AneuX Modeling – Shape as a Biomarker for Instability of Intracranial Aneurysms
Description
Aneurysm is a disease of blood vessel walls that causes deformation and enlargement of the vascular lumen. Clinical decision-making is currently based on the location and size of the aneurysm and on empirical clinical observations. Changes in the vessel wall result in shape modifications that can be analyzed by modern imaging methodologies for computational modeling.
Tools to assess the size and shape of aneurisms promise to help clinicians predict disease progression for improved decision-making. Clinical data will be combined with millimeter and submillimeter scale 3D imaging and immune-histopathology of aneurisms in humans and animals and information on wall shear stress and wall tension as well as in vitro analysis of molecular biomarkers and biochemical networks in vessel wall tissue and blood to identify a predictive signature for aneurysm growth and rupture.
The predictive power of the disease model developed will be tested in a clinical trial. The project AneuX is a collaborative venture led by Dr. Philippe Bijlenga of the Department of Clinical Neurosciences of the University of Geneva Hospital. Additional Swiss partners are ETH Prof. Niels Kuster of the IT'IS Foundation, Dr. Sven Hirsch of the Institute of Applied Simulation (ZHAW), Prof. Brenda Kwak of the Department of Pathology and Immunology of the University of Geneva, Prof. Brigitte von Rechenberg of the University of Zurich Vetsuisse Faculty Equine Department, and Prof. Daniel Rüfenacht of the University of Zurich Center for Applied Biotechnology and Molecular Medicine.
The aim of the project is to develop tools for the medical community to use to quantify and analyze the 3D shapes of aneurisms and to test the hypothesis that aneurysm 3D shape can be used as a proxy for disease status.
Key data
Projectlead
Project team
Roland Gassmann, Erich Zbinden, Dr. Norman Juchler, Dr. Sabine Schilling
Project partners
Hôpitaux universitaires de Genève; Université de Genève / Département de pathologie et d'immunologie; Forschungsstiftung für Informationstechnologie und Gesellschaft IT'IS; Universität Zürich UZH / Vetsuisse-Fakultät; Schweizerische Neuro Stiftung
Project status
completed, 03/2015 - 08/2019
Institute/Centre
Institute of Computational Life Sciences (ICLS)
Funding partner
SNF SystemsX.ch
Publications
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The role of shape for aneurysm risk assessment
2022 Juchler, Norman; Bijlenga, Philippe; Hirsch, Sven
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Exploring intracranial aneurysm instability markers to improve disease modeling
2022 Dupuy, Nicolas; Juchler, Norman; Morel, Sandrine; Kwak, Brenda R.; Hirsch, Sven; Bijlenga, Philippe
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Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
2021 Bakker, Mark K.; van der Spek, Rick A. A.; van Rheenen, Wouter; Morel, Sandrine; Bourcier, Romain; Hostettler, Isabel C.; Alg, Varinder S.; van Eijk, Kristel R.; Koido, Masaru; Akiyama, Masato; Terao, Chikashi; Matsuda, Koichi; Walters, Robin G.; Lin, Kuang; Li, Liming; Millwood, Iona Y.; Chen, Zhengming; Rouleau, Guy A.; Zhou, Sirui; Rannikmäe, Kristiina; Sudlow, Cathie L. M.; Houlden, Henry; van den Berg, Leonard H.; Dina, Christian; Naggara, Olivier; Gentric, Jean-Christophe; Shotar, Eimad; Eugène, François; Desal, Hubert; Winsvold, Bendik S.; Børte, Sigrid; Johnsen, Marianne Bakke; Brumpton, Ben M.; Sandvei, Marie Søfteland; Willer, Cristen J.; Hveem, Kristian; Zwart, John-Anker; Verschuren, W. M. Monique; Friedrich, Christoph M.; Hirsch, Sven; Schilling, Sabine; Dauvillier, Jérôme; Martin, Olivier; Jones, Gregory T.; Bown, Matthew J.; Ko, Nerissa U.; Kim, Helen; Coleman, Jonathan R. I.; Breen, Gerome; Zaroff, Jonathan G.; Klijn, Catharina J. M.; Malik, Rainer; Dichgans, Martin; Sargurupremraj, Muralidharan; Tatlisumak, Turgut; Amouyel, Philippe; Debette, Stéphanie; Rinkel, Gabriel J. E.; Worrall, Bradford B.; Pera, Joanna; Slowik, Agnieszka; Gaál-Paavola, Emília I.; Niemelä, Mika; Jääskeläinen, Juha E.; von Und Zu Fraunberg, Mikael; Lindgren, Antti; Broderick, Joseph P.; Werring, David J.; Woo, Daniel; Redon, Richard; Bijlenga, Philippe; Kamatani, Yoichiro; Veldink, Jan H.; Ruigrok, Ynte M.
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Radiomics approach to quantify shape irregularity from crowd-based qualitative assessment of intracranial aneurysms
2020 Juchler, Norman; Schilling, Sabine; Glüge, Stefan; Bijlenga, Philippe; Rüfenacht, Daniel; Kurtcuoglu, Vartan; Hirsch, Sven
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Shape-based analysis of intracranial aneurysms
2020 Juchler, Norman
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Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
2020 Bakker, Mark K.; van der Spek, Rick A. A.; van Rheenen, Wouter; Morel, Sandrine; Bourcier, Romain; Hostettler, Isabel C.; Alg, Varinder S.; van Eijk, Kristel R.; Koido, Masaru; Akiyama, Masato; Terao, Chikashi; Matsuda, Koichi; Walters, Robin G.; Lin, Kuang; Li, Liming; Millwood, Iona Y.; Chen, Zhengming; Rouleau, Guy A.; Zhou, Sirui; Rannikmäe, Kristiina; Sudlow, Cathie L. M.; Houlden, Henry; van den Berg, Leonard H.; Dina, Christian; Naggara, Olivier; Gentric, Jean-Christophe; Shotar, Eimad; Eugène, François; Desal, Hubert; Winsvold, Bendik S.; Børte, Sigrid; Johnsen, Marianne Bakke; Brumpton, Ben M.; Sandvei, Marie Søfteland; Willer, Cristen J.; Hveem, Kristian; Zwart, John-Anker; Verschuren, W. M. Monique; Friedrich, Christoph M.; Hirsch, Sven; Schilling, Sabine; Dauvillier, Jérôme; Martin, Olivier; Jones, Gregory T.; Bown, Matthew J.; Ko, Nerissa U.; Kim, Helen; Coleman, Jonathan R. I.; Breen, Gerome; Zaroff, Jonathan G.; Klijn, Catharina J. M.; Malik, Rainer; Dichgans, Martin; Sargurupremraj, Muralidharan; Tatlisumak, Turgut; Amouyel, Philippe; Debette, Stéphanie; Rinkel, Gabriel J. E.; Worrall, Bradford B.; Pera, Joanna; Slowik, Agnieszka; Gaál-Paavola, Emília I.; Niemelä, Mika; Jääskeläinen, Juha E.; von Und Zu Fraunberg, Mikael; Lindgren, Antti; Broderick, Joseph P.; Werring, David J.; Woo, Daniel; Redon, Richard; Bijlenga, Philippe; Kamatani, Yoichiro; Veldink, Jan H.; Ruigrok, Ynte M.
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Real and assumed insights : statistical models and imaging biomarkers for disease characterization of intracranial aneurysms
2019 Hirsch, Sven; Juchler, Norman
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Plea for an international Aneurysm Data Bank : description and perspectives
2019 Bijlenga, Philippe; Morel, Sandrine; Hirsch, Sven; Schaller, Karl; Rüfenacht, Daniel
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Clinical data sharing : a data scientist's perspective
2018 Juchler, Norman; Schilling, Sabine; Watanabe, Kazuhiro; Anzai, Hitomi; Rüfenacht, Daniel; Bijlenga, Philippe; Kurtcuoglu, Vartan; Hirsch, Sven
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Reproducing qualitative irregularity ratings by means of quantitative shape descriptors in intracranial aneurysms
2018 Juchler, Norman; Schilling, Sabine; Philippe, Bijlenga; Rüfenacht, Daniel; Kurtcuoglu, Vartan; Hirsch, Sven
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Using machine learning to identify shape biomarkers in intracranial aneurysm
2018 Hirsch, Sven; Juchler, Norman; Schilling, Sabine; Bijlenga, Philippe; Rüfenacht, Daniel
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External validation of cerebral aneurysm rupture probability model with data from two patient cohorts
2018 Detmer, Felicitas J.; Fajardo-Jiménez, Daniel; Mut, Fernando; Juchler, Norman; Hirsch, Sven; Pereira, Vitor Mendes; Bijlenga, Philippe; Cebral, Juan R.
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Endothelial cell elongation under shear stress : a computational model to consolidate observed cell shape changes
2017 Schilling, Sabine; Morel, Sandrine; Bochaton-Piallat, Marie-Luce; Kwak, Brenda; Hirsch, Sven
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Big Data : machine learning to identify shape biomarkers in intracranial aneurysm
2017 Hirsch, Sven; Juchler, Norman; Schilling, Sabine; Bijlenga, Philippe; Rüfenacht, Daniel
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PHASES score for the management of intracranial aneurysm
2017 Bijlenga, Philippe; Gondar, Renato; Schilling, Sabine; Morel, Sandrine; Hirsch, Sven; Cuony, Johanna; Corniola, Marco-Vincenzo; Perren, Fabienne; Rüfenacht, Daniel; Schaller, Karl
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What's ugly? : shape-based analysis of intracranial aneurysms
2016 Juchler, Norman; Schilling, Sabine; Vartan, Kurtcuoglu; Hirsch, Sven
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Shape-based assessment of intracranial aneurysm disease status
2016 Juchler, Norman; Schilling, Sabine; Vartan, Kurtcuoglu; Hirsch, Sven
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Shape-based assessment of intracranial aneurysm disease status – a machine learning approach
2016 Juchler, Norman; Schilling, Sabine; Bijlenga, Philippe; Kurtcuoglu, Vartan; Hirsch, Sven
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On the utility of 3D Zernike Moment Invariants to assess aneurysm disease status
2015 Juchler, Norman; Ebnöther, Ueli; Schilling, Sabine; Hirsch, Sven; Kurtcuoglu, Vartan
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Intracranial aneurysms rupture risk clinical assessment
2015 Bijlenga, Philippe; Hirsch, Sven
School of Life Sciences and Facility Management
Schloss
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