Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor (HYPERBOOST)
Beschreibung
Im Rahmen des Projektes sollen neue Methoden und Verfahren zur Therapieplanung Hyperthermie entwickelt und damit die Grundlage für eine Optimierung von Krebsbehandlungen mit Hyperthermie geschaffen werden. Der durch die ZHAW bearbeitete Teil fokussiert auf die biologische Therapieplanung. Dabei sollen präklinische und klinische Daten mittels Modell-basierter Datenanalyse zur Entwicklung geeigneter Planungssystem-Algorithmen genutzt werden.
Eckdaten
Projektleitung
Stellv. Projektleitung
Projektstatus
abgeschlossen, 12/2020 - 12/2025
Institut/Zentrum
Abteilung Informatik, Elektrotechnik und Mechatronik; Institut für Angewandte Mathematik und Physik (IAMP)
Drittmittelgeber
Horizon 2020 / Projekt Nr. 955625
Projektvolumen
245'000 CHF
Weiterführende Dokumente und Links
Publikationen
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The use of survival dose-rate dependencies as theoretical discrimination criteria for in-silico dynamic radiobiological models
2024 Mingo Barba, Sergio; Lobo-Cerna, Fernando; Krawczyk, Przemek M.; Lattuada, Marco; Füchslin, Rudolf M.; Petri-Fink, Alke; Scheidegger, Stephan
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Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico
2024 Mingo Barba, Sergio; Ademaj, Adela; Marder, Dietmar; Riesterer, Oliver; Lattuada, Marco; Füchslin, Rudolf Marcel; Petri-Fink, Alke; Scheidegger, Stephan
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Tumor Control Probability (TCP) study to theoretically assess the impact of different clinical conditions in Hyperthermia plus Radiotherapy (HT+RT) treatments
2023 Mingo Barba, Sergio; Ademaj, Adela; Marder, Dietmar; Riesterer, Oliver; Lattuada, Marco; Füchslin, Rudolf Marcel; Fink, Alke; Scheidegger, Stephan
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The effect of hyperthermia and radiotherapy sequence on cancer cell death and the immune phenotype of breast cancer cells
2022 Sengedorj, Azzaya; Hader, Michael; Heger, Lukas; Frey, Benjamin; Dudziak, Diana; Fietkau, Rainer; Ott, Oliver J.; Scheidegger, Stephan; Mingo Barba, Sergio; Gaipl, Udo S.; Rückert, Michael
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The effects of heat stress on the transcriptome of human cancer cells : a meta-analysis
2022 Scutigliani, Enzo M.; Lobo-Cerna, Fernando; Mingo Barba, Sergio; Scheidegger, Stephan; Krawczyk, Przemek M.
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Influence of the antigen pattern vector on the dynamics in a perceptron-based artificial immune - tumour- ecosystem during and after radiation therapy
2022 Scheidegger, Stephan; Mingo Barba, Sergio; Fellermann, Harold; Gaipl, Udo S.
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The use of qualitative and quantitative hyperthermic effects as discrimination criteria in radiobiological models
2022 Mingo Barba, Sergio; Lobo-Cerna, Fernando; Lattuada, Marco; Füchslin, Rudolf Marcel; Fink, Alke; Krawcyk, Prcemek M.; Scheidegger, Stephan
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The use of dose rate dependencies as a theoretical discrimination criteria in radiobiological models
2022 Mingo Barba, Sergio; Lattuada, Marco; Füchslin, Rudolf Marcel; Fink, Alke; Scheidegger, Stephan
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Repair protein damage vs. cell repair saturation : a comparison of its use in radiobiological models
2022 Mingo Barba, Sergio; Lattuada, Marco; Füchslin, Rudolf Marcel; Fink, Alke; Scheidegger, Stephan
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Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem
2021 Scheidegger, Stephan; Mingo Barba, Sergio; Gaipl, Udo S.
School of Engineering
Technikumstrasse 9
8400 Winterthur