Developing a gasotransmitter based treatment for pathological skin and tendon calcification
Key data
Projectlead
Project team
Stefan Germann
Project partners
Sulfiscon SA; Centre hospitalier universitaire vaudois CHUV
Project status
completed, 10/2021 - 09/2023
Institute/Centre
Institute of Chemistry and Biotechnology (ICBT)
Funding partner
Innovationsprojekt / Projekt Nr. 56394.1 IP-LS
Publications
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Allosteric activators of cystathionine γ lyase to augment endogenous hydrogen sulfide and inhibit pathologic calcification
2025 Nasi, Sonia; Ehirchiou, Driss; Blatter, Cindy; Chobaz, Veronique; Germann, Stefan; Brandenberger, Alexandra; Bommeli, Elias; Uchikawa, Emiko; Cirino, Giuseppe; Riedl, Rainer; So, Alexander; Busso, Nathalie
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Development of allosteric activators of cystathionine γ lyase (CSE) to augment hydrogen sulfide (H2S) and inhibit pathologic cartilage calcification
2025 Ehirchiou, Driss; Nasi, Sonia; Chobaz, Véronique; Riedl, Rainer; Germann, Stefan; Brandenberger, Alexandra; Bommeli, Elias; Blatter, Cindy; Cirino, Giuseppe; So, Alexander; Busso, Nathalie
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Development of allosteric activators of cystathionine γ lyase (CSE) to augment hydrogen sulfide (H2S) and inhibit pathologic cartilage calcification
2025 Ehirchiou, Driss; Nasi, Sonia; Chobaz, Véronique; Riedl, Rainer; Blatter, Cindy; Germann, Stefan; Brandenberger, Alexandra; Bommeli, Elias; So, Alexander; Busso, Nathalie
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Positive allosteric modulators (PAMS) of cystathionine gamma lyase (CSE) increase hydrogen sulfide (H2S) and inhibit NLRP3 activation
2025 Ehirchiou, Driss; Chirayath, Twinu; Nasi, Sonia; Chobaz, Veronique; Riedl, Rainer; Blatter, Cindy; Germann, Stefan; Brandenberger, Alexandra; Bommeli, Elias; Busso, Nathalie; So, Alexander