David Frasson

Projekte

• Antibiotika gegen hochresistente Gram-negative Bakterien / Teammitglied / abgeschlossen
• Modulatoren der MMP-Hemopexin-Domäne / Teammitglied / abgeschlossen
• Induktion der Wirkstoffbildung bei Actinomyceten / Teammitglied / abgeschlossen
• Plasmid-Toolbox für Enzymkaskaden / Teammitglied / abgeschlossen
• Identifizierung und Charakterisierung von Wirkstoffen aus Actinomyceten aus der Schweiz gegen pathogene Bakterien / Teammitglied / abgeschlossen
• Kinetische Struktur-Aktivitäts-Beziehungen und röntgenkristallographische Bestimmung des Bindungsmodus von niedermolekularen Wirkstoffmolekülen / Teammitglied / abgeschlossen
• Isolation, Identifikation und medizinalchemische Optimierung von biogenen Wirkstoffen / Teammitglied / abgeschlossen
• Culture Collection of Switzerland / Teammitglied / abgeschlossen

Publikationen

Beiträge in wissenschaftlicher Zeitschrift, peer-reviewed

• Fischer, T. et al. (2024) 'Phthalimide derivatives as a new class of papain-like protease inhibitors in SARS-CoV-2', Archiv der Pharmazie, 358(1), p. e2400714. doi: 10.1002/ardp.202400714.
• Fischer, T. et al. (2024) 'Phthalimide derivatives as a new class of papain‐like protease inhibitors in SARS‐CoV‐2', Archiv der Pharmazie, 358(1), p. e2400714. doi: 10.1002/ardp.202400714.
• Pothier, J. F. et al. (2023) 'High-quality draft genome sequence of Streptomyces albidoflavus CCOS 2040, isolated from a Swiss soil sample', Microbiology Resource Announcements, 12(3), pp. e01225–22. doi: 10.1128/mra.01225-22.
• Arn, F. et al. (2020) 'Isolation and identification of actinomycetes strains from Switzerland and their biotechnological potential', Chimia, 74(5), pp. 382–390. doi: 10.2533/chimia.2020.382.
• Lindenmann, U. et al. (2020) 'Discovery of a class of potent and selective non‐competitive sentrin‐specific protease 1 inhibitors', ChemMedChem, 15(8), pp. 675–679. doi: 10.1002/cmdc.202000067.
• Rutz, D. et al. (2019) 'Comparative genomic analysis of the biotechnological potential of the novel species Pseudomonas wadenswilerensis CCOS 864T and Pseudomonas reidholzensis CCOS 865T', Diversity, 2019(11), p. 204. doi: 10.3390/d11110204.
• Rutz, D. et al. (2019) 'High-quality draft genome sequence of Pseudomonas reidholzensis strain CCOS 865T', Microbiology Resource Announcements, 8(3). doi: 10.1128/MRA.01502-18.
• Smits, T. H. M. et al. (2019) 'Updated genome sequence and annotation for the full genome of Pseudomonas protegens CHA0', Microbiology Resource Announcements, 8(39). doi: 10.1128/MRA.01002-19.
• Peters, C. et al. (2019) 'Novel Old Yellow Enzyme subclasses', ChemBioChem. doi: 10.1002/cbic.201800770.
• Gall, F. et al. (2019) 'Von der Natur inspiriertes Wirkstoffdesign : kristallographische Detektion eines selbstgenerierten Inhibitor‐Grundgerüsts', Angewandte Chemie, 131(12), pp. 4091–4096. doi: 10.1002/ange.201812348.
• Gall, F. et al. (2019) 'Drug design inspired by nature : crystallographic detection of an auto‐tailored protease inhibitor template', Angewandte Chemie: International Edition, 58(12), pp. 4051–4055. doi: 10.1002/anie.201812348.
• Rutz, D. et al. (2018) 'High-quality draft genome sequence of pseudomonas wadenswilerensis CCOS 864T', Microbiology Resource Announcements, 7(16). doi: 10.1128/MRA.01059-18.
• Frasson, D. et al. (2017) 'Pseudomonas wadenswilerensis sp. nov. and Pseudomonas reidholzensis sp. nov. : two new species within the Pseudomonas putida group isolated from forest soil', International Journal of Systematic and Evolutionary Microbiology, 67, pp. 2853–2861. doi: 10.1099/ijsem.0.002035.
• Margesin, R. et al. (2016) 'Glaciimonas frigoris sp. nov., a psychrophilic bacterium isolated from ancient Siberian permafrost sediment, and emended description of the genus Glaciimonas', International Journal of Systematic and Evolutionary Microbiology, 66, pp. 744–748. doi: 10.1099/ijsem.0.000783.
• Frasson, D. et al. (2015) 'Glaciimonas alpina sp. nov. isolated from alpine glaciers and reclassification of Glaciimonas immobilis Cr9-12 as the type strain of Glaciimonas alpina sp. nov.', International Journal of Systematic and Evolutionary Microbiology, 65, pp. 1779–1785. doi: 10.1099/ijs.0.000174.
• Smits, T. H. M. et al. (2015) 'Complete genome sequence of the cyanogenic phosphate-solubilizing Pseudomonas sp. strain CCOS 191 : a close relative of Pseudomonas mosseli', Genome Announcements, 3(3). doi: 10.1128/genomeA.00616-15.
• Imseng, N. et al. (2014) 'Single-use wave-mixed versus stirred bioreactors for insect-cell/BEVS-based protein expression at benchtop scale', Engineering in Life Sciences, 14(3), pp. 264–271. doi: 10.1002/elsc.201300131.
• Hausammann, G. J. et al. (2013) 'Generation of an antibody toolbox to characterize hERG', Biochemical and Biophysical Research Communications, 431(1), pp. 70–75. doi: 10.1016/j.bbrc.2012.12.089.
• Sievers, M. et al. (2010) 'Culture Collections and the Biotechnology Deal', Chimia, 64(11), pp. 782–783. doi: 10.2533/chimia.2010.782.
• Schaller, A. and Frasson, D. (2001) 'Induction of wound response gene expression in tomato leaves by ionophores', Planta, 212(3), pp. 431–435. doi: 10.1007/s004250000413.

Weitere Publikationen

• Gall, F. et al. (2019) 'Durch die Natur inspiriertes Wirkstoffdesign', Transfer, 2019(1), p. 6. doi: 10.21256/zhaw-30046.
• Gall, F. et al. (2019) 'Cover picture : drug design inspired by nature : crystallographic detection of an auto‐tailored protease inhibitor template (Angew. Chem. Int. Ed. 12/2019)', Angewandte Chemie: International Edition, 58(12), p. 3653. doi: 10.1002/anie.201901671.
• Gall, F. M. et al. (2019) Titelbild: Von der Natur inspiriertes Wirkstoffdesign : kristallographische Detektion eines selbstgenerierten Inhibitor‐Grundgerüsts (Angew. Chem. 12/2019). Wiley. doi: 10.1002/ange.201901671.

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