Prof. Dr. Lars Fieseler

Projects

• Novel phage derived antimicrobials / Deputy project leader / Project ongoing
• SONEVA / Project co-leader / Project completed
• Contactless separation and concentration of Legionella species in drinking water installations / Project leader / Project completed
• PhageFire – An effective and environmentally friendly solution to control fire blight disease caused by Erwinia amylovora in pome fruit crops / Project leader / Project completed
• PhagePow(d)er / Project leader / Project completed
• Molecular mechanism of bacteriophage tail spike proteins in bacterial infection / Project co-leader / Project completed
• Engineered bacteriophages for the control of E. coli O157 / Project leader / Project completed
• Nachweis von E. coli und Coliformen in Lebensmitteln und von Oberflächenabstrichen mittels AquaSparkTM Technologie / Project leader / Project completed
• Persistence of STEC in grain, milling by-products, flour, and raw follow up products / Project leader / Project completed
• Platform Health / Project co-leader / Project completed
• Nachweis von L. monocytogenes und Salmonella in Lebensmitteln und von Oberflächenabstrichen mittels AquaSparkTM Technologie / Project leader / Project completed
• Rapid Quantification of Pseudomonas aeruginosa by flow-cytometry / Project leader / Project completed
• BIOPAC (Biopolymer based bioactive food packaging) / Team member / Project completed
• Mechanisms of phage resistance in Erwinia amylovora / Project leader / Project completed
• Legionellen im Kontext des FM / Team member / Project completed
• KJM – KleenlineJonmaster / Team member / Project completed
• Microbial and somatic cell monitoring of raw milk by imdedance flow cytometry / Project leader / Project completed

Publications

• Ullrich, Lisa; Gillich, Elodie; André, Amandine; Panarese, Sandra; Imhaus, Anne Flore; Fieseler, Lars; Chetschik, Irene,

  2023.

  Influence of ozone treatment during storage on odour-active compounds, total titratable acidity, and ascorbic acid in oranges and bananas.

  Applied Sciences.

  13(19), pp. 10885.

  Available from: https://doi.org/10.3390/app131910885

• Desroche, Nicolas; De Oliveira, Déborah; Imhaus, Anne-Flore; Hupfeld, Mario; Fieseler, Lars,

  2023.

  Validation of N-Light™ salmonella risk test kit for detection of Salmonella spp. on environmental surfaces : AOAC Performance Tested MethodsSM 072204.

  Journal of AOAC INTERNATIONAL.

  106(4), pp. 939-948.

  Available from: https://doi.org/10.1093/jaoacint/qsad017

• Witte, Sander; Huijboom, Linda; Klamert, Silvia; van de Straat, Leoni; Hagens, Steven; Fieseler, Lars; de Vegt, Bert T.; van Mierlo, Joël T.,

  2022.

  Application of bacteriophages EP75 and EP335 efficiently reduces viable cell counts of Escherichia coli O157 on beef and vegetables.

  Food Microbiology.

  104(103978).

  Available from: https://doi.org/10.1016/j.fm.2022.103978

• Knecht, Leandra E.; Heinrich, Nadine; Born, Yannick; Felder, Katja; Pelludat, Cosima; Loessner, Martin J.; Fieseler, Lars; et al.,

  2022.

  Bacteriophage S6 requires bacterial cellulose for Erwinia amylovora infection.

  Environmental Microbiology.

  24(8), pp. 3436-3450.

  Available from: https://doi.org/10.1111/1462-2920.15973

• Pacher, Nicola; Burtscher, Johanna; Johler, Sophia; Etter, Danai; Bender, Denisse; Fieseler, Lars; Domig, Konrad J.,

  2022.

  Ropiness in bread : a re-emerging spoilage phenomenon.

  Foods.

  11(19), pp. 3021.

  Available from: https://doi.org/10.3390/foods11193021

• Knecht, Leandra E.; Born, Yannick; Pelludat, Cosima; Pothier, Joël F.; Smits, Theo H. M.; Loessner, Martin J.; Fieseler, Lars,

  2022.

  Spontaneous resistance of Erwinia amylovora against bacteriophage Y2 affects infectivity of multiple phages.

  Frontiers in Microbiology.

  13(908346).

  Available from: https://doi.org/10.3389/fmicb.2022.908346

• Larose, Delphine; Desroche, Nicolas; Reinau, Lukas; Hupfeld, Mario; Fieseler, Lars,

  2021.

  Validation of N-Light™ L. monocytogenes for detection of Listeria monocytogenes on environmental surfaces : AOAC Performance Tested Method℠ 122002.

  Journal of AOAC INTERNATIONAL.

  Available from: https://doi.org/10.1093/jaoacint/qsab165

• Pertics, Botond Zsombor; Szénásy, Dalma; Dunai, Dániel; Born, Yannick; Fieseler, Lars; Kovács, Tamás; Schneider, György,

  2020.

  Isolation of a novel lytic bacteriophage against a nosocomial methicillin-resistant Staphylococcus aureus belonging to ST45.

  BioMed Research International.

  2020(5463801), pp. 1-10.

  Available from: https://doi.org/10.1155/2020/5463801

• Ganz, Giverny; Reinau, Lukas; Imhaus, Anne Flore; Hupfeld, Mario; Fieseler, Lars,

  2020.

  AquaSparkTM : rapid environmental monitoring of Listeria monocytogenes.

  Chimia.

  74(10), pp. 791-797.

  Available from: https://doi.org/10.2533/chimia.2020.791

• Knecht, Leandra E.; Veljkovic, Marjan; Fieseler, Lars,

  2020.

  Diversity and function of phage encoded depolymerases.

  Frontiers in Microbiology.

  10(2949).

  Available from: https://doi.org/10.3389/fmicb.2019.02949

• van Mierlo, Joël; Hagens, Steven; Witte, Sander; Klamert, Silvia; van de Straat, Leoni; Fieseler, Lars,

  2019.

  Complete genome sequences of escherichia coli phages vB_EcoM-EP75 and vB_EcoP-EP335.

  Microbiology Resource Announcements.

  8(16).

  Available from: https://doi.org/10.1128/MRA.00078-19

• Born, Yannick; Knecht, Leandra E.; Eigenmann, Mirjam; Bolliger, Michel; Klumpp, Jochen; Fieseler, Lars,

  2019.

  A major-capsid-protein-based multiplex PCR assay for rapid identification of selected virulent bacteriophage types.

  Archives of Virology.

  164(3), pp. 819-830.

  Available from: https://doi.org/10.1007/s00705-019-04148-6

• Roth-Konforti, Michal; Green, Ori; Hupfeld, Mario; Fieseler, Lars; Heinrich, Nadine; Ihssen, Julian; Vorberg, Raffael; Wick, Lukas; Spitz, Urs; Shabat, Doron,

  2019.

  Ultrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probes.

  Angewandte Chemie: International Edition.

  58(30), pp. 10361-10367.

  Available from: https://doi.org/10.1002/anie.201904719

• Knecht, Leandra E.; Born, Yannick; Pothier, Joël F.; Loessner, Martin J.; Fieseler, Lars,

  2018.

  Complete genome sequences of erwinia amylovora phages vB_EamP-S2 and vB_EamM-Bue1.

  Microbiology Resource Announcements.

  7(3).

  Available from: https://doi.org/10.1128/MRA.00891-18

• Buttimer, Colin; Born, Yannick; Lucid, Alan; Loessner, Martin J.; Fieseler, Lars; Coffey, Aidan,

  2018.

  Erwinia amylovora phage vB_EamM_Y3 represents another lineage of hairy myoviridae.

  Research in Microbiology.

  169(9), pp. 505-514.

  Available from: https://doi.org/10.1016/j.resmic.2018.04.006

• Born, Yannick; Fieseler, Lars; Thöny, Valentin; Leimer, Nadja; Duffy, Brion; Loessner, Martin J.,

  2017.

  Engineering of bacteriophages Y2::dpoL1-C and Y2::luxAB for efficient control and rapid detection of the fire blight pathogen, Erwinia amylovora.

  Applied and Environmental Microbiology.

  83(12), pp. e00341-17.

  Available from: https://doi.org/10.1128/AEM.00341-17

• Shen, Yang; Boulos, Samy; Sumrall, Eric; Gerber, Benjamin; Julian-Rodero, Alicia; Eugster, Marcel R.; Fieseler, Lars; Nyström, Laura; Ebert, Marc-Olivier; Loessner, Martin J.,

  2017.

  Structural and functional diversity inListeriacell wall teichoic acids.

  Journal of Biological Chemistry.

  292(43), pp. 17832-17844.

  Available from: https://doi.org/10.1074/jbc.M117.813964

• Schmitter, Sibylle; Fieseler, Lars; Klumpp, Jochen; Bertram, Ralph; Loessner, Martin J.,

  2017.

  TetR-dependent gene regulation in intracellular Listeria monocytogenes demonstrates the spatiotemporal surface distribution of ActA.

  Molecular Microbiology.

  105(3), pp. 413-425.

  Available from: https://doi.org/10.1111/mmi.13706

• Krapf, Tamara; Kuhn, Roger; Kauf, Peter; Gantenbein-Demarchi, Corinne; Fieseler, Lars,

  2016.

  Quantitative real time PCR does not reliably detect single fecal indicator bacteria in drinking water.

  Water Science and Technology.

  16(6), pp. 1674-1682.

  Available from: https://doi.org/10.2166/ws.2016.052

• Schwendimann, Livia Maya; Kauf, Peter; Fieseler, Lars; Gantenbein-Demarchi, Corinne; Miescher Schwenninger, Susanne,

  2015.

  Development of a quantitative PCR assay for rapid detection of Lactobacillus plantarum and Lactobacillus fermentum in cocoa bean fermentation.

  Journal of Microbiological Methods.

  115, pp. 94-99.

  Available from: https://doi.org/10.1016/j.mimet.2015.05.022

• Born, Yannick; Bosshard, Lars; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Protection of Erwinia amylovora bacteriophage Y2 from UV-induced damage by natural compounds.

  Bacteriophage.

  5(4), pp. e1074330.

  Available from: https://doi.org/10.1080/21597081.2015.1074330

• Fieseler, Lars; Doyscher, Dominik; Loessner, Martin; Schuppler, Markus,

  2014.

  Acanthamoeba release compounds which promote growth of Listeria monocytogenes and other bacteria.

  Applied Microbiology and Biotechnology.

  98(7), pp. 3091-3097.

  Available from: https://doi.org/10.1007/s00253-014-5534-9

• Born, Yannick; Fieseler, Lars; Klumpp, Jochen; Eugster, Marcel R.; Zurfluh, Katrin; Duffy, Brion; Loessner, Martin J.,

  2014.

  The tail-associated depolymerase of Erwinia amylovoraphage L1 mediates host cell adsorption and enzymatic capsule removal, which can enhance infection by other phage.

  Environmental Microbiology.

  16(7), pp. 2168-2180.

  Available from: https://doi.org/10.1111/1462-2920.12212

• Doyscher, Dominik; Fieseler, Lars; Dons, Lone; Loessner, Martin J.; Schuppler, Markus,

  2013.

  Acanthamoeba feature a unique backpacking strategy to trap and feed on Listeria monocytogenes and other motile bacteria.

  Environmental Microbiology.

  15(2), pp. 433-446.

  Available from: https://doi.org/10.1111/j.1462-2920.2012.02858.x

• Guenther, Susanne; Herzig, Oliver; Fieseler, Lars; Klumpp, Jochen; Loessner, Martin J.,

  2012.

  Biocontrol of Salmonella Typhimurium in RTE foods with the virulent bacteriophage FO1-E2.

  International Journal of Food Microbiology.

  154(1-2), pp. 66-72.

  Available from: https://doi.org/10.1016/j.ijfoodmicro.2011.12.023

• Born, Yannick; Fieseler, Lars; Marazzi, Janine; Lurz, Rudi; Duffy, Brion; Loessner, Martin J.,

  2011.

  Novel virulent and broad-host-range Erwinia amylovora bacteriophages reveal a high degree of mosaicism and a relationship to enterobacteriaceae phages.

  Applied and Environmental Microbiology.

  77(17), pp. 5945-5954.

  Available from: https://doi.org/10.1128/AEM.03022-10

• Fieseler, Lars; Loessner, Martin,

  2013.

  Bacteriophage biocontrol

  .

  In:

  Labbé, Ronald G.; García, Santos, eds.,

  Guide to foodborne pathogens.

  New York:

  Wiley.

  pp. 448-456.

  Available from: https://doi.org/10.1002/9781118684856.ch28

• Gayder, Steven; Fieseler, Lars; Castle, Alan; Svircev, Antonet,

  2022.

  A novel genome-wide, qPCR-based approach to identify genetic determinants of phage host range [poster].

  In:

  Viruses of Microbes (VoM), Guimarães, Portugal, 18-22 July 2022.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Available from: https://doi.org/10.21256/zhaw-27325

• Knecht, Leandra; Heinrich, Nadine; Felder, Katja; Born, Yannick; Pelludat, Cosima; Loessner, Martin; Fieseler, Lars,

  2018.

  Mutations in the bcs operon of Erwinia amylovora abolish infection by bacteriophages S6 and M7 [poster].

  In:

  Viruses of Microbes (VoM), Wroclaw, Poland, 9-13 July 2018.

• Buttimer, Collin; Born, Yannick; Hendrix, Hanne; Oliveria, Hugo; McAuliffe, Olivia; Neve, Horst; Ross, R. Paul; Hill, Colin; Noben, Jean-Paul; O'Mahony, Jim; Fieseler, Lars; Lavigne, Rob; Coffey, Aidan; et al.,

  2017.

  Hairy jumbo phages of Enterobacteriaceae [poster].

  In:

  2017 Evergreen International Phage Meeting, Evergreen State College, USA, 6-11 August 2017.

  ResearchGate.

  Available from: https://doi.org/10.13140/RG.2.2.19768.42243

• Gerber, Nicole; Fieseler, Lars; Hirsch, Sven; Neutsch, Lukas; Papadopoulou, Athina; Smits, Theo,

  2022.

  Zusammenarbeit und wissenschaftlicher Austausch sind der Schlüssel zu erfolgreicher Forschung : der ZHAW Health Research Hub bringt’s unter einen Hut.

  Clinicum.

  2022(6), pp. 80-81.

  Available from: https://doi.org/10.21256/zhaw-26376

• Stöppelmann, Felix; Fieseler, Lars,

  2020.

  Massnahmen zur Beherrschung mikrobiologischer Risiken verursacht durch Vibrio spp..

• Wetzel, Silvan; Fieseler, Lars,

  2020.

  Risk evaluation of E. coli ST 131 as a foodborne pathogen in Switzerland.

• Wetzel, Silvan; Fieseler, Lars,

  2020.

  Shiga-toxin producing escherichia coli in flour, wheat grain and flour products.

• Knecht, Leandra; Born, Yannick; Loessner, Martin; Fieseler, Lars,

  2016.

  Identification of phage receptors in Erwinia amylovora after transposon mutagenesis [poster].

  In:

  Viruses of Microbes (VoM), Liverpool, United Kingdom, 18-22 July 2016.

• Freimüller Leischtfeld, Susette; Weber, Stefan; Kuhn, Roger; Schmid, Jürg; Fieseler, Lars,

  2015.

  Molekulare Schnellmethode für den Legionellen-Test.

  Alimenta.

  2015(8).

• Born, Yannick; Fieseler, Lars,

  2015.

  A bacteriophage cocktail to control Salmonella Typhimurium [poster].

  In:

  21st Biennial Evergreen International Phage Biology Meeting, Olympia, USA, 2-7 August 2015.

• Born, Yannick; Knecht, Leandra; Pelludat, Cosima; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Bakteriophagen zur Bekämpfung von Feuerbrand [poster].

  In:

  1. Nationale Tagung - Gemeinsam gegen Feuerbrand, Wädenswil, 2015.

• Adlhart, Christian; Born, Yannick; Fuchs, Michael; Fieseler, Lars; Pavlovic, Branislav,

  2015.

  Encapsulation and controlled release of bacteriophages for food protection using electrospun nanofibers [paper].

  In:

  Proceedings of the NART conference 2015.

  NART 2015, Nanofibers, Applications and Related Technologies, Liberec, Czech Republic, 31 August - 2 September 2015.

  pp. 49-56.

• Gantenbein-Demarchi, Corinne; Kuhn, Roger; Kauf, Peter; Schmid, Jürg; Krapf, Tamara; Fieseler, Lars,

  2015.

  Fäkalindikatoren im Trinkwasser nachweisen.

  Alimenta.

• Born, Yannick; Klumpp, Jochen; Zurfluh, Katrin; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2015.

  Implications of the phage depolymerase DpoL1 on Erwinia amylovora [poster].

  In:

  21st Biennial Evergreen International Phage Biology Meeting, Olympia, USA, 2-7 August 2015.

• Leiblein, Thomas; Kroslakova, Ivana; Freimüller Leischtfeld, Susette; Fieseler, Lars; Hofer, Susanne,

  2015.

  Legionella in FM : Detection of Legionella pneumophila in waterlines of dental surgeries in the Canton of Zurich, Switzerland [paper].

  In:

  Alexander, Keith; Price, Ilfryn, eds.,

  EuroFM Research Papers, Section 5, Development Papers.

  EuroFM Conference 2015, Glasgow, Ireland, 1-3 June 2015.

  European Facilities Management Network (EuroFM).

  pp. 26-33.

• Fieseler, Lars,

  2015.

  Nachweis und Kontrolle der Keimbelastung im Lebensmittel.

  Lebensmittel-Technologie.

  2015(4), pp. 12-13.

• Fieseler, Lars; Gantenbein-Demarchi, Corinne; Miescher Schwenninger, Susanne; Kuhn, Roger; Kleinert, Michael,

  2013.

  Rope in bread : a critical challenge for the bakery industry [poster].

  In:

  4th MoniQA International Conference, Budapest, Hungary, 26 February - 1 March 2013.

• Gantenbein-Demarchi, Corinne; Kuhn, Roger; Krapf, Tamara; Fieseler, Lars,

  2012.

  Detection of faecal indicator organisms by RT-qPCR [poster].

  In:

  SGM Annual Congress 2012 - Swiss Society for Microbiology, St. Gallen, 21-22 June 2012.

• Fieseler, Lars; Loessner, Martin; Hagens, Steven,

  2011.

  Bacteriophages and food safety

  .

  In:

  Lacroix, Christophe, ed.,

  Protective cultures, antimicrobial metabolites and bacteriophages for food and beverage biopreservation.

  Oxford:

  Woodhead Publishing.

  pp. 161-178.

  Woodhead Publishing Series in Food Science, Technology and Nutrition ; 201.

  Available from: https://doi.org/10.1533/9780857090522.1.161

• Heller, Knut; Loessner, Martin; Fieseler, Lars,

  2011.

  Bakteriophagen : Grundlagen, Rolle in Lebensmitteln und Anwendungen zum Nachweis sowie der Kontrolle von Krankheitserregern.

  1. Auflage.

  Hamburg:

  Behr.

  ISBN 978-3-89947-594-4.

• Gayder, Steven; Kammerecker, Sandrine; Gervásio, Kellen; Henriques, André; Torres-Cortés, Gloria; Kőrösiné Papp, Szilvia; Kovács, Tamás; Raffai, Krisztina; Cabezón Largas, Sixto; de Santos Prieto, Borja; Fieseler, Lars,

  2022.

  A qPCR-based, population dynamics approach for the development of a bacteriophage-based biopesticide.

  In:

  Third International Symposium on Fire Blight of Rosaceous Plants, Dresden-Pillnitz, Germany, 6-9 September 2022.

• Kammerecker, Sandrine; Gayder, Steven; Gervásio, Kellen; Henriques, André; Torres-Cortés, Gloria; Kőrösiné Papp, Szilvia; Kovács, Tamás; Raffai, Krisztina; Cabezón Largas, Sixto; de Santos Prieto, Borja; Fieseler, Lars,

  2022.

  PhageFire : formulation of a bacteriophage-based biopesticide against Erwinia amylovora.

  In:

  Third International Symposium on Fire Blight of Rosaceous Plants, Dresden-Pillnitz, Germany, 6-9 September 2022.

• Fieseler, Lars,

  2017.

  Bacteriophages for the control of pathogenic bacteria.

  In:

  BioTech 2017 Conference, Prague, Czech Republic, 13-17 June 2017.

• Born, Yannick; Leimer, Nadja; Thöny, Valentin; Zurfluh, Katrin; Eugster, Marcel; Klumpp, Jochen; Duffy, Brion; Loessner, Martin; Fieseler, Lars,

  2016.

  Engineered phages for efficient control and rapid detection of viable Erwinia amylovora cells.

  In:

  Viruses of Microbes (VoM), Liverpool, United Kingdom, 18-22 July 2016.

• Born, Yannick; Fieseler, Lars,

  2016.

  The effectiveness of T5-like phages to control Salmonella enterica.

  In:

  3rd International Conference «Bacteriophages», Moscow, Russia, 13-15 October 2016.

• Fieseler, Lars; Klumpp, Jochen,

  2014.

  A cocktail of two bacteriophages is required to control Salmonella in vitro.

  In:

  Viruses of Microbes (VoM), Zurich, Switzerland, 14-18 July 2014.

• Fieseler, Lars,

  2014.

  Bakteriophagen zur Kontrolle von Salmonella Typhimurium in Lebensmitteln.

  In:

  7. Symposium: Schnellmethoden und Automatisierung in der Lebensmittel‐Mikrobiologie, Lemgo, Germany, 1-2 July 2014.

• Hinderling, Christian; Kroslakova, Ivana; Gantenbein-Demarchi, Corinne; Freimüller Leischtfeld, Susette; Delueg, Stephanie; Miescher Schwenninger, Susanne; Fieseler, Lars,

  2012.

  Development of an efficient strategy for the identification of the dominant microflora of cocoa fermentation.

  In:

  1st Swiss International Congress on Industrial Microbiology (MICROSCON), Olten, Switzerland, 16-17 October 2012.

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