Dr. Epifania Bono

Arbeit an der ZHAW

Tätigkeit

Wissenschaftliche Mitarbeiterin in Tissue Engineering und Automated Systems

Arbeits- und Forschungsschwerpunkte

Bioprinting / Primary human cell cultures (healthy, cancer) / Scaffold-free and scaffold-based 3D cell cultures / Automated 3D cell cultures / Tissues of interest : bone, muscle, liver, kidney, skin, osteosarcoma / Drug and substance screening

Berufserfahrung

Postdoc
Ibim CNR
10 / 2005 - 10 / 2006

Aus- und Weiterbildung

Ausbildung

• Dr. rer. nat. / Zell und Molekularbiologie
  Universität vom Palermo
  09 / 2002 - 01 / 2006
• Biologie Abschluss / Biologie
  Universität vom Palermo
  09 / 1996 - 12 / 2001

Netzwerk

Social Media

• Linkedin
• ResearchGate

Projekte

• Bioprinting von Biofilmen / Teammitglied / abgeschlossen

Publikationen

• Zumofen, Livia; Kopanska, Katarzyna S.; Bono, Epifania; Kirchheim, Andreas; De Haller, Emmanuel B.; Graf-Hausner, Ursula,

  2022.

  Properties of additive-manufactured open porous titanium structures for patient-specific load-bearing implants.

  Frontiers in Mechanical Engineering.

  7(830126).

  Verfügbar unter: https://doi.org/10.3389/fmech.2021.830126

• Alave Reyes-Furrer, Angela; De Andrade, Sonia; Bachmann, Dominic; Jeker, Heidi; Steinmann, Martin; Accart, Nathalie; Dunbar, Andrew; Rausch, Martin; Bono, Epifania; Rimann, Markus; Keller, Hansjörg,

  2021.

  Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses.

  Communications Biology.

  4(1), S. 1183.

  Verfügbar unter: https://doi.org/10.1038/s42003-021-02691-0

• Hendrawan, Siufui; Bono, Epifania; Hutter, Albert; Weber, Ursula; Lheman, Jennifer; Baer, Hans U.,

  2020.

  Evaluation of 3D PLLA scaffolds coated with nano‐thick collagen as carrier for hepatocytes.

  Journal of Biomedical Materials Research Part B : Applied Biomaterials.

  109(5), S. 723-732.

  Verfügbar unter: https://doi.org/10.1002/jbm.b.34738

• Hirsch, Cordula; Striegl, Britta; Mathes, Stephanie; Adlhart, Christian; Edelmann, Michael; Bono, Epifania; Gaan, Sabyasachi; Salmeia, Khalifah A.; Hölting, Lise; Krebs, Alice; Nyffeler, Johanna; Pape, Regina; Bürkle, Alexander; Leist, Marcel; Wick, Peter; Schildknecht, Stefan,

  2017.

  Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants.

  Archives of Toxicology.

  91(1), S. 407-425.

  Verfügbar unter: https://doi.org/10.1007/s00204-016-1680-4

• Rimann, Markus; Bono, Epifania; Annaheim, Helene; Bleisch, Matthias; Graf-Hausner, Ursula,

  2015.

  Standardized 3D bioprinting of soft tissue models with human primary cells.

  SLAS Technology: Translating Life Sciences Innovation.

  21(4), S. 496-509.

  Verfügbar unter: https://doi.org/10.1177/2211068214567146

• Bono, Epifania; Mathes, Stephanie H; Franscini, Nicola; Graf-Hausner, Ursula,

  2010.

  Tissue Engineering - the gateway to regenerative medicine.

  Chimia.

  64(11), S. 808-812.

  Verfügbar unter: https://doi.org/10.2533/chimia.2010.808

• Mauth, C; Bono, Epifania; Haas, S; Paesold, G.; Wiese, H.; Maier, G.; Boos, N.; Graf-Hausner, Ursula,

  2009.

  Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration.

  European Cells & Materials.

  18, S. 27-39.

  Verfügbar unter: https://doi.org/10.22203/eCM.v018a03

• Jung, C; Mathes, Stephanie; Bono, Epifania; Walker, C; Kessler, A; Straumann, L; de Wild, M; de Haller, EB,

  2015.

  Cell viability on titanium implant surfaces modified with antibacterial copper[Poster].

  In:

  Swiss Society for Biomaterials.

  S. 24.

  Verfügbar unter: https://doi.org/10.21256/zhaw-1761

• Bono, Epifania; Sheard, Jonathan; Mikkonen, Piia; Rimann, Markus,

  2022.

  Automation of 3D cell culture using cellulose-based scaffolds[Poster].

  In:

  Biointerfaces International Conference (BIC), Zurich, Switzerland, 12-15 September 2022.

  Winterthur:

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-25998

• Bono, Epifania,

  2020.

  Automated 3D cell culture using Corning® 96-well spheroid microplates on the Fluent® automation workstation.

  Tecan.

• Bono, Epifania; Evers, Christoph; Schmid, Franca; Graf-Hausner, Ursula; Rimann, Markus,

  2017.

  In vitro characterization of a new composite material for biomedical applications and 3D (bio)printing[Poster].

  In:

  TEDD Annual Meeting, Wädenswil, 8-9 November 2017.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-3587

• Rimann, Markus; Bono, Epifania; Picenoni, Armin; Felley-Bosco, Emanuela; Meyer, Andreas; Pelleaux, René; Hund, Corinna,

  2017.

  Development of a matrix-based technology platform for the high throughput analysis of 3D cell cultures[Poster].

  In:

  Swiss Medtech Day, Bern, 13 June 2017.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-3588

• Bono, Epifania; Mathes, Stephanie; Rimann, Markus,

  2017.

  Evaluation of 3D hepatic tissue models for bioprinting[Poster].

  In:

  TERMIS-EU 2017 Conference, Davos, 26-30 June 2017.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-3590

• Bono, Epifania; Hutter, Albert; Hendrawan, Siufui; Sutedja, Barlian; Baer, Hans Ulrich; Mathes, Stephanie,

  2016.

  3D PLLA-collagen matrices as carriers for hepatocytes[Poster].

  In:

  Swiss Medtech Day, Bern, 7 June 2016.

• Mathes, Stephanie; Bono, Epifania; Striegl, Britta; Hettwer, Stefan; Bänziger, Stefan; Suter, Brigit; Spezzaneve, Donato,

  2016.

  Development of an immune responsive in vitro 3D skin model for the examination of the immune suppressive and collagen stimulating activity of cosmetic actives[Poster].

  In:

  Swiss Medtech Day, Bern, 7 June 2016.

• Bono, Epifania; Cloes, Nastasia; Merk, Markus; Mathes, Stephanie,

  2016.

  In vitro models of human skin models featuring a glycated dermis[Poster].

  In:

  4th International Cosmetic Innovation Days «Cosminnov», Orléans, France, 24-25 May 2016.

• Bono, Epifania; Hutter, Albert; Hendrawan, Siufui; Sutedja, Barlian; Baer, Hans Ulrich; Mathes, Stephanie,

  2016.

  3D PLLA-collagen matrices as carriers for hepatocytes[Poster].

  In:

  3D Cell Culture 2016, Freiburg, Germany, 19-21 April 2016.

• Bono, Epifania; Hutter, Albert; Hendrawan, Siufui; Sutedja, Barlian; Baer, Hans Ulrich; Weber, Ursula; Mathes, Stephanie,

  2016.

  3D PLLA-collagen matrices as carrier for hepatocytes (type Chen-Baermed) an in vitro study[Poster].

  In:

  Sponsorenanlass Klinik Hirslanden, Zürich, 2016.

• Rimann, Markus; Laternser, Sandra; Bono, Epifania; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Hartmann, Lilian; Alave-Reyes, Angela; Thurner, Marc; Scheidegger, Andreas; Graf-Hausner, Ursula,

  2016.

  A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues[Poster].

  In:

  Swiss Medtech Day, Bern, 7 June 2016.

• Graf-Hausner, Ursula; Rimann, Markus; Bono, Epifania; Laternser, Sandra; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Richter, Jens; Alave, Angela; Thurner, Marc; Scheidegger, Andreas,

  2015.

  A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues[Poster].

  In:

  CTI Medtech Event, Bern, 8. September 2015.

• Jung, C.; Mathes, Stephanie; Bono, Epifania,

  2015.

  Cell viability on titanium implant surfaces modified with antibacterial copper[Poster].

  In:

  Medical Cluster [MEET THE EXPERTS] – Technologies and Innovation for Cost Reduction, Interlaken, Switzerland, 7–8 May 2015.

• Rimann, Markus; Laternser, Sandra; Bono, Epifania; Keller, Hansjörg; Leupin, Olivier; Fässler, Thomas; Eggmann, Kurt; Thurner, Marc; Graf-Hausner, Ursula,

  2015.

  Bioprinted muscle/tendon for drug assessment[Poster].

  In:

  NTN Swiss Biotech Innovation Day: The potential of industry-academia collaborations, Zug, 19 August 2015.

• Graf-Hausner, Ursula; Rimann, Markus; Bono, Epifania; Laternser, Sandra; Bleisch, Matthias; Eggmann, Kurt; Quidiello, Daniel; Munz, Peter; Hauer, Matthias; Keller, Hansjörg; Richter, Jens; Alave, Angela; Leupin, Olivier; Thurner, Marc; Scheidegger, Andreas,

  2014.

  A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues[Poster].

  In:

  CTI Medtech Event, Bern, 2. September 2014.

• Pörtner, Ralf; Wagner, Ilka; Atanasova, Tamara; Gautam, Richa; Gattlen, Jasmin; Rimann, Markus; Bono, Epifania; Graf-Hausner, Ursula; Marx, Uwe,

  2014.

  Aktuelle Trends bei der in vitro-Substanztestung in Deutschland und in der Schweiz.

  BIOspektrum.

  20(4), S. 470-472.

  Verfügbar unter: https://doi.org/10.1007/s12268-014-0466-6

• Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Meier, Christoph; Bossen, Anke; Graf-Hausner, Ursula,

  2014.

  Skin bioprinting : an innovative approach to produce standardized skin models on demand[Poster].

  In:

  Swiss Biotech Innovation Day 2014 «the Potential of Industry-Academia Collaborations», Basel, 28 August 2014.

• Striegl, Britta; Grad, S.; Eglin, D; Benneker, L.; Peroglio, M.; Alini, Mauro; Graf-Hausner, Ursula; Bono, Epifania,

  2012.

  Cell-seeded thermoreversible hydrogel-polyurethane composites for nucleus pulposus augmentation[Poster].

  In:

  Proceedings of the 3D Cell Culture 2012 congress.

  3D Cell Culture 2012: Zurich, 14-16 March 2012.

  Dechema Biotechnologie.

  Verfügbar unter: https://doi.org/10.21256/zhaw-1752

• Striegl, Britta; Grad, S.; Eglin, D.; Benneker, L.; Bono, Epifania; Alini, Mauro; Graf-Hausner, Ursula; Peroglio, M.,

  2012.

  Human disc cells and mesenchymal stem cells differentiation in a thermoreversible hydrogel : an in vitro and ex-vivo study[Poster].

  In:

  Orthopaedic Research Society Congress, San Francisco, USA, 4-7 February 2012.

• Santini, Diego; Bono, Epifania; Schmid, Daniel; Mathes, Stephanie; Graf-Hausner, Ursula,

  2012.

  Tissue engineering for drug development : defined organotypic skin models[Poster].

  In:

  3D Cell Culture 2012: Zurich, 14-16 March 2012.

  Dechema Biotechnologie.

  Verfügbar unter: https://doi.org/10.21256/zhaw-1753

• Striegl, Britta; Grad, Sibylle; Eglin, David; Benneker, Lorin; Bono, Epifania; Alini, Mauro; Graf-Hausner, Ursula; Peroglio, Marianna,

  2011.

  Ex-vivo evaluation of thermoreversible hylauronan-based hydrogel as mesenchymal stem cells carrier for nucleus pulposus repair[Poster].

  In:

  Proceedings of the New Horizons in Intervertebral Disc Research Conference.

  New Horizons in Intervertebral Disc Research, Philadelphia, USA, 2011.

• Graf-Hausner, Ursula; Schmid, Daniel; Bono, Epifania,

  2011.

  Plant extracts to overcome negative effects of glycation in human skin[Poster].

  In:

  CTI Medtech Event 2011, Bern, 23. August 2011.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Verfügbar unter: https://doi.org/10.21256/zhaw-1750

• Mauth, Corinna; Bono, Epifania; De Wild, Michel; Molenberg, Aart; Farine, Herve; Dard, Michel; Graf-Hausner, Ursula,

  2010.

  Development of a smart biomaterial for osseointegration in oral defects[Poster].

  In:

  Tissue Engineering and Regenerative Medicine International Societym, Galway, Ireland, 13 June 2010.

• Franscini, Nicola; Bono, Epifania; Durner, Roland; Wuertz, Karin; Boos, Norbert; Graf-Hausner, Ursula,

  2010.

  Disc regeneration : automation for a new cell-based approach[Poster].

  In:

  eCM XI «Cartilage & Disc: Repair and Regeneration», Davos, 28-30 June 2010.

• Mauth, Corinna; Bono, Epifania; Gruber, R.; Goebel, E.; Molenberg, Aart; De Wild, M.; Schiephake, H.; Dard, Michel; Graf-Hausner, Ursula,

  2010.

  SMART biomaterial : bioactive synthetic bone repair material for large oral bone defects[Poster].

  In:

  CTI Medtech Event, Bern, 31. August 2010.

• Franscini, Nicola; Bono, Epifania; Würtz, Karin; Patocchi-Tenzer, Isabel; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula,

  2009.

  Automation and standardization of tissue culture processes for regenerative medicine[Poster].

  In:

  CTI Medtech Event, Bern, 1. September 2009.

• Mauth, Corinna; Molenberg, Aart; Dard, Michel; Farine, Herve; Bono, Epifania; Steinhoff, Dirk; Graf-Hausner, Ursula,

  2009.

  Bioactive synthetic bone repair material for large oral bone defects[Paper].

  In:

  CTI Medtech Event, Bern, 1. September 2009.

• Franscini, Nicola; Bono, Epifania; Patocchi - Tenzer, Isabel; Durner, Roland; Wuertz, Karin; Boos, Norbert; Graf-Hausner, Ursula,

  2009.

  Economic production of quality controlled primary cells for cell based assays by automating tissue culture processes[Poster].

  In:

  MipTech - the leading European Event for Drug Discovery, Basel, 13-15 October 2009.

• Franscini, Nicola; Bono, Epifania; Würtz, Karin; Patocchi-Tenzer, Isabel; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula,

  2009.

  Intervertebral disc degeneration : automation of tissue culture processes for regenerative medicine[Poster].

  In:

  Annual Meeting European Society for Artificial Organs, Compiègne, France, 2-5 September 2009.

• Franscini, Nicola; Bono, Epifania; Würtz, Karin; Patocchi-Tenzer, Isabel; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula,

  2008.

  Automation and standardization of tissue culture processes for regenerative medicine[Poster].

  In:

  CTI Medtech Event, Bern, 2. September 2008.

• Mauth, Corinna; Molenberg, Aart; Dard, Michael; Farine, Herve; Bono, Epifania; Steinhoff, Dirk; Graf-Hausner, Ursula,

  2008.

  Biomaterial : bioactive synthetic bone repair material for large oral bone[Poster].

  In:

  CTI Medtech Event, Bern, 2. September 2008.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula; Raghunath, Michael,

  2017.

  3D bioprinted tissue models for substance testing.

  In:

  International Conference and Exhibition - Society for Laboratory Automation and Screening (SLAS 2017), Washington, USA, 4–8 February 2017.

• Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Graf-Hausner, Ursula,

  2016.

  Standardized 3D bioprinting of skin models for drug development.

  In:

  4th International Cosmetic Innovation Days «Cosminnov», Orléans, France, 24-25 May 2016.

• Rimann, Markus; Laternser, Sandra; Bono, Epifania; Nosswitz, Michael; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

  2016.

  Bioprinted tissues for substance testing.

  In:

  3D Cell Culture 2016, Freiburg, Germany, 19-21 April 2016.

• Rimann, Markus; Mathes, Stephanie; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Graf-Hausner, Ursula,

  2016.

  3D models for compound testing.

  In:

  3rd 3D Models & Drug Screening Conference, Berlin, Germany, 11-12 May 2016.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

  2016.

  3D tissue models : new perspectives in medicine.

  In:

  2016 Conference and Exhibition for Cutting-Edge Medicine (CLINAM 9), Basel, 26-29 June 2016.

• Graf-Hausner, Ursula; Rimann, Markus; Laternser, Sandra; Bono, Epifania; Eggmann, Kurt; Quidiello, Daniel; Fässler, Thomas; Keller, Hansjörg; Leupin, Olivier; Rausch, Martin; Hartmann, Lilian; Alave-Reyes, Angela; Thurner, Marc; Scheidegger, Andreas,

  2016.

  A novel multiwell device for drug development with bioprinted 3D human tendon and skeletal muscle tissues.

  In:

  Swiss Medtech Day, Bern, 7 June 2016.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

  2016.

  Bioprinted tissue models for substance evalution.

  In:

  Basel Life Science Week 2016, Basel, 19-23 September 2016.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula; Raghunath, Michael,

  2016.

  Bioprinted tissues for substance evaluation.

  In:

  Biointerfaces International 2016 Conference, Zurich, 23-25 August 2016.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Keller, Hansjörg; Leupin, Olivier; Graf-Hausner, Ursula,

  2015.

  Bioprinted soft tissue models for compound testing.

  In:

  International Conference on Biofabrication (Biofabrication 2015), Utrecht, Netherlands, 7-9 November 2015.

• Rimann, Markus; Bono, Epifania; Laternser, Sandra; Nosswitz, Michael; Morel, Alexandre; Keller, Hansjörg; Leupin, Olivier; Wagner, Carsten; Graf-Hausner, Ursula,

  2015.

  Soft tissue bioprinting in tissue engineering for drug development.

  In:

  Olten Meeting 2015: Antibiotics and Bioprinting - for a better life, Biotechnet Switzerland, Olten, 18 November 2015.

• Bono, Epifania; Rimann, Markus; Annaheim, Helene; Bleisch, Matthias; Kuster, Michael; Thurner, Marc; Meier, Christoph; Bossen, Anke; Graf-Hausner, Ursula,

  2014.

  Skin bioprinting : an approach to produce standardized skin models on demand.

  In:

  DECHEMA - 3D Cell Culture 2014, Freiburg, Germany, 25-27 June 2014.

• Striegl, Britta; Grad, S.; Benneker, L. M.; Bono, Epifania; Alini, Mauro; Graf-Hausner, Ursula; Peroglio, M.,

  2012.

  In vitro evaluation of a thermoreversible hyaluronan-based hydrogel loaded with cell-seeded polyurethane particles for nucleus pulposus repair.

  In:

  World Forum for Spine Research, Helsinki, Finland, 18-21 June 2012.

  AOSpine.

• Bono, Epifania; Mauth, Corinna; Molenberg, Aart; Farine, Herve; Dard, Michel; Graf-Hausner, Ursula,

  2010.

  Oral large bone defects : the suitability of a new biomaterial combination.

  In:

  23rd European Conference on Biomaterials (ESB 2010), Tampere, 11-15 September 2010.

• Franscini, Nicola; Bono, Epifania; Patocchi - Tenzer, Isabel; Durner, Roland; Wuertz, Karin; Boos, Norbert; Graf-Hausner, Ursula,

  2009.

  Intervertebral disc degeneration : automation of tissue culture processes for regenerative medicine applications.

  In:

  Deutscher Wirbelsäule Kongress, München, Deutschland, 10.-12. Dezember 2009.

• Bono, Epifania; Mauth, Corinna; Franscini, Nicola; Durner, Roland; Boos, Norbert; Graf-Hausner, Ursula,

  2009.

  Intervertebral disc regeneration : small and large scale systems.

  In:

  12th Annual Seminar & Meeting - Ceramics, Cells and Tissues, Faenza, Italy, 1 May 2009.

• Bono, Epifania,

  2008.

  Intervertebral disc augmentation : an alternative.

  In:

  International Summer School in Advanced Biotechnology, Palermo, Italy, 2008.

• Bono, Epifania,

  2008.

  Intervertebral disc augmentation : an alternative.

  In:

  Annual Meeting European Society for Artificial Organs, Geneva, 3.-6. September 2008.

• Bono, Epifania,

  2008.

  Tissue engineering of intervertebral discs : small and large scale options.

  In:

  Swiss-Japanese Meeting on Spine Research, Zurich, 2008.

Publikationen vor Tätigkeit an der ZHAW

• Properties of additive-manufactured open porous titanium structures for patient-specific load-bearing implants
• Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses
• Evaluation of 3D PLLA scaffolds coated with nano‐thick collagen as carrier for hepatocytes
• Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants
• Standardized 3D bioprinting of soft tissue models with human primary cells
• Tissue Engineering - the gateway to regenerative medicine
• Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration

Übrige Publikationen

• Thyroid Hormones Induce Sumoylation of the Cold Shock Domain-Containing Protein PIPPin in Developing Rat Brain and in Cultured Neurons
• Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture

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