Prof. Dr. Lars Fieseler

Work at ZHAW

Position

• Head Center for Food Safety and Quality Management
• Head Food Microbiology
• Head Phage Technology Center

Teaching

Lecturer in Food Science (Food Microbiology)

Experience

• Head Center of Phage Technology
  Zurich University of applied Sciences
  2022 - today
• Professor
  Zurich University of applied Sciences
  2013 - today
• Head Centre for Food Safety and Quality Management
  Zurich University of applied Sciences
  2013 - today
• Head Food Microbiology
  Zurich University of applied Sciences
  2011 - today
• scientific consultant
  Amt für Abfall, Wasser, Energie und Luft (AWEL), Sektion Biosicherheit und ABC-Schutz, Kanton Zürich
  2011 - 2019
• scientific assistant (Postdoc)
  ETH Zurich
  2006 - 2011
• scientific assistant (Postdoc)
  Würzburg University
  2005 - 2006

Education and Continuing education

Education

• PhD / Microbiology
  Würzburg University
  2001 - 2005
• Diploma / Biology
  University of Würzburg
  1995 - 2000

Continuing Education

• Leadership
  Zurich University of applied Sciences
  2016
• CAS "Didactics of University Teaching"
  Zurich University of applied Sciences
  2013

Network

ORCID digital identifier

ORCID ID: 0000-0001-9306-6436

Projects

• Zebrafish larvae for drug screening / Project leader / ongoing
• Novel phage derived antimicrobials / Deputy project leader / ongoing
• SONEVA / Co-project leader / completed
• Contactless separation and concentration of Legionella species in drinking water installations / Project leader / completed
• An effective and environmentally friendly solution to control fire blight disease caused by Erwinia amylovora in pome fruit crops / Project leader / completed
• Molecular mechanism of bacteriophage tail spike proteins in bacterial infection / Co-project leader / completed
• Engineered bacteriophages for the control of E. coli O157 / Project leader / completed
• Persistence of STEC in grain, milling by-products, flour, and raw follow up products / Project leader / completed
• Platform Health / Co-project leader / completed
• Rapid Quantification of Pseudomonas aeruginosa by flow-cytometry / Project leader / completed
• Biopolymer based bioactive food packaging / Team member / completed
• Analysis and optimisation of a laundry process for cleaning textiles / Team member / completed

Publications

• Dams, Dorien; Pas, Célia; Latka, Agnieszka; Drulis-Kawa, Zuzanna; Fieseler, Lars; Briers, Yves,

  2025.

  A VersaTile approach to reprogram the specificity of the R2-type tailocin towards different serotypes of Escherichia coli and Klebsiella pneumoniae.

  Antibiotics.

  14(1), pp. 104.

  Available from: https://doi.org/10.3390/antibiotics14010104

• Pacher, Nicola; Burtscher, Johanna; Bender, Denisse; Fieseler, Lars; Schreiner, Matthias; Domig, Konrad J.,

  2024.

  Operator-independent assessment of bread spoilage profiles caused by Bacillaceae reveals a high degree of inter- and intraspecies heterogeneity.

  Food Research International.

  197(115193).

  Available from: https://doi.org/10.1016/j.foodres.2024.115193

• Desroche, Nicolas; De Oliveira, Déborah; Imhaus, Anne-Flore; Hupfeld, Mario; Fieseler, Lars,

  2023.

  Validation of N-Light™ salmonella risk test kit for detection of Salmonella spp. on environmental surfaces : AOAC Performance Tested MethodsSM 072204.

  Journal of AOAC INTERNATIONAL.

  106(4), pp. 939-948.

  Available from: https://doi.org/10.1093/jaoacint/qsad017

• Witte, Sander; Huijboom, Linda; Klamert, Silvia; van de Straat, Leoni; Hagens, Steven; Fieseler, Lars; de Vegt, Bert T.; van Mierlo, Joël T.,

  2022.

  Application of bacteriophages EP75 and EP335 efficiently reduces viable cell counts of Escherichia coli O157 on beef and vegetables.

  Food Microbiology.

  104(103978).

  Available from: https://doi.org/10.1016/j.fm.2022.103978

• Knecht, Leandra E.; Heinrich, Nadine; Born, Yannick; Felder, Katja; Pelludat, Cosima; Loessner, Martin J.; Fieseler, Lars; et al.,

  2022.

  Bacteriophage S6 requires bacterial cellulose for Erwinia amylovora infection.

  Environmental Microbiology.

  24(8), pp. 3436-3450.

  Available from: https://doi.org/10.1111/1462-2920.15973

• Pacher, Nicola; Burtscher, Johanna; Johler, Sophia; Etter, Danai; Bender, Denisse; Fieseler, Lars; Domig, Konrad J.,

  2022.

  Ropiness in bread : a re-emerging spoilage phenomenon.

  Foods.

  11(19), pp. 3021.

  Available from: https://doi.org/10.3390/foods11193021

• Knecht, Leandra E.; Born, Yannick; Pelludat, Cosima; Pothier, Joël F.; Smits, Theo H. M.; Loessner, Martin J.; Fieseler, Lars,

  2022.

  Spontaneous resistance of Erwinia amylovora against bacteriophage Y2 affects infectivity of multiple phages.

  Frontiers in Microbiology.

  13(908346).

  Available from: https://doi.org/10.3389/fmicb.2022.908346

• Larose, Delphine; Desroche, Nicolas; Reinau, Lukas; Hupfeld, Mario; Fieseler, Lars,

  2021.

  Validation of N-Light™ L. monocytogenes for detection of Listeria monocytogenes on environmental surfaces : AOAC Performance Tested Method℠ 122002.

  Journal of AOAC INTERNATIONAL.

  Available from: https://doi.org/10.1093/jaoacint/qsab165

• Pertics, Botond Zsombor; Szénásy, Dalma; Dunai, Dániel; Born, Yannick; Fieseler, Lars; Kovács, Tamás; Schneider, György,

  2020.

  Isolation of a novel lytic bacteriophage against a nosocomial methicillin-resistant Staphylococcus aureus belonging to ST45.

  BioMed Research International.

  2020(5463801), pp. 1-10.

  Available from: https://doi.org/10.1155/2020/5463801

• Born, Yannick; Knecht, Leandra E.; Eigenmann, Mirjam; Bolliger, Michel; Klumpp, Jochen; Fieseler, Lars,

  2019.

  A major-capsid-protein-based multiplex PCR assay for rapid identification of selected virulent bacteriophage types.

  Archives of Virology.

  164(3), pp. 819-830.

  Available from: https://doi.org/10.1007/s00705-019-04148-6

• Roth-Konforti, Michal; Green, Ori; Hupfeld, Mario; Fieseler, Lars; Heinrich, Nadine; Ihssen, Julian; Vorberg, Raffael; Wick, Lukas; Spitz, Urs; Shabat, Doron,

  2019.

  Ultrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probes.

  Angewandte Chemie: International Edition.

  58(30), pp. 10361-10367.

  Available from: https://doi.org/10.1002/anie.201904719

• Buttimer, Colin; Born, Yannick; Lucid, Alan; Loessner, Martin J.; Fieseler, Lars; Coffey, Aidan,

  2018.

  Erwinia amylovora phage vB_EamM_Y3 represents another lineage of hairy myoviridae.

  Research in Microbiology.

  169(9), pp. 505-514.

  Available from: https://doi.org/10.1016/j.resmic.2018.04.006

• Born, Yannick; Fieseler, Lars; Thöny, Valentin; Leimer, Nadja; Duffy, Brion; Loessner, Martin J.,

  2017.

  Engineering of bacteriophages Y2::dpoL1-C and Y2::luxAB for efficient control and rapid detection of the fire blight pathogen, Erwinia amylovora.

  Applied and Environmental Microbiology.

  83(12), pp. e00341-17.

  Available from: https://doi.org/10.1128/AEM.00341-17

• Shen, Yang; Boulos, Samy; Sumrall, Eric; Gerber, Benjamin; Julian-Rodero, Alicia; Eugster, Marcel R.; Fieseler, Lars; Nyström, Laura; Ebert, Marc-Olivier; Loessner, Martin J.,

  2017.

  Structural and functional diversity inListeriacell wall teichoic acids.

  Journal of Biological Chemistry.

  292(43), pp. 17832-17844.

  Available from: https://doi.org/10.1074/jbc.M117.813964

• Schmitter, Sibylle; Fieseler, Lars; Klumpp, Jochen; Bertram, Ralph; Loessner, Martin J.,

  2017.

  TetR-dependent gene regulation in intracellular Listeria monocytogenes demonstrates the spatiotemporal surface distribution of ActA.

  Molecular Microbiology.

  105(3), pp. 413-425.

  Available from: https://doi.org/10.1111/mmi.13706

• Krapf, Tamara; Kuhn, Roger; Kauf, Peter; Gantenbein-Demarchi, Corinne; Fieseler, Lars,

  2016.

  Quantitative real time PCR does not reliably detect single fecal indicator bacteria in drinking water.

  Water Science and Technology.

  16(6), pp. 1674-1682.

  Available from: https://doi.org/10.2166/ws.2016.052

• Born, Yannick; Bosshard, Lars; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Protection of Erwinia amylovora bacteriophage Y2 from UV-induced damage by natural compounds.

  Bacteriophage.

  5(4), pp. e1074330.

  Available from: https://doi.org/10.1080/21597081.2015.1074330

• Doyscher, Dominik; Fieseler, Lars; Dons, Lone; Loessner, Martin J.; Schuppler, Markus,

  2013.

  Acanthamoeba feature a unique backpacking strategy to trap and feed on Listeria monocytogenes and other motile bacteria.

  Environmental Microbiology.

  15(2), pp. 433-446.

  Available from: https://doi.org/10.1111/j.1462-2920.2012.02858.x

• Buttimer, Collin; Born, Yannick; Hendrix, Hanne; Oliveria, Hugo; McAuliffe, Olivia; Neve, Horst; Ross, R. Paul; Hill, Colin; Noben, Jean-Paul; O'Mahony, Jim; Fieseler, Lars; Lavigne, Rob; Coffey, Aidan; et al.,

  2017.

  Hairy jumbo phages of Enterobacteriaceae[poster].

  In:

  2017 Evergreen International Phage Meeting, Evergreen State College, USA, 6-11 August 2017.

  ResearchGate.

  Available from: https://doi.org/10.13140/RG.2.2.19768.42243

• Gerber, Nicole; Fieseler, Lars; Hirsch, Sven; Neutsch, Lukas; Papadopoulou, Athina; Smits, Theo,

  2022.

  Zusammenarbeit und wissenschaftlicher Austausch sind der Schlüssel zu erfolgreicher Forschung : der ZHAW Health Research Hub bringt’s unter einen Hut.

  Clinicum.

  2022(6), pp. 80-81.

  Available from: https://doi.org/10.21256/zhaw-26376

• Knecht, Leandra; Born, Yannick; Loessner, Martin; Fieseler, Lars,

  2016.

  Identification of phage receptors in Erwinia amylovora after transposon mutagenesis[poster].

  In:

  Viruses of Microbes (VoM), Liverpool, United Kingdom, 18-22 July 2016.

• Born, Yannick; Fieseler, Lars,

  2015.

  A bacteriophage cocktail to control Salmonella Typhimurium[poster].

  In:

  21st Biennial Evergreen International Phage Biology Meeting, Olympia, USA, 2-7 August 2015.

• Born, Yannick; Knecht, Leandra; Pelludat, Cosima; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Bakteriophagen zur Bekämpfung von Feuerbrand[poster].

  In:

  1. Nationale Tagung - Gemeinsam gegen Feuerbrand, Wädenswil, 2015.

• Adlhart, Christian; Born, Yannick; Fuchs, Michael; Fieseler, Lars; Pavlovic, Branislav,

  2015.

  Encapsulation and controlled release of bacteriophages for food protection using electrospun nanofibers[paper].

  In:

  Proceedings of the NART conference 2015.

  NART 2015, Nanofibers, Applications and Related Technologies, Liberec, Czech Republic, 31 August - 2 September 2015.

  pp. 49-56.

• Born, Yannick; Klumpp, Jochen; Zurfluh, Katrin; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Implications of the phage depolymerase DpoL1 on Erwinia amylovora[poster].

  In:

  21st Biennial Evergreen International Phage Biology Meeting, Olympia, USA, 2-7 August 2015.

• Gantenbein-Demarchi, Corinne; Kuhn, Roger; Krapf, Tamara; Fieseler, Lars,

  2012.

  Detection of faecal indicator organisms by RT-qPCR[poster].

  In:

  SGM Annual Congress 2012 - Swiss Society for Microbiology, St. Gallen, 21-22 June 2012.

• Fieseler, Lars; Loessner, Martin; Hagens, Steven,

  2011.

  Bacteriophages and food safety.

  In:

  Lacroix, Christophe, ed.,

  Protective cultures, antimicrobial metabolites and bacteriophages for food and beverage biopreservation.

  Oxford:

  Woodhead Publishing.

  pp. 161-178.

  Woodhead Publishing Series in Food Science, Technology and Nutrition ; 201.

  Available from: https://doi.org/10.1533/9780857090522.1.161

• Fieseler, Lars,

  2017.

  Bacteriophages for the control of pathogenic bacteria.

  In:

  BioTech 2017 Conference, Prague, Czech Republic, 13-17 June 2017.

• Hinderling, Christian; Kroslakova, Ivana; Gantenbein-Demarchi, Corinne; Freimüller Leischtfeld, Susette; Delueg, Stephanie; Miescher Schwenninger, Susanne; Fieseler, Lars,

  2012.

  Development of an efficient strategy for the identification of the dominant microflora of cocoa fermentation.

  In:

  1st Swiss International Congress on Industrial Microbiology (MICROSCON), Olten, Switzerland, 16-17 October 2012.

Affiliations

Current Affiliations

• Schweizerische Gesellschaft für Lebensmittelhygiene (SGLH): President
  As president of SGLH (https://sglh.ch/) I am responsible for the organization of board meetings, general assemblies, the annual scientific meeting, and additinoal scientific or public activities. SGLH covers all aspects of food safety which fits well to the activities of the food microbiology research group at zhaw in terms of teaching, research, continued education, and services., Hirzel
  01 / 2023 - today
• phageSuisse: President elect
  As new president of phageSuisse (https://phagesuisse.ch/) I am responsible for the organization of board meetings, the general assembly, and scientific or public activities of the society. My activities at phageSuisse fit well to the research interests of the food microbiology research group at zhaw., Fribourg
  01 / 2024 - today
• Werder Stiftung: Board Member
  I am a member of the Board of Trustees of the Werder Foundation (https://www.werder-stiftung.ch/index.php). The Werder Foundation is committed to safeguarding food safety. The Board of Trustees awards the Werder Prize annually to honor personalities of Swiss nationality, and exceptionally also foreign researchers, who have made great contributions in the field of food quality and safety, in particular food chemistry, or in other ways to the control, legislation or technology of food., Bern
  07 / 2024 - today

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