Vivian Ott

Work at ZHAW

Position

Research Associate

Focus

• Cell Cultivation Techniques
• Single use technology for biopharmaceutical manufacturing
• Development of antibody production processes
• Process intensification
• Scale-up of cell culture processes

Education and Continuing education

Education

• Master of Science / Biotechnology
  Anhalt University of Applied Sciences
  10 / 2018 - 06 / 2020
• Bachelor of Science / Biotechnology
  Anhalt University of Applied Sciences
  10 / 2015 - 09 / 2018

Network

Membership of networks

• DECHEMA
• A3P

ORCID digital identifier

ORCID ID: 0000-0002-0208-3909

Media presence

• Evaluation of a single-use disc stack separator: GEA kytero single use separator
• Interview: A Thermo Fisher Scientific Collaboration with Zurich University of Applied Sciences

Projects

• Development of a perfusion filter for the continuous production of biopharmaceuticals / Team member / ongoing
• Mini disc stack separator for cell culture-based production processes / Deputy project leader / ongoing
• Intensification approaches for the production of an antibody with CHO cells / Team member / ongoing
• Online monitoring of cell health in antibody production processes / Deputy project leader / completed
• Glucose-Sensor based Optimization of mAb Production Processes / Deputy project leader / completed
• Novel Single-Use Mixer and Bioreactor / Team member / completed
• Valve qualification / Team member / completed
• Evaluation perfusion membrane / Team member / completed
• Human Embryonic Kidney cells (50 L) / Team member / completed
• USP Development with CHO Cells / Deputy project leader / completed
• Evaluation of cell separation using the GEA kytero® Single Use Pharma Separator with disk stack technology / Team member / completed
• Antibody production / Team member / completed
• IgG productions with CHO cells / Team member / completed

Publications

Articles in scientific journal, peer-reviewed

• Ott, V. et al. (2025) 'Perfusion-based antibody production in the Ambr® 250 Modular', Chimia, 79(5), pp. 330–338. doi: 10.2533/chimia.2025.330.
• Ott, V. et al. (2024) 'Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors', Processes, 12(4), p. 806. doi: 10.3390/pr12040806.
• Ott, J. et al. (2024) 'Process intensification by inoculating antibody production bioreactors directly from cryovials ', Chemie Ingenieur Technik, 96(4), pp. 453–461. doi: 10.1002/cite.202300189.
• Müller, J. et al. (2022) 'Seed train intensification using an ultra-high cell density cell banking process', Processes, 10(5), p. 911. doi: 10.3390/pr10050911.
• Ott, V. et al. (2022) 'Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production', Chemie Ingenieur Technik, 94(12), pp. 1936–1943. doi: 10.1002/cite.202200096.
• Müller, J. et al. (2022) 'Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes', Chemie Ingenieur Technik, 94(12), pp. 1977–1984. doi: 10.1002/cite.202200097.

Written conference contributions, peer-reviewed

• Ott, J. et al. (2024) 'Seed train intensification and production process automation for pilot-scale fed-batch and perfusion processes', in 28th ESACT Meeting, Edinburgh, United Kingdom, 23-26 June 2024.
• Müller, J. et al. (2022) 'Ultra-high cell density cell bank-based IgG production with CHO cells', in 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022. ESACT, European Association for Animal Cell Technology.
• Schirmer, C. et al. (2022) 'Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale', in 27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022. ESACT, European Association for Animal Cell Technology.

Other publications

• Ott, V. et al. (2022) 'A new single-use disk stack separator for pilot scale CHO cell-based antibody productions', in ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.
• Schirmer, C. et al. (2020) 'Integration of chemical-optical oxygen and pH sensors in existing control units : cultivation monitoring in a glass bioreactor system with subsequently integrated sensor spots', PreSens Publications. Available at: https://www.presens.de/knowledge/publications/application-note/integration-of-chemical-optical-oxygen-and-ph-sensors-in-existing-control-units-1692.

Oral conference contributions and abstracts

• Ott, V. and Grün, M. (2025) 'Accelerating and enabling consistency in bioprocessing scale-up', in Technologies Network Biopharma Webinar, online, September 2025.
• Ott, V. and Brühlmann, B. (2025) 'Perfusion-based mAb production at 250 mL scale using ATF technology', in GEN Genetic Engineering & Biotechnology News Webinar, online, 3 September 2025.
• Ott, V. (2025) 'ATF-based perfusion processes from 250 mL to 50 L scale', in 5th BIOTECH Conference, Freiburg, Germany, 16-18 June 2025.
• Ott, V. (2024) 'Maximizing performance and quality in fed-batch and perfusion-based IgG productions', in Thermo Fisher Scientific Webinar, online, 18 September 2024.
• Ott, V. (2024) 'Scale-up from flask through 50 L bioreactor : the effect of GibcoTM Media on maximizing performance and quality in fed-batch and perfusion processes', in 28th ESACT Meeting, Edinburgh, Scotland, 23-26 June 2024.
• Ott, V. and Müller, J. (2023) 'Antibody production in lab and pilot scale single-use bioreactors', in A3P Aseptic Processing, Milan, Italy, 10-11 May 2023.

Publications before appointment at the ZHAW

Generation of Doubled Haploid Barley by Interspecific Pollination with Hordeum bulbosum

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