Dr.-Ing. Cedric Schirmer

ZHAW Life Sciences und Facility Management
Fachstelle Biokatalyse und Prozesstechnologie
Grüentalstrasse 14
8820 Wädenswil

+41 (0) 58 934 54 64
cedric.schirmer@zhaw.ch

Arbeit an der ZHAW

Tätigkeit

Dozent
Stellvertretender Leiter Fachgruppe Bioprozesstechnologie

Arbeits- und Forschungsschwerpunkte

Verfahrenstechnische Charakterisierung und Entwicklung von Bioreaktoren
Bioprozess-, Verfahrens- und Fermentationstechnik
Scale-up von mikrobiellen und zellkulturtechnischen Prozessen
Single-use Technologie für die biopharmazeutische Produktion
Computational Fluid Dynamics (CFD)
Zellkulturtechnik, tierische Zellen, humane mesenchymale Stammzellen

Netzwerk

Mitglied in Netzwerken

DECHEMA

ORCID digital identifier

ORCID ID: 0000-0002-5779-4337

Projekte

Publikationen

Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed

Schirmer, C., Eibl-Schindler, R., Maschke, R., Mozaffari, F., Junne, S., Daumke, R., Ottinger, M., Göhmann, R., Ott, C., Wenk, I., Kubischik, J., & Eibl, D. (2022). Single‐use technology for the production of cellular agricultural products : where are we today? Chemie Ingenieur Technik, 94(12), 2018–2025. https://doi.org/10.1002/cite.202200092
Ott, V., Müller, J., Schirmer, C., Weiss, N., Göhmann, R., Biewald, A., Michel, A., Eibl, D., & Eibl-Schindler, R. (2022). Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production. Chemie Ingenieur Technik, 94(12), 1936–1943. https://doi.org/10.1002/cite.202200096
Schirmer, C., Maschke, R., Pörtner, R., & Eibl, D. (2021). An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-021-11180-7
Schirmer, C., Blaschczok, K., Husemann, U., Leupold, M., Zahnow, C., Rupprecht, J., Glöckler, R., Greller, G., Pörtner, R., Eibl-Schindler, R., & Eibl, D. (2017). Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes. Chemie Ingenieur Technik, 89(12). https://doi.org/10.1002/cite.201700039
Jossen, V., Schirmer, C., Mostafa Sindi, D., Eibl-Schindler, R., Kraume, M., Pörtner, R., & Eibl, D. (2016). Theoretical and practical issues that are relevant when scaling up hMSC microcarrier production processes. Stem Cells International, 2016(4760414). https://doi.org/10.1155/2016/4760414

Buchbeiträge, peer-reviewed

Seidel, S., Schirmer, C., Maschke, R., Rossi, L., Eibl-Schindler, R., & Eibl, D. (2023). Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review. In G. Ji & J. Dong (Eds.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications (pp. 53–82). IntechOpen Limited. https://doi.org/10.5772/intechopen.109848
Seidel, S., Schirmer, C., Maschke, R., Rossi, L., Eibl-Schindler, R., & Eibl, D. (2023). Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies. In G. Ji & J. Dong (Eds.), Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications (pp. 83–98). IntechOpen Limited. https://doi.org/10.5772/intechopen.109849
Schirmer, C., Müller, J., Steffen, N., Werner, S., Eibl-Schindler, R., & Eibl, D. (2020). How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale. In R. Pörtner (Ed.), Animal cell biotechnology : methods and protocols (pp. 169–186). Springer. https://doi.org/10.1007/978-1-0716-0191-4_10
Schirmer, C., Rothe, S., Jenness, E., & Eibl, D. (2019). Systems for coupling and sampling. In R. Eibl & D. Eibl (Eds.), Single-use technology in biopharmaceutical manufacture (pp. 53–68). Wiley. https://doi.org/10.1002/9781119477891.ch5
Schirmer, C., Nussbaumer, T., Schöb, R., Pörtner, R., Eibl-Schindler, R., & Eibl, D. (2018). Development, engineering and biological characterization of stirred tank bioreactors. In M.-K. Yeh & Y.-C. Chen (Eds.), Biopharmaceuticals (pp. 87–107). IntechOpen. https://doi.org/10.5772/intechopen.79444

Schriftliche Konferenzbeiträge, peer-reviewed

Schirmer, C., Nussbaumer, T., & Schöb, R. (2025, May). A small-scale bioreactor concept with magnetically levitated stirrer. Himmelfahrtstagung on Bioprocess Engineering 2025, Bremen, Germany, 26-28 May 2025. https://doi.org/10.21256/zhaw-33275
Schirmer, C., Ott, V., Müller, J., Göhmann, R., Biewald, A., Eibl-Schindler, R., & Eibl, D. (2022, June). Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale. 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.

Weitere Publikationen

Ott, V., Müller, J., Eibl-Schindler, R., Eibl, D., Schirmer, C., Göhmann, R., & Biewald, A. (2022, March). A new single-use disk stack separator for pilot scale CHO cell-based antibody productions. ECI: Single-Use Technologies V: Building the Future, Marseille, France, 20-23 March 2022.
Schirmer, C., Ott, V., John, G. T., & Eibl, D. (2020). Integration of chemical-optical oxygen and pH sensors in existing control units : cultivation monitoring in a glass bioreactor system with subsequently integrated sensor spots. PreSens Publications. https://www.presens.de/knowledge/publications/application-note/integration-of-chemical-optical-oxygen-and-ph-sensors-in-existing-control-units-1692
Werner, S., Schirmer, C., Steffen, N., Müller, J., Becheau, O., Cameau, E., Welsh, J. H., Jones, K., Capone, J., & Collignon, M.-L. (2019). Performance comparison of CHO-S cell cultivation and mAb production in the Allegro™ STR 200 single-use bioreactor and in conventional single-use bioreactor. 26th ESACT Meeting, Copenhagen, Denmark, 5-8 May 2019. https://www.pall.com/en/biotech/posters-presentations/performance-comparison-cho-s-cell-cultivation-mab-production-allegro-str-200-single-use-bioreactor-conventional-single-use-bioreactor.html
Schirmer, C., Dreher, T., Leupold, M., Glaser, R., Castan, A., Brown, J., Eibl, D., & Glöckler, R. (2019). Recommendation for biological evaluation of bioreactor performance for microbial processes (2. revised edition). DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V. https://dechema.de/dechema_media/Downloads/Positionspapiere/SingleUse_Microbial_ezl+2Ed+Sept2019-p-20005491.pdf
Rossi, L., Schirmer, C., Teale, M., Kurt, F., Rosenthal, F., & Eibl, D. (2019, July). Proof of concept study for cultivation of strict anaerobes in a single-use wave-mixed bioreactor. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.
Schirmer, C., Nussbaumer, T., Schöb, R., Pörtner, R., & Eibl, D. (2019, July). Development of an universally useable single-use bioreactor for the benchtop scale. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.
Schirmer, C., Nussbaumer, T., Schöb, R., Pörtner, R., & Eibl, D. (2019, May). A universal stirred bioreactor for the development of biotherapeutics. DECHEMA Himmelfahrtstagung: Intensification and Digitalisation for Integral Bioprocessing, Hamburg, Germany, 27-29 May 2019.
Schirmer, C., & Eibl, D. (2017). Rührwerk für moderne Bioreaktoren. Transfer, 2017(2), 4. https://doi.org/10.21256/zhaw-19304
von Blarer, D., Senn, Y., Kienle, K., Schirmer, C., Blaschczok, K., Husemann, U., Greller, G., Leupold, M., Rupprecht, J., Glöckler, R., & Eibl, D. (2016, September). Biological bioreactor characterization by means of an Escherichia coli model process. BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.
Jossen, V., Schirmer, C., Eibl-Schindler, R., Kraume, M., Pörtner, R., & Eibl, D. (2016, September). Expansion of human adipose tissue-derived stromal/stem cells in a wave-mixed single-use bioreactor : a proof-of-concept. BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.
Jossen, V., Schirmer, C., Eibl-Schindler, R., Kraume, M., Pörtner, R., & Eibl, D. (2016, April). How to successfully scale up a microcarrier based expansion process of human mesenchymal stem cells from adipose tissue. 4th BioProScale Symposium 2016, Berlin, Germany, 6-8 April 2016.

Mündliche Konferenzbeiträge und Abstracts

Schirmer, C. (2024, November 7). Implementation of an adaptive illumination strategy for algae growth in stirred systems. Bioprocess Symposium, Bern, Switzerland, 7 November 2024.
Schirmer, C. (2024, June 20). Magnetic levitation technology for stirred bioreactors : integration and evaluation. Levitronix Bioprocessing Conference 2024, Boston, MA, USA, 20 June 2024. https://www.levitronix.com/app/uploads/2024/07/Cedric-Shirmer_1_1.mp4
Schirmer, C. (2022, September 12). Animal cell culture-based cellular agriculture : basics and challenges of clean meat production. XVI. Biotechnet Summer School on Advanced Biotechnology, Innsbruck, Austria, 12-15 September 2022.
Seidel, S., Schirmer, C., & Eibl, D. (2022, June 2). Integration of a drive system based on magnetic levitation technology to power a stirred bioreactor. Levitronix Bioprocessing Conference, Boston, MA, USA, 2 June 2022. https://www.levitronix.com/app/uploads/2022/06/Stefan-2_1.mp4
Schirmer, C. (2020, May 27). Shear stress investigations on Levitronix single-use centrifugal pumps. Levitronix Bioprocessing Conference, Live Webinar Part 2, 27 May 2020.
Schirmer, C., & Kienle, K. (2019, July). Comparison of stirred single-use bioreactors : case study of an IgG production process. BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.
Schirmer, C. (2019, May). Biological evaluation of bioreactor performance for microbial processes. Knowledge Culture Workshop : Large-Scale Fermentation, Cramlington, United Kingdom, May 2019.
Jossen, V., Schirmer, C., Eibl-Schindler, R., Kraume, M., & Pörtner, R. (2017, May). Standardized expansion of human adipose tissue-derived stromal/stem cells (hASCs) in wave-mixed single-use bioreactors with one-dimensional motion. ECI: Single Use Technologies II: Bridging Polymer Science to Bioprocess Applications, Tomar, Portugal, 7–10 May 2017. https://pdfs.semanticscholar.org/9a61/98bcd2e950104f1457e8f0e7c7380323ebf5.pdf
Schirmer, C., Jossen, V., Mostafa Sindi, D., Eibl-Schindler, R., Böttcher, L., & Eibl, D. (2016). Standardized expansion of human mesenchymal stem cells in wave-mixed single-use bioreactors. ILMAC, Basel, 2016.

Publikationen vor Tätigkeit an der ZHAW

Goepfert, Christiane; Blume, Grit; Faschian, Rebecca; Meyer, Stefanie; Schirmer, Cedric; Müller-Wichards, Wiebke; Müller, Jörg; Fischer, Janine; Feyerabend, Frank; Pörtner, Ralf, 2013. A modular flow-chamber bioreactor concept as a tool for continuous 2D- and 3D-cell culture. BMC Proceedings.7(Suppl 6),P87.
Pörtner, Ralf; Goepfert, Christiane; Schirmer, Cedric; Hsu, Hao-Hsiang; Blume, Grit; Voigt, Miriam; Rapoport, Daniel Hans, 2016. Reaktionstechnische Charakterisierung von Bioreaktoren für die regenerative Medizin. In: Beckmann, D; Kaufhold, S, Hrsg., 18. Heiligenstädter Kolloquium: Technische Systeme für die Lebenswissenschaften. Heilbad-Heiligenstadt: Institut für Bioprozess- und Analysenmesstechnik e.V. S. 575-582. ISBN: 978-3-00-054165-0.

Übrige Publikationen

Schirmer, Cedric; Eibl, Dieter, 2018. Shear stress investigations of the magnetically levitated single-use centrifugal pump PuraLev® 600SU using the protein shear stress model for lysozyme, Zurich, Levitronix GmbH.

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