Novel cell-based immunization technology and functional validation of resulting antibodies
Description
Development of a novel immunization method in rabbits that improves the generation of antibodies against the native form of human proteins e.g. cell surface receptors. Subsequent validation of the method through functional characterization of candidate therapeutic antibodies in vitro and in vivo. The aim is the discovery of monoclonal antibodies as novel therapeutics for two different first in class targets in cancer.
Key data
Projectlead
Deputy Projectlead
Dr. Bruno Filippi
Co-Projectlead
Prof. Dr. Frank Stenner, Dr. Philippe Krebs
Project team
Leopold von Balthazar, Jenny Pally, Bettina Keller Abu Seda
Project partners
Memo Therapeutics AG
Project status
completed, 12/2017 - 11/2020
Institute/Centre
Institute of Chemistry and Biotechnology (ICBT)
Funding partner
KTI-Projekt / Projekt Nr. 26019.2 PFLS-LS
Project budget
1'581'835 CHF