An acute stroke refers to the sudden onset of an abnormal function in the body caused by a disruption in blood supply to the brain. This interruption can occur either due to a blockage in the blood vessels (ischemic stroke) or bleeding within the brain (hemorrhagic stroke) and requires immediate intervention to minimise brain damage.

The EU-funded GEMINI project aims to develop validated multi-organ and multi-scale digital twin computational models that simulate the physiological processes and characteristics of acute stroke and potential treatments. These models will leverage information on cerebral blood flow, brain perfusion, metabolism, and thrombosis along the heart-brain axis. GEMINI plans to demonstrate the added benefits of these models in personalised management and treatment of acute stroke in a multi-centre clinical trial.