David Frasson

Projekte

• Antibiotika gegen hochresistente Gram-negative Bakterien / Teammitglied / abgeschlossen
• Modulatoren der MMP-Hemopexin-Domäne / Teammitglied / abgeschlossen
• Induktion der Wirkstoffbildung bei Actinomyceten / Teammitglied / abgeschlossen
• Plasmid-Toolbox für Enzymkaskaden / Teammitglied / abgeschlossen
• Identifizierung und Charakterisierung von Wirkstoffen aus Actinomyceten aus der Schweiz gegen pathogene Bakterien / Teammitglied / abgeschlossen
• Kinetische Struktur-Aktivitäts-Beziehungen und röntgenkristallographische Bestimmung des Bindungsmodus von niedermolekularen Wirkstoffmolekülen / Teammitglied / abgeschlossen
• Isolation, Identifikation und medizinalchemische Optimierung von biogenen Wirkstoffen / Teammitglied / abgeschlossen
• Culture Collection of Switzerland / Teammitglied / abgeschlossen

Publikationen

Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed

• Fischer, T., Frasson, D., Sievers, M., & Riedl, R. (2024). Phthalimide derivatives as a new class of papain-like protease inhibitors in SARS-CoV-2. Archiv Der Pharmazie, 358(1), e2400714. https://doi.org/10.1002/ardp.202400714
• Fischer, T., Frasson, D., Sievers, M., & Riedl, R. (2024). Phthalimide derivatives as a new class of papain‐like protease inhibitors in SARS‐CoV‐2. Archiv Der Pharmazie, 358(1), e2400714. https://doi.org/10.1002/ardp.202400714
• Pothier, J. F., Bolt, V., Arn, F., Frasson, D., Rhyner, N., & Sievers, M. (2023). High-quality draft genome sequence of Streptomyces albidoflavus CCOS 2040, isolated from a Swiss soil sample. Microbiology Resource Announcements, 12(3), e01225–22. https://doi.org/10.1128/mra.01225-22
• Arn, F., Frasson, D., Kroslakova, I., Rezzonico, F., Pothier, J., Riedl, R., & Sievers, M. (2020). Isolation and identification of actinomycetes strains from Switzerland and their biotechnological potential. Chimia, 74(5), 382–390. https://doi.org/10.2533/chimia.2020.382
• Lindenmann, U., Brand, M., Gall, F., Frasson, D., Hunziker, L., Kroslakova, I., Sievers, M., & Riedl, R. (2020). Discovery of a class of potent and selective non‐competitive sentrin‐specific protease 1 inhibitors. ChemMedChem, 15(8), 675–679. https://doi.org/10.1002/cmdc.202000067
• Rutz, D., Frasson, D., Sievers, M., Blom, J., Rezzonico, F., Pothier, J. F., & Smits, T. H. M. (2019). Comparative genomic analysis of the biotechnological potential of the novel species Pseudomonas wadenswilerensis CCOS 864T and Pseudomonas reidholzensis CCOS 865T. Diversity, 2019(11), 204. https://doi.org/10.3390/d11110204
• Rutz, D., Frasson, D., Sievers, M., Blom, J., Rezzonico, F., Pothier, J. F., & Smits, T. H. M. (2019). High-quality draft genome sequence of Pseudomonas reidholzensis strain CCOS 865T. Microbiology Resource Announcements, 8(3). https://doi.org/10.1128/MRA.01502-18
• Smits, T. H. M., Rezzonico, F., Frasson, D., Vesga, P., Vacheron, J., Blom, J., Pothier, J. F., Keel, C., Maurhofer, M., & Sievers, M. (2019). Updated genome sequence and annotation for the full genome of Pseudomonas protegens CHA0. Microbiology Resource Announcements, 8(39). https://doi.org/10.1128/MRA.01002-19
• Peters, C., Frasson, D., Sievers, M., & Buller, R. (2019). Novel Old Yellow Enzyme subclasses. ChemBioChem. https://doi.org/10.1002/cbic.201800770
• Gall, F., Hohl, D., Frasson, D., Wermelinger, T., Mittl, P. R. E., Sievers, M., & Riedl, R. (2019). Drug design inspired by nature : crystallographic detection of an auto‐tailored protease inhibitor template. Angewandte Chemie: International Edition, 58(12), 4051–4055. https://doi.org/10.1002/anie.201812348
• Gall, F., Hohl, D., Frasson, D., Wermelinger, T., Mittl, P. R. E., Sievers, M., & Riedl, R. (2019). Von der Natur inspiriertes Wirkstoffdesign : kristallographische Detektion eines selbstgenerierten Inhibitor‐Grundgerüsts. Angewandte Chemie, 131(12), 4091–4096. https://doi.org/10.1002/ange.201812348
• Rutz, D., Frasson, D., Sievers, M., Blom, J., Rezzonico, F., Pothier, J., & Smits, T. (2018). High-quality draft genome sequence of pseudomonas wadenswilerensis CCOS 864T. Microbiology Resource Announcements, 7(16). https://doi.org/10.1128/MRA.01059-18
• Frasson, D., Opoku, M., Picozzi, T., Torossi, T., Balada, S., Smits, T., & Hilber, U. (2017). Pseudomonas wadenswilerensis sp. nov. and Pseudomonas reidholzensis sp. nov. : two new species within the Pseudomonas putida group isolated from forest soil. International Journal of Systematic and Evolutionary Microbiology, 67, 2853–2861. https://doi.org/10.1099/ijsem.0.002035
• Margesin, R., Zhang, D.-C., Frasson, D., & Brouchkov, A. (2016). Glaciimonas frigoris sp. nov., a psychrophilic bacterium isolated from ancient Siberian permafrost sediment, and emended description of the genus Glaciimonas. International Journal of Systematic and Evolutionary Microbiology, 66, 744–748. https://doi.org/10.1099/ijsem.0.000783
• Frasson, D., Udovičić, M., Frey, B., Lapanje, A., Zhang, D.-C., Margesin, R., & Sievers, M. (2015). Glaciimonas alpina sp. nov. isolated from alpine glaciers and reclassification of Glaciimonas immobilis Cr9-12 as the type strain of Glaciimonas alpina sp. nov. International Journal of Systematic and Evolutionary Microbiology, 65, 1779–1785. https://doi.org/10.1099/ijs.0.000174
• Smits, T. H. M., Pothier, J. F., Ruinelli, M., Blom, J., Frasson, D., Koechli, C., Fabbri, C., Brandl, H., Duffy, B., & Sievers, M. (2015). Complete genome sequence of the cyanogenic phosphate-solubilizing Pseudomonas sp. strain CCOS 191 : a close relative of Pseudomonas mosseli. Genome Announcements, 3(3). https://doi.org/10.1128/genomeA.00616-15
• Imseng, N., Steiger, N., Frasson, D., Sievers, M., Tappe, A., Greller, G., Eibl, D., & Eibl-Schindler, R. (2014). Single-use wave-mixed versus stirred bioreactors for insect-cell/BEVS-based protein expression at benchtop scale. Engineering in Life Sciences, 14(3), 264–271. https://doi.org/10.1002/elsc.201300131
• Hausammann, G. J., Heitkamp, T., Matile, H., Gsell, B., Thoma, R., Schmid, G., Frasson, D., Sievers, M., Hennig, M., & Grütter, M. G. (2013). Generation of an antibody toolbox to characterize hERG. Biochemical and Biophysical Research Communications, 431(1), 70–75. https://doi.org/10.1016/j.bbrc.2012.12.089
• Sievers, M., Dasen, G., Wermelinger, T., Landert, S., & Frasson, D. (2010). Culture Collections and the Biotechnology Deal. Chimia, 64(11), 782–783. https://doi.org/10.2533/chimia.2010.782
• Schaller, A., & Frasson, D. (2001). Induction of wound response gene expression in tomato leaves by ionophores. Planta, 212(3), 431–435. https://doi.org/10.1007/s004250000413

Weitere Publikationen

• Gall, F., Riedl, R., Sievers, M., Wermelinger, T., & Frasson, D. (2019). Durch die Natur inspiriertes Wirkstoffdesign. Transfer, 2019(1), 6. https://doi.org/10.21256/zhaw-30046
• Gall, F., Hohl, D., Frasson, D., Wermelinger, T., Mittl, P. R. E., Sievers, M., & Riedl, R. (2019). Cover picture : drug design inspired by nature : crystallographic detection of an auto‐tailored protease inhibitor template (Angew. Chem. Int. Ed. 12/2019). Angewandte Chemie: International Edition, 58(12), 3653. https://doi.org/10.1002/anie.201901671

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