Dr. Mathias Weyland

Projects

• Rad Dose and Image Qual Monitoring RADIM / Deputy project leader / ongoing
• Personalizing Hypofractionated RT / Deputy project leader / ongoing
• Bio-hybrid materials for bioprinting and tumour-targeted therapies (Bio-HhOST in ELM) / Co-project leader / ongoing
• Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) – Comprised of Live and Artificial Cells / Deputy project leader / ongoing
• Neurological ICU Data / Team member / completed
• PHARAO / Team member / completed
• Extension SARS-CoV-2 Intervention modelling / Team member / completed
• Decision support for pandemics / Team member / completed
• SARS-CoV2 Modeling of Interventions on the Dynamics of the Pandemics / Deputy project leader / completed
• Artificial Cells with Distributed Cores to Decipher Protein Function / Team member / completed
• OptiRad / Team member / completed
• Thermal Dosimetric Concept for Evaluating Synergistic Effect of Combined Hyperthermia-Radiotherapy / Team member / completed
• Phantom- and Model-based Optimisation of Medical Imaging Modalities / Team member / completed

Publications

Articles in scientific journal, peer-reviewed

• Rainford, P. F., Occhipinti, A., Wang, B., Stepney, S., Angione, C., Verma, S., Marucci, L., Sharma, K., Harris, S. A., Füchslin, R. M., Klipp, E., Grierson, C. S., Weyland, M. S., Mogre, A., Fellermann, H., Doan, L. M. T., Gherman, I. M., Pyne, A. L. B., Rudge, T. J., et al. (2026). Knowledge preservation in the era of big science and AI : strategies for sustainable scientific research. Nature Communications, 17(4069). https://doi.org/10.1038/s41467-026-72667-3
• Dieper, A., Scheidegger, S., Füchslin, R. M., Veltsista, P. D., Stein, U., Weyland, M., Gerster, D., Beck, M., Bengtsson, O., Zips, D., & Ghadjar, P. (2024). Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer. International Journal of Hyperthermia, 41(1), 2379992. https://doi.org/10.1080/02656736.2024.2379992
• Zellner, M., Tschauner, S., Weyland, M. S., Eggenberger Hotz, P., Scheidegger, S., & Kellenberger, C. J. (2024). Low-dose lung CT : optimizing diagnostic radiation dose – a phantom study. European Journal of Radiology Open, 13(100614). https://doi.org/10.1016/j.ejro.2024.100614
• Stocker, D., Sommer, C., Gueng, S., Stäuble, J., Özden, I., Griessinger, J., Weyland, M. S., Lutters, G., & Scheidegger, S. (2024). Probabilistic U-Net model observer for the DDC method in CT scan protocol optimization. Physics in Medicine & Biology, 69(11). https://doi.org/10.1088/1361-6560/ad4302
• Nytko, K. J., Weyland, M., Dressel-Böhm, S., Scheidegger, S., Salvermoser, L., Werner, C., Stangl, S., Carpinteiro, A. C., Alkotub, B., Multhoff, G., Bodis, S., & Rohrer Bley, C. (2023). Extracellular heat shock protein 70 levels in tumour-bearing dogs and cats treated with radiation therapy and hyperthermia. Veterinary and Comparative Oncology, 21(4), 605–615. https://doi.org/10.1111/vco.12923
• Fuchs, D., Rohrer Bley, C., Morandi, L., Tonon, C., Weyland, M. S., & Nytko, K. J. (2023). Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro. Veterinary Medicine and Science, 9(4), 1573–1583. https://doi.org/10.1002/vms3.1181
• Riesterer, O., Ademaj, A., Puric, E., Eberle, B., Beck, M., Gomez, S., Marder, D., Oberacker, E., Rogers, S., Hälg, R. A., Kern, T., Schwenne, S., Stein, J., Stutz, E., Timm, O., Zschaeck, S., Weyland, M. S., Veltsista, P. D., Wyler, S., et al. (2022). Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer : early results of a multicenter phase IIB study. International Journal of Hyperthermia, 39(1), 1078–1087. https://doi.org/10.1080/02656736.2022.2109763
• Sommer, C., Özden, I., Weyland, M. S., Duran, C., Lutters, G., & Scheidegger, S. (2022). Feasibility of a method for low contrast CT image quality assessment using difference detail curves for abdominal scans. Zeitschrift Für Medizinische Physik, 32(2), 209–217. https://doi.org/10.1016/j.zemedi.2022.01.001
• Cueni, C., Nytko, K. J., Thumser-Henner, P., Weyland, M. S., & Rohrer Bley, C. (2020). Methadone does not potentiate the effect of doxorubicin in canine tumour cell lines. Veterinary Medicine and Science, 6(3), 283–289. https://doi.org/10.1002/vms3.266
• Nytko, K. J., Thumser-Henner, P., Russo, G., Weyland, M. S., & Rohrer Bley, C. (2020). Role of HSP70 in response to (thermo)radiotherapy : analysis of gene expression in canine osteosarcoma cells by RNA-seq. Scientific Reports, 10(1), 12779. https://doi.org/10.1038/s41598-020-69619-2
• Marconato, L., Weyland, M. S., Tresch, N., Rossi, F., Leone, V., & Rohrer Bley, C. (2020). Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment. Veterinary and Comparative Oncology, 18(3), 362–369. https://doi.org/10.1111/vco.12557
• Weyland, M. S., Thumser-Henner, P., Nytko, K. J., Rohrer Bley, C., Ulzega, S., Petri-Fink, A., Lattuada, M., Füchslin, R. M., & Scheidegger, S. (2020). Holistic view on cell survival and DNA damage : how model-based data analysis supports exploration of dynamics in biological systems. Computational and Mathematical Methods in Medicine, 2020. https://doi.org/10.1155/2020/5972594
• Meier, V. S., Beatrice, L., Turek, M., Poirier, V. J., Cancedda, S., Stiborova, K., Körner, M., Marconato, L., Weyland, M. S., & Rohrer Bley, C. (2019). Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study. Veterinary and Comparative Oncology, 17(4), 528–536. https://doi.org/10.1111/vco.12517
• Pyka, M., Eschle, P., Sommer, C., Weyland, M. S., Kubik, R., & Scheidegger, S. (2018). Effect of thyroid shielding during mammography : measurements on phantom and patient as well as estimation with Monte Carlo simulation. European Radiology Experimental, 2(14). https://doi.org/10.1186/s41747-018-0042-9
• Dressel, S., Gosselin, M.-C., Capstick, M. H., Carrasco, E., Weyland, M., Scheidegger, S., Neufeld, E., Kuster, N., Bodis, S., & Rohrer Bley, C. (2017). Novel hyperthermia applicator system allows adaptive treatment planning : preliminary clinical results in tumour-bearing animals. Veterinary and Comparative Oncology, 16(2), 202–213. https://doi.org/10.1111/vco.12340
• Schulz, N., Chaachouay, H., Nytko, K. J., Weyland, M. S., Roos, M., Füchslin, R. M., Guscetti, F., Scheidegger, S., & Rohrer Bley, C. (2017). Dynamic in vivo profiling of DNA damage and repair after radiotherapy using canine patients as a model. International Journal of Molecular Sciences, 18(6/1176). https://doi.org/10.3390/ijms18061176
• Füchslin, R. M., Dumont, E., Flumini, D., Fuchs, H. U., Hauser, H., Jaeger, C., Scheidegger, S., Schönenberger-Deuel, J., Lichtensteiger, L., Luchsinger, R. H., & Weyland, M. (2014). Morphological control : a design principle for applications in space science. Journal of the British Interplanetary Society, 67, 305–313. http://adsabs.harvard.edu/abs/2014JBIS...67..305F
• Weyland, M. S., Fellermann, H., Hadorn, M., Sorek, D., Lancet, D., Rasmussen, S., & Füchslin, R. M. (2013). The MATCHIT automaton : exploiting compartmentalization for the synthesis of branched polymers. Computational and Mathematical Methods in Medicine, 2013(467428). https://doi.org/10.1155/2013/467428

Written conference contributions, peer-reviewed

• Hauser, T., Weyland, M. S., Jürgensen, D., Hooshmandabbasi, R., Guscetti, F., Maake, C., & Scheidegger, S. (2025). In-vitro modelling and measurement of focused ultrasound fields for use in sonodynamic therapy [Conference paper]. Current Directions in Biomedical Engineering, 11(1), 210–213. https://doi.org/10.1515/cdbme-2025-0154
• Weyland, M. S., Flumini, D., Schneider, J. J., Faggian, A., Patiño Diaz, A., & Füchslin, R. M. (2023). A chemical compiler for the synthesis of branched oligomers on standardized chemical reaction structures [Conference paper]. ALIFE 2023: Ghost in the Machine : Proceedings of the 2023 Artificial Life Conference, 105. https://doi.org/10.1162/isal_a_00648
• Schneider, J. J., Faggian, A., Jamieson, W. D., Weyland, M. S., Li, J., Castell, O., Matuttis, H.-G., Barrow, D. A., Patiño Diaz, A., Sanahuja, L. C., Holler, S., Casiraghi, F., Hanczyc, M. M., Flumini, D., Eggenberger Hotz, P., & Füchslin, R. M. (2023). Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer [Conference paper]. In C. De Stefano, F. Fontanella, & L. Vanneschi (Eds.), Artificial Life and Evolutionary Computation (pp. 107–118). Springer. https://doi.org/10.1007/978-3-031-31183-3_9
• Matuttis, H.-G., Schneider, J. J., Li, J., Barrow, D. A., Faggian, A., Patiño Diaz, A., Holler, S., Casiraghi, F., Sanahuja, L. C., Hanczyc, M. M., Weyland, M. S., Flumini, D., Eggenberger Hotz, P., Dimitriou, P., Jamieson, W. D., Castell, O., & Füchslin, R. M. (2023). Computational investigation of the clustering of droplets in widening pipe geometries [Conference paper]. In C. De Stefano, F. Fontanella, & L. Vanneschi (Eds.), Artificial Life and Evolutionary Computation (pp. 82–93). Springer. https://doi.org/10.1007/978-3-031-31183-3_7
• Schneider, J. J., Faggian, A., Patiño Diaz, A., Li, J., Holler, S., Casiraghi, F., Sanahuja, L. C., Matuttis, H.-G., Hanczyc, M. M., Barrow, D. A., Weyland, M. S., Flumini, D., Eggenberger Hotz, P., Dimitriou, P., Jamieson, W. D., Castell, O., Eschle, P., & Füchslin, R. M. (2023). Network creation during agglomeration processes of polydisperse and monodisperse systems of droplets [Conference paper]. In C. De Stefano, F. Fontanella, & L. Vanneschi (Eds.), Artificial Life and Evolutionary Computation (pp. 94–106). Springer. https://doi.org/10.1007/978-3-031-31183-3_8
• Schneider, J. J., Barrow, D. A., Li, J., Weyland, M. S., Flumini, D., Eggenberger Hotz, P., & Füchslin, R. M. (2023, January 22). Geometric restrictions to the agglomeration of spherical particles. Artificial Life and Evolutionary Computation. https://doi.org/10.1007/978-3-031-23929-8_7
• Schneider, J. J., Faggian, A., Matuttis, H.-G., Barrow, D. A., Li, J., Holler, S., Casiraghi, F., Cebolla Sanahuja, L., Hanczyc, M. M., Eschle, P., Weyland, M. S., Flumini, D., Eggenberger Hotz, P., & Füchslin, R. M. (2023, January 22). Obstacles on the pathway towards chemical programmability using agglomerations of droplets. Artificial Life and Evolutionary Computation. https://doi.org/10.1007/978-3-031-23929-8_4
• Füchslin, R. M., Ambühl, J., Faggian, A., Fellermann, H. M., Flumini, D., Geller, A., Hanczyc, M. M., Klinkert, A., Krütli, P., Matuttis, H.-G., Ott, T., Scheidegger, S., Schmid, G. B., Smieszek, T., Schneider, J. J., Steiner, A., & Weyland, M. S. (2023, January 22). Ethical aspects of computational modelling in science, decision support and communication. Artificial Life and Evolutionary Computation. https://doi.org/10.1007/978-3-031-23929-8_24
• Schneider, J. J., Weyland, M. S., Flumini, D., & Füchslin, R. M. (2023, January 22). Exploring the three-dimensional arrangement of droplets. Artificial Life and Evolutionary Computation. https://doi.org/10.1007/978-3-031-23929-8_6
• Artificial Life and Evolutionary Computation : 15th Italian Workshop, WIVACE 2021, Winterthur, Switzerland, September 15–17, 2021. (2023). In J. J. Schneider, M. S. Weyland, D. Flumini, & R. M. Füchslin (Eds.), XV International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Winterthur, Switzerland, 15-17 September 2021. Springer. https://doi.org/10.1007/978-3-031-23929-8
• Chehda Moreno, N., Weyland, M., Smieszek, T., Füchslin, R. M., Krütli, P., Schneider, J. J., & Scheidegger, S. (2021, November 30). Interpreting difference measures for social contact matrices : impact on the pandemic dynamics. 8th International Conference on Infectious Disease Dynamics (Epidemics8), Online, 30 November - 3 December 2021.
• Schneider, J. J., Weyland, M. S., Flumini, D., Matuttis, H.-G., Morgenstern, I., & Füchslin, R. M. (2020). Studying and simulating the three-dimensional arrangement of droplets [Conference paper]. In F. Cicirelli, A. Guerrieri, C. Pizzuti, A. Socievole, G. Spezzano, & A. Vinci (Eds.), Artificial Life and Evolutionary Computation. Springer. https://doi.org/10.1007/978-3-030-45016-8_16
• Flumini, D., Weyland, M. S., Schneider, J. J., Fellermann, H., & Füchslin, R. M. (2020). Towards programmable chemistries [Conference paper]. In F. Cicirelli, A. Guerrieri, C. Pizzuti, A. Socievole, G. Spezzano, & A. Vinci (Eds.), Artificial Life and Evolutionary Computation. Springer. https://doi.org/10.1007/978-3-030-45016-8_15
• Schneider, J. J., Weyland, M. S., Flumini, D., & Füchslin, R. M. (2020). Investigating three-dimensional arrangements of droplets [Conference paper]. In F. Cicirelli, A. Guerrieri, C. Pizzuti, A. Socievole, G. Spezzano, & A. Vinci (Eds.), Artificial Life and Evolutionary Computation (pp. 171–184). Springer. https://doi.org/10.1007/978-3-030-45016-8_17
• Weyland, M., Thumser-Henner, P., Rohrer Bley, C., Ulzega, S., Petri-Fink, A., Lattuada, M., Scheidegger, S., & Füchslin, R. M. (2019). Dynamic DNA damage and repair modelling : bridging the gap between experimental damage readout and model structure [Conference paper]. In S. Cagnoni, M. Mordonini, R. Pecori, A. Roli, & M. Villani (Eds.), Artificial Life and Evolutionary Computation (pp. 127–137). Springer. https://doi.org/10.1007/978-3-030-21733-4_10
• Schneider, J. J., Weyland, M., Flumini, D., & Füchslin, R. M. (2019, August). Simulation of a microfluidic system of droplets. Joint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society, Zurich, 26-30 August 2019.

Other publications

• Füchslin, R., Flumini, D., & Weyland, M. (2025). Chaos 2.0 – Formen der Unvorhersehbarkeit. ANG Fokus, 2025, 41–47. https://ang.ch/de/publikationen/uuid/i/ad4024db-d71e-5ad1-aa29-258d2f991872-ANG_Fokus_2025
• Füchslin, R., Eggenberger, P., Enayati, A., Luchsinger, R., Scheidegger, S., & Weyland, M. (2025). Life at the edge of chaos. ANG Fokus, 2025, 36–41. https://ang.ch/de/publikationen/uuid/i/ad4024db-d71e-5ad1-aa29-258d2f991872-ANG_Fokus_2025
• Schneider, J. J., Faggian, A., Holler, S., Casiraghi, F., Li, J., Sanahuja, L. C., Matuttis, H.-G., Hanczyc, M. M., Barrow, D. A., Weyland, M. S., Flumini, D., Eggenberger Hotz, P., Eschle, P., Patiño Diaz, A., & Füchslin, R. M. (2022). Paths in a network of polydisperse spherical droplets [Conference paper]. ALIFE 2022: The 2022 Conference on Artificial Life, 23. https://doi.org/10.1162/isal_a_00502
• Füchslin, R. M., Krütli, P., Ott, T., Scheidegger, S., Schneider, J. J., Seric, M., Smieszek, T., & Weyland, M. S. (2022). Minimal models for spatially resolved population dynamics : applications to coexistence in multi – trait models [Conference paper]. ALIFE 2022: The 2022 Conference on Artificial Life, 75. https://doi.org/10.1162/isal_a_00504
• Weyland, M. S., Flumini, D., Schneider, J. J., & Füchslin, R. M. (2020). A compiler framework to derive microfluidic platforms for manufacturing hierarchical, compartmentalized structures that maximize yield of chemical reactions [Conference paper]. ALIFE 2020: The 2020 Conference on Artificial Life, 602–604. https://doi.org/10.1162/isal_a_00303
• Weyland, M., Eberle, B., Dressel, S., Timm, O., Puric, E., Rohrer Bley, C., & Scheidegger, S. (2017). Comparison of thermal dose concepts in human and animal patients [Conference paper]. ESHO Annual Meeting, 87–88.

Oral conference contributions and abstracts

• Schneider, J. J., Barrow, D. A., Li, J., Weyland, M., Flumini, D., Eggenberger Hotz, P., & Füchslin, R. M. (2023, August 7). Bidisperse extension of the kissing number problem. 28th International Conference on Statistical Physics (Statphys28), Tokyo, Japan, 7-11 August 2023.
• Schneider, J. J., Faggian, A., Holler, S., Casiraghi, F., Li, J., Cebolla Sanahuja, L., Matuttis, H.-G., Hanczyc, M. M., Barrow, D. A., Weyland, M. S., Flumini, D., Eggenberger Hotz, P., & Füchslin, R. M. (2021). Influence of the geometry on the agglomeration of a polydisperse binary system of spherical particles. International Conference on Artificial Life (ALIFE), Online, 19-23 July 2021. https://www.youtube.com/watch?v=2uSgimAHU4I
• Sommer, C., Özden, I., Weyland, M., Duran, C., Lutters, G., & Scheidegger, S. (2021, June 16). Using difference detail curves to assess image quality of low contrast abdominal CT scans. 3rd European Congress of Medical Physics (ECMP), Virtual, 16 June - 31 December 2021.
• Füchslin, R. M., Scheidegger, S., Flumini, D., Schneider, J. J., & Weyland, M. (2019, December). Morphological computation and control in medicine and related sciences. BioDynaMo, Zurich, 2-3 December 2019.
• Flumini, D., & Weyland, M. (2019, September 20). Steps towards programmable chemistries. XIV International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Rende, Italy, 18-20 September 2019.
• Schneider, J. J., Weyland, M., Flumini, D., & Füchslin, R. M. (2019, September 19). Exploring the three-dimensional arrangement of droplets. XIV International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Rende, Italy, 18-20 September 2019.
• Weyland, M., Thumser-Henner, P., Rohrer Bley, C., Ulzega, S., Petri-Fink, A., Lattuada, M., Scheidegger, S., & Füchslin, R. M. (2018). Dynamic DNA damage and repair modeling : bridging the gap between experimental damage readout and model structure. XIII International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Parma, Italy, 10-12 September 2018.
• Weyland, M., Thumser-Henner, P., Nytko, K., Rohrer Bley, C., & Scheidegger, S. (2018). Extracting information about cellular repair processes after hyperthermia – radiotherapy by model-based data analysis : ambiguities in survival prediction as a challenge? [Conference presentation]. Strahlentherapie Und Onkologie, 194(5), 503. https://doi.org/10.1007/s00066-018-1295-1

Research data

• Eggenberger Hotz, Peter; Luchsinger, Rolf H.; Weyland, Mathias; Jamieson, W. David; Castell, Oliver; Füchslin, Rudolf M., 2026. Code for: Emergent predictability from parameter ambiguity in biochemical networks. Zenodo. Available from: https://doi.org/10.5281/zenodo.19485525
• Enayati, Aref; Baird, Hannah; Weyland, Mathias; Fink, Alke; Lattuada, Marco, Alke; Jamieson, William; Füchslin, Rudolf M.; Castell, Oliver, . Enhanced quantitative accuracy in single molecule imaging : a fidelity-guided denoising approach. Zenodo. Available from: https://doi.org/10.5281/zenodo.19498257

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