under company number CHE-438.939.011., Zürich
  08 / 2024 - today
• Consulting
  Member of the evaluation commission of the Czech Academy of Sciences for the evaluation of the institute of organic chemistry and biochemistry, Prague, Prag
  04 / 2025 - 12 / 2025

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