Dr. Epifania Bono

Arbeit an der ZHAW

Tätigkeit

Wissenschaftliche Mitarbeiterin in Tissue Engineering und Automated Systems

Arbeits- und Forschungsschwerpunkte

Bioprinting / Primary human cell cultures (healthy, cancer) / Scaffold-free and scaffold-based 3D cell cultures / Automated 3D cell cultures / Tissues of interest : bone, muscle, liver, kidney, skin, osteosarcoma / Drug and substance screening

Berufserfahrung

Postdoc
Ibim CNR
10 / 2005 - 10 / 2006

Aus- und Weiterbildung

Ausbildung

• Dr. rer. nat. / Zell und Molekularbiologie
  Universität vom Palermo
  09 / 2002 - 01 / 2006
• Biologie Abschluss / Biologie
  Universität vom Palermo
  09 / 1996 - 12 / 2001

Netzwerk

Social Media

• Linkedin
• ResearchGate

Projekte

• Bioprinting von Biofilmen / Teammitglied / abgeschlossen

Publikationen

Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed

• Deshmukh, D. V., Vuille‐dit‐Bille, E., Joshi, S., Gerber, N., Fux, C., Eichenberger, A., Bono, E., Rimann, M., Heub, S., Migliozzi, D., Boder‐Pasche, S., Weder, G., Dual, J., & Tibbitt, M. W. (2026). Acoustofluidic patterning for improved microtissue histology. Advanced NanoBiomed Research. https://doi.org/10.1002/anbr.202500079
• Zumofen, L., Kopanska, K. S., Bono, E., Kirchheim, A., De Haller, E. B., & Graf-Hausner, U. (2022). Properties of additive-manufactured open porous titanium structures for patient-specific load-bearing implants. Frontiers in Mechanical Engineering, 7(830126). https://doi.org/10.3389/fmech.2021.830126
• Alave Reyes-Furrer, A., De Andrade, S., Bachmann, D., Jeker, H., Steinmann, M., Accart, N., Dunbar, A., Rausch, M., Bono, E., Rimann, M., & Keller, H. (2021). Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses. Communications Biology, 4(1), 1183. https://doi.org/10.1038/s42003-021-02691-0
• Hendrawan, S., Bono, E., Hutter, A., Weber, U., Lheman, J., & Baer, H. U. (2020). Evaluation of 3D PLLA scaffolds coated with nano‐thick collagen as carrier for hepatocytes. Journal of Biomedical Materials Research Part B : Applied Biomaterials, 109(5), 723–732. https://doi.org/10.1002/jbm.b.34738
• Hirsch, C., Striegl, B., Mathes, S., Adlhart, C., Edelmann, M., Bono, E., Gaan, S., Salmeia, K. A., Hölting, L., Krebs, A., Nyffeler, J., Pape, R., Bürkle, A., Leist, M., Wick, P., & Schildknecht, S. (2017). Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants. Archives of Toxicology, 91(1), 407–425. https://doi.org/10.1007/s00204-016-1680-4
• Rimann, M., Bono, E., Annaheim, H., Bleisch, M., & Graf-Hausner, U. (2015). Standardized 3D bioprinting of soft tissue models with human primary cells. SLAS Technology: Translating Life Sciences Innovation, 21(4), 496–509. https://doi.org/10.1177/2211068214567146
• Bono, E., Mathes, S. H., Franscini, N., & Graf-Hausner, U. (2010). Tissue Engineering - the gateway to regenerative medicine. Chimia, 64(11), 808–812. https://doi.org/10.2533/chimia.2010.808
• Mauth, C., Bono, E., Haas, S., Paesold, G., Wiese, H., Maier, G., Boos, N., & Graf-Hausner, U. (2009). Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration. European Cells & Materials, 18, 27–39. https://doi.org/10.22203/eCM.v018a03

Schriftliche Konferenzbeiträge, peer-reviewed

Jung, C., Mathes, S., Bono, E., Walker, C., Kessler, A., Straumann, L., de Wild, M., & de Haller, E. (2015). Cell viability on titanium implant surfaces modified with antibacterial copper [Conference poster]. European Cells and Materials, 29, Supplement 2, 24. https://doi.org/10.21256/zhaw-1761

Weitere Publikationen

• Bono, E., Sheard, J., Mikkonen, P., & Rimann, M. (2022, September). Automation of 3D cell culture using cellulose-based scaffolds. Biointerfaces International Conference (BIC), Zurich, Switzerland, 12-15 September 2022. https://doi.org/10.21256/zhaw-25998
• Bono, E. (2020). Automated 3D cell culture using Corning® 96-well spheroid microplates on the Fluent® automation workstation. Tecan.
• Bono, E., Mathes, S., & Rimann, M. (2017). Evaluation of 3D hepatic tissue models for bioprinting. TERMIS-EU 2017 Conference, Davos, 26-30 June 2017. https://doi.org/10.21256/zhaw-3590
• Bono, E., Evers, C., Schmid, F., Graf-Hausner, U., & Rimann, M. (2017, November). In vitro characterization of a new composite material for biomedical applications and 3D (bio)printing. TEDD Annual Meeting, Wädenswil, 8-9 November 2017. https://doi.org/10.21256/zhaw-3587
• Rimann, M., Bono, E., Picenoni, A., Felley-Bosco, E., Meyer, A., Pelleaux, R., & Hund, C. (2017, June). Development of a matrix-based technology platform for the high throughput analysis of 3D cell cultures. Swiss Medtech Day, Bern, 13 June 2017. https://doi.org/10.21256/zhaw-3588
• Bono, E., Hutter, A., Hendrawan, S., Sutedja, B., Baer, H. U., Weber, U., & Mathes, S. (2016). 3D PLLA-collagen matrices as carrier for hepatocytes (type Chen-Baermed) an in vitro study. Sponsorenanlass Klinik Hirslanden, Zürich, 2016.
• Rimann, M., Laternser, S., Bono, E., Bleisch, M., Eggmann, K., Quidiello, D., Fässler, T., Keller, H., Leupin, O., Rausch, M., Hartmann, L., Alave-Reyes, A., Thurner, M., Scheidegger, A., & Graf-Hausner, U. (2016). A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues. Swiss Medtech Day, Bern, 7 June 2016.
• Bono, E., Hutter, A., Hendrawan, S., Sutedja, B., Baer, H. U., & Mathes, S. (2016, June 7). 3D PLLA-collagen matrices as carriers for hepatocytes. Swiss Medtech Day, Bern, 7 June 2016.
• Mathes, S., Bono, E., Striegl, B., Hettwer, S., Bänziger, S., Suter, B., & Spezzaneve, D. (2016, June 7). Development of an immune responsive in vitro 3D skin model for the examination of the immune suppressive and collagen stimulating activity of cosmetic actives. Swiss Medtech Day, Bern, 7 June 2016.
• Bono, E., Cloes, N., Merk, M., & Mathes, S. (2016, May). In vitro models of human skin models featuring a glycated dermis. 4th International Cosmetic Innovation Days «Cosminnov», Orléans, France, 24-25 May 2016.
• Bono, E., Hutter, A., Hendrawan, S., Sutedja, B., Baer, H. U., & Mathes, S. (2016, April). 3D PLLA-collagen matrices as carriers for hepatocytes. 3D Cell Culture 2016, Freiburg, Germany, 19-21 April 2016.
• Rimann, M., Laternser, S., Bono, E., Keller, H., Leupin, O., Fässler, T., Eggmann, K., Thurner, M., & Graf-Hausner, U. (2015). Bioprinted muscle/tendon for drug assessment. NTN Swiss Biotech Innovation Day: The Potential of Industry-Academia Collaborations, Zug, 19 August 2015.
• Graf-Hausner, U., Rimann, M., Bono, E., Laternser, S., Bleisch, M., Eggmann, K., Quidiello, D., Fässler, T., Keller, H., Leupin, O., Rausch, M., Richter, J., Alave, A., Thurner, M., & Scheidegger, A. (2015, September 8). A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues. CTI Medtech Event, Bern, 8. September 2015.
• Jung, C., Mathes, S., & Bono, E. (2015, May). Cell viability on titanium implant surfaces modified with antibacterial copper. Medical Cluster [MEET THE EXPERTS] – Technologies and Innovation for Cost Reduction, Interlaken, Switzerland, 7–8 May 2015.
• Bono, E., Rimann, M., Annaheim, H., Bleisch, M., Kuster, M., Thurner, M., Meier, C., Bossen, A., & Graf-Hausner, U. (2014). Skin bioprinting : an innovative approach to produce standardized skin models on demand. Swiss Biotech Innovation Day 2014 «the Potential of Industry-Academia Collaborations», Basel, 28 August 2014.
• Graf-Hausner, U., Rimann, M., Bono, E., Laternser, S., Bleisch, M., Eggmann, K., Quidiello, D., Munz, P., Hauer, M., Keller, H., Richter, J., Alave, A., Leupin, O., Thurner, M., & Scheidegger, A. (2014, September). A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues. CTI Medtech Event, Bern, 2. September 2014.
• Pörtner, R., Wagner, I., Atanasova, T., Gautam, R., Gattlen, J., Rimann, M., Bono, E., Graf-Hausner, U., & Marx, U. (2014). Aktuelle Trends bei der in vitro-Substanztestung in Deutschland und in der Schweiz. BIOspektrum, 20(4), 470–472. https://doi.org/10.1007/s12268-014-0466-6
• Striegl, B., Grad, S., Eglin, D., Benneker, L., Peroglio, M., Alini, M., Graf-Hausner, U., & Bono, E. (2012). Cell-seeded thermoreversible hydrogel-polyurethane composites for nucleus pulposus augmentation. Proceedings of the 3D Cell Culture 2012 Congress. https://doi.org/10.21256/zhaw-1752
• Santini, D., Bono, E., Schmid, D., Mathes, S., & Graf-Hausner, U. (2012). Tissue engineering for drug development : defined organotypic skin models. 3D Cell Culture 2012: Zurich, 14-16 March 2012. https://doi.org/10.21256/zhaw-1753
• Striegl, B., Grad, S., Eglin, D., Benneker, L., Bono, E., Alini, M., Graf-Hausner, U., & Peroglio, M. (2012). Human disc cells and mesenchymal stem cells differentiation in a thermoreversible hydrogel : an in vitro and ex-vivo study. Orthopaedic Research Society Congress, San Francisco, USA, 4-7 February 2012.
• Graf-Hausner, U., Schmid, D., & Bono, E. (2011). Plant extracts to overcome negative effects of glycation in human skin. CTI Medtech Event 2011, Bern, 23. August 2011. https://doi.org/10.21256/zhaw-1750
• Striegl, B., Grad, S., Eglin, D., Benneker, L., Bono, E., Alini, M., Graf-Hausner, U., & Peroglio, M. (2011). Ex-vivo evaluation of thermoreversible hylauronan-based hydrogel as mesenchymal stem cells carrier for nucleus pulposus repair. Proceedings of the New Horizons in Intervertebral Disc Research Conference.
• Franscini, N., Bono, E., Durner, R., Wuertz, K., Boos, N., & Graf-Hausner, U. (2010). Disc regeneration : automation for a new cell-based approach. eCM XI «Cartilage & Disc: Repair and Regeneration», Davos, 28-30 June 2010.
• Mauth, C., Bono, E., De Wild, M., Molenberg, A., Farine, H., Dard, M., & Graf-Hausner, U. (2010). Development of a smart biomaterial for osseointegration in oral defects. Tissue Engineering and Regenerative Medicine International Societym, Galway, Ireland, 13 June 2010.
• Mauth, C., Bono, E., Gruber, R., Goebel, E., Molenberg, A., De Wild, M., Schiephake, H., Dard, M., & Graf-Hausner, U. (2010). SMART biomaterial : bioactive synthetic bone repair material for large oral bone defects. CTI Medtech Event, Bern, 31. August 2010.
• Franscini, N., Bono, E., Würtz, K., Patocchi-Tenzer, I., Durner, R., Boos, N., & Graf-Hausner, U. (2009). Intervertebral disc degeneration : automation of tissue culture processes for regenerative medicine. Annual Meeting European Society for Artificial Organs, Compiègne, France, 2-5 September 2009.
• Franscini, N., Bono, E., Würtz, K., Patocchi-Tenzer, I., Durner, R., Boos, N., & Graf-Hausner, U. (2009). Automation and standardization of tissue culture processes for regenerative medicine. CTI Medtech Event, Bern, 1. September 2009.
• Mauth, C., Molenberg, A., Dard, M., Farine, H., Bono, E., Steinhoff, D., & Graf-Hausner, U. (2009). Bioactive synthetic bone repair material for large oral bone defects. CTI Medtech Event, Bern, 1. September 2009.
• Franscini, N., Bono, E., Patocchi - Tenzer, I., Durner, R., Wuertz, K., Boos, N., & Graf-Hausner, U. (2009). Economic production of quality controlled primary cells for cell based assays by automating tissue culture processes. MipTech - the Leading European Event for Drug Discovery, Basel, 13-15 October 2009.
• Mauth, C., Molenberg, A., Dard, M., Farine, H., Bono, E., Steinhoff, D., & Graf-Hausner, U. (2008). Biomaterial : bioactive synthetic bone repair material for large oral bone. CTI Medtech Event, Bern, 2. September 2008.
• Franscini, N., Bono, E., Würtz, K., Patocchi-Tenzer, I., Durner, R., Boos, N., & Graf-Hausner, U. (2008). Automation and standardization of tissue culture processes for regenerative medicine. CTI Medtech Event, Bern, 2. September 2008.

Mündliche Konferenzbeiträge und Abstracts

• Rimann, M., Bono, E., Laternser, S., Nosswitz, M., Morel, A., Keller, H., Leupin, O., Wagner, C., Graf-Hausner, U., & Raghunath, M. (2017). 3D bioprinted tissue models for substance testing. International Conference and Exhibition - Society for Laboratory Automation and Screening (SLAS 2017), Washington, USA, 4–8 February 2017.
• Rimann, M., Bono, E., Laternser, S., Nosswitz, M., Morel, A., Keller, H., Leupin, O., Wagner, C., & Graf-Hausner, U. (2016). 3D tissue models : new perspectives in medicine. 2016 Conference and Exhibition for Cutting-Edge Medicine (CLINAM 9), Basel, 26-29 June 2016.
• Rimann, M., Mathes, S., Bono, E., Laternser, S., Nosswitz, M., Morel, A., Keller, H., Leupin, O., & Graf-Hausner, U. (2016). 3D models for compound testing. 3rd 3D Models & Drug Screening Conference, Berlin, Germany, 11-12 May 2016.
• Graf-Hausner, U., Rimann, M., Laternser, S., Bono, E., Eggmann, K., Quidiello, D., Fässler, T., Keller, H., Leupin, O., Rausch, M., Hartmann, L., Alave-Reyes, A., Thurner, M., & Scheidegger, A. (2016). A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues. Swiss Medtech Day, Bern, 7 June 2016.
• Rimann, M., Bono, E., Laternser, S., Nosswitz, M., Morel, A., Keller, H., Leupin, O., Wagner, C., & Graf-Hausner, U. (2016). Bioprinted tissue models for substance evalution. Basel Life Science Week 2016, Basel, 19-23 September 2016.
• Rimann, M., Bono, E., Laternser, S., Nosswitz, M., Morel, A., Keller, H., Leupin, O., Wagner, C., Graf-Hausner, U., & Raghunath, M. (2016). Bioprinted tissues for substance evaluation. Biointerfaces International 2016 Conference, Zurich, 23-25 August 2016.
• Bono, E., Rimann, M., Annaheim, H., Bleisch, M., Kuster, M., Thurner, M., & Graf-Hausner, U. (2016, May). Standardized 3D bioprinting of skin models for drug development. 4th International Cosmetic Innovation Days «Cosminnov», Orléans, France, 24-25 May 2016.
• Rimann, M., Laternser, S., Bono, E., Nosswitz, M., Keller, H., Leupin, O., Wagner, C., & Graf-Hausner, U. (2016, April). Bioprinted tissues for substance testing. 3D Cell Culture 2016, Freiburg, Germany, 19-21 April 2016.
• Rimann, M., Bono, E., Laternser, S., Keller, H., Leupin, O., & Graf-Hausner, U. (2015). Bioprinted soft tissue models for compound testing. International Conference on Biofabrication (Biofabrication 2015), Utrecht, Netherlands, 7-9 November 2015.
• Rimann, M., Bono, E., Laternser, S., Nosswitz, M., Morel, A., Keller, H., Leupin, O., Wagner, C., & Graf-Hausner, U. (2015). Soft tissue bioprinting in tissue engineering for drug development. Olten Meeting 2015: Antibiotics and Bioprinting - for a Better Life, Biotechnet Switzerland, Olten, 18 November 2015.
• Bono, E., Rimann, M., Annaheim, H., Bleisch, M., Kuster, M., Thurner, M., Meier, C., Bossen, A., & Graf-Hausner, U. (2014, June). Skin bioprinting : an approach to produce standardized skin models on demand. DECHEMA - 3D Cell Culture 2014, Freiburg, Germany, 25-27 June 2014.
• Striegl, B., Grad, S., Benneker, L. M., Bono, E., Alini, M., Graf-Hausner, U., & Peroglio, M. (2012). In vitro evaluation of a thermoreversible hyaluronan-based hydrogel loaded with cell-seeded polyurethane particles for nucleus pulposus repair. World Forum for Spine Research, Helsinki, Finland, 18-21 June 2012.
• Bono, E., Mauth, C., Molenberg, A., Farine, H., Dard, M., & Graf-Hausner, U. (2010). Oral large bone defects : the suitability of a new biomaterial combination. 23rd European Conference on Biomaterials (ESB 2010), Tampere, 11-15 September 2010.
• Bono, E., Mauth, C., Franscini, N., Durner, R., Boos, N., & Graf-Hausner, U. (2009). Intervertebral disc regeneration : small and large scale systems. 12th Annual Seminar & Meeting - Ceramics, Cells and Tissues, Faenza, Italy, 1 May 2009.
• Franscini, N., Bono, E., Patocchi - Tenzer, I., Durner, R., Wuertz, K., Boos, N., & Graf-Hausner, U. (2009). Intervertebral disc degeneration : automation of tissue culture processes for regenerative medicine applications. Deutscher Wirbelsäule Kongress, München, Deutschland, 10.-12. Dezember 2009.
• Bono, E. (2008). Intervertebral disc augmentation : an alternative. Annual Meeting European Society for Artificial Organs, Geneva, 3.-6. September 2008.
• Bono, E. (2008). Intervertebral disc augmentation : an alternative. International Summer School in Advanced Biotechnology, Palermo, Italy, 2008.
• Bono, E. (2008). Tissue engineering of intervertebral discs : small and large scale options. Swiss-Japanese Meeting on Spine Research, Zurich, 2008.

Publikationen vor Tätigkeit an der ZHAW

• Properties of additive-manufactured open porous titanium structures for patient-specific load-bearing implants
• Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses
• Evaluation of 3D PLLA scaffolds coated with nano‐thick collagen as carrier for hepatocytes
• Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants
• Standardized 3D bioprinting of soft tissue models with human primary cells
• Tissue Engineering - the gateway to regenerative medicine
• Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration

Übrige Publikationen

• Thyroid Hormones Induce Sumoylation of the Cold Shock Domain-Containing Protein PIPPin in Developing Rat Brain and in Cultured Neurons
• Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture

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