Prof. Dr. Stephan Scheidegger

Work at ZHAW

Position

• Programme Director
• Professor for Medical Physics

Focus

• Medical Biophysics
• Systems Medicine
• Radiation Biophysics
• Radiation Protection

Teaching

• Biomedical Systems
• Medical Imaging & Radiation Oncology for Medical IT
• Biomedical Engineering: Medical Imaging & Ionizing Radiation
• Medical Diagnostics & Devices (MSE)
• Model-based Data Analysis for Clinical Application (ACLS Master)

Network

ORCID digital identifier

ORCID ID: 0000-0002-2622-2918

Projects

• Rad Dose and Image Qual Monitoring RADIM / Project leader / ongoing
• Personalizing Hypofractionated RT / Project leader / ongoing
• Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) – Comprised of Live and Artificial Cells / Team member / ongoing
• Neurological ICU Data / Team member / completed
• PHARAO / Project leader / completed
• Creation of advanced cancer treatment planning to boost the effect of Radiotherapy by combining with hyperthermia, heating the tumor / Project leader / completed
• SARS-CoV2 Modeling of Interventions on the Dynamics of the Pandemics / Team member / completed
• OptiRad / Project leader / completed
• Thermal Dosimetric Concept for Evaluating Synergistic Effect of Combined Hyperthermia-Radiotherapy / Project leader / completed
• Advanced Electronic Personal Dosemeter / Team member / completed
• Model-based optimisation of combined anti-cancer therapy with heat and radiation / Project leader / completed
• Dynamic in vivo profiling of DNA damage and -repair after ionizing radiation / Project leader / completed
• Phantom- and Model-based Optimisation of Medical Imaging Modalities / Project leader / completed

Publications

Articles in scientific journal, peer-reviewed

• Mingo Barba, S. et al. (2024) 'The use of survival dose-rate dependencies as theoretical discrimination criteria for in-silico dynamic radiobiological models', Dose-Response, 22(3). doi: 10.1177/15593258241279906.
• Mingo Barba, S. et al. (2024) 'Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico', International Journal of Hyperthermia, 41(1), p. 2320852. doi: 10.1080/02656736.2024.2320852.
• Dieper, A. et al. (2024) 'Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer', International Journal of Hyperthermia, 41(1), p. 2379992. doi: 10.1080/02656736.2024.2379992.
• Zellner, M. et al. (2024) 'Low-dose lung CT : optimizing diagnostic radiation dose – a phantom study', European Journal of Radiology Open, 13(100614). doi: 10.1016/j.ejro.2024.100614.
• Stocker, D. et al. (2024) 'Probabilistic U-Net model observer for the DDC method in CT scan protocol optimization', Physics in Medicine & Biology, 69(11). doi: 10.1088/1361-6560/ad4302.
• Nytko, K. J. et al. (2023) 'Extracellular heat shock protein 70 levels in tumour-bearing dogs and cats treated with radiation therapy and hyperthermia', Veterinary and Comparative Oncology, 21(4), pp. 605–615. doi: 10.1111/vco.12923.
• Riesterer, O. et al. (2022) 'Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer : early results of a multicenter phase IIB study', International Journal of Hyperthermia, 39(1), pp. 1078–1087. doi: 10.1080/02656736.2022.2109763.
• Scutigliani, E. M. et al. (2022) 'The effects of heat stress on the transcriptome of human cancer cells : a meta-analysis', Cancers, 15(1), p. 113. doi: 10.3390/cancers15010113.
• Sengedorj, A. et al. (2022) 'The effect of hyperthermia and radiotherapy sequence on cancer cell death and the immune phenotype of breast cancer cells', Cancers, 14(9), p. 2050. doi: 10.3390/cancers14092050.
• Sommer, C. et al. (2022) 'Feasibility of a method for low contrast CT image quality assessment using difference detail curves for abdominal scans', Zeitschrift für Medizinische Physik, 32(2), pp. 209–217. doi: 10.1016/j.zemedi.2022.01.001.
• Scheidegger, S., Mingo Barba, S. and Gaipl, U. S. (2021) 'Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem', Cancers, 13(22), p. 5764. doi: 10.3390/cancers13225764.
• Weyland, M. S. et al. (2020) 'Holistic view on cell survival and DNA damage : how model-based data analysis supports exploration of dynamics in biological systems', Computational and Mathematical Methods in Medicine, 2020. doi: 10.1155/2020/5972594.
• Nytko, K. J. et al. (2019) 'Cell line-specific efficacy of thermoradiotherapy in human and canine cancer cells in vitro', PLOS ONE, 14(5), p. e0216744. doi: 10.1371/journal.pone.0216744.
• Pyka, M. et al. (2018) 'Effect of thyroid shielding during mammography : measurements on phantom and patient as well as estimation with Monte Carlo simulation', European Radiology Experimental, 2(14). doi: 10.1186/s41747-018-0042-9.
• Schulz, N. et al. (2017) 'Dynamic in vivo profiling of DNA damage and repair after radiotherapy using canine patients as a model', International Journal of Molecular Sciences, 18(6/1176). doi: 10.3390/ijms18061176.
• D'Isidoro, F. et al. (2017) 'Determining 3D kinematics of the hip using video fluoroscopy : guidelines for balancing radiation dose and registration accuracy', Journal of Arthroplasty, 32(10), pp. 3213–3218. doi: 10.1016/j.arth.2017.05.036.
• Dressel, S. et al. (2017) 'Novel hyperthermia applicator system allows adaptive treatment planning : preliminary clinical results in tumour-bearing animals', Veterinary and Comparative Oncology, 16(2), pp. 202–213. doi: 10.1111/vco.12340.
• Sommer, C. et al. (2017) 'Evaluation of low contrast resolution and radiation dose in abdominal CT protocols by a difference detail curve (DDC) method', Current Directions in Biomedical Engineering, 3(2), pp. 517–519. doi: 10.1515/cdbme-2017-0109.
• Boye, D. et al. (2015) 'Effects of contour propagation and background corrections in different MRI flow software packages', Acta Radiologica Open, 4(6). doi: 10.1177/2058460115589124.
• Füchslin, R. M. et al. (2014) 'Morphological control : a design principle for applications in space science', Journal of the British Interplanetary Society, 67, pp. 305–313. Available at: http://adsabs.harvard.edu/abs/2014JBIS...67..305F.
• Füchslin, R. M. et al. (2013) 'Morphological computation and morphological control : steps toward a formal theory and applications', Artificial Life, 19(1), pp. 9–34. doi: 10.1162/ARTL_a_00079.
• Scheidegger, S. et al. (2013) 'Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach', Computational and Mathematical Methods in Medicine, 2013(587543). doi: 10.1155/2013/587543.
• Bässler, H. et al. (2012) '«RadioSurfVet» : ein E-Lernprogramm zur Unterstützung des Selbststudiums für das Modul «Allgemeine Radiologie» für Studierende der Veterinärmedizin im 1. Jahreskurs', Schweizer Archiv für Tierheilkunde, 154(3), pp. 125–126. doi: 10.1024/0036-7281/a000311.
• Scheidegger, S., Lutters, G. and Bodis, S. (2011) 'A LQ-based kinetic model formulation for exploring dynamics of treatment response of tumours in patients', Zeitschrift für Medizinische Physik, 21(3), pp. 164–173. doi: 10.1016/j.zemedi.2010.11.001.
• Lohse, I. et al. (2011) 'Effect of high dose per pulse flattening filter-free beams on cancer cell survival', Radiotherapy & Oncology, 101(1), pp. 226–232. doi: 10.1016/j.radonc.2011.05.072.
• Scheidegger, S., Lutters, G. and Bodis, S. (2010) 'A kinetic LQ-based model for exploring the tumor response onto radiation including the vascular system', Strahlentherapie und Onkologie, 186, p. 731.
• Spaeth, N. et al. (2004) 'Uptake of 18F-fluorocholine, 18F-fluoroethyl-l-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat : implications for separation of radiation necrosis from tumor recurrence', Journal of Nuclear Medicine, 45(11), pp. 1931–1938. Available at: http://jnm.snmjournals.org/content/45/11/1931.full.pdf+html.
• Scheidegger, S., Estermann, M. A. and Steurer, S. (2000) 'Correction of specimen absorption in X-ray diffuse scattering experiments with area-detector systems', Journal of Applied Crystallography, 33(1), pp. 35–48. doi: 10.1107/S0021889899011929.
• Estermann, M. A. et al. (1997) 'A helium beam path for an imaging-plate detector system', Journal of Applied Crystallography, 1997(30), pp. 1165–1166. doi: 10.1107/S0021889897005773.

Books, peer-reviewed

Scheidegger, S. (1999) Absorptionskorrekturen für diffuse Röntgenstreustrahlung bei Beugungsexperimenten mit Flächendetektoren. Doctoral dissertation. ETH Zürich.

Written conference contributions, peer-reviewed

• Hauser, T. et al. (2025) 'In-vitro modelling and measurement of focused ultrasound fields for use in sonodynamic therapy', in Current Directions in Biomedical Engineering. De Gruyter, pp. 210–213. doi: 10.1515/cdbme-2025-0154.
• Mingo Barba, S. et al. (2023) 'Tumor Control Probability (TCP) study to theoretically assess the impact of different clinical conditions in Hyperthermia plus Radiotherapy (HT+RT) treatments', in 35th Annual Meeting European Society for Hyperthermic Oncology, Cologne, Germany, 26-29 September 2023.
• Scheidegger, S., Füchslin, R. M. and Gaipl, U. S. (2023) 'Multi – vs. single – perceptron approach for modelling the pattern recognition and classification in a multi-compartment adaptive immune system model', in ALIFE 2023: Ghost in the Machine : Proceedings of the 2023 Artificial Life Conference. Cambridge: MIT Press, p. 7. doi: 10.1162/isal_a_00574.
• Füchslin, R. M. et al. (2023) 'Ethical aspects of computational modelling in science, decision support and communication', in Artificial Life and Evolutionary Computation. Cham: Springer. doi: 10.1007/978-3-031-23929-8_24.
• Scheidegger, S. et al. (2022) 'Influence of the antigen pattern vector on the dynamics in a perceptron-based artificial immune - tumour- ecosystem during and after radiation therapy', in Schneider, J. J. et al. (eds) Artificial Life and Evolutionary Computation. Cham: Springer, pp. 195–206. doi: 10.1007/978-3-031-23929-8_19.
• Mingo Barba, S. et al. (2022) 'Repair protein damage vs. cell repair saturation : a comparison of its use in radiobiological models', in 26th Annual SASRO Meeting, Baden, Switzerland, 1-3 September 2022.
• Chehda Moreno, N. et al. (2021) 'Interpreting difference measures for social contact matrices : impact on the pandemic dynamics', in 8th International Conference on Infectious Disease Dynamics (Epidemics8), online, 30 November - 3 December 2021.
• Weyland, M. et al. (2019) 'Dynamic DNA damage and repair modelling : bridging the gap between experimental damage readout and model structure', in Cagnoni, S. et al. (eds) Artificial Life and Evolutionary Computation. Cham: Springer, pp. 127–137. doi: 10.1007/978-3-030-21733-4_10.
• Scheidegger, S. and Fellermann, H. (2019) 'Optimizing radiation therapy treatments by exploring tumour ecosystem dynamics in-silico', in Fellermann, H. et al. (eds) Proceedings of the Artificial Life Conference 2019. Massachusetts Institute of Technology, pp. 236–242. doi: 10.1162/isal_a_00167.
• Lima, T. V. M. et al. (2018) 'Connecting the missing piece: a retrospective evaluation of image quality and dose in respect to the parameters variability for a clinical CT protocol', in ECR 2018, EuroSafe Imaging, Vienna, 28 February - 4 March 2018. doi: 10.1594/esi2018/ESI-0071.
• Chaachouay, H. et al. (2015) 'Monitoring of DNA damage and repair kinetics during radiotherapy in vivo : a minimally invasive approach using the dog as a model', in Molecular radiation biology/oncology : proceedings of 14th international wolfsbergmeeting, p. 22.
• Scheidegger, S. et al. (2015) 'A novel approach for thermal dosimetry', in Proceedings of the ESHO Annual Meeting 2015. Zürich: ESHO, p. 26.
• Scheidegger, S., Fuchs, H. U. and Füchslin, R. M. (2014) 'Computational methods for exploring the dynamics of cancer : the potential of state variables for description of complex biological systems', in Proceedings of the international symposium on nonlinear theory and its applications : NOLTA2014, Luzern, Switzerland, september 14-18, 2014. NOLTA Society, pp. 168–171. doi: 10.21256/zhaw-1764.
• Scheidegger, S., Grosse, N. and Füchslin, R. M. (2014) 'Homologous recombination in the view of the MHR-model', in Klöck, S. (ed.) Joint conference of the SSRMP, DGMP, ÖGMP : Dreiländertagung der Medizinischen Physik - Abstractbook. Zürich: SGSMP/DGMP/ÖGMP, pp. 194–195.
• Scheidegger, S. et al. (2013) 'Characterization of hyperthermia with radiotherapy : temporal homogeneity and limitations of the CEM concept', in Proceedings of the 28th annual meeting of the european society for hyperthermic oncology 2013, p. 131.
• Scheidegger, S. et al. (2012) 'Dynamic modelling of the synergistic effect of hyperthermia and radiotherapy', in Radiotherapy & Oncology. Elsevier, p. s356. doi: 10.1016/S0167-8140(12)71237-9.
• Füchslin, R. M. et al. (2011) 'Morphological computation : applications on different scales exploiting classical and statistical mechanics', in Proceedings of the 2nd international conference on morphological computation, pp. 41–44.
• Scheidegger, S. and Füchslin, R. M. (2011) 'Kinetic model for dose equivalent : an efficient way to predict systems response of irradiated cells', in Bödi, R. and Maurer, W. (eds) Proceedings of ASIM 2011 : Grundlagen, Methoden und Anwendungen in Modellbildung und Simulation. Arbeitsgemeinschaft Simulation. doi: 10.21256/zhaw-3558.
• Scheidegger, S., Lutters, G. and Bodis, S. (2010) 'Computer simulation of oxygenation and growth inhibition of tumours during fractionated radiotherapy : exploration of the dynamic system behaviour', in Radiotherapy & Oncology. Elsevier, pp. S510–S522. doi: 10.1016/S0167-8140(10)80076-3.

Other publications

• Füchslin, R. et al. (2025) 'Life at the edge of chaos', ANG Fokus, 2025, pp. 36–41. Available at: https://ang.ch/de/publikationen/uuid/i/ad4024db-d71e-5ad1-aa29-258d2f991872-ANG_Fokus_2025.
• Füchslin, R. M. et al. (2022) 'Minimal models for spatially resolved population dynamics : applications to coexistence in multi – trait models', in ALIFE 2022: The 2022 Conference on Artificial Life. Cambridge: MIT Press, p. 75. doi: 10.1162/isal_a_00504.
• Weyland, M. et al. (2017) 'Comparison of thermal dose concepts in human and animal patients', in ESHO Annual Meeting, pp. 87–88.
• Sommer, C. et al. (2015) 'Comparison of image quality and radiation exposure between dental volume tomography DVT and conventional CT by using a novel skull-DLP phantom', in SSRMP Annual Scientific Meeting 2015 Fribourg, 21st and 22nd October 2015. Fribourg: Swiss Society of Radiobiology and Medical Physics.
• Scheidegger, S. (2014) 'Exploring dose rate dependence of cancer risk by a dynamic LQ-type model', in Klöck, S. (ed.) Joint conference of the SSRMP, DGMP, ÖGMP : Dreiländertagung der Medizinischen Physik: Abstractbook. Zurich: SSRMP/DGMP/ÖGMP, pp. 367–368.
• Scheidegger, S. and Füchslin, R. M. (2014) 'In vitro, in vivo, in silico : Modellbildung und Computersimulation als komplementäre Labormethode', ANG Fokus, 1, pp. 82–97.
• Özden, I. and Scheidegger, S. (2014) 'The influence of scan length and collimation on the CTDIvol measurement in case of helical CT', in Klöck, S. (ed.) Joint conference of the SSRMP, DGMP, ÖGMP - Dreiländertagung der Medizinischen Physik: Abstractbook. Zürich: SGSMP/DGMP/ÖGMP, pp. 459–460.
• Haller, K. et al. (2012) 'Evaluation of the RADPAD® scatter protection shielding using an alderson phantom in a clinical situation (cardiology)', in SSRMP annual scientific meeting 2012 : Kongresshaus Biel 15th and 16th of november 2012. Biel: Swiss Society of Radiobiology and Medical Physics, p. 57.
• Haller, K., Scheidegger, S. and Lutters, G. (2012) 'Linac radiation shielding under clinical conditions : radiation protection case report', in SSRMP annual scientific meeting 2012 : Kongresshaus Biel 15th and 16th of november 2012. Biel: Swiss Society of Radiobiology and Medical Physics, p. 56.
• Meola, A. et al. (2011) 'Quality assurance of surface hyperthermia using a TLC-based measurement system', in Proceedings of the Annual Meeting of the Swiss Society for Biomedical Engineering (SSBE) 2011, p. 38.
• Scheidegger, S. and Lutters, G. (2010) 'A novel biophysical model describing repair modifications and growth inhibition of irradiated cells', SPG-Bulletin, 27, p. 41.
• Scheidegger, S. (2009) 'Comparison of image quality between a digital panorama X-ray unit with a CdTe-CMOS detector and panorama Xray units with other types of digital detectors', in SSRMP Annual Scientific Meeting 2009 : University Hospital Basel 19th and 20th of November 2009: Abstracts & Proceedings. Basel: SSRMP/DGMP/ÖGMP, pp. 63–69. Available at: http://www.ssrpm.ch/old/2009/proceedings-2009.pdf.
• Scharpf, R. and Scheidegger, S. (2009) 'Wie viel Freiheit erträgt der Lernprozess? : Erfahrungen in Projektunterricht und Maturarbeiten und Ansätze zu einem differenzierten Umgang mit offenen Lerngefässen', Gymnasium Helveticum, 9(3), pp. 30–34.
• Scheidegger, S., Lutters, G. and Bodis, S. (2009) 'Understanding tumour dynamics in vivo : the potential of kinetic models in radio-oncology', in SSRMP Annual Scientific Meeting 2009 : University Hospital Basel 19th and 20th of November 2009: Abstracts & Proceedings, pp. 18–23.
• Scheidegger, S. (2009) 'Fouriertransformation : exploratives Werkzeug im Unterricht', VSMP-Bulletin, 2009(109), pp. 11–18.
• Scheidegger, S. (2008) 'Computersimulation eines Teslatransformators', VSMP-Bulletin, 2008(107), pp. 10–17.
• Scheidegger, S. (2002) Physikalische Grundlagen der Dosimetrie im Strahlenschutz. 2. Auflage. Villigen: Paul Scherrer Institut.
• Scheidegger, S., Estermann, M. A. and Steurer, W. (1997) 'Diffuse scattering in aperiodic materials : the pixelwise absorption correction for area detectors', in de Boissieu, M., Verger-Gaugry, J.-L., and Currat, R. (eds) Aperiodic" 97 : proceedings of the international conference on aperiodic crystals, Alpe d'Huez, France, 27-31 august 1997. Singapore: World Scientific Publishing, pp. 473–477.

Oral conference contributions and abstracts

• Karimipourfard, M. et al. (2025) 'Identifying robust radiomic features in CT imaging for predicting object contrast variation', in 2025 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD). IEEE. doi: 10.1109/nss/mic/rtsd57106.2025.11286456.
• Mingo Barba, S. et al. (2022) 'The use of dose rate dependencies as a theoretical discrimination criteria in radiobiological models', in 4th European Congress of Medical Physics, Dublin, Ireland, 17-20 August 2022.
• Mingo Barba, S. et al. (2022) 'The use of qualitative and quantitative hyperthermic effects as discrimination criteria in radiobiological models', in 34th Annual Meeting European Society for Hyperthermic Oncology, Gothenburg, Sweden, 14-17 September 2022.
• Sommer, C. et al. (2021) 'Using difference detail curves to assess image quality of low contrast abdominal CT scans', in 3rd European Congress of Medical Physics (ECMP), virtual, 16 June - 31 December 2021.
• Füchslin, R. M. et al. (2019) 'Morphological computation and control in medicine and related sciences', in BioDynaMo, Zurich, 2-3 December 2019.
• Weyland, M. et al. (2018) 'Dynamic DNA damage and repair modeling : bridging the gap between experimental damage readout and model structure', in XIII International Workshop on Artificial Life and Evolutionary Computation (WIVACE), Parma, Italy, 10-12 September 2018.
• Weyland, M. et al. (2018) 'Extracting information about cellular repair processes after hyperthermia – radiotherapy by model-based data analysis : ambiguities in survival prediction as a challenge?', in Strahlentherapie und Onkologie. Springer, p. 503. doi: 10.1007/s00066-018-1295-1.
• Oezden, I. et al. (2015) 'The use of dose length product DLP, signal-to-noise ratio SNR and difference detail curve DDC for protocol characterization and optimization', in Annual Scientific Meeting 2015, Schweizerische Gesellschaft für Strahlenbiologie und Medizinische Physik (SSRMP), Fribourg, 21-22 October 2015.
• Scheidegger, S. et al. (2013) 'Potential of optimisation of CR- and DR-units', in Swiss Congress of Radiology (SCR 13), Lucerne, 30 May - 1 June 2013.
• De Abreu Vieira, L., Markert, B. and Scheidegger, S. (2013) 'CTDI measurements for clinical protocols and comparison to CTDI indications of CTs', in Swiss Congress of Radiology (SCR 13), Lucerne, 30 May - 1 June 2013.
• Füchslin, R. M. et al. (2013) 'Morphological control as guiding principle in physiology and medical applications', in Int. Workshop on Soft Robotics and Morphological Computation, Ascona, 19 July 2013.
• Scheidegger, S. et al. (2012) 'The dynamic view to hyperthermia : a comparison of the CEM43° concept', in Strahlentherapie und Onkologie. Springer, p. 738. doi: 10.1007/s00066-012-0181-5.
• Fässler, C. et al. (2011) 'CR-based method for measuring the dose distribution in an anthropomorphic phantom', in Abstractband: 3 Ländertagung der ÖGMP, DGMP und SGSMP : Medizinische Physik: Wien, 28.09.-01.10.2011, p. 96. Available at: https://dgmp.de/downloadfile/45be2030-0de8-f911-9891-a6c0612b6bd2/2011-dreilaendertagung-abstractband.pdf.
• Lohse, I. et al. (2011) 'Dose-rate effect of novel radiation technologies : relevance for the clinical use and radiobiological models', in Molecular Radiation Biology, Oncology. Verein zur Durchführung des Annual Wolfsberg Meeting on Molecular Radiation Biology, p. 48.
• Scheidegger, S., Zaugg, K. and Bodis, S. (2011) 'Induced repair as unique approach to model apoptotic and non-apoptotic cell survival', in Strahlentherapie und Onkologie. Springer, p. 520.
• Scheidegger, S., Lutters, G. and Bodis, S. (2009) 'A novel approach for biomathematical modelling to predict treatment response for combined radiotherapy modalities in vivo', in 11th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology, Ermatingen, 27-29 June 2009.

Affiliations

Current Affiliations

Naturama: councellor
advisory council, Aarau
04 / 2025 - today

go back