Prof. Dr. Lars Fieseler

Management role

• Head of Centre, Center for Food Safety and Quality Management
• Head, Head of Food Microbiology

Position at the ZHAW

Lecturer and researcher in food microbiology

www.zhaw.ch/ilgi

Professional development teaching

• CAS Food Quality Insight
• Differenzierung und Identifikation von Mikroorganismen
• Mikrobielle Lebensmittelsicherheit und -qualität: Wie werden sie beurteilt?
• Mikrobiologische Arbeitstechniken, mikrobielle Lebensmittelanalytik und Labororganisation
• Mikrobiologische Lebensmittelanalytik nach validierten kulturellen Methoden
• 15. Wädenswiler Lebensmittelrecht-Tagung

Expertise and research interests

Food Microbiology
Isolation and characterization of bacteriophages to control food borne pathogens and spoilage bacteria
biocontrol
detection of food borne pathogens

Membership of networks

• Schweizerische Gesellschaft für Mikrobiologie (SGM)
• Schweizerische Gesellschaft für Lebensmittelhygiene (SGLH)
• Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM)
• The American Society for Microbiology (ASM)
• European Hygienic Engineering & Design Group (EHEDG)
• International Society for Viruses of Microorganisms (ISVM)

• Molecular mechanism of bacteriophage tail spike proteins in bacterial infection / Project co-leader / Project ongoing
• Engineered bacteriophages for the control of E. coli O157 / Project leader / Project ongoing
• Nachweis von E. coli und Coliformen in Lebensmitteln und von Oberflächenabstrichen mittels AquaSparkTM Technologie / Project leader / Project ongoing
• Platform Health / Project co-leader / Project ongoing
• Persistence of STEC in grain, milling by-products, flour, and raw follow up products / Project leader / Project completed
• Nachweis von L. monocytogenes und Salmonella in Lebensmitteln und von Oberflächenabstrichen mittels AquaSparkTM Technologie / Project leader / Project completed
• Rapid Quantification of Pseudomonas aeruginosa by flow-cytometry / Project leader / Project completed
• BIOPAC (Biopolymer based bioactive food packaging) / Team member / Project completed
• Mechanisms of phage resistance in Erwinia amylovora / Project leader / Project completed
• Legionellen im Kontext des FM / Team member / Project completed
• KJM - KleenlineJonmaster / Team member / Project completed
• Microbial and somatic cell monitoring of raw milk by imdedance flow cytometry / Project leader / Project completed

• Knecht, Leandra E. ; Veljkovic, Marjan ; Fieseler, Lars,

  2020.

  Diversity and function of phage encoded depolymerases .

  Frontiers in Microbiology.

  10(2949).

  Available from : https://doi.org/10.21256/zhaw-19174

• van Mierlo, Joël; Hagens, Steven; Witte, Sander; Klamert, Silvia; van de Straat, Leoni; Fieseler, Lars,

  2019.

  Complete genome sequences of escherichia coli phages vB_EcoM-EP75 and vB_EcoP-EP335 .

  Microbiology Resource Announcements.

  8(16).

  Available from : https://doi.org/10.21256/zhaw-18116

• Born, Yannick; Knecht, Leandra E.; Eigenmann, Mirjam; Bolliger, Michel; Klumpp, Jochen; Fieseler, Lars,

  2019.

  A major-capsid-protein-based multiplex PCR assay for rapid identification of selected virulent bacteriophage types .

  Archives of Virology.

  164(3),

  pp. 819-830.

  Available from : https://doi.org/10.21256/zhaw-18117

• Roth-Konforti, Michal; Green, Ori; Hupfeld, Mario ; Fieseler, Lars; Heinrich, Nadine; Ihssen, Julian; Vorberg, Raffael; Wick, Lukas; Spitz, Urs; Shabat, Doron,

  2019.

  Ultrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probes .

  Angewandte Chemie: International Edition.

  58(30),

  pp. 10361-10367.

  Available from : https://doi.org/10.1002/anie.201904719

• Knecht, Leandra E.; Born, Yannick; Pothier, Joël F. ; Loessner, Martin J.; Fieseler, Lars,

  2018.

  Complete genome sequences of erwinia amylovora phages vB_EamP-S2 and vB_EamM-Bue1 .

  Microbiology Resource Announcements.

  7(3).

  Available from : https://doi.org/10.21256/zhaw-18118

• Buttimer, Colin; Born, Yannick; Lucid, Alan; Loessner, Martin J.; Fieseler, Lars; Coffey, Aidan,

  2018.

  Erwinia amylovora phage vB_EamM_Y3 represents another lineage of hairy myoviridae .

  Research in Microbiology.

  169(9),

  pp. 505-514.

  Available from : https://doi.org/10.1016/j.resmic.2018.04.006

• Born, Yannick; Fieseler, Lars; Thöny, Valentin; Leimer, Nadja; Duffy, Brion; Loessner, Martin J.,

  2017.

  Engineering of bacteriophages Y2::dpoL1-C and Y2::luxAB for efficient control and rapid detection of the fire blight pathogen, Erwinia amylovora .

  Applied and Environmental Microbiology.

  83(12),

  pp. e00341-17.

  Available from : https://doi.org/10.1128/AEM.00341-17

• Shen, Yang; Boulos, Samy; Sumrall, Eric; Gerber, Benjamin; Julian-Rodero, Alicia; Eugster, Marcel R.; Fieseler, Lars; Nyström, Laura; Ebert, Marc-Olivier; Loessner, Martin J.,

  2017.

  Structural and functional diversity inListeriacell wall teichoic acids .

  Journal of Biological Chemistry.

  292(43),

  pp. 17832-17844.

  Available from : https://doi.org/10.1074/jbc.M117.813964

• Schmitter, Sibylle; Fieseler, Lars; Klumpp, Jochen; Bertram, Ralph; Loessner, Martin J.,

  2017.

  TetR-dependent gene regulation in intracellular Listeria monocytogenes demonstrates the spatiotemporal surface distribution of ActA .

  Molecular Microbiology.

  105(3),

  pp. 413-425.

  Available from : https://doi.org/10.1111/mmi.13706

• Krapf, Tamara; Kuhn, Roger; Kauf, Peter; Gantenbein-Demarchi, Corinne ; Fieseler, Lars,

  2016.

  Quantitative real time PCR does not reliably detect single fecal indicator bacteria in drinking water .

  Water Science and Technology.

  16(6),

  pp. 1674-1682.

  Available from : https://doi.org/10.21256/zhaw-5523

• Schwendimann, Livia Maya; Kauf, Peter; Fieseler, Lars; Gantenbein-Demarchi, Corinne ; Miescher Schwenninger, Susanne ,

  2015.

  Development of a quantitative PCR assay for rapid detection of Lactobacillus plantarum and Lactobacillus fermentum in cocoa bean fermentation .

  Journal of Microbiological Methods.

  115,

  pp. 94-99.

  Available from : https://doi.org/10.1016/j.mimet.2015.05.022

• Born, Yannick; Bosshard, Lars; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Protection of Erwinia amylovora bacteriophage Y2 from UV-induced damage by natural compounds .

  Bacteriophage.

  5(4),

  pp. e1074330.

  Available from : https://doi.org/10.1080/21597081.2015.1074330

• Fieseler, Lars; Doyscher, Dominik; Loessner, Martin; Schuppler, Markus,

  2014.

  Acanthamoeba release compounds which promote growth of Listeria monocytogenes and other bacteria .

  Applied Microbiology and Biotechnology.

  98(7),

  pp. 3091-3097.

  Available from : https://doi.org/10.1007/s00253-014-5534-9

• Born, Yannick; Fieseler, Lars; Klumpp, Jochen; Eugster, Marcel R.; Zurfluh, Katrin; Duffy, Brion; Loessner, Martin J.,

  2014.

  The tail-associated depolymerase of Erwinia amylovoraphage L1 mediates host cell adsorption and enzymatic capsule removal, which can enhance infection by other phage .

  Environmental Microbiology.

  16(7),

  pp. 2168-2180.

  Available from : https://doi.org/10.1111/1462-2920.12212

• Doyscher, Dominik; Fieseler, Lars; Dons, Lone; Loessner, Martin J.; Schuppler, Markus,

  2013.

  Acanthamoeba feature a unique backpacking strategy to trap and feed on Listeria monocytogenes and other motile bacteria .

  Environmental Microbiology.

  15(2),

  pp. 433-446.

  Available from : https://doi.org/10.1111/j.1462-2920.2012.02858.x

• Guenther, Susanne; Herzig, Oliver; Fieseler, Lars; Klumpp, Jochen; Loessner, Martin J.,

  2012.

  Biocontrol of Salmonella Typhimurium in RTE foods with the virulent bacteriophage FO1-E2 .

  International Journal of Food Microbiology.

  154(1-2),

  pp. 66-72.

  Available from : https://doi.org/10.1016/j.ijfoodmicro.2011.12.023

• Born, Yannick; Fieseler, Lars; Marazzi, Janine; Lurz, Rudi; Duffy, Brion; Loessner, Martin J.,

  2011.

  Novel virulent and broad-host-range Erwinia amylovora bacteriophages reveal a high degree of mosaicism and a relationship to enterobacteriaceae phages .

  Applied and Environmental Microbiology.

  77(17),

  pp. 5945-5954.

  Available from : https://doi.org/10.1128/AEM.03022-10

• Fieseler, Lars; Loessner, Martin,

  2013.

  Bacteriophage biocontrol

  .

  In:

  Labbé, Ronald G.; García, Santos, eds. ,

  Guide to foodborne pathogens.

  New York:

  Wiley.

  pp. 448-456.

  Available from : https://doi.org/10.1002/9781118684856.ch28

• Stöppelmann, Felix; Fieseler, Lars;

  2020.

  Massnahmen zur Beherrschung mikrobiologischer Risiken verursacht durch Vibrio spp. .

• Wetzel, Silvan ; Fieseler, Lars;

  2020.

  Risk evaluation of E. coli ST 131 as a foodborne pathogen in Switzerland .

• Wetzel, Silvan ; Fieseler, Lars;

  2020.

  Shiga-toxin producing escherichia coli in flour, wheat grain and flour products .

• Freimüller Leischtfeld, Susette ; Weber, Stefan; Kuhn, Roger; Schmid, Jürg; Fieseler, Lars,

  2015.

  Molekulare Schnellmethode für den Legionellen-Test .

  Alimenta.

  2015(8).

  Available from : https://www.foodaktuell.ch/molekulare-schnellmethode-fuer-den-legionellen-test/

• Born, Yannick; Fieseler, Lars,

  2015.

  A bacteriophage cocktail to control Salmonella Typhimurium [ poster ].

  In:

  21st Biennial Evergreen International Phage Biology Meeting, Olympia, USA, 2-7 August 2015.

• Born, Yannick; Knecht, Leandra ; Pelludat, Cosima; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Bakteriophagen zur Bekämpfung von Feuerbrand [ poster ].

  In:

  1. Nationale Tagung - Gemeinsam gegen Feuerbrand, Wädenswil, 2015.

• Adlhart, Christian ; Born, Yannick; Fuchs, Michael; Fieseler, Lars; Pavlovic, Branislav,

  2015.

  Encapsulation and controlled release of bacteriophages for food protection using electrospun nanofibers [ paper ].

  In:

  Proceedings of the NART conference 2015.

  NART 2015, Nanofibers, Applications and Related Technologies, Liberec, Czech Republic, 31 August - 2 September 2015.

  pp. 49-56.

• Gantenbein-Demarchi, Corinne ; Kuhn, Roger; Kauf, Peter; Schmid, Jürg; Krapf, Tamara; Fieseler, Lars,

  2015.

  Fäkalindikatoren im Trinkwasser nachweisen .

  Alimenta.

• Born, Yannick; Klumpp, Jochen; Zurfluh, Katrin; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Implications of the phage depolymerase DpoL1 on Erwinia amylovora [ poster ].

  In:

  21st Biennial Evergreen International Phage Biology Meeting, Olympia, USA, 2-7 August 2015.

• Leiblein, Thomas; Kroslakova, Ivana ; Freimüller Leischtfeld, Susette ; Fieseler, Lars; Hofer, Susanne ,

  2015.

  Legionella in FM : Detection of Legionella pneumophila in waterlines of dental surgeries in the Canton of Zurich, Switzerland [ paper ].

  In:

  Alexander, Keith; Price, Ilfryn, eds. ,

  EuroFM Research Papers, Section 5, Development Papers.

  EuroFM Conference 2015, Glasgow, Ireland, 1-3 June 2015.

  European Facilities Management Network (EuroFM).

  pp. 26-33.

• Fieseler, Lars,

  2015.

  Nachweis und Kontrolle der Keimbelastung im Lebensmittel .

  Lebensmittel-Technologie.

  2015(4),

  pp. 12-13.

• Fieseler, Lars; Gantenbein-Demarchi, Corinne ; Miescher Schwenninger, Susanne ; Kuhn, Roger; Kleinert, Michael ,

  2013.

  Rope in bread : a critical challenge for the bakery industry [ poster ].

  In:

  4th MoniQA International Conference, Budapest, Hungary, 26 February - 1 March 2013.

• Gantenbein-Demarchi, Corinne ; Kuhn, Roger; Krapf, Tamara; Fieseler, Lars,

  2012.

  Detection of faecal indicator organisms by RT-qPCR [ poster ].

  In:

  SGM Annual Congress 2012 - Swiss Society for Microbiology, St. Gallen, 21-22 June 2012.

• Fieseler, Lars; Loessner, Martin; Hagens, Steven,

  2011.

  Bacteriophages and food safety

  .

  In:

  Lacroix, Christophe, ed. ,

  Protective cultures, antimicrobial metabolites and bacteriophages for food and beverage biopreservation.

  Oxford:

  Woodhead Publishing.

  pp. 161-178.

  Woodhead Publishing Series in Food Science, Technology and Nutrition ; 201.

  Available from : https://doi.org/10.1533/9780857090522.1.161

• Heller, Knut; Loessner, Martin; Fieseler, Lars,

  2011.

  Bakteriophagen : Grundlagen, Rolle in Lebensmitteln und Anwendungen zum Nachweis sowie der Kontrolle von Krankheitserregern .

  1. Auflage.

  Hamburg:

  Behr.

  ISBN 978-3-89947-594-4.

• Fieseler, Lars,

  2017.

  Bacteriophages for the control of pathogenic bacteria .

  In:

  BioTech 2017 Conference, Prague, Czech Republic, 13-17 June 2017.

• Born, Yannick; Leimer, Nadja; Thöny, Valentin; Zurfluh, Katrin; Eugster, Marcel; Klumpp, Jochen; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2016.

  Engineered phages for efficient control and rapid detection of viable Erwinia amylovora cells .

  In:

  Viruses of Microbes 2016 - EMBO Conference, Liverpool, United Kingdom, 18-22 July 2016.

• Knecht, Leandra ; Born, Yannick; Loessner, Martin; Fieseler, Lars,

  2016.

  Identification of phage receptors in Erwinia amylovora after transposon mutagenesis .

  In:

  Viruses of Microbes 2016 - EMBO Conference, Liverpool, United Kingdom, 18-22 July 2016.

• Born, Yannick; Fieseler, Lars,

  2016.

  The effectiveness of T5-like phages to control Salmonella enterica .

  In:

  3rd International Conference «Bacteriophages», Moscow, Russia, 13-15 October 2016.

• Fieseler, Lars; Klumpp, Jochen,

  2014.

  A cocktail of two bacteriophages is required to control Salmonella in vitro .

  In:

  Viruses of Microbes 2014 - EMBO Conference, Zurich, 14-18 July 2014.

• Fieseler, Lars,

  2014.

  Bakteriophagen zur Kontrolle von Salmonella Typhimurium in Lebensmitteln .

  In:

  7. Symposium: Schnellmethoden und Automatisierung in der Lebensmittel‐Mikrobiologie, Lemgo, Germany, 1-2 July 2014.

• Hinderling, Christian ; Kroslakova, Ivana ; Gantenbein-Demarchi, Corinne ; Freimüller Leischtfeld, Susette ; Delueg, Stephanie; Miescher Schwenninger, Susanne ; Fieseler, Lars,

  2012.

  Development of an efficient strategy for the identification of the dominant microflora of cocoa fermentation .

  In:

  1st Swiss International Congress on Industrial Microbiology (MICROSCON), Olten, Switzerland, 16-17 October 2012.

www.ncbi.nlm.nih.gov/pubmed/

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