Dr. Mathias Weyland

Projects

• Rad Dose and Image Qual Monitoring RADIM / Deputy project leader / ongoing
• Personalizing Hypofractionated RT / Deputy project leader / ongoing
• Bio-hybrid materials for bioprinting and tumour-targeted therapies (Bio-HhOST in ELM) / Co-project leader / ongoing
• Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) – Comprised of Live and Artificial Cells / Deputy project leader / ongoing
• Neurological ICU Data / Team member / completed
• PHARAO / Team member / completed
• Extension SARS-CoV-2 Intervention modelling / Team member / completed
• Decision support for pandemics / Team member / completed
• SARS-CoV2 Modeling of Interventions on the Dynamics of the Pandemics / Deputy project leader / completed
• Artificial Cells with Distributed Cores to Decipher Protein Function / Team member / completed
• OptiRad / Team member / completed
• Thermal Dosimetric Concept for Evaluating Synergistic Effect of Combined Hyperthermia-Radiotherapy / Team member / completed
• Phantom- and Model-based Optimisation of Medical Imaging Modalities / Team member / completed

Publications

Articles in scientific journal, peer-reviewed

• Rainford, P. F. et al. (2026) 'Knowledge preservation in the era of big science and AI : strategies for sustainable scientific research', Nature Communications, 17(4069). doi: 10.1038/s41467-026-72667-3.
• Dieper, A. et al. (2024) 'Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer', International Journal of Hyperthermia, 41(1), p. 2379992. doi: 10.1080/02656736.2024.2379992.
• Zellner, M. et al. (2024) 'Low-dose lung CT : optimizing diagnostic radiation dose – a phantom study', European Journal of Radiology Open, 13(100614). doi: 10.1016/j.ejro.2024.100614.
• Stocker, D. et al. (2024) 'Probabilistic U-Net model observer for the DDC method in CT scan protocol optimization', Physics in Medicine & Biology, 69(11). doi: 10.1088/1361-6560/ad4302.
• Nytko, K. J. et al. (2023) 'Extracellular heat shock protein 70 levels in tumour-bearing dogs and cats treated with radiation therapy and hyperthermia', Veterinary and Comparative Oncology, 21(4), pp. 605–615. doi: 10.1111/vco.12923.
• Fuchs, D. et al. (2023) 'Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro', Veterinary Medicine and Science, 9(4), pp. 1573–1583. doi: 10.1002/vms3.1181.
• Riesterer, O. et al. (2022) 'Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer : early results of a multicenter phase IIB study', International Journal of Hyperthermia, 39(1), pp. 1078–1087. doi: 10.1080/02656736.2022.2109763.
• Sommer, C. et al. (2022) 'Feasibility of a method for low contrast CT image quality assessment using difference detail curves for abdominal scans', Zeitschrift für Medizinische Physik, 32(2), pp. 209–217. doi: 10.1016/j.zemedi.2022.01.001.
• Cueni, C. et al. (2020) 'Methadone does not potentiate the effect of doxorubicin in canine tumour cell lines', Veterinary Medicine and Science, 6(3), pp. 283–289. doi: 10.1002/vms3.266.
• Nytko, K. J. et al. (2020) 'Role of HSP70 in response to (thermo)radiotherapy : analysis of gene expression in canine osteosarcoma cells by RNA-seq', Scientific Reports, 10(1), p. 12779. doi: 10.1038/s41598-020-69619-2.
• Marconato, L. et al. (2020) 'Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment', Veterinary and Comparative Oncology, 18(3), pp. 362–369. doi: 10.1111/vco.12557.
• Weyland, M. S. et al. (2020) 'Holistic view on cell survival and DNA damage : how model-based data analysis supports exploration of dynamics in biological systems', Computational and Mathematical Methods in Medicine, 2020. doi: 10.1155/2020/5972594.
• Meier, V. S. et al. (2019) 'Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study', Veterinary and Comparative Oncology, 17(4), pp. 528–536. doi: 10.1111/vco.12517.
• Pyka, M. et al. (2018) 'Effect of thyroid shielding during mammography : measurements on phantom and patient as well as estimation with Monte Carlo simulation', European Radiology Experimental, 2(14). doi: 10.1186/s41747-018-0042-9.
• Dressel, S. et al. (2017) 'Novel hyperthermia applicator system allows adaptive treatment planning : preliminary clinical results in tumour-bearing animals', Veterinary and Comparative Oncology, 16(2), pp. 202–213. doi: 10.1111/vco.12340.
• Schulz, N. et al. (2017) 'Dynamic in vivo profiling of DNA damage and repair after radiotherapy using canine patients as a model', International Journal of Molecular Sciences, 18(6/1176). doi: 10.3390/ijms18061176.
• Füchslin, R. M. et al. (2014) 'Morphological control : a design principle for applications in space science', Journal of the British Interplanetary Society, 67, pp. 305–313. Available at: http://adsabs.harvard.edu/abs/2014JBIS...67..305F.
• Weyland, M. S. et al. (2013) 'The MATCHIT automaton : exploiting compartmentalization for the synthesis of branched polymers', Computational and Mathematical Methods in Medicine, 2013(467428). doi: 10.1155/2013/467428.

Written conference contributions, peer-reviewed

• Hauser, T. et al. (2025) 'In-vitro modelling and measurement of focused ultrasound fields for use in sonodynamic therapy', in Current Directions in Biomedical Engineering. De Gruyter, pp. 210–213. doi: 10.1515/cdbme-2025-0154.
• Weyland, M. S. et al. (2023) 'A chemical compiler for the synthesis of branched oligomers on standardized chemical reaction structures', in ALIFE 2023: Ghost in the Machine : Proceedings of the 2023 Artificial Life Conference. Cambridge: MIT Press, p. 105. doi: 10.1162/isal_a_00648.
• Schneider, J. J. et al. (2023) 'Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer', in De Stefano, C., Fontanella, F., and Vanneschi, L. (eds) Artificial Life and Evolutionary Computation. Cham: Springer, pp. 107–118. doi: 10.1007/978-3-031-31183-3_9.
• Matuttis, H.-G. et al. (2023) 'Computational investigation of the clustering of droplets in widening pipe geometries', in De Stefano, C., Fontanella, F., and Vanneschi, L. (eds) Artificial Life and Evolutionary Computation. Cham: Springer, pp. 82–93. doi: 10.1007/978-3-031-31183-3_7.
• Schneider, J. J. et al. (2023) 'Network creation during agglomeration processes of polydisperse and monodisperse systems of droplets', in De Stefano, C., Fontanella, F., and Vanneschi, L. (eds) Artificial Life and Evolutionary Computation. Cham: Springer, pp. 94–106. doi: 10.1007/978-3-031-31183-3_8.
• Schneider, J. J. et al. (2023) 'Obstacles on the pathway towards chemical programmability using agglomerations of droplets', in Artificial Life and Evolutionary Computation. Cham: Springer. doi: 10.1007/978-3-031-23929-8_4.
• Füchslin, R. M. et al. (2023) 'Ethical aspects of computational modelling in science, decision support and communication', in Artificial Life and Evolutionary Computation. Cham: Springer. doi: 10.1007/978-3-031-23929-8_24.
• Schneider, J. J. et al. (2023) 'Geometric restrictions to the agglomeration of spherical particles', in Artificial Life and Evolutionary Computation. Cham: Springer. doi: 10.1007/978-3-031-23929-8_7.
• Schneider, J. J. et al. (2023) 'Exploring the three-dimensional arrangement of droplets', in Artificial Life and Evolutionary Computation. Cham: Springer. doi: 10.1007/978-3-031-23929-8_6.
• Schneider, J. J. et al. (eds) (2023) Artificial Life and Evolutionary Computation : 15th Italian Workshop, WIVACE 2021, Winterthur, Switzerland, September 15–17, 2021, XV International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Winterthur, Switzerland, 15-17 September 2021. Cham: Springer. doi: 10.1007/978-3-031-23929-8.
• Chehda Moreno, N. et al. (2021) 'Interpreting difference measures for social contact matrices : impact on the pandemic dynamics', in 8th International Conference on Infectious Disease Dynamics (Epidemics8), online, 30 November - 3 December 2021.
• Flumini, D. et al. (2020) 'Towards programmable chemistries', in Cicirelli, F. et al. (eds) Artificial Life and Evolutionary Computation. Springer. doi: 10.1007/978-3-030-45016-8_15.
• Schneider, J. J. et al. (2020) 'Studying and simulating the three-dimensional arrangement of droplets', in Cicirelli, F. et al. (eds) Artificial Life and Evolutionary Computation. Cham: Springer. doi: 10.1007/978-3-030-45016-8_16.
• Schneider, J. J. et al. (2020) 'Investigating three-dimensional arrangements of droplets', in Cicirelli, F. et al. (eds) Artificial Life and Evolutionary Computation. Cham: Springer, pp. 171–184. doi: 10.1007/978-3-030-45016-8_17.
• Weyland, M. et al. (2019) 'Dynamic DNA damage and repair modelling : bridging the gap between experimental damage readout and model structure', in Cagnoni, S. et al. (eds) Artificial Life and Evolutionary Computation. Cham: Springer, pp. 127–137. doi: 10.1007/978-3-030-21733-4_10.
• Schneider, J. J. et al. (2019) 'Simulation of a microfluidic system of droplets', in Joint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society, Zurich, 26-30 August 2019.

Other publications

• Füchslin, R. et al. (2025) 'Life at the edge of chaos', ANG Fokus, 2025, pp. 36–41. Available at: https://ang.ch/de/publikationen/uuid/i/ad4024db-d71e-5ad1-aa29-258d2f991872-ANG_Fokus_2025.
• Füchslin, R., Flumini, D. and Weyland, M. (2025) 'Chaos 2.0 – Formen der Unvorhersehbarkeit', ANG Fokus, 2025, pp. 41–47. Available at: https://ang.ch/de/publikationen/uuid/i/ad4024db-d71e-5ad1-aa29-258d2f991872-ANG_Fokus_2025.
• Schneider, J. J. et al. (2022) 'Paths in a network of polydisperse spherical droplets', in ALIFE 2022: The 2022 Conference on Artificial Life. Cambridge: MIT Press, p. 23. doi: 10.1162/isal_a_00502.
• Füchslin, R. M. et al. (2022) 'Minimal models for spatially resolved population dynamics : applications to coexistence in multi – trait models', in ALIFE 2022: The 2022 Conference on Artificial Life. Cambridge: MIT Press, p. 75. doi: 10.1162/isal_a_00504.
• Weyland, M. S. et al. (2020) 'A compiler framework to derive microfluidic platforms for manufacturing hierarchical, compartmentalized structures that maximize yield of chemical reactions', in ALIFE 2020: The 2020 Conference on Artificial Life. Cambridge: MIT Press, pp. 602–604. doi: 10.1162/isal_a_00303.
• Weyland, M. et al. (2017) 'Comparison of thermal dose concepts in human and animal patients', in ESHO Annual Meeting, pp. 87–88.

Oral conference contributions and abstracts

• Füchslin, R. M. and Weyland, M. (2024) 'Application-oriented modelling in science, technology and decision support : lessons from knowledge transfer across the boundaries of science', in G2W: Genomics to Whole Cell Workshop, Sheffield, United Kingdom, 23-25. October 2024.
• Schneider, J. J. et al. (2023) 'Bidisperse extension of the kissing number problem', in 28th International Conference on Statistical Physics (Statphys28), Tokyo, Japan, 7-11 August 2023.
• Schneider, J. J. et al. (2021) 'Influence of the geometry on the agglomeration of a polydisperse binary system of spherical particles', in International Conference on Artificial Life (ALIFE), online, 19-23 July 2021. Available at: https://www.youtube.com/watch?v=2uSgimAHU4I.
• Sommer, C. et al. (2021) 'Using difference detail curves to assess image quality of low contrast abdominal CT scans', in 3rd European Congress of Medical Physics (ECMP), virtual, 16 June - 31 December 2021.
• Füchslin, R. M. et al. (2019) 'Morphological computation and control in medicine and related sciences', in BioDynaMo, Zurich, 2-3 December 2019.
• Flumini, D. and Weyland, M. (2019) 'Steps towards programmable chemistries', in XIV International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Rende, Italy, 18-20 September 2019.
• Schneider, J. J. et al. (2019) 'Exploring the three-dimensional arrangement of droplets', in XIV International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Rende, Italy, 18-20 September 2019.
• Weyland, M. et al. (2018) 'Dynamic DNA damage and repair modeling : bridging the gap between experimental damage readout and model structure', in XIII International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Parma, Italy, 10-12 September 2018.
• Weyland, M. et al. (2018) 'Extracting information about cellular repair processes after hyperthermia – radiotherapy by model-based data analysis : ambiguities in survival prediction as a challenge?', in Strahlentherapie und Onkologie. Springer, p. 503. doi: 10.1007/s00066-018-1295-1.

Research data

• Eggenberger Hotz, Peter; Luchsinger, Rolf H.; Weyland, Mathias; Jamieson, W. David; Castell, Oliver; Füchslin, Rudolf M., 2026. Code for: Emergent predictability from parameter ambiguity in biochemical networks. Zenodo. Available from: https://doi.org/10.5281/zenodo.19485525
• Enayati, Aref; Baird, Hannah; Weyland, Mathias; Fink, Alke; Lattuada, Marco, Alke; Jamieson, William; Füchslin, Rudolf M.; Castell, Oliver, . Enhanced quantitative accuracy in single molecule imaging : a fidelity-guided denoising approach. Zenodo. Available from: https://doi.org/10.5281/zenodo.19498257

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