Prof. Dr. Jack Rohrer

Projects

• A platform enabling efficient and effective delivery and packaging of therapeutic molecules / Project leader / completed
• Novel cell-based immunization technology and functional validation of resulting antibodies / Project leader / completed
• Antibody discovery for therapy of pain / Project leader / completed

Publications

Articles in scientific journal, peer-reviewed

• Beffinger, M. et al. (2025) ‘FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma’, Nature Communications, 2025(16), p. 4751. doi: 10.1038/s41467-025-59971-0.
• Sabani, B. et al. (2023) ‘A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging’, Nanomedicine: Nanotechnology, Biology and Medicine, 47(102607). doi: 10.1016/j.nano.2022.102607.
• Kozono, T. et al. (2021) ‘The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region’, Scientific Reports, 11(753). doi: 10.1038/s41598-020-80258-5.
• Luginbühl, V. et al. (2018) ‘Intracellular drug delivery : potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy’, Biotechnology Advances, 36(3), pp. 613–623. doi: 10.1016/j.biotechadv.2018.02.005.
• Peanne, R. et al. (2011) ‘Differential effects of lobe A and lobe B of the conserved oligomeric golgi complex on the stability of β1,4-galactosyltransferase 1 and α2,6-sialyltransferase 1’, Glycobiology, 21(7), pp. 864–876. doi: 10.1093/glycob/cwq176.
• Schaub, B. E., Berger, E. G. and Rohrer, J. (2008) ‘Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition’, Cellular and Molecular Life Sciences, 65(22), pp. 3677–3687. doi: 10.1007/s00018-008-8446-y.
• Schaub, B. E. et al. (2006) ‘Transition of galactosyltransferase 1 from trans-golgi cisterna to the trans-golgi network is signal mediated’, Molecular Biology of the Cell, 17(12), pp. 5153–5162. doi: 10.1091/mbc.e06-08-0665.
• Nair, P. et al. (2005) ‘Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme’, Journal of Cell Science, 118(13), pp. 2949–2956. doi: 10.1242/jcs.02434.
• Pulipparacharuvil, S. et al. (2005) ‘Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules’, Journal of Cell Science, 118(16), pp. 3663–3673. doi: 10.1242/jcs.02502.
• Stöckli, J. and Rohrer, J. (2004) ‘The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes’, Molecular Biology of the Cell, 15(6), pp. 2617–2626. doi: 10.1091/mbc.e03-11-0808.
• Müntener, K. et al. (2004) ‘Exon skipping of cathepsin B : mitochondrial targeting of a lysosomal peptidase provokes cell death’, Journal of Biological Chemistry, 279(39), pp. 41012–41017. doi: 10.1074/jbc.M405333200.
• Stöckli, J., Höning, S. and Rohrer, J. (2004) ‘The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding’, Journal of Biological Chemistry, 279(22), pp. 23542–23549. doi: 10.1074/jbc.M313525200.
• Nair, P., Schaub, B. E. and Rohrer, J. (2003) ‘Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor’, Journal of Biological Chemistry, 278(27), pp. 24753–24758. doi: 10.1074/jbc.M300174200.
• Berger, E. G. and Rohrer, J. (2003) ‘Galactosyltransferase — still up and running’, Biochimie, 85(3-4), pp. 261–274. doi: 10.1016/S0300-9084(03)00008-7.
• Crottet, P. et al. (2002) ‘ARF1.GTP, tyrosine-based signals, and phosphatidylinositol 4,5-bisphosphate constitute a minimal machinery to recruit the AP-1 clathrin adaptor to membranes’, Molecular Biology of the Cell, 13(10), pp. 3672–3682. doi: 10.1091/mbc.e02-05-0309.
• Mathews, P. M. et al. (2002) ‘Alzheimer’s disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Aβ secretion : role for altered lysosomal hydrolase distribution in β-amyloidogenesis’, Journal of Biological Chemistry, 277(7), pp. 5299–5307. doi: 10.1074/jbc.M108161200.
• Lee, W.-S. et al. (2002) ‘Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme’, Journal of Biological Chemistry, 277(5), pp. 3544–3551. doi: 10.1074/jbc.M108531200.
• Rohrer, J. and Kornfeld, R. (2001) ‘Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network’, Molecular Biology of the Cell, 12(6), pp. 1623–1631. doi: 10.1091/mbc.12.6.1623.
• Schweizer, A., Stahl, P. D. and Rohrer, J. (2000) ‘A di-aromatic motif in the cytosolic tail of the mannose receptor mediates endosomal sorting’, Journal of Biological Chemistry, 275(38), pp. 29694–29700. doi: 10.1074/jbc.M000571200.
• Schweizer, A. et al. (1999) ‘Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family’, Journal of Biological Chemistry, 274(29), pp. 20450–20456. doi: 10.1074/jbc.274.29.20450.
• Schweizer, A., Löffler, B.-M. and Rohrer, J. (1999) ‘Palmitoylation of the three isoforms of human endothelin-converting enzyme-1’, Biochemical Journal, 340(3), pp. 649–656. doi: 10.1042/bj3400649.
• Olayioye, M. A. et al. (1998) ‘ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner’, Molecular and Cellular Biology, 18(9), pp. 5042–5051. doi: 10.1128/MCB.18.9.5042.
• Schweizer, A., Kornfeld, S. and Rohrer, J. (1997) ‘Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail’, Proceedings of the National Academy of Sciences of the United States of America, 94(26), pp. 14471–14476. doi: 10.1073/pnas.94.26.14471.
• Hicke, L. et al. (1997) ‘Transport through the yeast endocytic pathway occurs through morphologically distinct compartments and requires an active secretory pathway and Sec18p/N-ethylmaleimide-sensitive fusion protein’, Molecular Biology of the Cell, 8(1), pp. 13–31. doi: 10.1091/mbc.8.1.13.
• Rohrer, J. et al. (1996) ‘The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane’, Journal of Cell Biology, 132(4), pp. 565–576. doi: 10.1083/jcb.132.4.565.
• Schweizer, A., Kornfeld, S. and Rohrer, J. (1996) ‘Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting’, Journal of Cell Biology, 132(4), pp. 577–584. doi: 10.1083/jcb.132.4.577.
• Schweizer, A. et al. (1995) ‘Reassessment of the subcellular localization of p63’, Journal of Cell Science, 108, pp. 2477–2485. Available at: http://jcs.biologists.org/content/108/6/2477.
• Rohrer, J. et al. (1995) ‘A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes’, Journal of Cell Biology, 130(6), pp. 1297–1306. doi: 10.1083/jcb.130.6.1297.
• Schweizer, A., Rohrer, J. and Kornfeld, S. (1995) ‘Determination of the structural requirements for palmitoylation of p63’, Journal of Biological Chemistry, 270(16), pp. 9638–9644. doi: 10.1074/jbc.270.16.9638.
• Schweizer, A. et al. (1994) ‘Retention of p63 in an ER-Golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers’, Journal of Cell Biology, 126(1), pp. 25–39. doi: 10.1083/jcb.126.1.25.
• Schweizer, A. et al. (1993) ‘A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein’, Journal of Cell Science, 104, pp. 685–694. Available at: http://jcs.biologists.org/content/104/3/685.short.
• Rohrer, J. et al. (1993) ‘Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast’, Molecular Biology of the Cell, 4(5), pp. 511–521. doi: 10.1091/mbc.4.5.511.
• Raths, S. et al. (1993) ‘end3 and end4 : two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae’, Journal of Cell Biology, 120(1), pp. 55–65. doi: 10.1083/jcb.120.1.55.
• Rohrer, J. and Kuhn, A. (1990) ‘The function of a leader peptide in translocating charged amino acyl residues across a membrane’, Science, 250(4986), pp. 1418–1421. doi: 10.1126/science.2124001.
• Kuhn, A., Rohrer, J. and Gallusser, A. (1990) ‘Bacteriophages M13 and Pf3 tell us how proteins insert into the membrane’, Journal of Structural Biology, 104(1-3), pp. 38–43. doi: 10.1016/1047-8477(90)90055-H.

Other publications

• Raghunath, M. et al. (2016) ‘Zurich University of Applied Sciences : center for cell biology and tissue engineering’, in Roche Symposium, Basel, 2016.
• Rimann, M. et al. (2016) ‘Zurich university of applied sciences : center for cell biology and tissue engineering’, in Roche Symposium, Basel, 2016.
• Schaub, B. E., Nair, P. and Rohrer, J. (2005) ‘Analysis of protein transport to lysosomes’, Current Protocols in Cell Biology, 27(1). doi: 10.1002/0471143030.cb1508s27.

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